Wang, Shuyong Wang, Xuan Wang, Yunfang
Published in
Cellular and molecular gastroenterology and hepatology
The liver exhibits remarkable regenerative capacity. However, the limited ability of primary human hepatocytes to proliferate in vitro, combined with a compromised regenerative capacity induced by pathological conditions in vivo, presents significant obstacles to effective liver regeneration following liver injuries and diseases. Developing strateg...
Yang, Chunhua Sharma, Kripa Mow, Rabeya Jafrin Bolay, Eunice Srinivasan, Anand Merlin, Didier
Published in
Cellular and molecular gastroenterology and hepatology
Inflammatory bowel disease (IBD), marked by chronic gastrointestinal tract inflammation, poses a significant global medical challenge. Current treatments for IBD, including corticosteroids, immunomodulators, and biologics, often require frequent systemic administration through parenteral delivery, leading to nonspecific drug distribution, suboptima...
Dershowitz, Lori B Kaltschmidt, Julia A
Published in
Cellular and molecular gastroenterology and hepatology
The enteric nervous system (ENS) controls gastrointestinal (GI) motility, and defects in ENS development underlie pediatric GI motility disorders. In disorders such as Hirschsprung's disease (HSCR), pediatric intestinal pseudo-obstruction (PIPO), and intestinal neuronal dysplasia type B (INDB), ENS structure is altered with noted decreased neuronal...
Klochkova, Alena Karami, Adam L Fuller, Annie D Parham, Louis R Panchani, Surali R Natarajan, Shruthi Jackson, Jazmyne L Mu, Anbin Tan, Yinfei Cai, Kathy Q
...
Published in
Cellular and molecular gastroenterology and hepatology
Autophagy plays roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelial homeostasis. We generated tamoxifen-inducible, squamous epithelial-specific Atg7 (autophagy related 7) conditional knockout mice to evaluate effects on esophageal homeostasis and response to the carcinogen...
Raouf, Zachariah Steinway, Steve N Scheese, Daniel Lopez, Carla M Duess, Johannes W Tsuboi, Koichi Sampah, Maame Klerk, Daphne El Baassiri, Mahmoud Moore, Hannah
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Published in
Cellular and molecular gastroenterology and hepatology
The abdominal discomfort experienced by patients with colitis may be attributable in part to the presence of small intestinal dysmotility, yet mechanisms linking colonic inflammation with small-bowel motility remain largely unexplored. We hypothesize that colitis results in small intestinal hypomotility owing to a loss of enteroendocrine cells (EEC...
Ko, Sungjin
Published in
Cellular and molecular gastroenterology and hepatology
Hand, Nicholas J
Published in
Cellular and molecular gastroenterology and hepatology
Martinez-Uribe, Omar Becker, Thomas C Garman, Katherine S
Published in
Cellular and molecular gastroenterology and hepatology
This review was developed to provide a thorough and effective update on models relevant to esophageal metaplasia, dysplasia, and carcinogenesis, focusing on the advantages and limitations of different models of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). This expert review was written on the basis of a thorough review of the liter...
Sun, Mingyue Pylypenko, Olena Zhou, Zhe Xu, Mingqian Li, Qinghong Houdusse, Anne van IJzendoorn, Sven C D
Published in
Cellular and molecular gastroenterology and hepatology
Microvillus inclusion disease (MVID) is a rare condition that is present from birth and affects the digestive system. People with MVID experience severe diarrhea that is difficult to control, cannot absorb dietary nutrients, and struggle to grow and thrive. In addition, diverse clinical manifestations, some of which are life-threatening, have been ...
Sun, Jing Sepulveda, Jorge L Komissarova, Elena V Hills, Caitlin Seckar, Tyler D LeFevre, Narine M Simonyan, Hayk Young, Colin Su, Gloria Del Portillo, Armando
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Published in
Cellular and molecular gastroenterology and hepatology
Barrett's esophagus (BE) is the precursor of esophageal dysplasia and adenocarcinoma (EAC). CDKN2A-p16 deletions were reported in 34-74% of BE patients who progressed to dysplasia and EAC, suggesting that p16 loss may drive neoplastic progression. KRAS activation frequently occurs in EAC and pre-cancer lesions. LGR5+ stem cells in the squamocolumna...
