Notch and cancer: a double-edged sword
Notch and cancer: a double-edged sword
Mechanisms protecting host cells against bacterial pore-forming toxins
Pore-forming toxins (PFTs) are key virulence determinants produced and secreted by a variety of human bacterial pathogens. They disrupt the plasma membrane (PM) by generating stable protein pores, which allow uncontrolled exchanges between the extracellular and intracellular milieus, dramatically disturbing cellular homeostasis. In recent years, ma...
Correction to: Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo
Published in Cellular and Molecular Life Sciences
The section: “miRNA‑independent functions of DICER” was missed between the section “miRNA‑independent functions of DROSHA and DGCR8” and the section “The Dgcr8 knockout strategy to study miRNA functions” in the original publications.
Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progres...
...Published in Cellular and Molecular Life Sciences
Extracellular vesicles (EVs) are membrane-surrounded structures that transmit biologically important molecules from the releasing to target cells, thus providing a novel intercellular communication mechanism. Since EVs carry their cargo in a protected form and their secretion is generally increased in tumorigenesis, EVs hold a great potential for e...
Fbxo30 regulates chromosome segregation of oocyte meiosis
...Published in Cellular and Molecular Life Sciences
As the female gamete, meiotic oocytes provide not only half of the genome but also almost all stores for fertilization and early embryonic development. Because de novo mRNA transcription is absent in oocyte meiosis, protein-level regulations, especially the ubiquitin proteasome system, are more crucial. As the largest family of ubiquitin E3 ligases...
The role of the protein–RNA recognition code in neurodegeneration
Published in Cellular and Molecular Life Sciences
MicroRNAs are small endogenous RNAs that pair and bind to sites on mRNAs to direct post-transcriptional repression. However, there is a possibility that microRNAs directly influence protein structure and activity, and this influence can be termed post-translational riboregulation. This conceptual review explores the literature on neurodegenerative ...
AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking
Published in Cellular and Molecular Life Sciences
To correctly transfer information, neuronal networks need to continuously adjust their synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of their function and is, thus, tightly regulated. In glutamatergic neurons, synaptic strength is controlled by the number and function of AMPA receptors at the post...
Correction to: The coming-of-age of nucleocytoplasmic transport in motor neuron disease and neurodegeneration
Published in Cellular and Molecular Life Sciences
The original version of this article unfortunately contained the following misspelling and formatting mistakes.
Genetics and the heart rate response to exercise
Published in Cellular and Molecular Life Sciences
The acute heart rate response to exercise, i.e., heart rate increase during and heart rate recovery after exercise, has often been associated with all-cause and cardiovascular mortality. The long-term response of heart rate to exercise results in favourable changes in chronotropic function, including decreased resting and submaximal heart rate as w...
