Benedetti, Rossella Romeo, Maria Anele Arena, Andrea Gilardini Montani, Maria Saveria Di Renzo, Livia D’Orazi, Gabriella Cirone, Mara
Published in
Cell Death Discovery
Colon cancer represents one of the most common and aggressive cancers in its advanced state. Among the most innovative anti-cancer approaches, the manipulation of UPR is a promising one, effective also against cancers carrying dysfunctional p53. Interestingly, it is emerging that UPR cross-talks with DDR and that targeting the interplay between the...
Chen, Pengchen Wang, Wei Wong, Sin Wa Li, Junnan Wu, Qiushaung Zhang, Shu-Dong Lin, Yao Kwok, Hang Fai
Published in
Cell Death Discovery
Gastric neuroendocrine carcinoma (GNEC) is a common type of neuroendocrine carcinoma (NEC) with a poor prognosis and limited therapeutic options. The underlying mechanisms of chemoresistance in patients with GNEC and those with NEC are largely unknown, and thus, reliable biomarkers and therapeutic targets that could improve treatment outcomes in pa...
Muccioli, Silvia Ciaccio, Roberto Brillo, Valentina Leanza, Luigi
Published in
Cell Death Discovery
Tissue Transglutaminases (TGs) are crosslinking enzymes with pleiotropic functions that have been linked to the development and progression of numerous cancers, with a recent focus on their ability to remodel the tumor microenvironment. Although several pieces of evidence demonstrated their importance in the regulation of the major signaling pathwa...
Chen, Fagui Zhao, Huasi Li, Chenhui Li, Ping Zhang, Qichuan
Published in
Cell Death Discovery
Molecularly-targeted agents are still urgently needed for better non-small cell lung cancer (NSCLC) therapy. CC-115 is a potent DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) dual blocker. We evaluated its activity in different human NSCLC cells. In various primary human NSCLC cells and A549 cells, CC-115 potently in...
Liao, Yihao Zhou, Diansheng Wang, Pu Yang, Mengyue Jiang, Ning
Published in
Cell Death Discovery
Ubiquitination is a critical biological process in post-translational modification of proteins and involves multiple signaling pathways in protein metabolism, apoptosis, DNA damage, cell-cycle progression, and cancer development. Deubiquitinase, a specific enzyme that regulates the ubiquitination process, is also thought to be closely associated wi...
Hu, Jun Zhang, Wanping Xu, Lingjuan Hu, Lihua
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Cell death discovery
Corneal allograft rejection can be seen in some patients after corneal transplantation. The present study intends to investigate whether JAK2 gene knockout affects corneal allograft rejection through regulation of dendritic cells (DCs)-induced T cell immune tolerance. In order to identify the target gene related to corneal allograft rejection, high...
Wu, Zhiguo Tan, Jian Lin, Lichang Zhang, Wenting Yuan, Wanqiu
Published in
Cell death discovery
The incidence of post-operative cognitive dysfunction (POCD) remains a relatively prevalent complication in the elderly after surgery, especially in those receiving sevoflurane (Sevo) anesthesia. microRNA (miR)-140-3p has been demonstrated to orchestrate neuroinflammation and neuron apoptosis. However, the role of miR-140-3p in POCD remains largely...
Xu, Qiong Liu, Mingke Gu, Jielei Ling, Sisi Liu, Xiaolin Luo, Zhenyu Jin, Yangshuo Chai, Renjie Ou, Wenchao Liu, Shiming
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Cell death discovery
Myocardial ischemia/reperfusion (I/R) injury is a complex pathological process that is still not fully understood. The oxidative stress response has a critical role in the occurrence and progression of myocardial ischemia/reperfusion injury. This study investigated the specific mechanism of ubiquitin-specific protease 7 (USP7) regulation of myocard...
Alonzi, Tonino Aiello, Alessandra Repele, Federica Falasca, Laura Francalancia, Massimo Garbuglia, Anna Rosa Delogu, Giovanni Nicastri, Emanuele Piacentini, Mauro Goletti, Delia
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Published in
Cell death discovery
The novel SARS-CoV-2 variants of concern (VOC) represent a considerable global alarm because their mutations are known to affect transmissibility and cause immune escape. While preventing severe disease and deaths, the available vaccines do not avoid infection; therefore, COVID-19 disease management still requires effective therapies. We have recen...
Xu, Jichuan Xu, Jian Liu, Xinyuan Jiang, Jianxin
Published in
Cell Death Discovery
Non-coding RNAs (ncRNAs), which occupy the vast majority of human transcripts are known for their inability to encode proteins. NcRNAs consist of a diverse range of RNA species, including long non-coding RNAs (lncRNAs), which have significant meaning for epigenetic modification, post-transcriptional regulation of target genes, molecular interferenc...