Published in Cell Stem Cell
Reliable stem cell models of the early embryo would open new approaches to studying human development and infertility. Yanagida and colleagues used naive stem cells to generate human blastocyst-like structures comprising the three founding tissue layers for the extraembryonic membranes and the embryo.
Published in Cell Stem Cell
Human pluripotent stem cells (hPSCs) exist in naive or primed states, but it has been unclear whether these correspond to distinct developmental potencies. Here, Guo et al. show that naive hPSCs differentiate into trophectoderm, the founder tissue of the placenta, whereas primed hPSCs have lost this potential and instead form the amnion.
Published in Cell stem cell
The exocrine pancreas, consisting of ducts and acini, is the site of origin of pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Our understanding of the genesis and progression of human pancreatic diseases, including PDAC, is limited because of challenges in maintaining human acinar and ductal cells in culture. Here we report induction of ...
Published in Cell Stem Cell
Eriksen et al. show that SARS-CoV-2 antigens are expressed in COVID-19 patient samples and find robust infection of cadaveric ocular surface cells. Limbus cells derived from human donors and a hPSC whole-eye differentiation model seem more prone to infection and exhibit robust chemokine production and an impaired IFN-I/-III response.
Published in Cell Stem Cell
Harris et al. show that multiple cellular changes work in concert during early life to preserve the hippocampal stem cell population throughout adulthood in mice. In particular, more proliferating stem cells return to quiescence instead of differentiating. The changes are coordinated by increasing degradation of the pro-activation factor ASCL1.
Published in Cell Stem Cell
Over the past year, Cell Stem Cell has introduced early-career researchers impacted by the COVID-19 pandemic and subsequent closures to our readers. One year since our first introductions, we’ve invited several participants to reflect on their experiences and key issues. In this Story, Weiqi Zhang discusses her lab’s research focus and how they fou...
Published in Cell Stem Cell
Pediatric high-grade gliomas from different anatomical locations harbor distinct H3.3 mutations. Using human fetal neural stem cell models, Bressan et al. found that regional identity underlies cell-intrinsic competence for distinct oncogenic responses to K27M and G34R mutants. They show H3.3-G34R reinforces pre-existing forebrain-affiliated transc...
Published in Cell Stem Cell
COVID-19 has unfortunately halted lab work, conferences, and in-person networking, which is especially detrimental to researchers just starting their labs. Through social media and our reviewer networks, we met some early-career stem cell investigators impacted by the closures. Here, they introduce themselves and their research to our readers.
Published in Cell stem cell
Functional contributions of individual cellular components of the bone-marrow microenvironment to myelofibrosis (MF) in patients with myeloproliferative neoplasms (MPNs) are incompletely understood. We aimed to generate a comprehensive map of the stroma in MPNs/MFs on a single-cell level in murine models and patient samples. Our analysis revealed t...
Published in Cell Stem Cell
