Solon, Margaret Ge, Nianfeng Hambro, Shannon Haller, Susan Jiang, Jian Baca, Miriam Preston, Jessica Maltzman, Allie Wickliffe, Katherine E Liang, Yuxin
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Cell death and differentiation
Necroptosis is a lytic form of cell death that is mediated by the kinase RIPK3 and the pseudokinase MLKL when caspase-8 is inhibited downstream of death receptors, toll-like receptor 3 (TLR3), TLR4, and the intracellular Z-form nucleic acid sensor ZBP1. Oligomerization and activation of RIPK3 is driven by interactions with the kinase RIPK1, the TLR...
Young, Ming-Jer Wang, Shao-An Chen, Yung-Ching Liu, Chia-Yu Hsu, Kai-Cheng Tang, Sin-Wei Tseng, Yau-Lin Wang, Yi-Ching Lin, Shih-Min Hung, Jan-Jong
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Cell death and differentiation
Drug resistance in cancer therapy is the major reason for poor prognosis. Addressing this clinically unmet issue is important and urgent. In this study, we found that targeting USP24 by the specific USP24 inhibitors, USP24-i and its analogues, dramatically activated autophagy in the interphase and mitotic periods of lung cancer cells by inhibiting ...
Jin, Xing Liu, Lei Liu, Dan Wu, Jia Wang, Congcong Wang, Siliang Wang, Fengying Yu, Guanzhen Jin, Xiaoxia Xue, Yu-Wen
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Cell Death and Differentiation
Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with notable metabolic reprogramming, yet the pivotal metabolic feature driving ESCC progression remains elusive. Here, we show that methionine cycle exhibits robust activation in ESCC and is reversely associated with patient survival. ESCC cells readily harness exogenous methionine t...
Tran, Hong Tri Kratina, Tobias Coutansais, Auriane Michalek, Dominika Hogan, Benjamin M. Lawlor, Kate E. Vince, James E. Silke, John Lalaoui, Najoua
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Cell Death and Differentiation
Caspase-8 activity is required to inhibit necroptosis during embryogenesis in mice. In vitro studies have suggested that caspase-8 directly cleaves RIPK1, CYLD and the key necroptotic effector kinase RIPK3 to repress necroptosis. However, recent studies have shown that mice expressing uncleavable RIPK1 die during embryogenesis due to excessive apop...
Albert, Marie-Christine Uranga-Murillo, Iratxe Arias, Maykel De Miguel, Diego Peña, Natacha Montinaro, Antonella Varanda, Ana Beatriz Theobald, Sebastian J. Areso, Itziar Saggau, Julia
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Cell Death and Differentiation
The dysregulated immune response and inflammation resulting in severe COVID-19 are still incompletely understood. Having recently determined that aberrant death-ligand-induced cell death can cause lethal inflammation, we hypothesized that this process might also cause or contribute to inflammatory disease and lung failure following SARS-CoV-2 infec...
Schweighofer, Sarah V. Jans, Daniel C. Keller-Findeisen, Jan Folmeg, Anne Ilgen, Peter Bates, Mark Jakobs, Stefan
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Cell Death and Differentiation
One hallmark of apoptosis is the oligomerization of BAX and BAK to form a pore in the mitochondrial outer membrane, which mediates the release of pro-apoptotic intermembrane space proteins into the cytosol. Cells overexpressing BAX or BAK fusion proteins are a powerful model system to study the dynamics and localization of these proteins in cells. ...
Jiao, Huipeng James, Sharmy J Png, Chin Wen Cui, Chaoyu Li, Heng Li, Liang Chia, Wan Ni Min, Nyo Li, Weiyun Claser, Carla
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Cell death and differentiation
Detection of cytosolic nucleic acids by pattern recognition receptors, including STING and RIG-I, leads to the activation of multiple signalling pathways that culminate in the production of type I interferons (IFNs) which are vital for host survival during virus infection. In addition to protective immune modulatory functions, type I IFNs are also ...
Garcia-Saez, Ana J
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Cell death and differentiation
Nechanitzky, Robert Ramachandran, Parameswaran Nechanitzky, Duygu Li, Wanda Y Wakeham, Andrew C Haight, Jillian Saunders, Mary E Epelman, Slava Mak, Tak W
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Cell death and differentiation
PirB is an inhibitory cell surface receptor particularly prominent on myeloid cells. PirB curtails the phenotypes of activated macrophages during inflammation or tumorigenesis, but its functions in macrophage homeostasis are obscure. To elucidate PirB-related functions in macrophages at steady-state, we generated and compared single-cell RNA-sequen...
Zhang, Bin Li, Jie Wang, Yijun Liu, Xixi Yang, Xiao Liao, Zhiyun Deng, Suke Deng, Yue Zhou, Zhiyuan Tian, Yu
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Cell death and differentiation
Cisplatin-based chemotherapy improves the control of distant metastases in patients with nasopharyngeal carcinoma (NPC); however, around 30% of patients fail treatment due to acquired drug resistance. Epigenetic regulation is known to contribute to cisplatin resistance; nevertheless, the underlying mechanisms remain poorly understood. Here, we show...