Published in Cell Reports
Fenwick et al. identify a highly potent anti-SAR-CoV-2 antibody that retains full activity against all variants of concern, demonstrates in vivo prophylactic protection in a hamster challenge model, and could be used prophylactically, as it has an extended in vivo half-life.
Published in Cell Reports
Published in Cell Reports
Lam et al. develop a model of SARS-CoV-2 infection in laboratory mice. This allows the researchers to study the threat of emerging variants in a more physiological context than cell culture systems. Interactions between SARS-CoV-2 variants and immunity is explored in the airway of mice.
Published in Cell Reports
McDonald et al. uncover a role of a circulating microRNA, miR-2392, as a potential biomarker for COVID-19 and begin development of a potential COVID-19 therapeutic and antiviral to inhibit miR-2392.
Published in Cell Reports
The coronavirus Nsp1 protein binds the 40S ribosomal subunit to induce host translational suppression and mRNA cleavage. Mendez et al. reveal that mutation of specific residues in the Nsp1 N terminus destabilizes its interaction with the 40S subunit and eliminates the protection of viral-leader-sequence-containing transcripts from translational rep...
Published in Cell Reports
Banach et al. report a SARS-CoV-2 neutralizing antibody along with genetic, structural, and functional features of public antibody responses targeting SARS-CoV-2. These data reveal how structural interactions with the SARS-CoV-2 receptor-binding domain correlate with viral neutralization and demonstrate the importance of native antibody heavy:light...
Published in Cell Reports
The B.1.617.2 (Delta) variant challenges efforts to control the COVID-19 pandemic. Arora et al. provide evidence that B.1.617.2 may enter human lung cells and fuse neighboring cells more efficiently than the initially circulating virus. Further, the study suggests that B.1.617.2 may evade neutralization by antibodies elicited upon infection and vac...
Published in Cell Reports
Wheatley et al. identify potent human monoclonal antibodies that block SARS-CoV-2 virus entry and ameliorate SARS-CoV-2 infection in mice and hamsters. Structural analyses reveal the diverse epitope landscape of neutralizing antibodies that will be potentially useful in future anti-SARS-CoV-2 therapeutics.
Published in Cell Reports
Memory B cells (MBCs) generated by different types of primary immune responses may have functional differences. Pape et al. find that SARS-CoV-2 spike-specific MBCs induced by infection had better antigen-binding capacity than did vaccine-induced primary MBCs and were more efficient at generating plasmablasts and secondary MBCs.
Published in Cell Reports
Simeoni et al. demonstrate that the Forkhead factor FOXC1 recruits a repressor complex of RUNX1, HDAC1, and Groucho family member TLE3 to a discrete set of enhancers distributed close to genes controlling monocyte/macrophage differentiation, thereby contributing to the differentiation block, which is the pathognomonic feature of acute myeloid leuke...
