Chen, Ke Xi, Min Huang, Qihong Wu, Hao Lu, Guirong Song, Shaohui Shi, Wei
Published in
Cell cycle (Georgetown, Tex.)
Long non-coding RNAs (lncRNAs) are crucial drivers in the progression of human diseases such as myocardial infarction (MI). However, the impact of lncRNA MCM3AP antisense RNA 1 (MCM3AP-AS1) on MI remains unknown. This research was determined to explore the effect of MCM3AP-AS1 modulating microRNA-24-3p (miR-24-3p) and eukaryotic translation initiat...
Liu, Shaosheng Li, Yuanyuan Li, Zhaoxia
Published in
Cell cycle (Georgetown, Tex.)
To study the effect of Salidroside on nasopharyngeal carcinoma (NPC) cells and its mechanism. NPC cells were cultured, MTT was used to detect the effect of Salidroside on cell proliferation, apoptosis detected by flow cytometry assay, Western blot was used to detect the related protein expression. MiR-4262 and GRP78 used qRT-PCR for evaluation. Mim...
Chen, Anbin Kristiansen, Cecilie Katrin Høyland, Lena Elise Ziegler, Mathias Wang, Jian Sullivan, Gareth John Li, Xingang Bindoff, Laurence A Liang, Kristina Xiao
Published in
Cell cycle (Georgetown, Tex.)
We showed previously that POLG mutations cause major changes in mitochondrial function, including loss of mitochondrial respiratory chain (MRC) complex I, mitochondrial DNA (mtDNA) depletion and an abnormal NAD+/NADH ratio in both neural stem cells (NSCs) and astrocytes differentiated from induced pluripotent stem cells (iPSCs). In the current stud...
Qi, Chunxiao Lei, Lei Hu, Jinqu Wang, Gang Liu, Jiyuan Ou, Shaowu
Published in
Cell Cycle
Aberrant expression of coding genes of the V-ATPase subunits has been reported in glioma patients that can activate oncogenic pathways and result in worse prognosis. However, the predictive effect of a single gene is not specific or sensitive enough. In this study, by using a series of bioinformatics analyses, we identified five coding genes (ATP6V...
Nelson, Luke J Castro, Kyleen E Xu, Binzhi Li, Junyi Dinh, Nguyen B Thompson, Jordan M Woytash, Jordan Kipp, Kevin R Razorenova, Olga V
Published in
Cell Cycle
Clear cell renal cell carcinoma (CC-RCC) remains one of the most deadly forms of kidney cancer despite recent advancements in targeted therapeutics, including tyrosine kinase and immune checkpoint inhibitors. Unfortunately, these therapies have not been able to show better than a 16% complete response rate. In this study we evaluated a cyclin-depen...
Hu, Langtao Yang, Kai Mai, Xing Wei, Jiali Ma, Chunyang
Published in
Cell cycle (Georgetown, Tex.)
Dysfunctional histone deacetylases (HDACs) elicit unrestrained fibrosis and damage to organs. With regard to the link between HDACs and fibrosis, this research is practiced to decipher the concrete mechanism of HDAC3 in hyperuricemia (HN)-induced renal interstitial fibrosis (RIF) from microRNA-19b-3p/splicing factor 3b subunit 3 (miR-19b-3p/SF3B3) ...
Ni, Tiangen Guo, Dan Tan, Ling Xiao, Zhesi Shi, Yanjie
Published in
Cell cycle (Georgetown, Tex.)
Thyroid cancer (TC) is a prevailing malignant disease in endocrine system. Recent reports have demonstrated that long non-coding RNAs (lncRNAs) are crucial participators in TC progression. In our study, we majorly investigated the molecular mechanism of neuropeptide S receptor 1 antisense RNA 1 (NPSR1-AS1) in TC. Western blot and qPCR analyses were...
Liu, Ying Li, Lei Song, Xiang
Published in
Cell cycle (Georgetown, Tex.)
This study aims to probe the mechanism by which circPVT1 in lung cancer (LC)-derived exosomes (Exos) promotes proliferation, invasion and migration of LC cells by regulating macrophage polarization through miR-124-3p/EZH2 axis. The expressions of circPVT1 in blood-derived Exos extracted from lung adenocarcinoma (LA) patients were measured. Loss or ...
Sanchez, Annie C Thren, Elise D Iovine, M Kathryn Skibbens, Robert V
Published in
Cell cycle (Georgetown, Tex.)
Cornelia de Lange syndrome (CdLS) and Roberts syndrome (RBS) are severe developmental maladies that arise from mutation of cohesin (including SMC3, CdLS) and ESCO2 (RBS). Though ESCO2 activates cohesin, CdLS and RBS etiologies are currently considered non-synonymous and for which pharmacological treatments are unavailable. Here, we identify a unify...
Lin, Zhen Liu, Haiyan Chen, Hongzhi Cao, Hongshi Liu, Xiaochang Zhu, Haichao Zhao, Lu Chen, Zhiming
Published in
Cell cycle (Georgetown, Tex.)
Rrp14 is a conserved protein that plays an important role in rRNA processing and ribosomal biogenesis. In Schizosaccharomyces pombe, the rrp14 gene is split into SPAC8C9.10 c (rrp14) and SPBC947.07 (rrp1402). Although the SPAC8C9.10 c gene is not essential for S. pombe survival, deletion of the gene causes the yeast cells to grow sick and to exhibi...
