Orsini, Marion Chateauvieux, Sébastien Rhim, Jiyun Gaigneaux, Anthoula Cheillan, David Christov, Christo Dicato, Mario Franck Morceau Marc Diederich
Published in
Cell Death and Differentiation
Elevated levels of the pro-inflammatory cytokine tumor necrosis factor-α (TNFα) inhibit erythropoiesis and cause anemia in patients with cancer and chronic inflammatory diseases. TNFα is also a potent activator of the sphingomyelinase (SMase)/ ceramide pathway leading to ceramide synthesis and regulating cell differentiation, proliferation, apoptos...
Tóth, K Sarang, Z Scholtz, B Brázda, P Ghyselinck, N Chambon, P Fésüs, L Szondy, Z
Published in
Cell Death and Differentiation
Glucocorticoid-induced apoptosis of thymocytes is one of the first recognized forms of programmed cell death. It was shown to require gene activation induced by the glucocorticoid receptor (GR) translocated into the nucleus following ligand binding. In addition, the necessity of the glucocorticoid-induced, but transcription-independent phosphorylat...
Gama, V Gomez, J A Mayo, L D Jackson, M W Danielpour, D Song, K Haas, A L Laughlin, M J Matsuyama, S
Published in
Cell death and differentiation
Earlier, we have reported that 70 kDa subunit of Ku protein heterodimer (Ku70) binds and inhibits Bax activity in the cytosol and that ubiquitin (Ub)-dependent proteolysis of cytosolic Ku70 facilitates Bax-mediated apoptosis. We found that Hdm2 (human homolog of murine double minute) has an ability to ubiquitinate Ku70 and that Hdm2 overexpression ...
Spender, L C O'Brien, D I Simpson, D Dutt, D Gregory, C D Allday, M J Clark, L J Inman, G J
Published in
Cell death and differentiation
Transforming growth factor-beta (TGF-beta) potently induces apoptosis in Burkitt's lymphoma (BL) cell lines and in explanted primary human B lymphocytes. The physiological relevance and mechanism of TGF-beta-mediated apoptosis induction in these cells remains to be determined. Here we demonstrate the requirement for TGF-beta-mediated regulation of ...
Mastino, A. Basu, S. Brunner, T. Ricci, J. E. Marc Diederich
Published in
Cell Death and Differentiation
It is not yet time to move to a more exciting and fertile field of research! For those who attended the ‘Apoptosis World 2008—From Mechanisms to Applications’ meeting at the European Congress Center in Kirchberg, in the neighbourhood of Luxembourg, this is the reassuring message they can bring home. There is still a lot of work to be done for resea...
