Florent, Romane Weiswald, Louis-Bastien Lambert, Bernard Brotin, Emilie Abeilard, Edwige Louis, Marie-Hélène Babin, Guillaume Poulain, Laurent N’Diaye, Monique
Published in
Cell Death & Disease
Ovarian cancer represents the first cause of mortality from gynecologic malignancies due to frequent chemoresistance occurrence. Increasing the [BH3-only Bim, Puma, Noxa proapoptotic]/[Bcl-xL, Mcl-1 antiapoptotic] proteins ratio was proven to efficiently kill ovarian carcinoma cells and development of new molecules to imbalance Bcl-2 member equilib...
Wu, Dechao Jian, Chongshu Peng, Qi Hou, Tingting Wu, Keling Shang, Bizhi Zhao, Minglei Wang, Yanru Zheng, Wen Ma, Qi
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Published in
Cell Death & Disease
Fatty acids are the most major substrate source for adult cardiac energy generation. Prohibitin 2 (PHB2), a highly conserved protein located in mitochondrial inner membrane, plays key roles in cellular energy metabolic homeostasis. However, its functions in regulating cardiac fatty acid metabolism have remained largely unknown. Our study demonstrat...
Roger, Elodie Martel, Sylvie Bertrand-Chapel, Adrien Depollier, Arnaud Chuvin, Nicolas Pommier, Roxane M. Yacoub, Karam Caligaris, Cassandre Cardot-Ruffino, Victoire Chauvet, Véronique
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Published in
Cell Death & Disease
Pancreatic ductal adenocarcinoma (PDAC) is one of the solid tumors with the poorest prognosis. The stroma of this tumor is abundant and composed of extracellular matrix and stromal cells (including cancer-associated fibroblasts and immune cells). Nerve fibers invading this stroma represent a hallmark of PDAC, involved in neural remodeling, which pa...
Nie, Anzheng Sun, Bao Fu, Zhihui Yu, Dongsheng
Published in
Cell Death & Disease
Aminoacyl-tRNA synthetases (ARSs) play a vital role in protein synthesis by linking amino acids to their cognate transfer RNAs (tRNAs). This typical function has been well recognized over the past few decades. However, accumulating evidence reveals that ARSs are involved in a wide range of physiological and pathological processes apart from transla...
Gagliardi, Mara Cotella, Diego Santoro, Claudio Corà, Davide Barlev, Nickolai A. Piacentini, Mauro Corazzari, Marco
Published in
Cell Death & Disease
The incidence of melanoma is increasing over the years with a still poor prognosis and the lack of a cure able to guarantee an adequate survival of patients. Although the new immuno-based coupled to target therapeutic strategy is encouraging, the appearance of targeted/cross-resistance and/or side effects such as autoimmune disorders could limit it...
Wang, Faxi Sun, Fei Luo, Jiahui Yue, Tiantian Chen, Longmin Zhou, Haifeng Zhang, Jing Yang, Chunliang Luo, Xi Zhou, Qing
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Published in
Cell Death & Disease
Type 1 diabetes (T1D) is characterized by the selective autoimmune destruction of the islet β cells, and macrophages play a significant role in this process. Small ubiquitin-like modification (SUMOylation) is an important posttranslational modification involved in T1D pathogenesis, but its function in macrophages remains unexplored. We presently de...
Liang, Jinqian Zhang, Xiang-yang Zhen, Yun-Fang Chen, Chong Tan, Haining Hu, Jianhua Tan, Ming-sheng
Published in
Cell Death & Disease
Activation of nuclear-factor-E2-related factor 2 (Nrf2) cascade can alleviate dexamethasone (DEX)-induced oxidative injury and death of human osteoblasts. A recent study has shown that phosphoglycerate kinase 1 (PGK1) inhibition/depletion will lead to Kelch-like ECH-associated protein 1 (Keap1) methylglyoxal modification, thereby activating Nrf2 si...
Rigo, Antonella Ferrarini, Isacco Lorenzetto, Erika Darra, Elena Liparulo, Irene Bergamini, Christian Sissa, Cinzia Cavalieri, Elisabetta Vinante, Fabrizio
Published in
Cell Death & Disease
α-Bisabolol (BSB) is a plant-derived sesquiterpene alcohol able to trigger regulated cell death in transformed cells, while deprived of the general toxicity in several mouse models. Here, we investigated the involvement of lysosomal and mitochondrial compartments in the cytotoxic effects of BSB, with a specific focus on the BH3-only activator prote...
Li, Yanrong Jiang, Weiyu Niu, Qiaona Sun, Yingjie Meng, Chunchun Tan, Lei Song, Cuiping Qiu, Xusheng Liao, Ying Ding, Chan
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Cell Death & Disease
Newcastle disease virus (NDV) causes severe infectious disease in poultry and selectively kills tumor cells, by inducing apoptosis and cytokines secretion. In this report, we study the mechanisms underlying NDV-induced apoptosis by investigating the unfolded protein response (UPR). We found that NDV infection activated all three branches of the UPR...
Qi, Lihua Chi, Xiaochun Zhang, Xi Feng, Xueqian Chu, Wenhui Zhang, Shengchang Wu, Junzhou Song, Yao Zhang, Youyi Kong, Wei
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Published in
Cell Death & Disease
Kindlin-2 plays an important role in the regulation of cardiac structure and function. Depletion of Kindlin-2 contributes to cardiac hypertrophy and progressive heart failure, however, the precise mechanisms involved in this process remain unclear. GATA4 is a critical transcription factor in regulating cardiogenesis. We found that Kindlin-2 suppres...
