Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2
...Published in Cell Reports
Gasser et al. highlight the importance of IgM in the capacity of plasma from convalescent donors to neutralize SARS-CoV-2.
SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO
...Published in Cell Reports
The reason why COVID-19 patients experience innate immunosuppression at the early stage of SARS-CoV-2 infection is unclear. Wu et al. report that ORF9b accumulates immediately during SARS-CoV-2 infection and antagonizes the RIG-I-MAVS antiviral type I interferon response by interrupting the K63-linked polyubiquitination of the interferon signaling ...
A snapshot of translation in Mycobacterium tuberculosis during exponential growth and nutrient starvation revealed by ri...
Published in Cell Reports
Sawyer et al. use ribosome profiling to characterize the translational landscape of Mycobacterium tuberculosis . They find widespread translation of non-canonical transcripts lacking canonical bacterial translation signals. Ribosome positioning reveals differences in initiation mechanisms, and factors that stabilize intact ribosomes may ensure cont...
Rare variant burden analysis within enhancers identifies CAV1 as an ALS risk gene
...Published in Cell Reports
Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion
...Published in Cell Reports
In this article, Hu et al. show the importance, for gene regulation, of a genomic region harboring GWAS variants that affect type 2 diabetes risk at the STARD10 locus. They also identify FCHSD2 as a likely mediator of the effects of these variants on insulin secretion.
The immunodominant and neutralization linear epitopes for SARS-CoV-2
...Published in Cell Reports
Lu et al. predict and validate B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins of SARS-CoV-2 using structure-based approaches. The immunodominant epitopes vary between D614 and G614 SARS-CoV-2. The epitopes on the S protein elicit neutralizing antibodies against D614 and G614 SARS-CoV-2.
Aspergillus fumigatus tryptophan metabolic route differently affects host immunity
...Published in Cell Reports
Mammalians use the kynurenine pathway for tryptophan degradation inducing tolerogenic immune responses. Zelante et al. report that similarly, the fungus Aspergillus fumigatus uses the kynurenine pathway. Pathogenic immune response occurs when the fungus catabolizes tryptophan via the indolepyruvate pathway, which targets host AhR. Administration of...
Cross-reactivity of SARS-CoV structural protein antibodies against SARS-CoV-2
Published in Cell Reports
Bates et al. extensively examine the cross-reactivity of selected monoclonal antibodies raised against SARS-CoV structural proteins with SARS-CoV-2. Although most SARS-CoV antibodies display remarkable cross-reactivity toward SARS-CoV-2 proteins, the spike antibodies of SARS-CoV show minimal cross-neutralization of live SARS-CoV-2 virus.
Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVI...
...Published in Cell Reports
Tan et al. longitudinally analyzed the virological and immunological parameters in COVID-19 patients from disease onset until resolution or death. Early induction of functional SARS-CoV-2-specific T cells was observed in patients with mild disease and rapid viral clearance. This supports the prognostic value of detecting SARS-CoV-2-specific T cells...
Trophectoderm mechanics direct epiblast shape upon embryo implantation
Published in Cell Reports
Weberling and Zernicka-Goetz characterize the remodeling of the mouse epiblast upon implantation. Its transformation from oval to cup shaped is driven by the polar trophectoderm tissue. Comparative analyses with human embryos and inhibitor treatments suggest the polar trophectoderm as an evolutionarily conserved regulator of epiblast shape upon imp...
