Mohammedi, Kamel Harrap, Stephen Mancia, Giuseppe Marre, Michel Poulter, Neil Chalmers, John Woodward, Mark
Published in
Cardiovascular Diabetology
BackgroundIndividuals with diabetes and lower-limb complications are at high risk for cardiovascular and all-cause mortality, but uncertainties remain in terms of cancer-related death in this population. We investigated this relationship in a large cohort of people with type 2 diabetes.MethodsWe used data from the Action in Diabetes and Vascular Di...
Saw, Eng Leng Pearson, James T. Schwenke, Daryl O. Munasinghe, Pujika Emani Tsuchimochi, Hirotsugu Rawal, Shruti Coffey, Sean Davis, Philip Bunton, Richard Van Hout, Isabelle
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Published in
Cardiovascular Diabetology
Background Acetylcholine (ACh) plays a crucial role in the function of the heart. Recent evidence suggests that cardiomyocytes possess a non-neuronal cholinergic system (NNCS) that comprises of choline acetyltransferase (ChAT), choline transporter 1 (CHT1), vesicular acetylcholine transporter (VAChT), acetylcholinesterase (AChE) and type-2 muscarin...
Lejeune, Sibille Roy, Clotilde Slimani, Alisson Pasquet, Agnès Vancraeynest, David Vanoverschelde, Jean-Louis Gerber, Bernhard L. Beauloye, Christophe Pouleur, Anne-Catherine
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Cardiovascular Diabetology
Background Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome, with several underlying etiologic and pathophysiologic factors. The presence of diabetes might identify an important phenotype, with implications for therapeutic strategies. While diabetes is associated with worse prognosis in HFpEF, the prognostic impact...
Li, Man Duan, Lei Cai, Yulun Hao, Benchuan Chen, Jianqiao Li, Huiying Liu, Hongbin
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Cardiovascular Diabetology
Background Soluble suppression of tumorigenesis-2 (sST2) is implicated in myocardial overload and has long been recognized as an inflammatory marker related to heart failure and acute coronary syndrome, but data on the prognostic value of sST2 in patients with coronary artery disease (CAD) remain limited. This study sought to investigate the progno...
Wang, Anxin Wang, Guangyao Liu, Qian Zuo, Yingting Chen, Shuohua Tao, Boni Tian, Xue Wang, Penglian Meng, Xia Wu, Shouling
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Cardiovascular Diabetology
Background Triglyceride-glucose (TyG) index was recently suggested to be a reliable surrogate marker of insulin resistance. We aim to investigate the associations between baseline and long-term TyG index with subsequent stroke and its subtypes in a community-based cohort. Methods A total of 97,653 participants free of history of stroke in the Kailu...
Bryk, Agata Hanna Konieczyńska, Małgorzata Polak, Maciej Plicner, Dariusz Bochenek, Maciej Undas, Anetta
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Cardiovascular Diabetology
Background Patients with type 2 diabetes mellitus (T2DM) are at high risk of cardiovascular mortality, but the mechanisms behind this remain unclear. Prothrombotic fibrin clot properties have been shown in T2DM and cardiovascular disease. We hypothesized that formation of denser clots, which are resistant to fibrinolysis, has a negative impact on c...
Nandula, Seshagiri Rao Kundu, Nabanita Awal, Hassan B. Brichacek, Beda Fakhri, Mona Aimalla, Nikhila Elzarki, Adrian Amdur, Richard L. Sen, Sabyasachi
Published in
Cardiovascular Diabetology
Background Endothelial progenitor cells (EPCs) has been shown to be dysfunctional in both type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) leading to poor regeneration of endothelium and renal perfusion. EPCs have been shown to be a robust cardiovascular disease (CVD) risk indicator. Effect of sodium glucose channel inhibitors (SGLT...
Peng, Jia Zhu, Cheng-Gang Li, Jian-Jun
Published in
Cardiovascular Diabetology
Increasing data including ours have suggested that proprotein convertase subtilisin/kexin type 9 (PCSK9), a novel regulator of cholesterol metabolism, may also play an important role in the development of type 2 diabetes mellitus (T2DM) and is associated with clinical outcomes in diabetic patients. Previous studies revealed that elevated plasma PCS...
Papazoglou, Andreas S Kartas, Anastasios Samaras, Athanasios Vouloagkas, Ioannis Vrana, Eleni Moysidis, Dimitrios V Akrivos, Evangelos Kotzampasis, Georgios Baroutidou, Amalia Papanastasiou, Anastasios
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Published in
Cardiovascular diabetology
There are limited data on the association of diabetes mellitus (DM) and levels of glycated hemoglobin (HbA1c) with outcomes in patients with atrial fibrillation (AF). This retrospective cohort study included patients who were recently hospitalized with a primary or secondary diagnosis of AF from December 2015 through June 2018. Kaplan-Meier curves ...
Tanaka, Atsushi Node, Koichi
Published in
Cardiovascular diabetology
Clinical trials are often performed to investigate the effects of various types of cardiometabolic therapies on cardiovascular surrogate markers, including vascular function and biomarkers. This study platform has the potential to provide information on the suspected actions of drugs and mechanistic insights into their prognostic impact. However, d...