Chaudhary, Surbhi Patidar, Anil Dhiman, Asmita Chaubey, Gaurav Kumar Dilawari, Rahul Talukdar, Sharmila Modanwal, Radheshyam Raje, Manoj
Published in
Cell death & disease
Rapid clearance of apoptotic cells by phagocytes is crucial for organogenesis, tissue homeostasis, and resolution of inflammation. This process is initiated by surface exposure of various 'eat me' ligands. Though phosphatidylserine (PS) is the best recognized general recognition ligand till date, recent studies have shown that PS by itself is not s...
Zhang, Zijian Zeng, Deshun Zhang, Wei Chen, Ailin Lei, Jie Liu, Fang Deng, Bing Zhuo, Junxiao He, Bin Yan, Min
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Published in
Cell death & disease
Uncontrolled mitosis is one of the most important features of cancer, and mitotic kinases are thought to be ideal targets for anticancer therapeutics. However, despite numerous clinical attempts spanning decades, clinical trials for mitotic kinase-targeting agents have generally stalled in the late stages due to limited therapeutic effectiveness. A...
Hernández-Torres, Marcela Silva do Nascimento, Rogério Rebouças, Monica Cardozo Cassado, Alexandra Matteucci, Kely Catarine D'Império-Lima, Maria Regina Vasconcelos, José Ronnie C Bortoluci, Karina R Alvarez, José Maria Amarante-Mendes, Gustavo P
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Published in
Cell death & disease
Zhang, Shugeng Liang, Shuhang Wu, Dehai Guo, Hongrui Ma, Kun Liu, Lianxin
Published in
Cell death & disease
The Hippo and mammalian target of rapamycin complex 1 (mTORC1) pathways are the two predominant pathways that regulate tumour growth and metastasis. Therefore, we explored the potential crosstalk between these two functionally relevant pathways to coordinate their tumour growth-control functions. We found that a Hippo pathway-related long noncoding...
Luo, Hong Zhou, Zhicheng Huang, Shan Ma, Mengru Zhao, Manyu Tang, Lixu Quan, Yuan Zeng, Yiming Su, Li Kim, Jongchan
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Published in
Cell death & disease
Failures to treat triple-negative breast cancer (TNBC) are mainly due to chemoresistance or radioresistance. We and others previously discovered that zinc finger E-box-binding homeobox 1 (ZEB1) is a massive driver causing these resistance. However, how to dynamically modulate the intrinsic expression of ZEB1 during cell cycle progression is elusive...
Hannes, Sabine Karlowitz, Rebekka van Wijk, Sjoerd J L
Published in
Cell death & disease
Pancreatic cancer (PC) still remains a major cause of cancer-related death worldwide and alternative treatments are urgently required. A common problem of PC is the development of resistance against apoptosis that limits therapeutic success. Here we demonstrate that the prototypical Smac mimetic BV6 cooperates with the stimulator of interferon (IFN...
Yu, Yajie Ding, Jane Zhu, Shunqin Alptekin, Ahmet Dong, Zheng Yan, Chunhong Zha, Yunhong Ding, Han-Fei
Published in
Cell death & disease
Metabolic reprogramming is an integral part of the growth-promoting program driven by the MYC family of oncogenes. However, this reprogramming also imposes metabolic dependencies that could be exploited therapeutically. Here we report that the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is an attractive therapeutic target fo...
Gu, Xiaobin Shi, Yonggang Dong, Meilian Jiang, Li Yang, Jing Liu, Zheyan
Published in
Cell death & disease
The occurrence of radioresistance is a clinical obstacle to endometrial cancer (EC) treatment and induces tumor relapse. In this study, we found that tumor-associated macrophages (TAMs) enriched in EC specimens were determined to present an M2-like phenotype. In vitro, the coculture of M2-polarized macrophages significantly downregulated the radios...
Cao, Yanyan Liu, Kai Xiong, Ying Zhao, Chunyue Liu, Lei
Published in
Cell death & disease
Neuronal necrosis induced by excessive glutamate release is well known to contribute morbidity and mortality in ischemic stroke. Over the past decades, strategies on targeting glutamate receptor did not achieve desirable clinical outcomes. Finding the downstream mechanism of the glutamate receptor activation may provide new targets to suppress the ...
Cao, Yaochen Chen, Xin Sun, Hongming
Published in
Cell death & disease
Hypocalcemia, associated with Calcium neurotoxicity, has been reported to induce nerve dysfunction, which is a significant problem of renal failure. This study identifies a molecular mechanism of the O-linked N-acetylglucosamine transferase (OGT)-mediated enhancer of zeste homolog 2 (EZH2)/krüppel-like factor 2 (KLF2)/chemokine (C-X-C motif) ligand...
