Cinquegrani, Gloria Spigoni, Valentina Iannozzi, Nicolas Thomas Parello, Vanessa Bonadonna, Riccardo C Dei Cas, Alessandra
Published in
Cell biology and toxicology
The inflammatory potential of SARS-CoV-2 Spike S1 (Spike) has never been tested in human primary macrophages (MΦ). Different recombinant Spikes might display different effects in vitro, according to protein length and glycosylation, and endotoxin (lipopolysaccharide, LPS) contamination. To assess (1) the effects of different Spikes on human primary...
Chen, Yu-Chen Sung, Hsin-Ching Chuang, Tzu-Yi Lai, Tsai-Chun Lee, Tzu-Lin Lee, Chiang-Wen Lee, I-Ta Chen, Yuh-Lien
Published in
Cell biology and toxicology
Previous work has shown an association between vitamin D3 deficiency and an increased risk for acquiring various inflammatory diseases. Vitamin D3 can reduce morbidity and mortality in these patients via different mechanisms. Lung inflammation is an important event in the initiation and development of respiratory disorders. However, the anti-inflam...
Shi, Hui Yu, Ying Liu, Xiaoxiao Yu, Yong Li, Minghui Wang, Yucheng Zou, Yunzeng Chen, Ruizhen Ge, Junbo
Published in
Cell biology and toxicology
Cardiomyocyte apoptosis is critical for the development of viral myocarditis (VMC), which is one of the leading causes of cardiac sudden death in young adults. Our previous studies have demonstrated that elevated calpain activity is involved in the pathogenesis of VMC. This study aimed to further explore the underlying mechanisms. Neonatal rat card...
Nagappan, Arulkumar Kim, Ki-Hyung Moon, Yuseok
Published in
Cell Biology and Toxicology
Among epithelial ovarian cancers, ovarian clear cell carcinoma (OCCC) remains markedly resistant to platinum-based chemotherapy, leading to poor clinical outcomes. In response to xenobiotic insults, caveolar platforms play crucial roles in modulating stress signaling responses in cancer cells. It has been hypothesized that caveolin-1 (Cav-1), a mai...
Bhat, Samatha Adiga, Divya Shukla, Vaibhav Guruprasad, Kanive Parashiva Kabekkodu, Shama Prasada Satyamoorthy, Kapaettu
Published in
Cell biology and toxicology
Senescence induction and epithelial-mesenchymal transition (EMT) events are the opposite sides of the spectrum of cancer phenotypes. The key molecules involved in these processes may get influenced or altered by genetic and epigenetic changes during tumor progression. Double C2-like domain beta (DOC2B), an intracellular vesicle trafficking protein ...
Abdelfatah, Sara Naß, Janine Knorz, Caroline Klauck, Sabine M Küpper, Jan-Heiner Efferth, Thomas
Published in
Cell biology and toxicology
Pyrrolizidine alkaloids (PAs) are a large group of highly toxic chemical compounds, which are found as cross-contaminants in numerous food products (e.g., honey), dietary supplements, herbal teas, and pharmaceutical herbal medicines. PA contaminations are responsible for serious hepatotoxicity and hepatocarcinogenesis. Health authorities have to se...
Wuputra, Kenly Tsai, Ming-Ho Kato, Kohsuke Yang, Ya-Han Pan, Jia-Bin Ku, Chia-Chen Noguchi, Michiya Kishikawa, Shotaro Nakade, Koji Chen, Hua-Ling
...
Published in
Cell biology and toxicology
The aryl hydrocarbon receptor (AhR) is a ligand-binding protein that responds to environmental aromatic hydrocarbons and stimulates the transcription of downstream phase I enzyme-related genes by binding the cis element of dioxin-responsive elements (DREs)/xenobiotic-responsive elements. Dimethyl sulfoxide (DMSO) is a well-known organic solvent tha...
Li, Jingquan Zhang, Zihao Feng, Xu Shen, Zhuqing Sun, Ji Zhang, Xiuwen Bu, Fengjiao Xu, Midie Tan, Cong Wang, Ziliang
...
Published in
Cell biology and toxicology
Stanniocalcin-2 (STC2) has been proved to regulate a variety of signaling pathways including cell growth, metastasis, and therapeutic resistance. However, the role of STC2 in the regulation of nasopharyngeal carcinoma (NPC) remains poorly understood. In this study, we investigated the regulatory function of STC2 on epithelial-mesenchymal transition...
Choi, Seri Choi, Jiwoong Cheon, Seongmin Song, Jihong Kim, Seung-Yeon Kim, Ji-eun Nam, Dae-Hwan Manzar, Gohar Kim, Su-Man Kang, Hyung-Sik
...
Published in
Cell Biology and Toxicology
Human lung organoids (hLOs) are useful for disease modelling and drug screening. However, a lack of immune cells in hLOs limits the recapitulation of in vivo cellular physiology. Here, we generated hLOs containing alveolar macrophage (AMφ)–like cells derived from pluripotent stem cells (PSC). To bridge hLOs with advanced human lung high-resolution ...
Qiu, Tianming Wu, Chenbing Yao, Xiaofeng Han, Qiuyue Wang, Ningning Yuan, Weizhuo Zhang, Jingyuan Shi, Yan Jiang, Liping Liu, Xiaofang
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Published in
Cell Biology and Toxicology
N6-methyladenosine (m6A) messenger RNA methylation is the most widespread gene regulatory mechanism affecting liver functions and disorders. However, the relationship between m6A methylation and arsenic-induced hepatic insulin resistance (IR), which is a critical initiating event in arsenic-induced metabolic syndromes such as type 2 diabetes (T2D) ...
