Publishing in a Pandemic: The View from Cell Reports
Published in Cell Reports
Ensemble-Level Organization of Human Kinetochores and Evidence for Distinct Tension and Attachment Sensors
Published in Cell Reports
Roscioli et al. use subpixel imaging and computational methods to determine the ensemble-level 3D organization of the human kinetochore. They show how kinetochores undergo distinct rearrangements in response to the loss of attachment and tension.
Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative ...
...Published in Cell Reports
Noll et al. use the Collaborative Cross, a mouse genetic reference population, to map genetic loci associated with variation in the humoral response to influenza virus infection. Cross-dataset comparison shows that mapped loci are important for antibody response to multiple pathogens, and candidate genes with likely translational relevance are iden...
HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies
...Published in Cell Reports
Rantalainen et al. explore approaches to assemble HIV envelope glycoprotein into lipid assemblies, creating a more native environment for structural studies of MPER targeting antibodies. Results illustrate the dynamics of the glycoprotein and show that, in these assemblies, MPER targeting antibodies tilt the glycoprotein in relation to the bilayer....
Genome-wide Screens Implicate Loss of Cullin Ring Ligase 3 in Persistent Proliferation and Genome Instability in TP53 -D...
...Published in Cell Reports
Drainas et al. show that inactivation of genes in the neddylation pathway increases persistent proliferation in TP53 -deficient cells. TP53- and CUL3 -deficient cells induce an oncogenic transcriptional program, leading to partial EMT and heightened genomic instability. These cells show increased vulnerability to ATM inhibitors.
The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induc...
...Published in Cell Reports
Using a combination of pharmacological and genetic approaches, Keating et al. show that the Set7 methyltransferase is a regulator of trained immunity induced by β-glucan. Activation of Set7 increases oxidative phosphorylation in trained cells via histone lysine methylation at gene enhancers of key enzymes of the TCA cycle.
PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells
...Published in Cell Reports
Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infe...
...Published in Cell Reports
Thiele et al. show that importin-α3 is one of the major nuclear transporters of NF-κB in the mammalian lung. High-level TNF-α-inducing HPAIVs inhibit importin-α3 mRNA transcription by interfering with its promoter activity. Thus, HPAIVs may evade antiviral immunity in the respiratory tract by generating a bottleneck in importin-α3 availability.
Thermodynamic and Evolutionary Coupling between the Native and Amyloid State of Globular Proteins
...Published in Cell Reports
Langenberg et al. show that amyloid propensity favors protein stability. This results from the energetic correlation of mutation in the native and amyloid state. The genetic code tightens this relationship so that stable amyloidogenic sequences are deeply conserved. Positive selection of amyloidogenic sequences could therefore have favored the evol...
Gene Regulatory and Expression Differences between Mouse and Pig Limb Buds Provide Insights into the Evolutionary Emerge...
Published in Cell Reports
Tissières et al. show that, in comparison to the pentadactyl mouse limb, the expression and regulation of key developmental pathways are altered during pig limb bud development. These changes likely contributed to the morphological evolution of the highly specialized pig limb skeleton, with two weight-bearing and two reduced digits.
