Currey, Marilena L Kandula, Viswajit Biggs, Ronald Marko, John F Stephens, Andrew D
Published in
Cellular and molecular bioengineering
Force measurements of the nucleus, the strongest organelle, have propelled the field of mechanobiology to understand the basic mechanical components of the nucleus and how these components properly support nuclear morphology and function. Micromanipulation force measurement provides separation of the relative roles of nuclear mechanical components ...
Fabiano, Emily D
Published in
Cellular and molecular bioengineering
First-generation college students face unique challenges compared to non-first-generation college students, especially in STEM fields. First-generation STEM students drop out of their major at higher rates than non-first-generation students. This may be due to a lack of role models or mentorship in the college environment or in the field, a challen...
King, Michael R
Published in
Cellular and molecular bioengineering
Zeraatpisheh, Zahra Shamsi, Fatemeh Sarkoohi, Parisa Torabi, Somayyeh Alipour, Hamed Aligholi, Hadi
Published in
Cellular and molecular bioengineering
The present study aimed to evaluate the effects of FTY720 as a neuromodulatory drug on the behaviors of neural stem/progenitor cells (NS/PCs) in two-dimensional (2-D) and three-dimensional (3-D) cultures and in spinal cord injury (SCI). The NS/PCs isolated from the ganglionic eminence of the 13.5-day old embryos were cultured as free-floating spher...
Ebben, Alessandra Dabagh, Mahsa
Published in
Cellular and molecular bioengineering
Introduction-Local hemodynamics impact the mechanotransduction in endothelial cells (ECs) lining the vascular network. On the other hand, cancer cells are shown to influence the local hemodynamics in their vicinity, in microvasculature. The first objective of present study is to explore how cancer cell-induced changes in local hemodynamics can impa...
Kohs, Tia C L Olson, Sven R Pang, Jiaqing Jordan, Kelley R Zheng, Tony J Xie, Aris Hodovan, James Muller, Matthew McArthur, Carrie Johnson, Jennifer
...
Published in
Cellular and molecular bioengineering
Inflammatory activation of the vascular endothelium leads to overexpression of adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1), contributing to the pro-thrombotic state underpinning atherogenesis. While the role of TEC family kinases (TFKs) in mediating inflammatory cell and platelet activation is well defined, the role of TFK...
Chen, Hao Zhou, Yaodong Dong, Qirong
Published in
Cellular and Molecular Bioengineering
Introduction Human bone morphogenetic proteins (BMPs) constitute a large family of cytokines related to members of the transforming growth factor-β superfamily, which fulfill biological functions by specificity binding to their cognate type I (BRI) and type II (BRII) receptors through conformational wrist and linear knuckle epitopes, respectively. ...
Forconi, Flavia Apa, Ludovica Pisu, Simona Casola, Irene Musarò, Antonio Rizzuto, Emanuele Del Prete, Zaccaria
Published in
Cellular and Molecular Bioengineering
Introduction The neuromuscular junction (NMJ) is a chemical synapse responsible for converting electrical pulses generated by the motor neuron into electrical activity in muscle fibers, and is severely impaired in various diseases, such as Amyotrophic Lateral Sclerosis (ALS). Here, we proposed a novel technique to measure, for the first time, NMJ f...
Kang, Xiaofang Li, Xiaocong Li, Yanli
Published in
Cellular and molecular bioengineering
Sevoflurane (SEV) has been shown to inhibit the malignant progression in many cancers, including colorectal cancer (CRC). However, it is not clear whether SEV regulates the progression of CRC by mediating the circular RNA (circRNA) axis. Different concentrations of SEV were used to treat CRC cells. Cell proliferation, migration and invasion were de...
Rosch, Jonah C Hoogenboezem, Ella N Sorets, Alexander G Duvall, Craig L Lippmann, Ethan S
Published in
Cellular and molecular bioengineering
Short interfering RNAs (siRNAs) are potent nucleic acid-based drugs designed to target disease driving genes that may otherwise be undruggable with small molecules. However, therapeutic potential of siRNA in vivo is limited by poor pharmacokinetic properties, including rapid renal clearance and nuclease degradation. Backpacking on natural carriers ...
