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Metabolic interactions between cysteamine and epigallocatechin gallate.

Published in Cell cycle (Georgetown, Tex.)

Phase II clinical trials indicate that the combination of cysteamine plus epigallocatechin gallate (EGCG) is effective against cystic fibrosis in patients bearing the most frequent etiological mutation (CFTRΔF508). Here, we investigated the interaction between both agents on cultured respiratory epithelia cells from normal and CFTRΔF508-mutated don...

Fasting improves anticancer immunosurveillance via autophagy induction in malignant cells.

Published in Cell cycle (Georgetown, Tex.)

The WEE1 regulators CPEB1 and miR-15b switch from inhibitor to activators at G2/M.

Published in Cell cycle (Georgetown, Tex.)

MicroRNAs (miRNAs) in the AGO-containing RISC complex control messenger RNA (mRNA) translation by binding to mRNA 3' untranslated region (3'UTR). The relationship between miRNAs and other regulatory factors that also bind to mRNA 3'UTR, such as CPEB1 (cytoplasmic polyadenylation element-binding protein), remains elusive. We found that both CPEB1 an...

Metabolic epistasis among apoptosis-inducing factor and the mitochondrial import factor CHCHD4

Published in Cell Cycle

Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo.

Published in Cell cycle (Georgetown, Tex.)

Recently, we reported that saturated and unsaturated fatty acids trigger autophagy through distinct signal transduction pathways. Saturated fatty acids like palmitate (PA) induce autophagic responses that rely on phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3, best known as VPS34) and beclin 1 (BECN1). Conversely, unsaturated fatty...

SQSTM1/p62 regulates the expression of junctional proteins through epithelial-mesenchymal transition factors.

Published in Cell cycle (Georgetown, Tex.)

The epithelial to mesenchymal transition (EMT) is an essential process during development and during tumor progression. Here, we observed the accumulation of the selective autophagy receptor and signaling adaptor sequestosome-1 (SQSTM1/p62) during growth factor-induced EMT in immortalized and tumor-derived epithelial cell lines. Modulation of the p...

Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes

Published in Cell Cycle

The oncolytic peptide LTX-315 triggers necrotic cell death

Published in Cell Cycle

Fitting WWP-1 in the dietary restriction network.

Published in Cell cycle (Georgetown, Tex.)

The oncolytic peptide LTX-315 triggers necrotic cell death.

Published in Cell cycle (Georgetown, Tex.)

The oncolytic peptide LTX-315 has been designed for killing human cancer cells and turned out to stimulate anti-cancer immune responses when locally injected into tumors established in immunocompetent mice. Here, we investigated the question whether LTX-315 induces apoptosis or necrosis. Transmission electron microscopy or morphometric analysis of ...