Reiterer, Moritz Rajan, Mangala Gómez-Banoy, Nicolás Lau, Jennifer D. Gomez-Escobar, Luis G. Ma, Lunkun Gilani, Ankit Alvarez-Mulett, Sergio Sholle, Evan T. Chandar, Vasuretha
...
Published in
Cell Metabolism
Here, Reiterer et al. report that hyperglycemia in critically ill patients with COVID-19 is caused mainly by insulin resistance and is associated with decreased circulating adiponectin. SARS-CoV-2 is shown to directly infect human adipocytes, trigger an inflammatory antiviral response in the adipose tissue, and cause its dysfunction.
Fan, Zheng Turiel, Guillermo Ardicoglu, Raphaela Ghobrial, Moheb Masschelein, Evi Kocijan, Tea Zhang, Jing Tan, Ge Fitzgerald, Gillian Gorski, Tatiane
...
Published in
Cell Metabolism
Fan et al. discover two populations of muscle endothelial cells (mECs) that have differential ATF3/4 expression. Notably, ATF3/4+ mECs lie next to oxidative myofibers and have higher expression of amino acid metabolic genes, which metabolically prepare mECs for exercise-induced vascular expansion. Consequently, EC-specific loss of Atf4 impairs exer...
Gómez-Valadés, Alicia G. Pozo, Macarena Varela, Luis Boudjadja, Mehdi Boutagouga Ramírez, Sara Chivite, Iñigo Eyre, Elena Haddad-Tóvolli, Roberta Obri, Arnaud Milà-Guasch, Maria
...
Published in
Cell Metabolism
Gómez-Valadés et al. report that mitochondrial cristae dynamically reshape in POMC neurons in response to nutritional state. With genetic targeting, they reveal that the cristae-remodeling protein OPA1 is essential to sustain cristae structure and mitochondrial Ca2+ homeostasis in POMC neurons, ensuring appropriate modulation of α-MSH release, the ...
Tang, Xuming Uhl, Skyler Zhang, Tuo Xue, Dongxiang Li, Bo Vandana, J Jeya Acklin, Joshua A Bonnycastle, Lori L Narisu, Narisu Erdos, Michael R
...
Published in
Cell metabolism
Recent clinical data have suggested a correlation between coronavirus disease 2019 (COVID-19) and diabetes. Here, we describe the detection of SARS-CoV-2 viral antigen in pancreatic beta cells in autopsy samples from individuals with COVID-19. Single-cell RNA sequencing and immunostaining from ex vivo infections confirmed that multiple types of pan...
Borgmann, Diba Ciglieri, Elisa Biglari, Nasim Brandt, Claus Cremer, Anna Lena Backes, Heiko Tittgemeyer, Marc Wunderlich, F. Thomas Brüning, Jens C. Fenselau, Henning
...
Published in
Cell Metabolism
Borgmann et al. devise an intersectional genetic approach to probe the contribution of molecularly defined sensory neurons in gut-brain communication. They identify that distinct gut-innervating vagal afferents differentially control food intake and peripheral glucose metabolism, and engage distinct downstream circuits in the brain.
Gruber, Tim Pan, Chenchen Contreras, Raian E. Wiedemann, Tobias Morgan, Donald A. Skowronski, Alicja A. Lefort, Sandrine De Bernardis Murat, Cahuê Le Thuc, Ophelia Legutko, Beata
...
Published in
Cell Metabolism
Here, Gruber et al. show that during diet-induced obesity in mice there is a profound remodeling of the gliovascular interface in the hypothalamus, resulting in arterial hypertension. This process is driven by elevated leptin levels and upregulation of a HIF1α-VEGF signaling axis in local astrocytes.
Wu, Chien-Ting Lidsky, Peter V. Xiao, Yinghong Lee, Ivan T. Cheng, Ran Nakayama, Tsuguhisa Jiang, Sizun Demeter, Janos Bevacqua, Romina J. Chang, Charles A.
...
Published in
Cell Metabolism
Diabetic patients are at risk for severe COVID-19, but the virus may further damage insulin-secreting β cells. Wu et al. found that patient β cells are virally infected and the highly expressed neuropilin-1 receptor is critical for viral entry, causing cell death and reduced insulin secretion, exacerbating diabetes in patients.
Sadiku, Pranvera Willson, Joseph A Ryan, Eilise M Sammut, David Coelho, Patricia Watts, Emily R Grecian, Robert Young, Jason M Bewley, Martin Arienti, Simone
...
Published in
Cell metabolism
Zhang, Qian Delessa, Challa Tenagne Augustin, Robert Bakhti, Mostafa Colldén, Gustav Drucker, Daniel J. Feuchtinger, Annette Caceres, Cristina Garcia Grandl, Gerald Harger, Alexandra
...
Published in
Cell Metabolism
Zhang et al. report that CNS GIPR plays a significant role in regulating food intake. They show that treatment with acyl-GIP or with a GLP-1/GIP dual-agonist lowers body weight and food intake in wild-type mice but shows blunted efficacy in CNS-Gipr KO mice.
Mimouni, Nour El Houda Paiva, Isabel Barbotin, Anne-Laure Timzoura, Fatima Ezzahra Plassard, Damien Le Gras, Stephanie Ternier, Gaetan Pigny, Pascal Catteau-Jonard, Sophie Simon, Virginie
...
Published in
Cell Metabolism
Polycystic ovary syndrome (PCOS) is the most common female reproductive and metabolic disorder, but its pathogenesis is still unknown. Here, Mimouni, Paiva et al. report that in mice, transmission of PCOS-like traits to multiple generations occurs via an altered landscape of DNA methylation and transcriptome expression. These authors also identify ...
