Garreta, Elena Prado, Patricia Stanifer, Megan L Monteil, Vanessa Marco, Andrés Ullate-Agote, Asier Moya-Rull, Daniel Vilas-Zornoza, Amaia Tarantino, Carolina Romero, Juan Pablo
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Published in
Cell metabolism
It is not well understood why diabetic individuals are more prone to develop severe COVID-19. To this, we here established a human kidney organoid model promoting early hallmarks of diabetic kidney disease development. Upon SARS-CoV-2 infection, diabetic-like kidney organoids exhibited higher viral loads compared with their control counterparts. Ge...
Liu, Yang Méric, Guillaume Havulinna, Aki S. Teo, Shu Mei Åberg, Fredrik Ruuskanen, Matti Sanders, Jon Zhu, Qiyun Tripathi, Anupriya Verspoor, Karin
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Published in
Cell Metabolism
The predictive capacity of the gut microbiome for future liver diseases is investigated using machine learning in a large prospective cohort.
Wenes, Mathias Jaccard, Alison Wyss, Tania Maldonado-Pérez, Noelia Teoh, Shao Thing Lepez, Anouk Renaud, Fabrice Franco, Fabien Waridel, Patrice Yacoub Maroun, Céline
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Published in
Cell Metabolism
Wenes et al. show that lactate oxidation via pyruvate conversion and mitochondrial import may sustain antitumor function of cytotoxic T cells in the tumor microenvironment. In contrast, short-term inhibition of the mitochondrial pyruvate carrier in recently activated T cells promotes memory differentiation, which enhances antitumor activity upon ad...
Wei, Yu-Miao Li, Xiang Xu, Ming Abais, Justine M. Chen, Yang Riebling, Christopher R. Boini, Krishna M. Li, Pin-Lan Zhang, Yang
Published in
Cellular Physiology and Biochemistry
Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes...
Reiser, Jochen Spear, Ryan Luo, Shengyuan
Published in
Cell Metabolism
SARS-CoV-2 can cause diverse severe and lasting damage to the kidneys. In the latest issue of Cell Stem Cell , Jansen et al. utilized data gleaned from human kidney autopsies and human induced pluripotent stem cell-derived kidney organoids to investigate the direct effects of SARS-CoV-2 infection on kidney cells. They found that such infections res...
Li, Zilun Peng, Meixiu Chen, Pin Liu, Chenshu Hu, Ao Zhang, Yixin Peng, Jiangyun Liu, Jiang Li, Yihui Li, Wenxue
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Published in
Cell Metabolism
Li et al. identify imatinib and methazolamide as enzymatic activators of ACE2, which improve metabolic complications under SARS-CoV-2 infection and reduce viral entry via allosteric inhibition of binding between ACE2 and spike protein, suggesting that activation of ACE2 might be a conceptually new strategy to treat metabolic sequelae of COVID-19.
Ramírez, Sara Haddad-Tóvolli, Roberta Radosevic, Marija Toledo, Miriam Pané, Adriana Alcolea, Daniel Ribas, Vicent Milà-Guasch, Maria Pozo, Macarena Obri, Arnaud
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Published in
Cell Metabolism
Ramírez et al. show that reduced hypothalamic pregnenolone levels, in the context of metabolic diseases, are associated with cognitive deterioration. POMC neuron-derived pregnenolone is a key mediator of cognition, but not metabolism, acting via hippocampal mechanisms. These results identify an unsuspected role for POMC neuron-derived pregnenolone ...
Mito, Takayuki Vincent, Amy E. Faitg, Julie Taylor, Robert W. Khan, Nahid A. McWilliams, Thomas G. Suomalainen, Anu
Published in
Cell Metabolism
Mito et al. reveal a mosaic pattern of mitophagy activation in mitochondrial myopathy muscle fibers. Increased mitophagy zones surround central nuclei, while mitophagy halts in advanced disease. The findings provide evidence as to why mtDNA variants accumulate in muscle. Rescue of mitophagy by rapamycin suggests mitophagy activation as a therapeuti...
Vila, Isabelle K. Chamma, Hanane Steer, Alizée Saccas, Mathilde Taffoni, Clara Turtoi, Evgenia Reinert, Line S. Hussain, Saqib Marines, Johanna Jin, Lei
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Published in
Cell Metabolism
The stimulator of interferon genes (STING) is a central regulator of nucleic acid-associated inflammatory responses. Here, Vila et al. discover that STING regulates polyunsaturated fatty acid (PUFA) metabolism, and in turn, PUFAs inhibit STING-dependent inflammation. This cross-regulation is central to the maintenance of metabolic homeostasis.
Saveljeva, Svetlana Sewell, Gavin W. Ramshorn, Katharina Cader, M. Zaeem West, James A. Clare, Simon Haag, Lea-Maxie de Almeida Rodrigues, Rodrigo Pereira Unger, Lukas W. Iglesias-Romero, Ana Belén
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Published in
Cell Metabolism
Saveljeva et al. identify a biochemical mechanism in dendritic cells that restrains T cell priming and prevents immunopathology but dampens tumor surveillance. FAMIN enables a purine nucleotide cycle, which prevents cytoplasmic NADH/NAD+ reductive stress that augments antigen presentation, and it generates inosine, which inhibits T cell activation....
