Górski, Andrzej Jończyk-Matysiak, Ewa Łusiak-Szelachowska, Marzanna Międzybrodzki, Ryszard Weber-Dąbrowska, Beata Borysowski, Jan
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Cellular and molecular life sciences : CMLS
In addition to their established role as a physical barrier to invading pathogens and other harmful agents, intestinal epithelial cells (IEC) are actively involved in local immune reactions. In the past years, evidence has accumulated suggesting the role of IEC in the immunopathology of intestinal inflammatory disorders (IBD). Recent advances in re...
Naudet, Nicolas Moutal, Aubin Vu, Hong Nhung Chounlamountri, Naura Watrin, Chantal Cavagna, Sylvie Malleval, Céline Benetollo, Claire Bardel, Claire Dronne, Marie-Aimée
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Cellular and molecular life sciences : CMLS
Transcriptional regulation of proteins involved in neuronal polarity is a key process that underlies the ability of neurons to transfer information in the central nervous system. The Collapsin Response Mediator Protein (CRMP) family is best known for its role in neurite outgrowth regulation conducting to neuronal polarity and axonal guidance, inclu...
Deborde, Sylvie Wong, Richard J
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Cellular and molecular life sciences : CMLS
Recent studies have demonstrated a critical role for nerves in enabling tumor progression. The association of nerves with cancer cells is well established for a variety of malignant tumors, including pancreatic, prostate and the head and neck cancers. This association is often correlated with poor prognosis. A strong partnership between cancer cell...
Golick, Lena Han, Youngah Kim, Yoo Park, Sang Won
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Cellular and molecular life sciences : CMLS
Reduced hepatic expression levels of bromodomain-containing protein 7 (BRD7) have been suggested to play a role in the development of glucose intolerance in obesity. However, the molecular mechanism by which BRD7 regulates glucose metabolism has remained unclear. Here, we show that BRD7 increases phosphorylation of glycogen synthase kinase 3β (GSK3...
Wujak, Lukasz Böttcher, Ralph T Pak, Oleg Frey, Helena El Agha, Elie Chen, Ying Schmitt, Sigrid Bellusci, Saverio Schaefer, Liliana Weissmann, Norbert
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Cellular and molecular life sciences : CMLS
Low density lipoprotein receptor-related protein (LRP) 1 modulates cell adhesion and motility under normal and pathological conditions. Previous studies documented that LRP1 binds several integrin receptors and mediates their trafficking to the cell surface and endocytosis. However, the mechanism by which LRP1 may regulate integrin activation remai...
Holdt, Lesca M Kohlmaier, Alexander Teupser, Daniel
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Cellular and molecular life sciences : CMLS
Protein-coding and noncoding genes in eukaryotes are typically expressed as linear messenger RNAs, with exons arranged colinearly to their genomic order. Recent advances in sequencing and in mapping RNA reads to reference genomes have revealed that thousands of genes express also covalently closed circular RNAs. Many of these circRNAs are stable an...
Dahal, Sumedha Dubey, Shubham Raghavan, Sathees C
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Cellular and molecular life sciences : CMLS
Mitochondrial DNA is frequently exposed to oxidative damage, as compared to nuclear DNA. Previously, we have shown that while microhomology-mediated end joining can account for DNA deletions in mitochondria, classical nonhomologous DNA end joining, the predominant double-strand break (DSB) repair pathway in nucleus, is undetectable. In the present ...
Goetz, Alexandra E Wilkinson, Miles
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Cellular and molecular life sciences : CMLS
The original version of this article unfortunately contained errors in the section entitled "NMD in stress responses in plants".
Peek, Stacey L Mah, Kar Men Weiner, Joshua A
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Cellular and molecular life sciences : CMLS
The protocadherins (Pcdhs), which make up the most diverse group within the cadherin superfamily, were first discovered in the early 1990s. Data implicating the Pcdhs, including ~60 proteins encoded by the tandem Pcdha, Pcdhb, and Pcdhg gene clusters and another ~10 non-clustered Pcdhs, in the regulation of neural development have continually accum...
Sun, Tao Li, Yuan Li, Ting Ma, Huixian Guo, Yunyun Jiang, Xingyu Hou, Ming Huang, Shuhong Chen, Zheyu
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Cellular and molecular life sciences : CMLS
Long-range anterograde axonal transport of TrkB is important for neurons to exert appropriate BDNF responses. TrkB anterograde axonal delivery is mediated by kinesin-1, which associates with TrkB via the adaptor protein JIP3 or the Slp1/Rab27B/CRMP-2 protein complex. However, little is known about the activation mechanisms of TrkB-loaded kinesin-1....
