Published in Neuropsychobiology
Background: The results of studies examining the response to experimental pain during the menstrual cycle are conflicting because of differences in the definitions of the menstrual period, outcome measures and types of experimental pain stimulation. So far, there have been only a few studies correlating experimental pain with the levels of gonadal ...
Published in Cell Stem Cell
In the midst of a global public health emergency, some businesses are taking advantage of widespread fears by marketing purported stem cell treatments for COVID-19. Such businesses target prospective clients with misleading claims, expose patients to potentially risky stem cells-based products, and undermine efforts to develop evidence-based treatm...
Published in Cell Stem Cell
In this review, Basil et al. discuss the complex architecture of the mammalian respiratory system and elaborate on the key aspects of lung repair and regeneration. They also discuss current and future directions for basic research of the respiratory system and the development of new therapeutic avenues.
Published in Cell Stem Cell
Van Rheenen and colleagues study Lgr5+ cancer stem cells during colorectal cancer metastasis. They demonstrate that the majority of metastases are seeded by Lgr5− cells, which upon arrival seed metastases in which Lgr5+ cells appear. This plasticity can occur independently of stemness-inducing factors and is indispensable for long-term metastatic g...
Published in Cell Stem Cell
Umbilical cord blood (UCB) HSCs offer several clinical advantages, but many units are too small for use. NOV rapidly increases the number of functional HSCs in single UCB units by recruitment rather than expansion. Manipulation of stem cell state transitions offers an alternative approach to enhance HSC activity.
Published in Cell Stem Cell
Published in Cell Stem Cell
The landscape of lung epithelial stem cells is getting more nuanced. In this issue of Cell Stem Cell , Kathiriya et al. (2020) describe a novel distal airway epithelial cell population with high regenerative potential.
Published in Cell Stem Cell
The physical properties of stem cell niches are thought to mediate important regulatory functions. Here we provide a proteomic resource of the neural stem cell niche in comparison to gliogenic brain parenchyma, highlighting stiffness and the enzyme transglutaminase 2 as key regulators of neurogenesis.
Medulloblastoma (MB), the most frequent malignant childhood brain tumor, can arise from cellular malfunctions during hindbrain development. Here we generate humanized models for Sonic Hedgehog (SHH)-subgroup MB via MYCN overexpression in primary human hindbrain-derived neuroepithelial stem (hbNES) cells or iPSC-derived NES cells, which display a ra...
Published in Cell Stem Cell
Chen and colleagues identify an Apln+ subpopulation of bone marrow endothelial cells (ECs), which are distinct from other sinusoidal ECs. Apln+ ECs regulate HSC maintenance, hematopoiesis, hematopoietic reconstitution, and vascular regeneration after irradiation. Crosstalk between Apln+ ECs and donor-cell-derived VEGF-A can be manipulated to improv...
