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Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue.

Published in Cellular and molecular life sciences : CMLS

Chronic inflammation that affects primarily metabolic organs, such as white adipose tissue (WAT), is considered as a major cause of human obesity-associated co-morbidities. However, the molecular mechanisms initiating this inflammation in WAT are poorly understood. By combining transcriptomics, ChIP-seq and modeling approaches, we studied the globa...

SEMA6C: a novel adhesion-independent FAK and YAP activator, required for cancer cell viability and growth

Published in Cellular and Molecular Life Sciences

Tubb3 expression levels are sensitive to neuronal activity changes and determine microtubule growth and kinesin-mediated...

Published in Cellular and Molecular Life Sciences

Microtubules are dynamic polymers of α/β-tubulin. They regulate cell structure, cell division, cell migration, and intracellular transport. However, functional contributions of individual tubulin isotypes are incompletely understood. The neuron-specific β-tubulin Tubb3 displays highest expression around early postnatal periods characterized by exub...

Structure and function of the N-terminal extension of the formin INF2

Published in Cellular and Molecular Life Sciences

In INF2—a formin linked to inherited renal and neurological disease in humans—the DID is preceded by a short N-terminal extension of unknown structure and function. INF2 activation is achieved by Ca2+-dependent association of calmodulin (CaM). Here, we show that the N-terminal extension of INF2 is organized into two α-helices, the first of which is...

Distinctive aspects of the placental epigenome and theories as to how they arise.

Published in Cellular and molecular life sciences : CMLS

The placenta has a methylome dramatically unlike that of any somatic cell type. Among other distinctions, it features low global DNA methylation, extensive "partially methylated domains" packed in dense heterochromatin and methylation of hundreds of CpG islands important in somatic development. These features attract interest in part because a subs...

In human astrocytes neurotropic flaviviruses increase autophagy, yet their replication is autophagy-independent.

Published in Cellular and molecular life sciences : CMLS

Astrocytes, an abundant type of glial cells, are the key cells providing homeostasis in the central nervous system. Due to their susceptibility to infection, combined with high resilience to virus-induced cell death, astrocytes are now considered one of the principal types of cells, responsible for virus retention and dissemination within the brain...

Basal Gp78-dependent mitophagy promotes mitochondrial health and limits mitochondrial ROS.

Published in Cellular and molecular life sciences : CMLS

Mitochondria are major sources of cytotoxic reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, that when uncontrolled contribute to cancer progression. Maintaining a finely tuned, healthy mitochondrial population is essential for cellular homeostasis and survival. Mitophagy, the selective elimination of mitochondria by autopha...

Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism

Published in Cellular and Molecular Life Sciences

Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms associated with disease-causing genetic variants. The human 17β-hydroxysteroid dehydrogenase 10 (HSD10) is a moonlighting enzyme with at least two structurally and catalytically unrelated functions. HSD10 disease was originally described as a disorder of isol...

Proteome alterations during clonal isolation of established human pancreatic cancer cell lines

Published in Cellular and Molecular Life Sciences

Clonal isolation is an integral step of numerous workflows in genome editing and cell engineering. It comprises the isolation of a single progenitor cell from a defined cell line population with subsequent expansion to obtain a monoclonal cell population. This process is associated with transient loss of cell–cell contacts and absence of a multicel...

Characterization of microtubule-associated protein tau isoforms and Alzheimer’s disease-like pathology in normal sheep (...

Published in Cellular and Molecular Life Sciences

Alzheimer’s disease is a chronic neurodegenerative disease that accounts for up to 80% of all dementias. Characterised by deteriorations of memory and cognitive function, the key neuropathological features are accumulations of β-amyloid and hyperphosphorylated tau, as ‘plaques’ and ‘tangles’, respectively. Despite extensive study, however, the exac...