Published in Cell
To identify potential therapeutic targets for SARS-CoV-2 and related pathogenic coronaviruses, Wei et al. conduct genome-wide CRISPR screens in Vero-E6 cells using SARS-CoV-2, MERS-CoV or pseudoviruses presenting SARS-CoV-1 or -2 spike proteins. They identify pro-viral genes and pathways including HMGB1 and the SWI/SNF chromatin remodeling complex ...
Published in Cell
The SARS-CoV-2 pandemic has revealed that Africa needs a new public health order to be resilient, adapt, and cope with 21st-century disease threats. The new order will need strengthened continental and national public health institutions; local manufacturing of vaccines, therapeutics, and diagnostics; attraction, training, and retention of a public...
Published in Cell
Vaccines save millions of lives from infectious diseases caused by viruses and bacteria. As the world awaits safe and effective COVID-19 vaccines, we celebrate the progresses made and highlight challenges ahead in vaccines and the science behind them.
Published in Cell
Infectious diseases killed hundreds of million people, made empires and civilizations vulnerable, and recently took away our freedom to go out, walk, work, travel, meet friends, and visit relatives during the Covid-19 lockdown. Vaccination freed humans from most of infectious diseases of the past. By starting with a virus grown in a cow, vaccinatio...
Published in Cell
Tragic events such as pandemics can be remembered as well as foreshadowed by works of art. Paintings by the artists Edvard Munch and John Singer Sargent (1918–19) tell us in real time what it was like to be stricken by the Spanish flu. Paintings by Edward Hopper (1940s and ’50s) foretell the lockdown and social distancing of today’s COVID-19 pandem...
Published in Cell
Examining the past and future of virology, vaccinations, and immunology through the lens of COVID-19: what have we learned, and what must be revisited?
Published in Cell
Aid et al. show that SARS-CoV-2 causes endothelial disruption and vascular thrombosis in both human and rhesus macaques lungs by inducing an upregulation of proinflammatory cytokines. Using an approach that combines histopathology and multiomics in macaques, they show the progression to vascular disease over time, which involves complement, macroph...
Published in Cell
SARS-CoV-2 proteins directly engage host RNAs to dysregulate essential steps of protein production and suppress the interferon response.
Published in Cell
Analyses of CD4+ T cells from 40 COVID-19 patients show that hospitalization is associated with increased cytotoxic follicular helper cells and cytotoxic T helper cells and a reduction in regulatory T cells.
Published in Cell
In humans and mice, the hippocampus supports inferential reasoning by computing a prospective code to predict upcoming events, before extracting logical links between discrete events during rest to form a mnemonic short cut for inferred relationships.
