Alsharif, Sarah Sharma, Pooja Bursch, Karina Milliken, Rachel Lam, Van Fallatah, Arwa Phan, Thuc Collins, Meagan Dohlman, Priya Tiufekchiev, Sarah
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Cell Adhesion & Migration
A cytoskeletal protein keratin 19 (K19) is highly expressed in breast cancer but its effects on breast cancer cell mechanics are unclear. In MCF7 cells where K19 expression is ablated, we found that K19 is required to maintain rounded epithelial-like shape and tight cell-cell adhesion. A loss of K19 also lowered cell surface E-cadherin levels. Inhi...
Lei, Xing Liu, Bin Wu, Hao Wu, Xiao Wang, Xiu-Li Song, Yue Zhang, Shuai-Shuai Li, Jun-Qin Bi, Long Pei, Guo-Xian
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Cell adhesion & migration
In this study, we aimed to study the effect of fluid shear stress on fibroblasts and BMSCs on plane and groove topographies. The results showed that 0.6-Hz stress had the greatest influence on the alignment, polarity, migration and adhesion of fibroblasts on plane by increasing the expression of reoriented actin and vinculin; whereas 1.0-Hz stress ...
Romayor, Irene Badiola, Iker Olaso, Elvira
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Cell adhesion & migration
DDR1 is a receptor tyrosine kinases for collagen and an adverse prognostic factor in primary and metastatic tumors.Despite this, DDR1 signaling and its functional consequences in tumor development remain unclear. RT-PCR and Western blot show that A375, colon carcinoma HT29 and liver carcinoma SK-HEP human cell lines express functional DDR1 that pho...
Mizutani, Yusuke Omagari, Daisuke Hayatsu, Manabu Nameta, Masaaki Komiyama, Kazuo Mikami, Yoshikazu Ushiki, Tatsuo
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Cell adhesion & migration
To elucidate the underlying mechanism of secretory leukocyte protease inhibitor (SLPI)-induced cell migration, we compared SLPI-deleted human gingival carcinoma Ca9-22 (ΔSLPI) cells and original (wild-type: wt) Ca9-22 cells using several microscopic imaging methods and gene expression analysis. Our results indicated reduced migration of ΔSLPI cells...
Schmidt, Mariana Costa Braga Morais, Katia L P Almeida, Maíra Estanislau Soares de Iqbal, Asif Goldfeder, Mauricio Barbugiani Chudzinski-Tavassi, Ana Marisa
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Cell adhesion & migration
In a tumor microenvironment, endothelial cell migration and angiogenesis allow cancer to spread to other organs causing metastasis. Indeed, a number of molecules that are involved in cytoskeleton re-organization and intracellular signaling have been investigated for their effects on tumor cell growth and metastasis. Alongside that, Amblyomin-X, a r...
Li, Pengcheng Butcher, Neville J Minchin, Rodney F
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Cell adhesion & migration
Reducted arylamine N-acetyltransferase (NAT1) in breast cancers is associated with poor patient survival. NAT1 has also been associated with changes in cancer cell survival and invasion both in vitro and in vivo. Here, we report the effects of NAT1 in cancer cell invasion by addressing its role in adherence, migration, and invasion in vitro. The NA...
Han, Ning Li, Hai Wang, Hui
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Cell Adhesion & Migration
The present study aimed to evaluate the underlying mechanism of microRNA-203 (miR-203) in renal cell carcinoma (RCC) involving the PI3K/AKT signaling pathway. The results revealed downregulated miR-203 and upregulated CAV1 in RCC tissues. Upregulated miR-203 and downregulated CAV1 increased E-cadherin expression and cell apoptosis, decreased β-cate...
Khanna, Anoushka Indracanti, Namita Chakrabarti, Rina Indraganti, Prem Kumar
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Cell Adhesion & Migration
For successful transplantation of Hematopoietic Stem cells (HSCs), it is quite necessary that efficient homing, engraftment and retention of HSC self-renewal capacity takes place, which is often restricted due to inadequate number of adult HSCs. Here, we report that short-term ex-vivo treatment of mouse bone marrow mononuclear cells (BMMNCs) to Sod...
Tsirtsaki, Katerina Gkretsi, Vasiliki
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Cell Adhesion & Migration
Cell-extracellular matrix interactions, or focal adhesions (FA), are crucial for tissue homeostasis but are also implicated in cancer. Integrin-Linked Kinase (ILK) is an abundantly expressed FA protein involved in multiple signaling pathways. Here, we reviewed the current literature on the role of ILK in breast cancer (BC). Articles included in vit...
Sun, Lan Zhou, Xiaona Li, Yanmeng Chen, Wei Wu, Shanna Zhang, Bei Yao, Jingyi Xu, Anjian
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Cell Adhesion & Migration
Krüppel-like factor 5 (KLF5) can both promote and suppress cell migration, but the underlying mechanisms have not been elucidated. In this study, we show that the function of KLF5 in epithelial-mesenchymal transition (EMT) and migration of liver cancer cells depends on the status of the cellular tumor antigen p53 (p53). Furthermore, zinc finger E-b...
