Published in Cell Reports
Romani et al. demonstrate that aging is typified by muscle amyloidosis in a cross-species conserved manner and that late-life treatments aimed at restoring NAD+ levels and mitochondrial homeostasis also increase cellular and organismal proteostasis, therefore beneficially impacting on health- and lifespan in a pleiotropic fashion.
Published in Cell Reports
This study describes neutralization by antibodies and convalescent sera of SARS-CoV-2 spike mutants. Rees-Spear et al. show that SARS-CoV amino acid substitutions and the B.1.1.7 variant can block monoclonal antibody neutralization and that serum samples collected following mild illness are less resilient to spike variation than those following sev...
Published in Cell Reports
The precise immunological defects that correlate with disease severity in COVID-19 have yet to be determined. Based on immune-metabolic profiling, Thompson et al. identify unique populations of T cells and myeloid cells that correlate with disease severity. These findings highlight metabolic pathways as possible therapeutic targets for COVID-19.
Published in Cell Reports
Rapid development of postexposure therapies is necessary for emerging viral threats such as SARS-CoV-2. Cross et al. demonstrate therapeutic reduction of disease severity using convalescent sera with high concentrations of SARS-CoV-2 neutralizing antibodies in the African green monkey model of COVID-19, suggesting this as a possible treatment appro...
Published in Cell Reports
Wang et al. show how transcription and replication affect each other in human cells. They find that transcription start sites are not fully replicated together with their neighboring regions and observe hundreds of cases in which duplication is completed only when cells are entering mitosis.
Published in Cell Reports
Kondo et al. reveal metabolic heterogeneity in breast cancer by using biosensors, including variable coupling of PI3K to glycolysis. Glucose levels are linked to cell density by cofilin, enabling increased uptake by migrating cells. High-glucose cells grow slowly without pyruvate but are rescued by other cancer cells or stromal fibroblasts.
Published in Cell Reports
Gasser et al. highlight the importance of IgM in the capacity of plasma from convalescent donors to neutralize SARS-CoV-2.
Published in Cell Reports
Using single-cell RNA sequencing, Sutton et al. show that a population of “atypical” B cells, normally associated with disease, are part of a wider landscape of alternative B cells that participate in normal responses to vaccination.
Published in Cell Reports
Zhu et al. show that pig primordial germ cells (PGCs) undergo DNA demethylation, histone remodeling, and X chromosome reactivation after specification. Pig PGCs retain few methylated loci after genome-wide demethylation, with potential for transgenerational inheritance. Species comparisons shows close similarities in transcriptional profiles of pig...
Published in Cell Reports
Glucocorticoids such as dexamethasone are widely used immunomodulators. Combining proteomics, ChIP-seq, RNA-seq, and genetic loss-of-function studies in murine macrophages, Greulich et al. show that recruitment of the SETD1A/COMPASS complex to cis -regulatory elements by the glucocorticoid receptor mediates some of their anti-inflammatory actions.
