Ebelt, Henning Domagala, Thomas Offhaus, Alexandra Wiora, Matthias Schwenzky, Andreas Hoyme, Matthias Anacker, Jelena Röhl, Peter
Published in
Cardiovascular drugs and therapy
The article "Fusion Imaging of X-ray and Transesophageal Echocardiography Improves the Procedure of Left Atrial Appendage Closure."
Manzoni, A G Passos, D F Doleski, P H Leitemperger, J W Loro, V L Leal, D B R
Published in
Cardiovascular drugs and therapy
Hyperlipidemia, characterized by an increase in circulating lipid levels, doubles the chance of developing cardiovascular diseases. It prompts inflammation, immune activation, and oxidative stress in the bloodstream and organs of rats. Thus, we theorized that the metabolism of purines, an immunomodulatory mechanism, is altered in cells involved in ...
Fan, Wenjun Tong, Corey Wong, Nathan D
Published in
Cardiovascular drugs and therapy
The Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial showed the cardiovascular disease (CVD) benefits of liraglutide therapy among patients with type 2 diabetes mellitus (T2DM). We applied this trial to US adults with T2DM in terms of eligibility and preventable CVD events. We included US adults...
Montarello, Nicholas J Nguyen, Mau T Wong, Dennis T L Nicholls, Stephen J Psaltis, Peter J
Published in
Cardiovascular drugs and therapy
Atherosclerotic coronary artery disease has a complex pathogenesis which extends beyond cholesterol intimal infiltration. It involves chronic inflammation of the coronary artery wall driven by systemic and local activation of both the adaptive and innate immune systems, which can ultimately result in the rupture or erosion of atherosclerotic plaque...
Zuo, Wei Tian, Ran Chen, Qian Wang, Lun Gu, Qing Zhao, Hongmei Huang, Chunmei Liu, Yingxian Li, Jingyi Yang, Xinglin
...
Published in
Cardiovascular drugs and therapy
The Nod-like receptor protein-3 (NLRP3) inflammasome signalling pathway is involved in the inflammatory reaction of myocardial ischaemia-reperfusion (I/R) injury. Our previous study showed that miR-330-5p was differentially expressed in both cerebral and myocardial I/R injury, and thus might be a biomarker for I/R injury-related diseases. Another s...
Maldonado, Claudio Nguyen, Mai-Dung Bauer, Phillip Nakamura, Shunichi Khundmiri, Syed J Perez-Abadia, Gustavo Stowers, Heather L Wu, Wen-Jian Tang, Xian-Liang
Published in
Cardiovascular drugs and therapy
Plasma membranes constitute a gathering point for lipids and signaling proteins. Lipids are known to regulate the location and activity of signaling proteins under physiological and pathophysiological conditions. Membrane lipid therapies (MLTs) that gradually modify lipid content of plasma membranes have been developed to treat chronic disease; how...
Bai, Xiao-Jie Hao, Jun-Tao Zheng, Rong-Hua Yan, Cai-Ping Wang, Jin Yang, Cai-Hong Zhang, Wei-Fang Zhao, Zhi-Qing
Published in
Cardiovascular drugs and therapy
This study aimed to investigate whether inhibition of glucagon-like peptide-1 (GLP-1) on pressure overload induced cardiac hypertrophy and apoptosis is related to activation of ATP sensitive potassium (KATP) channels. Male SD rats were randomly divided into five groups: sham, control (abdominal aortic constriction), GLP-1 analog liraglutide (0.3 mg...
Uthman, Laween Kuschma, Marius Römer, Gregor Boomsma, Marleen Kessler, Jens Hermanides, Jeroen Hollmann, Markus W Preckel, Benedikt Zuurbier, Coert J Weber, Nina C
...
Published in
Cardiovascular drugs and therapy
Vascular inflammation and disturbed metabolism are observed in heart failure and type 2 diabetes mellitus. Glycolytic enzyme hexokinase II (HKII) is upregulated by inflammation. We hypothesized that SGLT2 inhibitors Canagliflozin (Cana), Empagliflozin (Empa) or Dapagliflozin (Dapa) reduces inflammation via HKII in endothelial cells, and that HKII-d...
Lee, Hyoung Youn Mamadjonov, Najmiddin Jeung, Kyung Woon Jung, Yong Hun Lee, Byung Kook Moon, Kyung-Sub Heo, Tag Min, Yong Il
Published in
Cardiovascular drugs and therapy
Pralidoxime potentiated the pressor effect of adrenaline and facilitated restoration of spontaneous circulation (ROSC) after prolonged cardiac arrest. In this study, we hypothesised that pralidoxime would hasten ROSC in a model with a short duration of untreated ventricular fibrillation (VF). We also hypothesised that potentiation of the pressor ef...
Pourhanifeh, Mohammad Hossein Dehdashtian, Ehsan Hosseinzadeh, Azam Sezavar, Seyed Hashem Mehrzadi, Saeed
Published in
Cardiovascular drugs and therapy
Cardiovascular diseases (CVDs) are the leading global cause of mortality and disability, tending to happen in younger individuals in developed countries. Despite improvements in medical treatments, the therapy and long-term prognosis of CVDs such as myocardial ischemia-reperfusion, atherosclerosis, heart failure, cardiac hypertrophy and remodeling,...