Mukai, Yosuke Ueno, Hideki
Published in
Cancer science
Approximately one in two Japanese people are estimated to be diagnosed with cancer during their lifetime. Cancer still remains the leading cause of death in Japan; therefore, the government of Japan has decided to develop a better cancer control policy and launched the Cancer Genomic Medicine (CGM) program. The Ministry of Health, Labour and Welfar...
Murakami, Shoko Tanaka, Hiroyuki Nakayama, Takahisa Taniura, Naoko Miyake, Toru Tani, Masaji Kushima, Ryoji Yamamoto, Gaku Sugihara, Hiroyuki Mukaisho, Ken-Ichi
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Published in
Cancer science
Metabolic programming of cancer cells is an essential step in transformation and tumor growth. We established two-dimensional (2D) monolayer and three-dimensional (3D) cultures, the latter called a "tissueoid cell culture system", using four types of tongue cancer cell lines. We also undertook a comprehensive metabolome analysis of three groups tha...
Liu, Yufeng Wu, Di Cheng, Hanghang Chen, Lei Zhang, Weidi Zou, Liping Gao, Qiongmei Zhao, Zhonghua Chen, Qi Zeng, Wenjiao
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Published in
Cancer science
Dysregulation of wingless-type (Wnt) signaling is implicated in hepatocellular carcinoma (HCC). Wnt family member 8B (Wnt8B), one of the canonical Wnt ligands, is implicated in oncogenesis. However, the role of Wnt8B in human HCCs and its transcriptional regulation mechanism are presently unknown . Here, we report that Wnt8B expression was frequent...
Yokogawa, Tatsushi Yano, Wakako Tsukioka, Sayaka Osada, Akiko Wakasa, Takeshi Ueno, Hiroyuki Hoshino, Takuya Yamamura, Keisuke Fujioka, Akio Fukuoka, Masayoshi
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Published in
Cancer science
Deficiency in DNA repair proteins confers susceptibility to DNA damage, making cancer cells vulnerable to various cancer chemotherapies. 5-Fluorouracil (5-FU) is an anticancer nucleoside analog that both inhibits thymidylate synthase (TS) and causes DNA damage via the misincorporation of FdUTP and dUTP into DNA under the conditions of dTTP depletio...
Machitani, Mitsuhiro Yasukawa, Mami Nakashima, Jotaro Furuichi, Yasuhiro Masutomi, Kenkichi
Published in
Cancer science
A recent outbreak of coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 has driven a global pandemic with catastrophic consequences. The rapid development of promising therapeutic strategies against COVID-19 is keenly anticipated. Family Coronaviridae comprises positive, single-stranded RNA viruses th...
Song, Linjiang Chen, Xian Mi, Ling Liu, Chi Zhu, Shaomi Yang, Tianlin Luo, Xiaohong Zhang, Qinxiu Lu, Hua Liang, Xin
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Published in
Cancer science
Abnormal activation of the nuclear factor-kappa B (NF-κB) signaling pathway is closely implicated in triple-negative breast cancer growth, metastasis, and tumor immune escape. In this study, the anti-cancer effects of icariin, a natural flavonol glycoside, toward breast cancer cells and the underlying mechanisms were investigated. This investigatio...
Torii, Satoru Honda, Shinya Murohashi, Michiko Yamaguchi, Hirofumi Shimizu, Shigeomi
Published in
Cancer science
Various clinical and experimental findings have revealed the causal relationship between autophagy failure and oncogenesis, and several mechanisms have been suggested to explain this relationship. We recently proposed two additional mechanisms: centrosome number dysregulation and the failure of autophagic cell death. Here, we detail the mechanical ...
Nanishi, Kenji Konishi, Hirotaka Shoda, Katsutoshi Arita, Tomohiro Kosuga, Toshiyuki Komatsu, Shuhei Shiozaki, Atsushi Kubota, Takeshi Fujiwara, Hitoshi Okamoto, Kazuma
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Published in
Cancer science
Circular RNA is a novel endogenous non-coding RNA that can serve as a biomarker because of its stable loop structure. We investigated and examined the utility of plasma circERBB2 as a prognostic biomarker in 70 patients with gastric cancer who underwent gastrectomy. We investigated by real-time quantitative PCR the circERBB2 concentrations in the p...
Nishikawa, Daisuke Suzuki, Hidenori Beppu, Shintaro Terada, Hoshino Sawabe, Michi Kadowaki, Shigenori Sone, Michihiko Hanai, Nobuhiro
Published in
Cancer science
Although nivolumab, a programmed cell death 1 (PD-1) inhibitor, is a standard therapy for platinum-refractory recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC), no definitive biomarkers have been reported thus far. This study aimed to select promising prognostic markers in nivolumab therapy and to create a novel prognostic s...
Kunimoto, Hiroyoshi Nakajima, Hideaki
Published in
Cancer science
Regulation of genome-wide DNA methylation is fundamental for a variety of biological processes such as mammalian development, stem cell function, cellular proliferation/differentiation, and oncogenesis. Among the regulators of DNA methylation, ten-eleven translocation 2 (TET2) is one of the most frequently mutated genes in clonal hematopoiesis of i...