Xu, Fei Hua, Qian Zhang, Aimi Di, Zhang Wang, Yining Zhao, Li Yang, Hao Liu, Jianjun Huang, Gang
Published in
Cancer science
Long non-coding RNA AC020978 (lncRNA AC020978) is an oncogenic regulator of non-small cell lung cancer (NSCLC). However, the function of AC020978 in regulating NSCLC metastasis and the potential molecular mechanism remains largely unknown. In this study, we evaluated the expression levels of AC020978 in a series of NSCLC tissues using FISH assays a...
Omar Faruk, Mohammad Ichimura, Yoshinobu Komatsu, Masaaki
Published in
Cancer science
While starvation-induced autophagy is thought to randomly degrade cellular components, under certain circumstances autophagy selectively recognizes, sequesters, and degrades specific targets via autophagosomes. This process is called selective autophagy, and it contributes to cellular homeostasis by degrading specific soluble proteins, supramolecul...
Zou, Jiahuan Xia, Hongwei Zhang, Chenliang Xu, Huanji Tang, Qiulin Zhu, Gongmin Li, Jielang Bi, Feng
Published in
Cancer science
Immunotherapy targeting the PD-L1/PD-1 pathway is a novel type of clinical cancer treatment, but only small subsets of patients can benefit from it because of multiple factors. PD-L1/PD-1 expression is a biomarker for predicting the efficacy of anti-PD-L1/PD-1 therapy, which highlights the importance of understanding the regulatory mechanisms of PD...
Hangai, Sho Kimura, Yoshitaka Taniguchi, Tadatsugu Yanai, Hideyuki
Published in
Cancer science
The signal-transducing innate receptors represent classes of pattern recognition receptors (PRRs) that play crucial roles in the first line of the host defense against infections by the recognition of pathogen-derived molecules. Because of their poorly discriminative nature compared with antigen receptors of the adaptive immune system, they also re...
Chen, Siteng Jiang, Liren Zheng, Xinyi Shao, Jialiang Wang, Tao Zhang, Encheng Gao, Feng Wang, Xiang Zheng, Junhua
Published in
Cancer science
Traditional histopathology performed by pathologists by the naked eye is insufficient for accurate and efficient diagnosis of bladder cancer (BCa). We collected 643 H&E-stained BCa images from Shanghai General Hospital and The Cancer Genome Atlas (TCGA). We constructed and cross-verified automatic diagnosis and prognosis models by performing a mach...
Terui, Yasuhito Rai, Shinya Izutsu, Koji Yamaguchi, Motoko Takizawa, Jun Kuroda, Junya Ishikawa, Takayuki Kato, Koji Suehiro, Youko Fukuhara, Noriko
...
Published in
Cancer science
Polatuzumab vedotin (pola) is a CD79b-targeted antibody-drug conjugate delivering a potent antimitotic agent (monomethyl auristatin E) to B cells. This was an open-label, single-arm study of pola 1.8 mg/kg, bendamustine 90 mg/m2 , rituximab 375 mg/m2 (pola + BR) Q3W for up to six cycles in patients with relapsed/refractory (R/R) diffuse large B-cel...
Okubo, Satoshi Suzuki, Toshihiro Hioki, Masayoshi Shimizu, Yasuhiro Toyama, Hirochika Morinaga, Soichiro Gotohda, Naoto Uesaka, Katsuhiko Ishii, Genichiro Takahashi, Shinichiro
...
Published in
Cancer science
Several therapeutic regimens, including neoadjuvant chemoradiation therapy (NACRT), have been reported to serve as anticancer immune effectors. However, there remain insufficient data regarding the immune response after NACRT in pancreatic ductal adenocarcinoma (PDAC) patients. Data from 40 PDAC patients that underwent surgical resection after NACR...
Liu, Yun Su, Peng Zhao, Wuchen Li, Xin Yang, Xiao Fan, Jianing Yang, Huijie Yan, Cheng Mao, Lanzhi Ding, Yinlu
...
Published in
Cancer science
Breast cancer is one of the most commonly diagnosed malignancies worldwide, while the triple negative breast cancer (TNBC) is the most aggressive and virulent subtype in breast cancers. Compared with luminal type breast cancers, which could be well controlled by endocrine treatment, TNBC is worse in prognosis and lack of effective targeted therapy....
Shi, Hanxiao Niimi, Atsuko Takeuchi, Toshiyuki Shiogama, Kazuya Mizutani, Yasuyoshi Kajino, Taisuke Inada, Kenichi Hase, Tetsunari Hatta, Takahiro Shibata, Hirofumi
...
Published in
Cancer science
Ceramide synthase 6 (CERS6) promotes lung cancer metastasis by stimulating cancer cell migration. To examine the underlying mechanisms, we performed luciferase analysis of the CERS6 promoter region and identified the Y-box as a cis-acting element. As a parallel analysis of database records for 149 non-small-cell lung cancer (NSCLC) cancer patients,...
Hu, Xin Que, Weitao Hirano, Hiroshi Wang, Zhidan Nozawa, Naoko Ishii, Takuya Ishizuka, Masahiro Ito, Hidenori Takahashi, Kiwamu Nakajima, Motowo
...
Published in
Cancer science
Mitochondria are key cytoplasmic organelles. Their activation is critical for the generation of T cell proliferation and cytotoxicity. Exhausted tumor-infiltrating T cells show a decreased mitochondrial function and mass. 5-Aminolevulinic acid (5-ALA), a natural amino acid that is only produced in the mitochondria, has been shown to influence metab...
