Hu, Jia Wei, Min Mirzaei, Hamed Madia, Federica Mirisola, Mario Amparo, Camille Chagoury, Shawna Kennedy, Brian Longo, Valter D
Published in
Aging cell
In mammals, extended periods of fasting leads to the accumulation of blood ketone bodies including acetoacetate. Here we show that similar to the conversion of leucine to acetoacetate in fasting mammals, starvation conditions induced ketone body-like acetic acid generation from leucine in S. cerevisiae. Whereas wild-type and ras2Δ cells accumulated...
Yun, Jeanho Finkel, Toren
Published in
Cell metabolism
For many years, mitochondria were viewed as semiautonomous organelles, required only for cellular energetics. This view has been largely supplanted by the concept that mitochondria are fully integrated into the cell and that mitochondrial stresses rapidly activate cytosolic signaling pathways that ultimately alter nuclear gene expression. Remarkabl...
Published in
Cell Metabolism
Summary Obesity is associated with infiltration of macrophages into adipose tissue (AT), contributing to insulin resistance and diabetes. However, relatively little is known regarding the origin of AT macrophages (ATMs). We discovered that murine models of obesity have prominent monocytosis and neutrophilia, associated with proliferation and expans...
Im, Seung-Soon Young, Stephen G Raffatellu, Manuela Osborne, Timothy F
Published in
Cell metabolism
de la Cova, Claire Senoo-Matsuda, Nanami Ziosi, Marcello Wu, D Christine Bellosta, Paola Quinzii, Catarina M Johnston, Laura A
Published in
Cell metabolism
In growing tissues, cell fitness disparities can provoke interactions that promote stronger cells at the expense of the weaker in a process called cell competition. The mechanistic definition of cell fitness is not understood, nor is it understood how fitness differences are recognized. Drosophila cells with extra Myc activity acquire "supercompeti...
Harbauer, Angelika B Zahedi, René P Sickmann, Albert Pfanner, Nikolaus Meisinger, Chris
Published in
Cell metabolism
Mitochondria fulfill central functions in bioenergetics, metabolism, and apoptosis. They import more than 1,000 different proteins from the cytosol. It had been assumed that the protein import machinery is constitutively active and not subject to detailed regulation. However, recent studies indicate that mitochondrial protein import is regulated at...
Brissova, Marcela Aamodt, Kristie Brahmachary, Priyanka Prasad, Nripesh Hong, Ji-Young Dai, Chunhua Mellati, Mahnaz Shostak, Alena Poffenberger, Greg Aramandla, Radhika
...
Published in
Cell metabolism
Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular endothelial growth factor-A (VEGF-A) signaling are important for islet differentiation and the formation of highly vascularized islets. To dissect how VEGF-A signaling modulates intra-islet vasculature, islet microenvironment, and β cell mass, we transiently...
Hondares, Elayne Gallego-Escuredo, José M Flachs, Pavel Frontini, Andrea Cereijo, Ruben Goday, Alberto Perugini, Jessica Kopecky, Pavel Giralt, Marta Cinti, Saverio
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Published in
Metabolism: clinical and experimental
Human BAT, but not WAT, expresses FGF21. The expression of FGF21 is especially high in inducible, also called beige/brite, neonatal BAT, but it is also found in the interscapular, developmentally-programmed, BAT of neonates.
De Nardo, Dominic Labzin, Larisa I Kono, Hajime Seki, Reiko Schmidt, Susanne V Beyer, Marc Xu, Dakang Zimmer, Sebastian Lahrmann, Catharina Schildberg, Frank A
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Published in
Nature immunology
High-density lipoprotein (HDL) mediates reverse cholesterol transport and is known to be protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties that may be critical for protection against other inflammatory diseases. The molecular mechanisms of how HDL can modulate inflammation, particularly in immune cells suc...
Rasmussen, Brittany A Breen, Danna M Duca, Frank A Côté, Clémence D Zadeh-Tahmasebi, Melika Filippi, Beatrice M Lam, Tony K T
Published in
Cell metabolism
The fat-derived hormone leptin binds to its hypothalamic receptors to regulate glucose homeostasis. Leptin is also synthesized in the stomach and subsequently binds to its receptors expressed in the intestine, although the functional relevance of such activation remains largely unknown. We report here that intrajejunal leptin administration activat...
