Published in Cell stem cell
Adult stem cells constantly react to local changes to ensure tissue homeostasis. In the main body of the stomach, chief cells produce digestive enzymes; however, upon injury, they undergo rapid proliferation for prompt tissue regeneration. Here, we identified p57Kip2 (p57) as a molecular switch for the reserve stem cell state of chief cells in mice...
Published in Cell stem cell
The autonomic nervous system is a master regulator of homeostatic processes and stress responses. Sympathetic noradrenergic nerve fibers decrease bone mass, but the role of cholinergic signaling in bone has remained largely unknown. Here, we describe that early postnatally, a subset of sympathetic nerve fibers undergoes an interleukin-6 (IL-6)-indu...
Published in Cell Stem Cell
Merkle and Ghosh et al. describe insights from the whole-genome sequences of commonly used human embryonic stem cell (hESC) lines. Analyses of these sequences show that while hESC genomes have more large structural variants than humans do from genetic inheritance, hESCs do not have an observable excess of finer-scale variants. However, many hESC li...
Published in Cell Stem Cell
Taubenschmid-Stowers et al. discover human 8-cell-like cells that express transcription programs resembling zygotic genome activation in vitro . As these 8CLCs express genes, endogenous retroviruses, and proteins similar to 8-cell embryos, they can be used to study the molecular principles of human embryonic genome activation in stem cells in vitro...
Published in Cell Stem Cell
In this manuscript, Forbes and colleagues isolate and expand human biliary epithelial cells (hBECs) from discarded livers. Upon transplantation into a mouse model of biliary disease, hBECs regenerate and repair damaged bile ducts, offering a potential therapy for biliary disease.
Published in Cell stem cell
Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney indepe...
Published in Cell Stem Cell
It is not known when genes are first active in newly formed human embryos. Asami and colleagues show that this activity begins soon after fertilization, at the one-cell stage. Gene activation mirrors early embryonic processes, is disrupted in abnormal embryos, and predicts links to cancer-associated transcription regulators.
Published in Cell Stem Cell
Mesial temporal lobe epilepsy belongs to treatment-refractory forms of human epilepsy. Lentini et al. show that reactive glia proliferating in the epileptic hippocampus can be reprogrammed into GABAergic induced neurons that reduce chronic seizure activity. This study uncovers glia-to-neuron reprogramming as a potential disease-modifying strategy t...
Published in Cell Stem Cell
Published in Cell Stem Cell
The dynamics of tissue maintenance in the adult exocrine pancreas are largely unknown. In this study, Lodestijn et al. use a combination of experimental and computational methods to reveal that there is no hierarchy in the adult exocrine pancreas and that all cells can act as bona fide progenitors.
