Huang, Yanni Zheng, Yizi Yao, Ling Qiao, Feng Hou, Yifeng Hu, Xin Li, Daqiang Shao, Zhiming
Published in
Cancer science
RNA binding proteins (RBPs) play pivotal roles in breast cancer (BC) development. As an RBP, Processing of precursor 7 (POP7) is one of the subunits of RNase P and RNase MRP, however, its exact function and mechanism in BC remain unknown. Here, we showed that expression of POP7 was frequently increased in BC cells and in primary breast tumors. Upre...
Miyakawa, Kazuko Miyashita, Naoya Horie, Masafumi Terasaki, Yasuhiro Tanaka, Hidenori Urushiyama, Hirokazu Fukuda, Kensuke Okabe, Yugo Ishii, Takashi Kuwahara, Naomi
...
Published in
Cancer science
Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumor with dismal prognosis. Recently, molecular subtypes of SCLC have been defined by the expression status of ASCL1, NEUROD1, YAP1, and POU2F3 transcription regulators. ASCL1 is essential for neuroendocrine differentiation and is expressed in the majority of SCLC. Although previo...
Mao, Rui Ren, Zhengyun Yang, Fan Yang, Peng Zhang, Tongtong
Published in
Cancer science
Senescence is an effective barrier to tumor progression. Mutations that inhibit senescence and promote cell division are mandatory for the development of cancer. Therefore, it is particularly important to explore the differences between cutaneous melanoma (CM) patients with severe and mild degrees of senescence. We clustered all the patients with C...
Nishio, Shin Yonemori, Kan Usami, Tomoka Minobe, Shinichiro Yunokawa, Mayu Iwata, Takashi Okamoto, Aikou Aoki, Yoichi Itamochi, Hiroaki Takekuma, Munetaka
...
Published in
Cancer science
Pembrolizumab plus chemotherapy with or without bevacizumab demonstrated prolonged progression-free survival (PFS) and overall survival (OS) versus chemotherapy in patients with persistent, recurrent, or metastatic cervical cancer in the phase 3, randomized, double-blind, placebo-controlled KEYNOTE-826 study. We report outcomes in patients enrolled...
Shirai, Takanobu Sekai, Miho Kozawa, Kei Sato, Nanami Tanimura, Nobuyuki Kon, Shunsuke Matsumoto, Tomohiro Murakami, Takeru Ito, Shoko Tilston-Lunel, Andrew
...
Published in
Cancer science
At the initial stage of carcinogenesis, oncogenic transformation occurs in single cells within epithelial layers. However, the behavior and fate of the newly emerging transformed cells remain enigmatic. Here, using originally established mouse models, we investigate the fate of RasV12-transformed cells that appear in a mosaic manner within epitheli...
Yonemori, Kan Yunokawa, Mayu Ushijima, Kimio Sakata, Jun Shikama, Ayumi Minobe, Shinichiro Usami, Tomoka Enomoto, Takayuki Takehara, Kazuhiro Hasegawa, Kosei
...
Published in
Cancer science
Study 309/KEYNOTE-775 is a phase 3 open-label, randomized trial of lenvatinib plus pembrolizumab versus treatment of physician's choice (TPC) in patients with advanced endometrial cancer with progression after platinum-based therapy. Primary endpoints of superiority for lenvatinib plus pembrolizumab were met for progression-free survival (PFS) and ...
Liu, Jie Wang, Huxia Zhang, Miao Li, Yazhao Wang, Ruiqi Chen, He Wang, Bo Gao, Xiaoqian Song, Shaoran Wang, Yaochun
...
Published in
Cancer science
Multiple cancers have been reported to be associated with angiogenesis and are sensitive to anti-angiogenic therapies. Vascular normalization, by restoring proper tumor perfusion and oxygenation, could limit tumor cell invasiveness and improve the effectiveness of anticancer treatments. However, the underlying anticancer mechanisms of antiangiogeni...
Tao, Xuxiu Wu, Xia Zhou, Peijun Yu, Xuehui Zhao, Chen Peng, Xingzhi Zhang, Kun Shen, Liangfang Peng, Jinwu Yang, Lifang
...
Published in
Cancer science
Glioblastoma (GBM) is the most frequent and aggressive malignant glioma. Due to its poor prognosis of patients, it is of great clinical significance to determine new targets that may improve GBM treatment. In the present study, we showed that ubiquitin-conjugating enzyme E2T (UBE2T) was significantly overexpressed in GBM and it could promote prolif...
Manevich, Lev Okita, Yukari Okano, Yasuhito Sugasawa, Takehito Kawanishi, Kunio Poullikkas, Thanasis Dang Cao, Linda T L Zheng, Ling Nakayama, Masahiro Matsumoto, Shin
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Published in
Cancer science
Laryngeal squamous cell carcinoma (LSCC), although one of the most common head and neck cancers, has a static or slightly decreased survival rate because of difficulties in early diagnosis, lack of effective molecular targeting therapy, and severe dysfunction after radical surgical treatments. Therefore, a novel therapeutic target is crucial to inc...
Li, Xia Chen, Wuya Gao, Yijun Song, Jing Gu, Yangcong Zhang, Jianming Cheng, Xiufeng Ai, Yilong
Published in
Cancer science
The high prevalence of oral squamous cell carcinoma (OSCC) in South Asia is associated with habitual areca nut chewing. Arecoline, a primary active carcinogen within areca nut extract, is known to promote OSCC pathological development. Dysregulation of N6-methyladenosine (m6A) modification has begun to emerge as a significant contributor to cancer ...
