Jia, Jie Yue, Xihua Zhu, Lianhui Jing, Shuaiyang Wang, Yijing Gim, Bopil Qian, Yi Lee, Intaek
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Cellular and molecular life sciences : CMLS
KDEL receptor cycles between the ER and the Golgi to retrieve ER-resident chaperones that get leaked to the secretory pathway during protein export from the ER. Recent studies have shown that a fraction of KDEL receptor may reside in the plasma membrane and function as a putative cell surface receptor. However, the trafficking itinerary and mechani...
Chen, Qi Gu, Meng Cai, Zhi-Kang Zhao, Hu Sun, Shi-Cheng Liu, Chong Zhan, Ming Chen, Yan-Bo Wang, Zhong
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Cellular and molecular life sciences : CMLS
CD44 is a marker of cancer stem cell (CSC) in many types of tumors. Alternative splicing of its 20 exons generates various CD44 isoforms that have different tissue specific expression and functions, including the CD44 standard isoform (CD44s) encoded by the constant exons and the CD44 variant isoforms (CD44v) with variant exon insertions. Switching...
Carriba, Paulina Davies, Alun M
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Cellular and molecular life sciences : CMLS
CD40-activated CD40L reverse signaling is a major physiological regulator of axon and dendrite growth from developing hippocampal pyramidal neurons. Here we have studied how CD40L-mediated reverse signaling promotes the growth of these processes. Cultures of hippocampal pyramidal neurons were established from Cd40-/- mouse embryos to eliminate endo...
Li, Zhen-Lu Müller-Greven, Jeannine Kim, SoonJeung Tamagnone, Luca Buck, Matthias
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Cellular and molecular life sciences : CMLS
Plexins receive guidance cues from semaphorin ligands and transmit their signal through the plasma membrane. This family of proteins is unique amongst single-pass transmembrane receptors as their intracellular regions interact directly with several small GTPases, which regulate cytoskeletal dynamics and cell adhesion. Here, we characterize the GTPa...
El-Darzi, Nicole Mast, Natalia Petrov, Alexey M Dao, Tung Astafev, Artem A Saadane, Aicha Prendergast, Erin Schwarz, Emmy Bederman, Ilya Pikuleva, Irina A
...
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Cellular and molecular life sciences : CMLS
Apolipoprotein D (APOD) is an atypical apolipoprotein with unknown significance for retinal structure and function. Conversely, apolipoprotein E (APOE) is a typical apolipoprotein with established roles in retinal cholesterol transport. Herein, we immunolocalized APOD to the photoreceptor inner segments and conducted ophthalmic characterizations of...
Cole, Alexander J Dickson, Kristie-Ann Liddle, Christopher Stirzaker, Clare Shah, Jaynish S Clifton-Bligh, Roderick Marsh, Deborah J
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Cellular and molecular life sciences : CMLS
Modification of the cancer-associated chromatin landscape in response to therapeutic DNA damage influences gene expression and contributes to cell fate. The central histone mark H2Bub1 results from addition of a single ubiquitin on lysine 120 of histone H2B and is an important regulator of gene expression. Following treatment with a platinum-based ...
Fischer, Caroline Endle, Heiko Schumann, Lana Wilken-Schmitz, Annett Kaiser, Julia Gerber, Susanne Vogelaar, Christina F Schmidt, Mirko H H Nitsch, Robert Snodgrass, Isabel
...
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Cellular and molecular life sciences : CMLS
Recent studies suggest that synaptic lysophosphatidic acids (LPAs) augment glutamate-dependent cortical excitability and sensory information processing in mice and humans via presynaptic LPAR2 activation. Here, we studied the consequences of LPAR2 deletion or antagonism on various aspects of cognition using a set of behavioral and electrophysiologi...
Lingelem, Anne Berit Dyve Kavaliauskiene, Simona Halsne, Ruth Klokk, Tove Irene Surma, Michal A Klose, Christian Skotland, Tore Sandvig, Kirsten
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Cellular and molecular life sciences : CMLS
The membrane lipids diacylglycerol (DAG) and phosphatidic acid (PA) are important second messengers that can regulate membrane transport by recruiting proteins to the membrane and by altering biophysical membrane properties. DAG and PA are involved in the transport from the Golgi apparatus to endosomes, and we have here investigated whether changes...
Prevost, Marie S Bouchenaki, Hichem Barilone, Nathalie Gielen, Marc Corringer, Pierre-Jean
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Cellular and molecular life sciences : CMLS
Nicotinic acetylcholine receptors (nAChRs) are pentameric ion channels expressed in the central nervous systems. nAChRs containing the α4, β2 and α5 subunits are specifically involved in addictive processes, but their functional architecture is poorly understood due to the intricacy of assembly of these subunits. Here we constrained the subunit ass...
Xu, Wei Dielubanza, Elodi Maisel, Amanda Leung, Kai Mustoe, Thomas Hong, Seok Galiano, Robert
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Cellular and molecular life sciences : CMLS
Chronic wounds have been considered as major medical problems that may result in expensive healthcare. One of the common causes of chronic wounds is bacterial contamination that leads to persistent inflammation and unbalanced host cell immune responses. Among the bacterial strains that have been identified from chronic wounds, Staphylococcus aureus...
