Stiefbold, Madison Zhang, Haokang Wan, Leo Q
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Cellular and molecular life sciences : CMLS
Congenital heart defects are associated with significant health challenges, demanding a deep understanding of the underlying biological mechanisms and, thus, better devices or platforms that can recapitulate human cardiac development. The discovery of human pluripotent stem cells has substantially reduced the dependence on animal models. Recent adv...
Liu, Meng He, Li
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Cellular and molecular life sciences : CMLS
The high-protein diet (HPD) has emerged as a potent dietary approach to curb obesity. Peroxisome, a highly malleable organelle, adapts to nutritional changes to maintain homeostasis by remodeling its structure, composition, and quantity. However, the impact of HPD on peroxisomes and the underlying mechanism remains elusive. Using Drosophila melanog...
Marrocco, Remi Bernard, Isabelle Joulia, Emeline Barascud, Rebecca Dejean, Anne S Lesourne, Renaud Saoudi, Abdelhadi
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Cellular and molecular life sciences : CMLS
The susceptibility to autoimmune diseases is conditioned by the association of modest genetic alterations which altogether weaken self-tolerance. The mechanism whereby these genetic interactions modulate T-cell pathogenicity remains largely uncovered. Here, we investigated the epistatic interaction of two interacting proteins involved in T Cell Rec...
Da Cunha, Dylan Miro, Julie Van Goethem, Charles Notarnicola, Cécile Hugon, Gérald Carnac, Gilles Cossée, Mireille Koenig, Michel Tuffery-Giraud, Sylvie
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Cellular and molecular life sciences : CMLS
Deposition of the exon junction complex (EJC) upstream of exon-exon junctions helps maintain transcriptome integrity by preventing spurious re-splicing events in already spliced mRNAs. Here we investigate the importance of EJC for the correct splicing of the 2.2-megabase-long human DMD pre-mRNA, which encodes dystrophin, an essential protein involv...
Li, Guohao Zhao, Xiangqian Zheng, Zuda Zhang, Hucheng Wu, Yundi Shen, Yangkun Chen, Qi
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Cellular and molecular life sciences : CMLS
Type I interferons (IFN-I) play pivotal roles in tumor therapy for three decades, underscoring the critical importance of maintaining the integrity of the IFN-1 signaling pathway in radiotherapy, chemotherapy, targeted therapy, and immunotherapy. However, the specific mechanism by which IFN-I contributes to these therapies, particularly in terms of...
Liu, Kaijing Wehling, Lilija Wan, Shan Weiler, Sofia M E Tóth, Marcell Ibberson, David Marhenke, Silke Ali, Adnan Lam, Macrina Guo, Te
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Cellular and molecular life sciences : CMLS
The Hippo pathway and its transcriptional effectors yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are targets for cancer therapy. It is important to determine if the activation of one factor compensates for the inhibition of the other. Moreover, it is unknown if YAP/TAZ-directed perturbation affects cell-...
Mao, Shuyu Xie, Chong Liu, Yufeng Zhao, Ye Li, Mengxia Gao, Han Xiao, Yue Zou, Yongkang Zheng, Zhiguo Gao, Ya
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Cellular and molecular life sciences : CMLS
APE1 is an essential gene involved in DNA damage repair, the redox regulation of transcriptional factors (TFs) and RNA processing. APE1 overexpression is common in cancers and correlates with poor patient survival. Stress granules (SGs) are phase-separated cytoplasmic assemblies that cells form in response to environmental stresses. Precise regulat...
Gowd, Vemana Kass, Joseph D'Amato Sarkar, Nandini Ramakrishnan, Parameswaran
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Cellular and molecular life sciences : CMLS
Sam68 is a ubiquitously expressed KH-domain containing RNA-binding protein highly studied for its involvement in regulating multiple steps of RNA metabolism. Sam68 also contains multiple protein-protein interaction regions such as proline-rich regions, tyrosine phosphorylation sites, and arginine methylation sites, all of which facilitate its parti...
Lattmann, Evelyn Räss, Luca Tognetti, Marco Gómez, Julia M Martínez Lapaire, Valérie Bruderer, Roland Reiter, Lukas Feng, Yuehan Steinmetz, Lars M Levesque, Mitchell P
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Cellular and molecular life sciences : CMLS
Extracellular vesicles (EVs) are important players in melanoma progression, but their use as clinical biomarkers has been limited by the difficulty of profiling blood-derived EV proteins with high depth of coverage, the requirement for large input amounts, and complex protocols. Here, we provide a streamlined and reproducible experimental workflow ...
Wang, Hao Li, Qi Yuan, Ying-Chao Han, Xue-Chun Cao, Yong-Ting Yang, Jin-Kui
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Cellular and molecular life sciences : CMLS
Glucose-stimulated insulin secretion (GSIS) in pancreatic islet β-cells primarily relies on electrophysiological processes. Previous research highlighted the regulatory role of KCNH6, a member of the Kv channel family, in governing GSIS through its influence on β-cell electrophysiology. In this study, we unveil a novel facet of KCNH6's function con...