Published in Cell reports
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.2 sub-lineage has gained in proportion relative to BA.1. Because spike (S) protein variations may underlie differences in their pathobiology, here we determine cryoelectron microscopy (cryo-EM) structures of the BA.2 S ectodomain and compare these with previously determined...
Published in Cell Reports
Chen et al. find that BET inactivation, by suppressing antiviral responses, enhances SARS-CoV-2 infection. This effect is phenocopied by the viral envelope (E) protein, which is acetylated in cells and has evolved to antagonize induction of the interferon response by binding and inhibiting BET proteins through their bromodomains.
Published in Cell Reports
Published in Cell reports
Emerging infectious diseases, especially if caused by bat-borne viruses, significantly affect public health and the global economy. There is an urgent need to understand the mechanism of interspecies transmission, particularly to humans. Viral genetics; host factors, including polymorphisms in the receptors; and ecological, environmental, and popul...
Published in Cell reports
Published in Cell reports
The recently emerged B.1.1.529 (Omicron) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant has a highly divergent spike (S) glycoprotein. We compared the functional properties of B.1.1.529 BA.1 S with those of previous globally prevalent SARS-CoV-2 variants, D614G and B.1.617.2. Relative to these variants, B.1.1.529 S exhibits de...
Published in Cell reports
While severe coronavirus 2019 (COVID-19) is associated with immune activation at the maternal-fetal interface, responses to asymptomatic/mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy remain unknown. Here, we assess immunological adaptations in blood and term decidua in response to asymptomatic/mild dis...
Published in Cell reports
Despite the ubiquitous function of macrophages across the body, the diversity, origin, and function of adrenal gland macrophages remain largely unknown. We define the heterogeneity of adrenal gland immune cells using single-cell RNA sequencing and use genetic models to explore the developmental mechanisms yielding macrophage diversity. We define po...
Published in Cell Reports
Nayrac et al., show that a 16-week interval BNT162b2 regimen elicits robust SARS-CoV-2-specific B and T cell responses in SARS-CoV-2 naive and previously infected individuals. Immune response kinetics differs after the first dose between cohorts but converges after boosting, which elicits a multifaceted cellular recall response and functional memor...
Published in Cell Reports
Elko et al. use a multiplexed assay to track epitope-specific antibody responses to COVID-19 vaccination. They identify conserved sites where antibodies cross-recognize endemic coronaviruses, but with divergent kinetics compared with SARS-CoV-2. The evolving recognition of polymorphic residues within otherwise conserved sites may influence the form...
