Xie, Ying Liu, Yi-Ke Guo, Zong-Pei Guan, Hua Liu, Xiao-Dan Xie, Da-Fei Jiang, Yi-Guo Ma, Teng Zhou, Ping-Kun
Published in
Cell death and differentiation
End resection of DNA double-strand breaks (DSBs) to form 3' single-strand DNA (ssDNA) is critical to initiate the homologous recombination (HR) pathway of DSB repair. HR pathway is strictly limited in the G1-phase cells because of lack of homologous DNA as the templates. Exonuclease 1 (EXO1) is the key molecule responsible for 3' ssDNA formation of...
Arreal, Leire Piva, Marco Fernández, Sonia Revandkar, Ajinkya Schaub-Clerigué, Ariane Villanueva, Josep Zabala-Letona, Amaia Pujana, Mikel Astobiza, Ianire Cortazar, Ana Rosa
...
Published in
Cell death and differentiation
Oncogene addiction postulates that the survival and growth of certain tumor cells is dependent upon the activity of one oncogene, despite their multiple genetic and epigenetic abnormalities. This phenomenon provides a foundation for molecular targeted therapy and a rationale for oncogene-based stratification. We have previously reported that the Pr...
Tan, Honglin Chen, Mina Pang, Dejiang Xia, Xiaoqiang Du, Chongyangzi Yang, Wanchun Cui, Yiyuan Huang, Chao Jiang, Wanxiang Bi, Dandan
...
Published in
Cell death and differentiation
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive loss of motor neurons. Improving neuronal survival in ALS remains a significant challenge. Previously, we identified Lanthionine synthetase C-like protein 1 (LanCL1) as a neuronal antioxidant defense gene, the genetic deletion of which causes apopt...
Martínez-Lagunas, Kristel Yamaguchi, Yoshifumi Becker, Cora Geisen, Caroline DeRuiter, Marco C Miura, Masayuki Fleischmann, Bernd K Hesse, Michael
Published in
Cell death and differentiation
Despite the great progress on the cell biology of programmed cell death (PCD), its incidence and exact time course during embryonic and particular heart development are still unclear. This is also due to the lack of models enabling to directly identify and monitor PCD cells at different time points in vivo. Herein we report generation of transgenic...
Zhang, Yu Xue, Weili Zhang, Wenquan Yuan, Yangmian Zhu, Xiuqin Wang, Qing Wei, Yujuan Yang, Dong Yang, Chen Chen, Yan
...
Published in
Cell death and differentiation
Acute liver injury is commonly caused by bacterial endotoxin/lipopolysaccharide (LPS), and by drug overdose such as acetaminophen (APAP). The exact role of epigenetic modification in acute liver injury remains elusive. Here, we investigated the role of histone methyltransferase G9a in LPS- or APAP overdose-induced acute liver injury. Under D-galact...
Yuan, Kefei Xie, Kunlin Lan, Tian Xu, Lin Chen, Xiangzheng Li, Xuefeng Liao, Mingheng Li, Jiaxin Huang, Jiwei Zeng, Yong
...
Published in
Cell death and differentiation
Metastasis is one of the main contributors to the poor prognosis of hepatocellular carcinoma (HCC). However, the underlying mechanism of HCC metastasis remains largely unknown. Here, we showed that TXNDC12, a thioredoxin-like protein, was upregulated in highly metastatic HCC cell lines as well as in portal vein tumor thrombus and lung metastasis ti...
Chen, Ruo-Yu Yen, Chia-Jui Liu, Yao-Wen Guo, Chun-Guo Weng, Chieh-Yu Lai, Chien-Hsien Wang, Ju-Ming Lin, Yih-Jyh Hung, Liang-Yi
Published in
Cell death and differentiation
Centrosomal P4.1-associated protein (CPAP) is overexpressed in hepatocellular carcinoma (HCC) and positively correlated with recurrence and vascular invasion. Here, we found that CPAP plays an important role in HCC malignancies. Functional characterization indicated that CPAP overexpression increases tumor growth, angiogenesis, and metastasis ex vi...
Nieto, Ainhoa Hara, Makoto R Quereda, Victor Grant, Wayne Saunders, Vanessa Xiao, Kunhong McDonald, Patricia H Duckett, Derek R
Published in
Cell death and differentiation
Cellular DNA is constantly under threat from internal and external insults, consequently multiple pathways have evolved to maintain chromosomal fidelity. Our previous studies revealed that chronic stress, mediated by continuous stimulation of the β2-adrenergic-βarrestin-1 signaling axis suppresses activity of the tumor suppressor p53 and impairs ge...
Riegel, Kristina Schlöder, Janine Sobczak, Marco Jonuleit, Helmut Thiede, Bernd Schild, Hansjörg Rajalingam, Krishnaraj
Published in
Cell death and differentiation
RAF kinases (ARAF, BRAF, and CRAF) are highly conserved enzymes that trigger the RAF-MEK1/2-ERK1/2 (MAPK) pathway upon activation of RAS. Despite enormous clinical interest, relatively little is known on the role of RAFs in mediating immune responses. Here, we investigated the role of RAF kinases and MEK1/2 in dendritic cells (DCs), the central reg...
Li, Kun-Po Ladle, Brian H Kurtulus, Sema Sholl, Allyson Shanmuganad, Sharmila Hildeman, David A
Published in
Cell death and differentiation
Most effector CD8+ T cells die, while some persist and become either "effector" (TEM) or "central" (TCM) memory T cells. Paradoxically, effector CD8+ T cells with greater memory potential have higher levels of the pro-apoptotic molecule Bim. Here, we report, using a novel Bim-mCherry knock-in mouse, that cells with high levels of Bim preferentially...
