Mattoo, Hamid Pillai, Shiv
Published in
Cellular and Molecular Life Sciences
Fibrotic diseases take a very heavy toll in terms of morbidity and mortality equal to or even greater than that caused by metastatic cancer. In this review, we examine the pathogenesis of fibrotic diseases, mainly addressing triggers for induction, processes that lead to progression, therapies and therapeutic trials. For the most part, we have focu...
Ci, Yali Shi, Lei
Published in
Cellular and molecular life sciences : CMLS
Flaviviruses are positive-sense single-stranded RNA viruses that pose a considerable threat to human health. Flaviviruses replicate in compartmentalized replication organelles derived from the host endoplasmic reticulum (ER). The characteristic architecture of flavivirus replication organelles includes invaginated vesicle packets and convoluted mem...
Low, Teck Yew Syafruddin, Saiful Effendi Mohtar, M. Aiman Vellaichamy, Adaikkalam A Rahman, Nisa Syakila Pung, Yuh-Fen Tan, Chris Soon Heng
Published in
Cellular and Molecular Life Sciences
Protein–protein interactions are fundamental to various aspects of cell biology with many protein complexes participating in numerous fundamental biological processes such as transcription, translation and cell cycle. MS-based proteomics techniques are routinely applied for characterising the interactome, such as affinity purification coupled to ma...
Chrestia, Juan Facundo Bruzzone, Ariana Esandi, María del Carmen Bouzat, Cecilia
Published in
Cellular and Molecular Life Sciences
The α7 nicotinic acetylcholine receptor is involved in neurological, neurodegenerative, and inflammatory disorders. It operates both as a ligand-gated cationic channel and as a metabotropic receptor in neuronal and non-neuronal cells. As protein phosphorylation is an important cell function regulatory mechanism, deciphering how tyrosine phosphoryla...
Szade, Agata Szade, Krzysztof Mahdi, Mahdi Józkowicz, Alicja
Published in
Cellular and molecular life sciences : CMLS
Hematopoietic system transports all necessary nutrients to the whole organism and provides the immunological protection. Blood cells have high turnover, therefore, this system must be dynamically controlled and must have broad regeneration potential. In this review, we summarize how this complex system is regulated by the heme oxygenase-1 (HO-1)-an...
Holland, Amy Marie Bon-Frauches, Ana Carina Keszthelyi, Daniel Melotte, Veerle Boesmans, Werend
Published in
Cellular and molecular life sciences : CMLS
A highly conserved but convoluted network of neurons and glial cells, the enteric nervous system (ENS), is positioned along the wall of the gut to coordinate digestive processes and gastrointestinal homeostasis. Because ENS components are in charge of the autonomous regulation of gut function, it is inevitable that their dysfunction is central to t...
Basak, I Wicky, H E McDonald, K O Xu, J B Palmer, J E Best, H L Lefrancois, S Lee, S Y Schoderboeck, L Hughes, S M
...
Published in
Cellular and molecular life sciences : CMLS
Neuronal Ceroid Lipofuscinosis (NCL), also known as Batten disease, is an incurable childhood brain disease. The thirteen forms of NCL are caused by mutations in thirteen CLN genes. Mutations in one CLN gene, CLN5, cause variant late-infantile NCL, with an age of onset between 4 and 7 years. The CLN5 protein is ubiquitously expressed in the majorit...
Seclì, Laura Fusella, Federica Avalle, Lidia Brancaccio, Mara
Published in
Cellular and molecular life sciences : CMLS
In addition to exerting several essential house-keeping activities in the cell, heat shock proteins (HSPs) are crucial players in a well-structured molecular program activated in response to stressful challenges. Among the different activities carried out by HSPs during emergency, they reach the extracellular milieu, from where they scout the surro...
ter Huurne, Menno Stunnenberg, Hendrik G.
Published in
Cellular and Molecular Life Sciences
During early embryonic development both the rapid increase in cell number and the expression of genes that control developmental decisions are tightly regulated. Accumulating evidence has indicated that these two seemingly independent processes are mechanistically intertwined. The picture that emerges from studies on the cell cycle of embryonic ste...
Lau, Shun-Fat Fu, Amy K. Y. Ip, Nancy Y.
Published in
Cellular and Molecular Life Sciences
Genetic analyses have revealed the pivotal contribution of microglial dysfunctions to the pathogenesis of Alzheimer’s disease (AD). Along AD progression, the accumulation of danger-associated molecular patterns (DAMPs) including beta-amyloid and hyperphosphorylated tau continuously stimulates microglia, which results in their chronic activation. Ch...
