Xiao, Rong Zhao, Hai-Chun Yan, Tian-Tian Zhang, Qiong Huang, Yue-Sheng
Published in
Cardiovascular diagnosis and therapy
The purpose of this study was to explore the role of protein kinase C (PKC) isozymes and reactive oxygen species (ROS) in hypoxia and angiotensin (Ang) II-induced autophagy. Primary cardiomyocytes were isolated from Sprague-Dawley (SD) neonatal rats and cultured in hypoxia and/or Ang II conditions. Dihydroethidium fluorescence staining was used to ...
Dai, Xu Yu, Yarong Yu, Lihua Zhang, Lei Zhang, Jiayin
Published in
Cardiovascular diagnosis and therapy
Coronary computed tomography angiography (CCTA) combined with dynamic CT myocardial perfusion imaging (CT-MPI) and CCTA combined with CT fractional flow reserve (CT-FFR) are both expected to be efficient one-stop shop imaging strategies to guide clinical management. The aim of the study is to determine which of these two methods has superiority in ...
Li, Yanchuan Yuan, Xiaohua Shi, Ziyun Wang, Haili Ren, Duomei Zhang, Ya Fan, Yangyang Liu, Yanfeng Cui, Zhangxia
Published in
Cardiovascular diagnosis and therapy
Gestational diabetes mellitus (GDM) is increasingly common in pregnancy. This study's purpose was to identify the expression of XIST and manifest the potential mechanism of XIST in GDM. Ninety-three patients with GDM and 93 normal pregnant women were included in this investigation. qRT-PCR was conducted to evaluate the expression of miR-497-5p and ...
Xu, Bo Kocyigit, Duygu Godoy-Rivas, Carlos Betancor, Jorge Rodriguez, L Leonardo Menon, Venu Jaber, Wael Grimm, Richard Flamm, Scott D Schoenhagen, Paul
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Published in
Cardiovascular diagnosis and therapy
Sinus of Valsalva aneurysms (SVAs) are rare. We assessed the role of multimodality imaging in guiding the contemporary management. A single-center retrospective cohort study over a 20-year period was performed. Between January 1997 and June 2017, 103 patients were diagnosed with SVAs (median age: 58 years). Eighty patients presented with non-ruptur...
Chen, Minghe Guo, Yini Sun, Zongli Meng, Xiangjiang
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Cardiovascular diagnosis and therapy
Myocardial cell apoptosis is one of the main reasons for the occurrence of acute myocardial infarction (AMI). The role of smooth muscle and endothelial cell enriched migration/differentiation-associated lncRNA (SENCR) in the cardiomyocyte apoptosis induced by hypoxia/reoxygenation (H/R) injury and its potential mechanism were investigated in this s...
Liu, Shangyu Yang, Shengwen Xing, Anlu Zheng, Lihui Shen, Lishui Tu, Bin Yao, Yan
Published in
Cardiovascular diagnosis and therapy
Traditional prognostic risk assessment in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI) is based on a limited selection of clinical and imaging findings. Machine learning (ML) can consider a higher number and complexity of variables and may be useful for characterising cardiovascular risk, predicting outc...
Qiu, Mei Ding, Liang-Liang Zhou, Hai-Rong
Published in
Cardiovascular diagnosis and therapy
The efficacy of sodium-glucose transporter 2 inhibitors (SGLT2is) on heart failure outcomes is unestablished in various subgroups defined by clinically important factors. We intended to evaluate the effects of six important factors on the efficacy of SGLT2is on heart failure outcomes. We included cardiovascular outcome trials (CVOTs) concerning SGL...
Hasun, Matthias Dörler, Jakob Alber, Hannes F Bauer, Axel Berger, Rudolf Christ, Günter Frick, Matthias Hoppe, Uta C Huber, Kurt Lamm, Gudrun
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Published in
Cardiovascular diagnosis and therapy
Randomised controlled trials have shown diverse results for radial access in patients undergoing primary percutaneous coronary intervention (PPCI). Moreover, it is questionable whether radial access improves outcome in patients with cardiogenic shock undergoing PPCI. We aimed to investigate the outcome according to access site in patients with or w...
Huang, Guangyong Liu, Jingwen Wang, Yuehai Xiang, Youzhang
Published in
Cardiovascular diagnosis and therapy
This study aims to analyze the differential expression profiles of lncRNA in Keshan disease (KSD) and to explore the molecular mechanism of the disease occurrence and development. RNA-seq technology was used to construct the lncRNA/mRNA expression library of a KSD group (n=10) and a control group (n=10), and then Cuffdiff software was used to obtai...
Femia, Giuseppe Langlois, Neil Raleigh, Jim Perumal, Sunthara Rajan Semsarian, Christopher Puranik, Rajesh
Published in
Cardiovascular diagnosis and therapy
Post-mortem cardiac magnetic resonance (CMR) is a non-invasive alternative to conventional autopsy. At present, diagnostic guidelines for cardiovascular conditions such as hypertrophic cardiomyopathy have not been established. We correlated post-mortem CMR images to definite conventional autopsy findings and hypothesed that elevated T2-weighted sig...
