Saito, Ryoichi Smith, Christof C Utsumi, Takanobu Bixby, Lisa M Kardos, Jordan Wobker, Sara E Stewart, Kyle G Chai, Shengjie Manocha, Ujjawal Byrd, Kevin Matthew
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Published in
Cancer research
High-grade urothelial cancer contains intrinsic molecular subtypes that exhibit differences in underlying tumor biology and can be divided into luminal-like and basal-like subtypes. We describe here the first subtype-specific murine models of bladder cancer and show that Upk3a-CreERT2; Trp53L/L; PtenL/L; Rosa26LSL-Luc (UPPL: luminal-like) and BBN (...
Alam, Hunain Li, Na Dhar, Shilpa S Wu, Sarah J Lv, Jie Chen, Kaifu Flores, Elsa R Baseler, Laura Lee, Min Gyu
Published in
Cancer research
Lung adenocarcinoma (LUAD) is a major form of lung cancer, which is the leading cause of cancer death. Histone methylation reader proteins mediate the effect of histone methylation, a hallmark of epigenetic and transcriptional regulation of gene expression. However, their roles in LUAD are poorly understood. Here our bioinformatic screening and ana...
Saputra, Elysia C Huang, Lu Chen, Yihui Tucker-Kellogg, Lisa
Published in
Cancer research
The search for effective combination therapies for cancer has focused heavily on synergistic combinations because they exhibit enhanced therapeutic efficacy at lower doses. Although synergism is intuitively attractive, therapeutic success often depends on whether drug resistance develops. The impact of synergistic combinations (vs. antagonistic or ...
Ahmed, Mansoor M Coleman, C Norman Mendonca, Marc Bentzen, Soren Vikram, Bhadrasain Seltzer, Stephen M Goodhead, Dudley Obcemea, Ceferino Mohan, Radhe Prise, Kevin M
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Published in
Cancer research
Avanzato, Daniele Pupo, Emanuela Ducano, Nadia Isella, Claudio Bertalot, Giovanni Luise, Chiara Pece, Salvatore Bruna, Alejandra Rueda, Oscar M Caldas, Carlos
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Published in
Cancer research
USP6NL, also named RN-tre, is a GTPase activating protein (GAP) involved in control of endocytosis and signal transduction. Here we report that USP6NL is overexpressed in breast cancer (BC), mainly of the basal-like/integrative cluster 10 subtype. Increased USP6NL levels were accompanied by gene amplification and were associated with worse prognosi...
Heim, Lisanne Friedrich, Juliane Engelhardt, Marina Trufa, Denis I Geppert, Carol I Rieker, Ralf Joachim Sirbu, Horia Finotto, Susetta
Published in
Cancer research
Nuclear factor of activated T cells 1 (NFATc1) is a transcription factor activated by T cell receptor (TCR) and Ca2+-signaling that affects T cell activation and effector function. Upon tumor antigen challenge, TCR and calcium-release-activated channels are induced, promoting NFAT dephosphorylation and translocation into the nucleus. In this study,...
Tanaka, Miho Fine, Jason H Kirkham, Christina L Aguilar, Oscar A Belcheva, Antoaneta Martin, Alberto Ketela, Troy Moffat, Jason Allan, David Sj Carlyle, James R
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Published in
Cancer research
Natural killer (NK) cells express receptors specific for MHC class I (MHC-I) molecules involved in "missing-self" recognition of cancer and virus-infected cells. Here we elucidate the role of MHC-I-independent NKR-P1B:Clr-b interactions in the detection of oncogenic transformation by NK cells. Ras oncogene overexpression was found to promote a real...
Zhang, Daoxiang Li, Lin Jiang, Hongmei Li, Qiong Wang-Gillam, Andrea Yu, Jinsheng Head, Richard Liu, Jingxia Ruzinova, Marianna B Lim, Kian-Huat
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Published in
Cancer research
Targeting the desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) holds promise to augment the effect of chemotherapy, but success in the clinic has thus far been limited. Preclinical mouse models suggest that near-depletion of cancer-associated fibroblasts (CAF) carries a risk of accelerating PDAC progression, underscoring the need to c...
Yan, Ting-Ting Ren, Lin-Lin Shen, Chao-Qin Wang, Zhen-Hua Yu, Ya-Nan Liang, Qian Tang, Jia-Yin Chen, Ying-Xuan Sun, Dan-Feng Zgodzinski, Witold
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Published in
Cancer research
Colorectal cancer includes an invasive stem-like/mesenchymal subtype, but its genetic drivers, functional, and clinical relevance are uncharacterized. Here we report the definition of an altered miRNA signature defining this subtype that includes a major genomic loss of miR-508. Mechanistic investigations showed that this miRNA affected the express...
Walker-Samuel, Simon Roberts, Thomas A Ramasawmy, Rajiv Burrell, Jake S Johnson, Sean Peter Siow, Bernard M Richardson, Simon Gonçalves, Miguel R Pendse, Douglas Robinson, Simon P
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Published in
Cancer research
Several distinct fluid flow phenomena occur in solid tumors, including intravascular blood flow and interstitial convection. Interstitial fluid pressure is often raised in solid tumors, which can limit drug delivery. To probe low-velocity flow in tumors resulting from raised interstitial fluid pressure, we developed a novel MRI technique named conv...
