Di Rocco, Giuliana Baldari, Silvia Pani, Giovambattista Toietta, Gabriele
Published in
Cellular and Molecular Life Sciences
Stem cells drive embryonic and fetal development. In several adult tissues, they retain the ability to self-renew and differentiate into a variety of specialized cells, thus contributing to tissue homeostasis and repair throughout life span. Alcohol consumption is associated with an increased risk for several diseases and conditions. Growing and de...
De Bosscher, Karolien Beck, Ilse M. Dejager, Lien Bougarne, Nadia Anthoula Gaigneaux Sébastien Chateauvieux Ratman, Dariusz Bracke, Marc Tavernier, Jan Vanden Berghe, Wim
...
Published in
Cellular and Molecular Life Sciences
Glucocorticoids (GCs) block inflammation via interference of the liganded glucocorticoid receptor (GR) with the activity of pro-inflammatory transcription factors NF-κB and AP-1, a mechanism known as transrepression. This mechanism is believed to involve the activity of GR monomers. Here, we explored how the GR monomer-favoring Compound A (CpdA) af...
Li, Li Hartley, Robert Reiss, Bjoern Sun, Yaohui Pu, Jin Wu, Dan Lin, Francis Hoang, Trung Yamada, Soichiro Jiang, Jianxin
...
Published in
Cellular and Molecular Life Sciences
In wound healing and development, large epithelial sheets migrate collectively, in defined directions, and maintain tight cell-cell adhesion. This type of movement ensures an essential function of epithelia, a barrier, which is lost when cells lose connection and move in isolation. Unless wounded, epithelial sheets in cultures normally do not have ...
Panková, K Rösel, D Novotný, M Brábek, Jan
Published in
Cellular and molecular life sciences : CMLS
Tumor cells exhibit at least two distinct modes of migration when invading the 3D environment. A single tumor cell's invasive strategy follows either mesenchymal or amoeboid patterns. Certain cell types can use both modes of invasiveness and undergo transitions between them. This work outlines the signaling pathways involved in mesenchymal and amoe...
Karolien De Bosscher Ilse M. Beck Lien Dejager Nadia Bougarne Anthoula Gaigneaux Sébastien Chateauvieux Dariusz Ratman Marc Bracke Jan Tavernier Wim Vanden Berghe
...
Published in
Cellular and Molecular Life Sciences
Martin, Ma Hurd, Dd Saxton, Wm
Published in
Cellular and Molecular Life Sciences
Both the development and the maintenance of neurons require a great deal of active cytoplasmic transport. Much of this transport is driven by microtubule motor proteins. Membranous organelles and other macromolecular assemblies bind motor proteins that then use cycles of adenosine 5 -triphosphate hydrolysis to move these cargoes along microtubule...
Martin, Ma Hurd, Dd Saxton, Wm
Published in
Cellular and Molecular Life Sciences
Both the development and the maintenance of neurons require a great deal of active cytoplasmic transport. Much of this transport is driven by microtubule motor proteins. Membranous organelles and other macromolecular assemblies bind motor proteins that then use cycles of adenosine 5 -triphosphate hydrolysis to move these cargoes along microtubule...
Li, L Hartley, R Reiss, B Yao-Hui Sun Pu, J Wu, D Francis Lin Hoang, T Yamada, S Jiang, J
...
Published in
Cellular and Molecular Life Sciences
In wound healing and development, large epithelial sheets migrate collectively, in defined directions, and maintain tight cell-cell adhesion. This type of movement ensures an essential function of epithelia, a barrier, which is lost when cells lose connection and move in isolation. Unless wounded, epithelial sheets in cultures normally do not have ...
Cao, L Pu, J Min Zhao
Published in
Cellular and Molecular Life Sciences
Endogenous electrical fields (EFs) at corneal and skin wounds send a powerful signal that directs cell migration during wound healing. This signal therefore may serve as a fundamental regulator directing cell polarization and migration. Very little is known of the intracellular and molecular mechanisms that mediate EF-induced cell polarization and ...
