Gillot, Lionel Lebeau, Alizée Baudin, Louis Pottier, Charles Louis, Thomas Durré, Tania Longuespée, Rémi Mazzucchelli, Gabriel Nizet, Christophe Blacher, Silvia
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Cellular and molecular life sciences : CMLS
Although lymph node (LN) metastasis is an important prognostic parameter in cervical cancer, the tissue remodeling at a pre-metastatic state is poorly documented in LNs. We here identified periostin (POSTN) as a component of non-metastatic LNs by applying proteomic analyses and computerized image quantifications on LNs of patients with cervical can...
Dietrich, Bianca Haider, Sandra Meinhardt, Gudrun Pollheimer, Jürgen Knöfler, Martin
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Cellular and molecular life sciences : CMLS
Correct development of the human placenta and its differentiated epithelial cells, syncytial trophoblasts (STBs) and extravillous trophoblasts (EVTs), is crucial for a successful pregnancy outcome. STBs develop by cell fusion of mononuclear cytotrophoblasts (CTBs) in placental floating villi, whereas migratory EVTs originate from specialized villi ...
Choi, Gee Euhn Chae, Chang Woo Park, Mo Ran Yoon, Jee Hyeon Jung, Young Hyun Lee, Hyun Jik Han, Ho Jae
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Cellular and molecular life sciences : CMLS
Exposure to maternal stress irreversibly impairs neurogenesis of offspring by inducing life-long effects on interaction between neurons and glia under raging differentiation process, culminating in cognitive and neuropsychiatric abnormalities in adulthood. We identified that prenatal exposure to stress-responsive hormone glucocorticoid impaired neu...
Chen, Si-Qi Chen, Xue-Yan Cui, Ying-Zhe Yan, Bing-Xi Zhou, Yuan Wang, Zhao-Yuan Xu, Fan Huang, Yan-Zhou Zheng, Yu-Xin Man, Xiao-Yong
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Cellular and molecular life sciences : CMLS
Recent studies have illustrated that psoriatic lesions are innervated by dense sensory nerve fibers. Psoriatic plaques appeared to improve after central or peripheral nerve injury. Therefore, the nervous system may play a vital role in psoriasis. We aimed to clarify the expression of nerve fibers in psoriasis and their relationship with immune cell...
Wu, Fan Hill, Kayla Fang, Qiaojun He, Zuhong Zheng, Hongwei Wang, Xianren Xiong, Hao Sha, Su-Hua
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Cellular and molecular life sciences : CMLS
The Ca2+/calmodulin-dependent protein kinase kinases (CaMKKs) are serine/threonine-directed protein kinases that are activated following increases in intracellular calcium, playing a critical role in neuronal signaling. Inner-ear-trauma-induced calcium overload in sensory hair cells has been well documented in the pathogenesis of traumatic noise-in...
Sim, Sang Wan Jang, Yuyeon Park, Tae Sub Park, Byung-Chul Lee, Young Mok Jun, Hyun Sik
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Cellular and molecular life sciences : CMLS
Glycogen storage disease type Ib (GSD-Ib), characterized by impaired glucose homeostasis, neutropenia, and neutrophil dysfunction, is caused by a deficiency in glucose-6-phosphate transporter (G6PT). Neutropenia in GSD-Ib has been known to result from enhanced apoptosis of neutrophils. However, it has also been raised that neutrophil maturation arr...
Gass, Maximilian M Borkowsky, Sarah Lotz, Marie-Luise Siwek, Rebecca Schröter, Rita Nedvetsky, Pavel Luschnig, Stefan Rohlmann, Astrid Missler, Markus Krahn, Michael P
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Cellular and molecular life sciences : CMLS
Drosophila nephrocytes are an emerging model system for mammalian podocytes and proximal tubules as well as for the investigation of kidney diseases. Like podocytes, nephrocytes exhibit characteristics of epithelial cells, but the role of phospholipids in polarization of these cells is yet unclear. In epithelia, phosphatidylinositol(4,5)bisphosphat...
Min, Yanan Hao, Long Liu, Xinguang Tan, Shuai Song, Hui Ni, Hao Sheng, Zi Jooss, Natalie Liu, Xuena Malmström, Rickard E
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Cellular and molecular life sciences : CMLS
Platelets are an able regulator of CD4+ T cell immunity. Herein, the mechanisms underlying platelet-regulated effector responses of naïve CD4+ T (Tn) cells were investigated. Platelet-Tn cell co-cultures of human cells, genetically modified murine models, and high-throughput bioinformatic analyses were combined to elucidate molecular mechanisms of ...
Zhang, Zhiye Shen, Chuanbin Fang, Mingqian Han, Yajun Long, Chengbo Liu, Weihui Yang, Min Liu, Ming Zhang, Dengdeng Cao, Qiqi
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Cellular and molecular life sciences : CMLS
Ischemic stroke is a leading cause of death and disability worldwide. Increasing evidence indicates that ischemic stroke is a thromboinflammatory disease in which the contact-kinin pathway has a central role by activating pro-coagulant and pro-inflammatory processes. The blocking of distinct members of the contact-kinin pathway is a promising strat...
Wei, Tao Liu, Hongsen Zhu, Huihui Chen, Wenqi Wu, Tingting Bai, Yuerong Zhang, Xueyan Miao, Yujuan Wang, Fei Cai, Yong
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Cellular and molecular life sciences : CMLS
Human males absent on the first (MOF), a histone acetyltransferase (HAT), forms male-specific lethal (MSL) and non-specific lethal (NSL), two multiprotein HATs, in cells. MSL was originally discovered in dosage compensation study in Drosophila that can specifically acetylate H4K16, while NSL can simultaneously catalyze the H4 at K5, K8, and K16 sit...
