Doundoulakis, Ioannis Gavriilaki, Maria Tsiachris, Dimitris Arsenos, Petros Antoniou, Christos-Konstantinos Dimou, Smaro Soulaidopoulos, Stergios Farmakis, Ioannis Akrivos, Evangelos Stoiloudis, Panagiotis
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Published in
Cardiovascular drugs and therapy
Atrial high-rate episodes (AHREs) recorded with cardiac implantable electronic devices (CIEDs) have been associated with the development of clinical atrial fibrillation (AF) and increase in stroke and death risk. We sought to perform a systematic review with a meta-analysis to evaluate the prevalence of AHREs detected by CIEDs, their association wi...
Birnbaum, Yochai Chen, Huan Tran, Dat Nylander, Sven Ye, Yumei
Published in
Cardiovascular drugs and therapy
Ticagrelor and dapagliflozin can suppress the activation of the NOD-like receptor 3 (NLRP3)-inflammasome and activate AMP-activated protein kinase (AMPK). The anti-inflammatory effects of dapagliflozin has been shown to depend on AMPK activation. Dapagliflozin and ticagrelor have been shown to have additive effects on the progression of diabetic ca...
Li, Youmei Mao, Qi Liu, Huanyun Zhou, Denglu Zhao, Jianhua
Published in
Cardiovascular drugs and therapy
To compare the effects of paclitaxal-coated balloon (PCB) versus conventional balloon (CB) on side branch (SB) lesion and cardiovascular outcomes in patients with de novo true bifurcation lesions. In total, 219 patients with de novo true bifurcation lesions were enrolled and divided into PCB group (102 cases) and CB group (117 cases) according to a...
Davidson, Sean M Lukhna, Kishal Gorog, Diana A Salama, Alan D Castillo, Alejandro Rosell Giesz, Sara Golforoush, Pelin Kalkhoran, Siavash Beikoghli Lecour, Sandrine Imamdin, Aqeela
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Cardiovascular drugs and therapy
Talic, Stella Marquina, Clara Ofori-Asenso, Richard Petrova, Marjana Liew, Danny Owen, Alice J Lybrand, Sean Thomson, David Ilomaki, Jenni Zomer, Ella
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Published in
Cardiovascular drugs and therapy
Statins are widely prescribed for the primary and secondary prevention of cardiovascular disease (CVD), but their effectiveness is dependent on the level of adherence and persistence. This study aimed to explore the patterns of switching, adherence and persistence among the Australian general population with newly dispensed statins. A retrospective...
Mavromatis, Kreton Gershlick, Anthony
Published in
Cardiovascular drugs and therapy
The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial is the latest in a series of studies evaluating the role of coronary revascularization plus optimal medical therapy (invasive management) as compared to optimal medical therapy alone (conservative management) in the management of patien...
Benamouzig, Robert Guenoun, Maxime Deutsch, David Fauchier, Laurent
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Cardiovascular drugs and therapy
Although direct oral anticoagulants (DOACs) are associated with an overall favourable safety profile, the risk of gastrointestinal bleeding with DOACs compared with vitamin K antagonists (VKAs) remains controversial. Accordingly, we aimed to provide a focused overview of the risk of gastrointestinal bleeding associated with dabigatran, rivaroxaban,...
Nowbar, Alexandra N Francis, Darrel P Al-Lamee, Rasha K
Published in
Cardiovascular drugs and therapy
The main aims of therapy in chronic stable angina are to reduce the risk of myocardial infarction and death and improve symptoms and quality of life (QoL). Unblinded trials have shown that revascularization does not reduce the risk of myocardial infarction or death but does appear to improve symptoms. However, symptoms are susceptible to the placeb...
Brown, David L
Published in
Cardiovascular drugs and therapy
The chronic coronary syndromes (CCS) include patients with a classic history of angina pectoris in the presence of either risk factors for or known atherosclerotic coronary artery disease. Randomized, controlled trials conducted in the optimal medical therapy (OMT) era have convincingly demonstrated that adherence to the outdated paradigm focused o...
Wen, Songnan Pislaru, Cristina Monahan, Kristi H Barnes, Stephanie M Hodge, David O Packer, Douglas L Pislaru, Sorin V Asirvatham, Samuel J
Published in
Cardiovascular drugs and therapy
Both warfarin and non-vitamin K antagonist oral anticoagulants (NOACs) have pleiotropic effects including anti-inflammatory and anti-fibrotic properties. This study aims to explore whether arrhythmia recurrence after AF ablation is influenced by the choice of oral anticoagulant. We retrospectively studied all patients who underwent primary AF ablat...
