Zhu, Lanwei Peng, Qi Wu, Yingjie Yao, Xinsheng
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Cellular and molecular life sciences : CMLS
Since the initial report of V (D) J "allelic exclusion/inclusion" (allelic exclusion rearrangement or allelic inclusion rearrangement) and the concept of the "dual B cell receptor (BCR)" in 1961, despite ongoing discoveries, the precise proportion and source mechanism of dual BCR under physiological conditions have been puzzling immuologists. This ...
Lampart, Agata Krowarsch, Daniel Biadun, Martyna Sorensen, Vigdis Szymczyk, Jakub Sluzalska, Katarzyna Wiedlocha, Antoni Otlewski, Jacek Zakrzewska, Malgorzata
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Cellular and molecular life sciences : CMLS
Fibroblast growth factor 1 (FGF1) acts by activating specific tyrosine kinase receptors on the cell surface. In addition to this classical mode of action, FGF1 also exhibits intracellular activity. Recently, we found that FGF1 translocated into the cell interior exhibits anti-apoptotic activity independent of receptor activation and downstream sign...
Yu, Xiaohong Yuan, Hui Yang, Yanan Zheng, Wei Zheng, Xuejing Lu, Shih-Hsin Jiang, Wei Yu, Xiying
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Cellular and molecular life sciences : CMLS
Self-renewing, damage-repair and differentiation of mammalian stratified squamous epithelia are subject to tissue homeostasis, but the regulation mechanisms remain elusive. Here, we investigate the esophageal squamous epithelial tissue homeostasis in vitro and in vivo. We establish a rat esophageal organoid (rEO) in vitro system and show that the l...
Guan, Teng Zhou, Ting Zhang, Xiaosha Guo, Ying Yang, Chaoxian Lin, Justin Zhang, Jiasi Vicky Cheng, Yongquan Marzban, Hassan Wang, Yu Tian
...
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Cellular and molecular life sciences : CMLS
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. There is no cure currently. The discovery that mutations in the gene SOD1 are a cause of ALS marks a breakthrough in the search for effective treatments for ALS. SOD1 is an antioxidant that is highly expressed in motor neurons. Human SOD1 is prone to aberrant modificati...
Seo, Bong Jong Na, Seung Bin Choi, Joonhyuk Ahn, Byeongyong Habib, Omer Park, Chankyu Hong, Kwonho Do, Jeong Tae
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Cellular and molecular life sciences : CMLS
Mitochondria are versatile organelles that continuously change their morphology via fission and fusion. However, the detailed functions of mitochondrial dynamics-related genes in pluripotent stem cells remain largely unclear. Here, we aimed to determine the effects on energy metabolism and differentiation ability of mouse embryonic stem cells (ESCs...
Ivanov, Konstantin I Samuilova, Olga V Zamyatnin, Andrey A Jr
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Cellular and molecular life sciences : CMLS
Recent advances in RNA sequencing technologies helped uncover what was once uncharted territory in the human genome-the complex and versatile world of long noncoding RNAs (lncRNAs). Previously thought of as merely transcriptional "noise", lncRNAs have now emerged as essential regulators of gene expression networks controlling development, homeostas...
Alves, Victoria Cunha Figueiro-Silva, Joana Ferrer, Isidre Carro, Eva
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Cellular and molecular life sciences : CMLS
Modulation of brain olfactory (OR) and taste receptor (TASR) expression was recently reported in neurological diseases. However, there is still limited evidence of these genes' expression in the human brain and the transcriptional regulation mechanisms involved remain elusive. We explored the possible expression and regulation of selected OR and TA...
Cheema, U Brown, R A Alp, B MacRobert, A J
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Cellular and molecular life sciences : CMLS
Sarramegna, V Muller, I Milon, A Talmont, F
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Cellular and molecular life sciences : CMLS
Hua, Jennifer Garcia de Paco, Elvira Linck, Nathalie Maurice, Tangui Desrumaux, Catherine Manoury, Bénédicte Rassendren, François Ulmann, Lauriane
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Cellular and molecular life sciences : CMLS
Numerous evidences support that microglia contributes to the progression of Alzheimer's disease. P2X4 receptors are ATP-gated channels with high calcium permeability, which are de novo expressed in a subset of reactive microglia associated with various pathological contexts, contributing to microglial functions. P2X4 receptors are mainly localized ...
