Li, Li Gong, Yijia Tang, Jun Yan, Chun Li, Lili Peng, Weiyan Cheng, Zhaobo Yu, Renjie Xiang, Qin Deng, Chaoqun
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Published in
Cellular and Molecular Life Sciences
Breast cancer is the leading cause of cancer death in female. Until now, advanced breast cancer is still lack effective treatment strategies and reliable prognostic markers. In the present article, we introduced the physiologic and pathologic functions and regulation mechanisms of ZBTB28, a tumor suppressor gene, in breast cancer. ZBTB28 is frequen...
Lehmann, Johannes Narcisi, Roberto Franceschini, Natasja Chatzivasileiou, Danai Boer, Cindy G. Koevoet, Wendy J. L. M. Putavet, Diana Drabek, Dubravka van Haperen, Rien de Keizer, Peter L. J.
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Published in
Cellular and Molecular Life Sciences
Senescence, the irreversible cell cycle arrest of damaged cells, is accompanied by a deleterious pro-inflammatory senescence-associated secretory phenotype (SASP). Senescence and the SASP are major factors in aging, cancer, and degenerative diseases, and interfere with the expansion of adult cells in vitro, yet little is known about how to countera...
Topa, Justyna Grešner, Peter Żaczek, Anna J. Markiewicz, Aleksandra
Published in
Cellular and Molecular Life Sciences
Circulating tumor cells (CTCs) mediate dissemination of solid tumors and can be an early sign of disease progression. Moreover, they show a great potential in terms of non-invasive, longitudinal monitoring of cancer patients. CTCs have been extensively studied in breast cancer (BC) and were shown to present a significant phenotypic plasticity conne...
De Filippis, Francesca Esposito, Alessia Ercolini, Danilo
Published in
Cellular and Molecular Life Sciences
Probiotics currently available on the market generally belong to a narrow range of microbial species. However, recent studies about the importance of the gut microbial commensals on human health highlighted that the gut microbiome is an unexplored reservoir of potentially beneficial microbes. For this reason, academic and industrial research is foc...
Kulikauskas, Molly R. X, Shaka Bautch, Victoria L.
Published in
Cellular and Molecular Life Sciences
Blood vessels expand via sprouting angiogenesis, and this process involves numerous endothelial cell behaviors, such as collective migration, proliferation, cell–cell junction rearrangements, and anastomosis and lumen formation. Subsequently, blood vessels remodel to form a hierarchical network that circulates blood and delivers oxygen and nutrient...
Fiore, Nicholas J. Ganat, Yosif M. Devkota, Kapil Batorsky, Rebecca Lei, Ming Lee, Kyongbum Cowen, Lenore J. Croft, Gist Noggle, Scott A. Nieland, Thomas J. F.
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Published in
Cellular and Molecular Life Sciences
Three-dimensional (3D) in vitro culture systems using human induced pluripotent stem cells (hiPSCs) are useful tools to model neurodegenerative disease biology in physiologically relevant microenvironments. Though many successful biomaterials-based 3D model systems have been established for other neurogenerative diseases, such as Alzheimer’s diseas...
Wang, Maohua Dong, Ying Gao, Song Zhong, Zhenhua Cheng, Cheng Qiang, Ruiying Zhang, Yuhua Shi, Xinyi Qian, Xiaoyun Gao, Xia
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Published in
Cellular and Molecular Life Sciences
The Hippo/Yes-associated protein (YAP) signaling pathway has been shown to be able to maintain organ size and homeostasis by regulating cell proliferation, differentiation, and apoptosis. The abuse of aminoglycosides is one of the main causes of sensorineural hearing loss (SSNHL). However, the role of the Hippo/YAP signaling pathway in cochlear hai...
Chakrabarti, Anirikh Geurts, Lucie Hoyles, Lesley Iozzo, Patricia Kraneveld, Aletta D. La Fata, Giorgio Miani, Michela Patterson, Elaine Pot, Bruno Shortt, Colette
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Published in
Cellular and Molecular Life Sciences
The gut and brain link via various metabolic and signalling pathways, each with the potential to influence mental, brain and cognitive health. Over the past decade, the involvement of the gut microbiota in gut–brain communication has become the focus of increased scientific interest, establishing the microbiota–gut–brain axis as a field of research...
Medina-Carbonero, Marta Sanz-Alcázar, Arabela Britti, Elena Delaspre, Fabien Cabiscol, Elisa Ros, Joaquim Tamarit, Jordi
Published in
Cellular and Molecular Life Sciences
Friedreich Ataxia (FA) is a rare neuro-cardiodegenerative disease caused by mutations in the frataxin (FXN) gene. The most prevalent mutation is a GAA expansion in the first intron of the gene causing decreased frataxin expression. Some patients present the GAA expansion in one allele and a missense mutation in the other allele. One of these mutati...
Barbagallo, Davide Palermo, Concetta Ilenia Barbagallo, Cristina Battaglia, Rosalia Caponnetto, Angela Spina, Vittoria Ragusa, Marco Di Pietro, Cinzia Scalia, Guido Purrello, Michele
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Published in
Cellular and Molecular Life Sciences
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new member of the Betacoronaviridae family, responsible for the recent pandemic outbreak of COVID-19. To start exploring the molecular events that follow host cell infection, we queried VirusCircBase and identified a circular RNA (circRNA) predicted to be synthesized by SARS-CoV-2, c...
