Adam, Aziza Hussein Bakheit de Haan, Laura H J Estruch, Ignacio Miro Hooiveld, Guido J E J Louisse, Jochem Rietjens, Ivonne M C M
Published in
Cell biology and toxicology
Diethylstilbestrol (DES) is a synthetic estrogen and proven human teratogen and carcinogen reported to act via the estrogen receptor α (ERα). Since the endogenous ERα ligand 17β-estradiol (E2) does not show these adverse effects to a similar extent, we hypothesized that DES' interaction with the ERα differs from that of E2. The current study aimed ...
Wang, William Wang, Xiangdong
Published in
Cell biology and toxicology
Song, Chenjian Liu, Lingjing Chen, Junjie Hu, Yiran Li, Jingli Wang, Beibei Bellusci, Saverio Chen, Chengshui Dong, Nian
Published in
Cell biology and toxicology
Particulate matter (PM) is an environmental pollutant closely associated with human airway inflammation. However, the molecular mechanisms of PM-related airway inflammation remains to be fully elucidated. It is known that COX-2/PGE2 play key roles in the pathogenesis of airway inflammation. Filaggrin is a transmembrane protein contributing to tight...
Du, Lei Wang, Jin Chen, Yibing Li, Xizhi Wang, Lei Li, Yuan Jin, Xiaoping Gu, Xiaoke Hao, Meng Zhu, Xia
...
Published in
Cell Biology and Toxicology
Inflammation reaction mediated by NLRP3 inflammasome and Nrf2-related oxidative stress are vital participants in the development of diabetic nephropathy (DN) and closely associated to kidney fibrosis. Nrf2, a known antioxidative transcription factor, has been reported to activate NLRP3 inflammasome through its downstream factors (HO-1, NQO1, etc.) ...
Sanchez, Aniel Kuras, Magdalena Murillo, Jimmy Rodriguez Pla, Indira Pawlowski, Krzysztof Szasz, A Marcell Gil, Jeovanis Nogueira, Fábio C S Perez-Riverol, Yasset Eriksson, Jonatan
...
Published in
Cell biology and toxicology
In the advanced stages, malignant melanoma (MM) has a very poor prognosis. Due to tremendous efforts in cancer research over the last 10 years, and the introduction of novel therapies such as targeted therapies and immunomodulators, the rather dark horizon of the median survival has dramatically changed from under 1 year to several years. With the ...
Yan, Litao Wu, Xing
Published in
Cell biology and toxicology
Animal and clinical studies have shown that mesenchymal stem cells (MSCs) play an important role in cartilage repair. The therapeutic effect of mesenchymal stem cells based therapies has been increasingly demonstrated to exosome-mediated paracrine secretion. Here, we investigated the cellular processes and mechanism of exosomes produced by conventi...
Hotham, W E Henson, F M D
Published in
Cell biology and toxicology
Large animal models have been widely used to facilitate the translation of mesenchymal stem cells (MSC) from the laboratory to patient. MSC, with their multi-potent capacity, have been proposed to have therapeutic benefits in a number of pathological conditions. Laboratory studies allow the investigation of cellular and molecular interactions, whil...
Doumandji, Zahra Safar, Ramia Lovera-Leroux, Mélanie Nahle, Sara Cassidy, Hilary Matallanas, David Rihn, Bertrand Ferrari, Luc Joubert, Olivier
Published in
Cell Biology and Toxicology
Metal oxide nanoparticles (NPs), such as ZnO, ZnFe2O4, and Fe2O3, are widely used in industry. However, little is known about the cellular pathways involved in their potential toxicity. Here, we particularly investigated the key molecular pathways that are switched on after exposure to sub-toxic doses of ZnO, ZnFe2O4, and Fe2O3 in the in vitro rat ...
Lopes-Pacheco, Miquéias Robba, Chiara Rocco, Patricia Rieken Macêdo Pelosi, Paolo
Published in
Cell Biology and Toxicology
The acute respiratory distress syndrome (ARDS) is a multifaceted lung disorder in which no specific therapeutic intervention is able to effectively improve clinical outcomes. Despite an improved understanding of molecular mechanisms and advances in supportive care strategies, ARDS remains associated with high mortality, and survivors usually face l...
Nazipova, Nafisa N Shabalina, Svetlana A
Published in
Cell biology and toxicology
