Duot, Matthieu Viel, Roselyne Viet, Justine Le Goff-Gaillard, Catherine Paillard, Luc Lachke, Salil A Gautier-Courteille, Carole Reboutier, David
Published in
Cells
Cataract, the opacification of the lens, is the leading cause of blindness worldwide. Although effective, cataract surgery is costly and can lead to complications. Toward identifying alternate treatments, it is imperative to develop organoid models relevant for lens studies and drug screening. Here, we demonstrate that by culturing mouse lens epith...
Corano Scheri, Katia Hsieh, Yi-Wen Jeong, Eunji Fawzi, Amani A
Published in
Cells
The progression to fibrosis and traction in retinopathy of prematurity (ROP) and other ischemic retinopathies remains an important clinical and surgical challenge, necessitating a comprehensive understanding of its pathogenesis. Fibrosis is an unbalanced deposition of extracellular matrix components responsible for scar tissue formation with conseq...
Sharma, Himadri Chang, Keun-A Hulme, John An, Seong Soo A
Published in
Cells
A form of dementia distinct from healthy cognitive aging, Alzheimer's disease (AD) is a complex multi-stage disease that currently afflicts over 50 million people worldwide. Unfortunately, previous therapeutic strategies developed from murine models emulating different aspects of AD pathogenesis were limited. Consequently, researchers are now devel...
Provasek, Vincent E Kodavati, Manohar Guo, Wenting Wang, Haibo Boldogh, Istvan Van Den Bosch, Ludo Britz, Gavin Hegde, Muralidhar L
Published in
Cells
Fused-in sarcoma (FUS) gene mutations have been implicated in amyotrophic lateral sclerosis (ALS). This study aimed to investigate the impact of FUS mutations (R521H and P525L) on the transcriptome of induced pluripotent stem cells (iPSCs) and iPSC-derived motor neurons (iMNs). Using RNA sequencing (RNA Seq), we characterized differentially express...
Kale, Ajinath Shelke, Vishwadeep Lei, Yutian Gaikwad, Anil Bhanudas Anders, Hans-Joachim
Published in
Cells
Calcineurin inhibitors (CNI) can suppress allo- and autoimmunity by suppressing T cell function but also have anti-proteinuric effects by stabilizing the cellular components of the kidney's filtration barrier. Therefore, CNI are used in autoimmune kidney diseases with proteinuria. However, the traditional CNI, cyclosporine A and tacrolimus, have a ...
Qiao, Xiaojing Yang, Yang Zhao, Yan Wu, Xiuju Zhang, Li Cai, Xinjiang Ji, Jaden Boström, Kristina I Yao, Yucheng
Published in
Cells
Glucocorticoid-induced bone loss is a severe and toxic effect of long-term therapy with glucocorticoids, which are currently prescribed for millions of people worldwide. Previous studies have uncovered that glucocorticoids reciprocally converted osteoblast lineage cells into endothelial-like cells to cause bone loss and showed that the modulations ...
Devine, Scott E
Published in
Genes
Three mobile element classes, namely Alu, LINE-1 (L1), and SVA elements, remain actively mobile in human genomes and continue to produce new mobile element insertions (MEIs). Historically, MEIs have been discovered and studied using several methods, including: (1) Southern blots, (2) PCR (including PCR display), and (3) the detection of MEI copies ...
Bukreeva, Inna Gulimova, Victoria I Krivonosov, Yuri S Buzmakov, Alexey V Junemann, Olga Cedola, Alessia Fratini, Michela Maugeri, Laura Begani Provinciali, Ginevra Palermo, Francesca
...
Published in
Cells
The proximal caudal vertebrae and notochord in thick-toed geckos (TG) (Chondrodactylus turneri, Gray, 1864) were investigated after a 30-day space flight onboard the biosatellite Bion-M1. This region has not been explored in previous studies. Our research focused on finding sites most affected by demineralization caused by microgravity (G0). We use...
Epshtein, Yulia Mathew, Biji Chen, Weiguo Jacobson, Jeffrey R
Published in
Cells
GADD45a is a gene we previously reported as a mediator of responses to acute lung injury. GADD45a-/- mice express decreased Akt and increased Akt ubiquitination due to the reduced expression of UCHL1 (ubiquitin c-terminal hydrolase L1), a deubiquitinating enzyme, while GADD45a-/- mice have increased their susceptibility to radiation-induced lung in...
Reichlmeir, Marina Canet-Pons, Júlia Koepf, Gabriele Nurieva, Wasifa Duecker, Ruth Pia Doering, Claudia Abell, Kathryn Key, Jana Stokes, Matthew P Zielen, Stefan
...
Published in
Cells
The autosomal recessive disorder Ataxia-Telangiectasia is caused by a dysfunction of the stress response protein, ATM. In the nucleus of proliferating cells, ATM senses DNA double-strand breaks and coordinates their repair. This role explains T-cell dysfunction and tumour risk. However, it remains unclear whether this function is relevant for postm...
