Pietras, Eric M Reynaud, Damien Kang, Yoon-A Carlin, Daniel Calero-Nieto, Fernando J Leavitt, Andrew D Stuart, Joshua M Göttgens, Berthold Passegué, Emmanuelle
Published in
Cell stem cell
Despite great advances in understanding the mechanisms underlying blood production, lineage specification at the level of multipotent progenitors (MPPs) remains poorly understood. Here, we show that MPP2 and MPP3 are distinct myeloid-biased MPP subsets that work together with lymphoid-primed MPP4 cells to control blood production. We find that all ...
Laurenti, Elisa Frelin, Catherine Xie, Stephanie Ferrari, Robin Dunant, Cyrille F. Zandi, Sasan Neumann, Andrea Plumb, Ian Doulatov, Sergei Chen, Jing
...
Regulated blood production is achieved through the hierarchical organization of dormant hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division frequency, with long-term (LT)-HSCs dividing the least. The molecular mechanisms underlying this variability in HSC division kinetics are unknown. We report here that quiesc...
Huang, Kevin Maruyama, Toru Fan, Guoping
Published in
Cell stem cell
Here we use a systems biology approach to comprehensively assess the conservation of gene networks in naive pluripotent stem cells (PSCs) with preimplantation embryos. While gene networks in murine naive and primed pluripotent states are reproducible across data sets, different sources of human stem cells display high degrees of variation, partly r...
Li, Ling Osdal, Tereza Ho, Yinwei Chun, Sookhee McDonald, Tinisha Agarwal, Puneet Lin, Allen Chu, Su Qi, Jing Li, Liang
...
Published in
Cell stem cell
The FLT3-ITD mutation is frequently observed in acute myeloid leukemia (AML) and is associated with poor prognosis. In such patients, FLT3 tyrosine kinase inhibitors (TKIs) are only partially effective and do not eliminate the leukemia stem cells (LSCs) that are assumed to be the source of treatment failure. Here, we show that the NAD-dependent SIR...
Charbord, Pierre Pouget, Claire Binder, Hans Dumont, Florent Stik, Grégoire Levy, Pacifique Allain, Fabrice Marchal, Céline Richter, Jenna Uzan, Benjamin
...
Published in
Cell Stem Cell
Bats, Anne-Sophie Blons, Helene Narjoz, Celine Le Frere-Belda, Marie-Aude Pierre Laurent-Puig Lecuru, Fabrice
Published in
Cell Stem Cell
MSI analysis in uterine cavity washings may be a promising screening tool for Lynch syndrome-associated endometrial cancer diagnosis.
Sun, Deqiang Luo, Min Jeong, Mira Rodriguez, Benjamin Xia, Zheng Hannah, Rebecca Wang, Hui Le, Thuc Faull, Kym F. Chen, Rui
...
Published in
Cell Stem Cell
To investigate the cell-intrinsic aging mechanisms that erode the function of somatic stem cells during aging, we have conducted a comprehensive integrated genomic analysis of young and aged cells. We profiled the transcriptome, DNA methylome, and histone modifications of young and old murine hematopoietic stem cells (HSCs). Transcriptome analysis ...
Barna, Maria Ruggero, Davide
Published in
Cell Stem Cell
Translation control is a prevalent form of gene expression regulation in developmental and stem cell biology. A recent paper by Signer et al. (2014) measures protein synthesis rates in the mouse hematopoietic compartment and reveals the importance of diminished protein production for maintaining hematopoietic stem cell function and restraining onco...
Mathieu, Julie Zhou, Wenyu Xing, Yalan Sperber, Henrik Ferreccio, Amy Agoston, Zsuzsa Kuppusamy, Kavitha T. Moon, Randall T. Ruohola-Baker, Hannele
Published in
Cell Stem Cell
Both HIF1α and HIF2α are required during early stages of reprogramming human cells to iPSCs, whereas HIF2α inhibits later stages of reprogramming by regulating the expression of TRAIL.
Nakamura, Sou Takayama, Naoya Hirata, Shinji Seo, Hideya Endo, Hiroshi Ochi, Kiyosumi Fujita, Ken-ichi Koike, Tomo Harimoto, Ken-ichi Dohda, Takeaki
...
Published in
Cell Stem Cell
This study describes a clinically applicable strategy for the derivation of functional platelets from human induced pluripotent stem cells (iPSCs) using the establishment of stable immortalized megakaryocyte progenitor lines from the iPSCs.
