Wang, Anqi Yang, Wen Li, Yue Zhang, Yang Zhou, Jieqi Zhang, Ruochen Zhang, Weijie Zhu, Jianjie Zeng, Yuanyuan Liu, Zeyi
...
Published in
Cell Communication and Signaling
BackgroundNon-small cell lung cancer (NSCLC) is the most common type of lung cancer and the most lethal tumour worldwide. Copine 1 (CPNE1) was identified as a novel oncogene in NSCLC in our previous study. However, its specific function and relative mechanisms remain poorly understood.MethodsThe biological role of CPNE1 and RACK1 in NSCLC was inves...
Kagan, Terri Stoyanova, Gloria Lockshin, Richard A. Zakeri, Zahra
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Cell Communication and Signaling
Ceramide and sphingomyelin reportedly are important both for differentiation of nerve cells and for their death. We studied PC12 cells, which can differentiate into neuron-like cells in the presence of nerve growth factor and cells that overexpress receptors for nerve growth factor. By combining various inhibitors, we conclude that in the presence ...
Salami, Raziyeh Salami, Marziyeh Mafi, Alireza Vakili, Omid Asemi, Zatollah
Published in
Cell Communication and Signaling
Glioblastoma multiforme (GBM), as a deadly and almost incurable brain cancer, is the most invasive form of CNS tumors that affects both children and adult population. It accounts for approximately half of all primary brain tumors. Despite the remarkable advances in neurosurgery, radiotherapy, and chemotherapeutic approaches, cell heterogeneity and ...
Yuan, Yi Jiao, Pengfei Wang, Zeyu Chen, Mengqi Du, Hongming Xu, Liang Xu, Juanyong Dai, Youjin Wu, Fu-gen Zhang, Yaqin
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Published in
Cell Communication and Signaling
BackgroundEndoplasmic reticulum (ER) stress has been found to foster the escape of cancer cells from immune surveillance and upregulate PD-L1 expression. However, the underlying mechanisms are unknown.MethodsWhile analyzing the protein levels using immunofluorescence and Western blotting, the RNA levels were measured using qRT-PCR. Ten injection of...
Liu, Jiaxing Peng, Xueqiang Yang, Shuo Li, Xinyu Huang, Mingyao Wei, Shibo Zhang, Sheng He, Guangpeng Zheng, Hongyu Fan, Qing
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Published in
Cell Communication and Signaling
Programmed cell death 1 ligand 1 (PD-L1) is the ligand for programmed death protein-1 (PD-1), is associated with immunosuppression. Signaling via PD-1/PD-L1 will transmits negative regulatory signals to T cells, inducing T-cell inhibition, reducing CD8+ T-cell proliferation, or promoting T-cell apoptosis, which effectively reduces the immune respon...
Heydarzadeh, Shabnam Moshtaghie, Ali Asghar Daneshpour, Maryam Hedayati, Mehdi
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Cell Communication and Signaling
Pustelny, Katarzyna Kuska, Katarzyna Gorecki, Andrzej Musielak, Bogdan Dobosz, Ewelina Wladyka, Benedykt Koziel, Joanna Czarna, Anna Holak, Tad Dubin, Grzegorz
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Published in
Cell Communication and Signaling
BackgroundA universal adaptor protein, MyD88, orchestrates the innate immune response by propagating signals from toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R). Receptor activation seeds MyD88 dependent formation of a signal amplifying supramolecular organizing center (SMOC)—the myddosome. Alternatively spliced variant MyD88S, lacki...
Zhang, Huan Xing, Juan Dai, Zhujiang Wang, Daorong Tang, Dong
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Cell Communication and Signaling
Pancreatic cancer is one of the most common malignancies. Unfortunately, the lack of effective methods of treatment and diagnosis has led to poor prognosis coupled with a very high mortality rate. So far, the pathogenesis and progression mechanisms of pancreatic cancer have been poorly characterized. Exosomes are small vesicles secreted by most cel...
Petrozziello, Tiziana Boscia, Francesca Tedeschi, Valentina Pannaccione, Anna de Rosa, Valeria Corvino, Angela Severino, Beatrice Annunziato, Lucio Secondo, Agnese
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Cell Communication and Signaling
BackgroundThe cycad neurotoxin beta-methylamino-l-alanine (L-BMAA), one of the environmental trigger factor for amyotrophic lateral sclerosis/Parkinson-dementia complex (ALS/PDC), may cause neurodegeneration by disrupting organellar Ca2+ homeostasis. Through the activation of Akt/ERK1/2 pathway, the Cu,Zn-superoxide dismutase (SOD1) and its non-met...
Pan, Jiabin Sheng, Shiyang Ye, Ling Xu, Xiaonan Ma, Yizhao Feng, Xuanran Qiu, Lisha Fan, Zhaohuan Wang, Yi Xia, Xiaohuan
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Published in
Cell Communication and Signaling
BackgroundGlioblastomas are lethal brain tumors under the current combinatorial therapeutic strategy that includes surgery, chemo- and radio-therapies. Extensive changes in the tumor microenvironment is a key reason for resistance to chemo- or radio-therapy and frequent tumor recurrences. Understanding the tumor-nontumor cell interaction in TME is ...
