Villa, Elodie Paul, Rachel Meynet, Ophélie Volturo, Sophie Pinna, Guillaume Ricci, Jean-Ehrland
Published in
Cell Death & Disease
Escape from cell death is a key event in cancer establishment/progression. While apoptosis is often considered as the main cell death pathway, upon caspase inhibition, cell death is rather delayed than blocked leading to caspase-independent cell death (CICD). Although described for years, CICD’s underlying mechanism remains to be identified. Here, ...
Huang, Xiaozhong Shi, Yujuan Chen, Hongjin Le, Rongrong Gong, Xiaohua Xu, Ke Zhu, Qihan Shen, Feixia Chen, Zimiao Gu, Xuemei
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Published in
Cell Death & Disease
Diabetic nephropathy (DN) as a global health concern is closely related to inflammation and oxidation. Isoliquiritigenin (ISL), a natural flavonoid compound, has been demonstrated to inhibit inflammation in macrophages. Herein, we investigated the effect of ISL in protecting against the injury in STZ-induced type 1 DN and in high glucose-induced NR...
Alaimo, Alessandro Lorenzoni, Marco Ambrosino, Paolo Bertossi, Arianna Bisio, Alessandra Macchia, Alice Zoni, Eugenio Genovesi, Sacha Cambuli, Francesco Foletto, Veronica
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Published in
Cell Death & Disease
Therapy resistance is a major roadblock in oncology. Exacerbation of molecular dysfunctions typical of cancer cells have proven effective in twisting oncogenic mechanisms to lethal conditions, thus offering new therapeutic avenues for cancer treatment. Here, we demonstrate that selective agonists of Transient Receptor Potential cation channel subfa...
Kang, Weiting Wang, Qiang Dai, Yun Wang, Hanbo Wang, Muwen Wang, Jin Zhang, Dong Sun, Peng Qi, Taiguo Jin, Xunbo
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Published in
Cell Death & Disease
Apart from being potential prognostic biomarkers and therapeutic targets, long non-coding RNAs (lncRNAs) modulate the development and progression of multiple cancers. PlncRNA-1 is a newly discovered lncRNA that exhibits the above properties through multiple regulatory pathways. However, the clinical significance and molecular mechanisms of PlncRNA-...
Hu, Hai-Jun Liang, Xiu Li, Hai-Lang Du, Chun-Ming Hao, Jia-Li Wang, Huai-Yuan Gu, Jin-Fa Ni, Ai-Min Sun, Lan-Ying Xiao, Jing
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Published in
Cell Death & Disease
ZD55-IL-24 is similar but superior to the oncolytic adenovirus ONYX-015, yet the exact mechanism underlying the observed therapeutic effect is still not well understood. Here we sought to elucidate the underlying antitumor mechanism of ZD55-IL-24 in both immunocompetent and immunocompromised mouse model. We find that ZD55-IL-24 eradicates establish...
Chen, Ling Cai, Shang Wang, Jing-mei Huai, Ying-ying Lu, Pei-Hua Chu, Qian
Published in
Cell Death & Disease
Bromodomain testis-specific factor (BRDT) is a member of the bromodomain and extra-terminal (BET) family proteins. Its expression and potential functions in ovarian cancer were examined. We show that BRDT is overexpressed in human ovarian cancer tissues and in established (CaOV3)/primary ovarian cancer cells. However, its expression is low in ovari...
Constantin, Daniel Widmann, Christian
Published in
Cell Death & Disease
It is of clinical importance to identify biomarkers predicting the efficacy of DNA damaging drugs (genotoxins) so that nonresponders are not unduly exposed to the deleterious effects of otherwise inefficient drugs. Here, we initially focused on the bleomycin genotoxin because of the limited information about the genes implicated in the sensitivity ...
Fichtner, Michael Bozkurt, Emir Salvucci, Manuela McCann, Christopher McAllister, Katherine A. Halang, Luise Düssmann, Heiko Kinsella, Sinéad Crawford, Nyree Sessler, Tamas
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Published in
Cell Death & Disease
Colorectal cancer is a molecularly heterogeneous disease. Responses to genotoxic chemotherapy in the adjuvant or palliative setting vary greatly between patients, and colorectal cancer cells often resist chemotherapy by evading apoptosis. Antagonists of an inhibitor of apoptosis proteins (IAPs) can restore defective apoptosis signaling by degrading...
Chiu, Ching-Chi Weng, Yi-Hsin Huang, Ying-Zu Chen, Rou-Shayn Liu, Yu-Chuan Yeh, Tu-Hsueh Lu, Chin-Song Lin, Yan-Wei Chen, Yu-Jie Hsu, Chia-Chen
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Cell Death & Disease
Patients with familial type 17 of Parkinson’s disease (PARK17) manifest autosomal dominant pattern and late-onset parkinsonian syndromes. Heterozygous (D620N) mutation of vacuolar protein sorting 35 (VPS35) is genetic cause of PARK17. We prepared heterozygous VPS35D620N/+ knockin mouse, which is an ideal animal model of (D620N) VPS35-induced autoso...
Ploeger, Carolin Huth, Thorben Sugiyanto, Raisatun Nisa Pusch, Stefan Goeppert, Benjamin Singer, Stephan Tabti, Redouane Hausser, Ingrid Schirmacher, Peter Désaubry, Laurent
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Published in
Cell Death & Disease
Chromosome 8p is frequently deleted in various cancer entities and has been shown to correlate with poor patient survival. SH2D4A is located on chromosome 8p and prevents the nuclear translocation of the pro-tumorigenic transcription factor STAT3. Here, we investigated the interaction of SH2D4A and STAT3 to shed light on the non-canonical functions...