Kasperkiewicz, Michael
Published in
Cell stress & chaperones
A link between Covid-19 and development of autoimmunity has been reported. A possible explanation could be molecular mimicry between SARS-CoV-2 and human proteins. Peptide sharing has been found between antigenic epitopes of this virus and heat shock proteins (Hsp) 60 and 90, both of which are associated with autoimmune diseases including those of ...
Bressler, Kamiko R Ross, Joseph A Ilnytskyy, Slava Vanden Dungen, Keiran Taylor, Katrina Patel, Kush Zovoilis, Athanasios Kovalchuk, Igor Thakor, Nehal
Published in
Cell stress & chaperones
During the integrated stress response (ISR), global translation initiation is attenuated; however, noncanonical mechanisms allow for the continued translation of specific transcripts. Eukaryotic initiation factor 5B (eIF5B) has been shown to play a critical role in canonical translation as well as in noncanonical mechanisms involving internal ribos...
Chow-Shi-Yée, Mélanie Grondin, Melanie Ouellet, Francois Averill-Bates, Diana A
Published in
Cell stress & chaperones
Cryopreservation is used for long-term storage of cells and tissues. Cryoprotectants such as dimethyl disulfoxide (DMSO) are used to protect cells against freeze-thaw damage. Despite the use of cryoprotectants, hepatocytes are sensitive to stresses imposed by freeze and thaw processes, which cause physical damage, loss of functionality, or cell dea...
Kumar, Saurabh Suyal, Deep Chandra Yadav, Amit Shouche, Yogesh Goel, Reeta
Published in
Cell stress & chaperones
Himalayan mountains are distinctly characterized for their unique climatic and topographic variations; therefore, unraveling the cold-adaptive mechanisms and processes of native life forms is always being a matter of concern for scientific community. In this perspective, the proteomic response of psychrophilic diazotroph Pseudomonas helmanticensis ...
Clegg, James S
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Cell stress & chaperones
Amara, Ines Salah, Amal Timoumi, Rim Annabi, Emna Scuto, Maria Trovato, Angela Neffati, Fadwa Calabrese, Vittorio Abid-Essefi, Salwa
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Cell stress & chaperones
Environmental toxicants such as phthalate have been involved in multiple health disorders including renal diseases. Oxidative damage is implicated in many alterations caused by phthalate especially the di(2-ethylhexyl) phthalate (DEHP), which is the most useful phthalate. However, information regarding its mechanism of renal damage is lacking. The ...
Ramsøe, Abigail Clark, Melody S Sleight, Victoria A
Published in
Cell stress & chaperones
A computationally predicted gene regulatory network (GRN), generated from mantle-specific gene expression profiles in the Antarctic clam Laternula elliptica, was interrogated to test the regulation and interaction of duplicated inducible hsp70 paralogues. hsp70A and hsp70B were identified in the GRN with each paralogue falling into unique submodule...
Budnar, Prashanth Singh, Narendra Pratap Rao, Ch Mohan
Published in
Cell stress & chaperones
Oxidative stress is one of the major and continuous stresses, an organism encounters during its lifetime. Tissues such as the brain, liver and muscles are more prone to damage by oxidative stress due to their metabolic activity, differences in physiological and adaptive processes. One of the defence mechanisms against continuous oxidative stress is...
Samadi, Mahrokh Aziz, Shiva Gholizadeh-Ghaleh Naderi, Roya
Published in
Cell stress & chaperones
Tropisetron is a 5-HT3 receptor antagonist that exerts protective effect against DN. The aim of this study was to investigate the possible molecular mechanisms associated with the renoprotective effects of tropisetron in STZ-induced diabetic rats. Animals were subdivided into 5 equal groups; control, tropisetron, diabetes, tropisetron + diabetes, a...
Abdel Hafez, Sara Mohamed Naguib Allam, Fatma Alzhraa Fouad Abdelbaky Elbassuoni, Eman
Published in
Cell stress & chaperones
Chronic stress has been related to multiple diseases. Inflammation is proposed strongly to link stress to stress-related diseases in different organs, such as small intestine, colon, and brain. However, stress cellular effect on the pancreatic tissue, especially the exocrine one, had received relatively little attention. This work aimed to evaluate...
