Stanek, Ewa Pacia, Marta Z. Kaczor, Agnieszka Czamara, Krzysztof
Published in
Cellular and Molecular Life Sciences
Spectroscopy-based analysis of chemical composition of cells is a tool still scarcely used in biological sciences, although it provides unique information about the cell identity accessible in vivo and in situ. Through time-lapse spectroscopic monitoring of adipogenesis in brown and white adipose tissue-derived stem cells we have demonstrated that ...
Jin, Xuejiao Zhou, Min Chen, Shuxin Li, Danqi Cao, Xiuling Liu, Beidong
Published in
Cellular and Molecular Life Sciences
Upon stress challenges, proteins/RNAs undergo liquid–liquid phase separation (LLPS) to fine-tune cell physiology and metabolism to help cells adapt to adverse environments. The formation of LLPS has been recently linked with intracellular pH, and maintaining proper intracellular pH homeostasis is known to be essential for the survival of organisms....
Pronot, Marie Poupon, Gwénola Pizzamiglio, Lara Prieto, Marta Chato-Astrain, Isabel Lacagne, Iliona Schorova, Lenka Folci, Alessandra Brau, Frédéric Martin, Stéphane
...
Published in
Cellular and molecular life sciences : CMLS
SUMOylation is a post-translational modification essential to cell homeostasis. A tightly controlled equilibrium between SUMOylation and deSUMOylation processes is also critical to the neuronal function including neurotransmitter release and synaptic transmission and plasticity. Disruption of the SUMOylation homeostasis in neurons is associated wit...
Oria, Victor O. Zhang, Hongyi Zito, Christopher R. Rane, Chetan K. Ma, Xian-Yong Provance, Olivia K. Tran, Thuy T. Adeniran, Adebowale Kluger, Yuval Sznol, Mario
...
Published in
Cellular and Molecular Life Sciences
We aimed to study mechanisms controlling metastatic outgrowth of melanoma into clinically relevant lesions, a critical process responsible for the majority of melanoma deaths. To this end, we developed novel in vivo models and identified molecular events that can be ascribed to their distinct phenotypes, indolent or highly metastatic. Induction of ...
Douvris, Adrianna Viñas, Jose Burns, Kevin D.
Published in
Cellular and Molecular Life Sciences
MicroRNAs (miRNAs) are short non-coding RNAs, highly conserved between species, that are powerful regulators of gene expression. Aberrant expression of miRNAs alters biological processes and pathways linked to human disease. miR-486-5p is a muscle-enriched miRNA localized to the cytoplasm and nucleus, and is highly abundant in human plasma and enri...
Abati, Elena Manini, Arianna Comi, Giacomo Pietro Corti, Stefania
Published in
Cellular and Molecular Life Sciences
Myostatin is a negative regulator of skeletal muscle growth secreted by skeletal myocytes. In the past years, myostatin inhibition sparked interest among the scientific community for its potential to enhance muscle growth and to reduce, or even prevent, muscle atrophy. These characteristics make it a promising target for the treatment of muscle atr...
Malara, Mariagiovanna Lutz, Anne-Kathrin Incearap, Berra Bauer, Helen Friedericke Cursano, Silvia Volbracht, Katrin Lerner, Joanna Janina Pandey, Rakshita Delling, Jan Philipp Ioannidis, Valentin
...
Published in
Cellular and Molecular Life Sciences
Mutations or deletions of the SHANK3 gene are causative for Phelan–McDermid syndrome (PMDS), a syndromic form of autism spectrum disorders (ASDs). We analyzed Shank3Δ11(−/−) mice and organoids from PMDS individuals to study effects on myelin. SHANK3 was found to be expressed in oligodendrocytes and Schwann cells, and MRI analysis of Shank3Δ11(−/−) ...
Zhao, Shanjiang Heng, Nuo Wang, Huan Wang, Haoyu Zhang, Haobo Gong, Jianfei Hu, Zhihui Zhu, Huabin
Published in
Cellular and Molecular Life Sciences
Germ cell formation and embryonic development require ATP synthesized by mitochondria. The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are essential for the generation of energy. Mitofusin1 and mitofusin2, the homologues of Fuzzy onions in yeast and Drosophila, are critical regulators of mitochondrial fusion i...
Gallo, Carmela Manzo, Emiliano Barra, Giusi Fioretto, Laura Ziaco, Marcello Nuzzo, Genoveffa d’Ippolito, Giuliana Ferrera, Francesca Contini, Paola Castiglia, Daniela
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Published in
Cellular and Molecular Life Sciences
Objective The immune response arises from a fine balance of mechanisms that provide for surveillance, tolerance, and elimination of dangers. Sulfavant A (SULF A) is a sulfolipid with a promising adjuvant activity. Here we studied the mechanism of action of SULF A and addressed the identification of its molecular target in human dendritic cells (hDC...
Matsuoka, Ryota L. Buck, Luke D. Vajrala, Keerti P. Quick, Rachael E. Card, Olivia A.
Published in
Cellular and Molecular Life Sciences
Dynamic brain activity requires timely communications between the brain parenchyma and circulating blood. Brain–blood communication is facilitated by intricate networks of brain vasculature, which display striking heterogeneity in structure and function. This vascular cell heterogeneity in the brain is fundamental to mediating diverse brain functio...
