Chauhan, Anil K. Li, Ping Sun, Yingming Wani, Gulzar Zhu, Qianzheng Wani, Altaf A.
Published in
Cell Cycle
Mineralocorticoid and androgen receptor antagonist, spironolactone, was recently identified as an inhibitor of nucleotide excision repair (NER), acting via induction of proteolysis of TFIIH component Xeroderma Pigmentosum B protein (XPB). This activity provides a strong rationale for repurposing spironolactone for cancer therapy. Here, we report th...
Tchakarska, Guergana Sola, Brigitte
Published in
Cell cycle (Georgetown, Tex.)
The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and integrates extracellular mitogenic signals and cell cycle progression. When deregulated (overexpressed, accumulated, inappropriately located), cyclin D1 becomes an on...
Bazzar, Wesam Bocci, Matteo Hejll, Eduar Högqvist Tabor, Vedrana Hydbring, Per Grandien, Alf Alzrigat, Mohammad Larsson, Lars-Gunnar
Published in
Cell Cycle
Deregulated expression of the MYC oncogene is a frequent event during tumorigenesis and generally correlates with aggressive disease and poor prognosis. While MYC is a potent inducer of apoptosis, it often suppresses cellular senescence, which together with apoptosis is an important barrier against tumor development. For this latter function, MYC i...
Theise, Neil D. Arment, Anthony R. Chakravarty, Dimple Gregg, John M. H. Jacobson, Ira M. Jung, Kie Hoon Nair, Sujit S. Tewari, Ashutosh K. Thurston, Archie W. Van Drie, John
...
Published in
Cell Cycle
PT150 is a clinical-stage molecule, taken orally, with a strong safety profile having completed Phase 1 and Phase 2 clinical trials for its original use as an antidepressant. It has an active IND for COVID-19. Antiviral activities have been found for PT150 and other members of its class in a variety of virus families; thus, it was now tested agains...
Ghashghaeinia, Mehrdad Dreischer, Peter Wieder, Thomas Köberle, Martin
Published in
Cell Cycle
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19. Until now, diverse drugs have been used for the treatment of COVID-19. These drugs are associated with severe side effects, e.g. induction of erythrocyte death, named eryptosis. This massively affects the oxygen (O2) supply of the organism. Therefore, three elementary...
Xiong, Mingmei Guo, Meihua Huang, Dongjian Li, Jing Zhou, Yan
Published in
Cell Cycle
COPD is a common chronic disease with genetic predisposition. TRPV1 is mainly expressed in peripheral neuron which widely exists in entire respiratory tract. In present study, we aimed to study the relationship between single nucleotide polymorphisms (SNPs) of transient receptor potential vanilloid-1 (TRPV1) and the risk of chronic obstructive pulm...
Hays, Emily Nettleton, Elizabeth Carter, Caitlin Morales, Mariangel Vo, Lynn Passo, Max Vélez-Cruz, Renier
Published in
Cell Cycle
DNA double strand breaks (DSBs) are among the most toxic DNA lesions and can be repaired accurately through homologous recombination (HR). HR requires processing of the DNA ends by nucleases (DNA end resection) in order to generate the required single-stranded DNA (ssDNA) regions. The SWI/SNF chromatin remodelers are 10–15 subunit complexes that co...
Sherman, John Wang, Ruoning
Published in
Cell Cycle
The precise control of the cell cycle G2 phase to Mitosis (M phase) transition is central for cell fate determination. The commonly used methods for assessing G2 to M phase progression are based on synchronizing cells and involve perturbation of the natural cell cycle progression. Additionally, these methods are often time-consuming and labor-inten...
Roci, Irena Watrous, Jeramie D Lagerborg, Kim A Jain, Mohit Nilsson, Roland
Published in
Cell cycle (Georgetown, Tex.)
Proliferating cells must synthesize a wide variety of macromolecules while progressing through the cell cycle, but the coordination between cell cycle progression and cellular metabolism is still poorly understood. To identify metabolic processes that oscillate over the cell cycle, we performed comprehensive, non-targeted liquid chromatography-high...
Nguyen, Chi H Grandits, Alexander M Purton, Louise E Sill, Heinz Wieser, Rotraud
Published in
Cell cycle (Georgetown, Tex.)
Acute myeloid leukemia (AML) is an aggressive, often fatal hematopoietic malignancy. All-trans retinoic acid (atRA), one of the first molecularly targeted drugs in oncology, has greatly improved the outcome of a subtype of AML, acute promyelocytic leukemia (APL). In contrast, atRA has so far provided little therapeutic benefit in the much larger gr...