Russell, Tobias Watad, Abdulla Bridgewood, Charlie Rowe, Hannah Khan, Almas Rao, Abhay Loughenbury, Peter Millner, Peter Dunsmuir, Robert Cuthbert, Richard
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Cells
Objective: The spondylarthritides (SpA) are intimately linked to new bone formation and IL-17A and TNF pathways. We investigated spinal soft tissue and bone mesenchymal stem cell (MSC) responses to IL-17A and TNF, including their osteogenesis, adipogenesis, and stromal supportive function and ability to support lymphocyte recruitment. Methods: Norm...
Lah, Tamara T. Novak, Metka Pena Almidon, Milagros A. Marinelli, Oliviero Žvar Baškovič, Barbara Majc, Bernarda Mlinar, Mateja Bošnjak, Roman Breznik, Barbara Zomer, Roby
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Published in
Cells
Simple Summary Among primary brain tumours, glioblastoma is the most aggressive. As early relapses are unavoidable despite standard-of-care treatment, the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) alone or in combination have been suggested as a combined treatment strategy for glioblastomas. However, the known psychoacti...
Grönroos, Pyry Ilmarinen, Tanja Skottman, Heli
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Cells
The most crucial function of corneal endothelial cells (CEnCs) is to maintain optical transparency by transporting excess fluid out of stroma. Unfortunately, CEnCs are not able to proliferate in vivo in the case of trauma or dystrophy. Visually impaired patients with corneal endothelial deficiencies that are waiting for transplantation due to massi...
Ma, Gang Zhang, Lancui Kudaka, Rin Inaba, Hayato Furuya, Takuma Kitamura, Minami Kitaya, Yurika Yamamoto, Risa Yahata, Masaki Matsumoto, Hikaru
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Cells
Combined spraying of gibberellin (GA) and prohydrojasmon (PDJ) was an effective method to reduce peel puffing in Satsuma mandarins. However, in the GA-and-PDJ combined treatment, fruit color development was delayed during the ripening process. In the present study, to improve the coloration of the GA and PDJ-treated fruit, the effects of exogenous ...
Lee, Kwanuk Leister, Dario Kleine, Tatjana
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Cells
Plastid gene expression (PGE) is essential for chloroplast biogenesis and function and, hence, for plant development. However, many aspects of PGE remain obscure due to the complexity of the process. A hallmark of nuclear-organellar coordination of gene expression is the emergence of nucleus-encoded protein families, including nucleic-acid binding ...
Mottola, Filomena Santonastaso, Marianna Iovine, Concetta Feola, Veronica Pacifico, Severina Rocco, Lucia
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Cells
The aquatic environment is involved in the pollutants spreading mechanisms, including nanomaterials and heavy metals. The aims of this study were to assess the in vivo genotoxicity of Cd (1 mg/L) and to investigate the genomic effects generated by its co-exposure with TiO2-NPs (10 µg/L). The study was performed using zebrafish as a model for 5, 7, ...
Cheng, Jing Lucas, Peter C McAllister-Lucas, Linda M
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Cells
G protein-coupled receptor kinase 2 (GRK2) is emerging as a key integrative signaling node in a variety of biological processes ranging from cell growth and proliferation to migration and chemotaxis. As such, GRK2 is now implicated as playing a role in the molecular pathogenesis of a broad group of diseases including heart failure, cancer, depressi...
Lee, Myung-Jun Lee, Won-Tae Jeon, Chang-Jin
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Cells
Neuropeptide Y (NPY) is found throughout the central nervous system where it appears to be involved in the regulation of a wide range of physiological effects. The Mongolian gerbil, a member of the rodent family Muridae, is a diurnal animal and has been widely used in various aspects of biomedical research. This study was conducted to investigate t...
Siddhuraj, Premkumar Clausson, Carl-Magnus Sanden, Caroline Alyamani, Manar Kadivar, Mohammad Marsal, Jan Wallengren, Joanna Bjermer, Leif Erjefält, Jonas S
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Cells
The mast cell granule metalloprotease CPA3 is proposed to have important tissue homeostatic functions. However, the basal CPA3 mRNA and protein expression among mast cell populations has remained poorly investigated. Using a novel histology-based methodology that yields quantitative data on mRNA and protein expression at a single-cell level, the pr...
Germic, Nina Fettrelet, Timothée Stojkov, Darko Hosseini, Aref Horn, Michael P Karaulov, Alexander Simon, Dagmar Yousefi, Shida Simon, Hans-Uwe
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Cells
Eosinophils are a subset of granulocytes characterized by a high abundance of specific granules in their cytoplasm. To act as effector cells, eosinophils degranulate and form eosinophil extracellular traps (EETs), which contain double-stranded DNA (dsDNA) co-localized with granule proteins. The exact molecular mechanism of EET formation remains unk...
