Farria, Aimee T Plummer, Joshua B Salinger, Andrew P Shen, Jianjun Lin, Kevin Lu, Yue McBride, Kevin M Koutelou, Evangelia Dent, Sharon Y R
Published in
Cancer research
Overexpression of the MYC oncoprotein is an initiating step in the formation of several cancers. MYC frequently recruits chromatin-modifying complexes to DNA to amplify the expression of cancer-promoting genes, including those regulating cell cycle, proliferation, and metabolism, yet the roles of specific modifiers in different cancer types are not...
Sapkota, Yadav Qin, Na Ehrhardt, Matthew J Wang, Zhaoming Chen, Yan Wilson, Carmen L Estepp, Jeremie Rai, Parul Hankins, Jane S Burridge, Paul W
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Published in
Cancer research
Cardiomyopathy occurs at significantly higher rates in survivors of childhood cancer than the general population, but few studies have evaluated racial or ethnic disparities, and none have assessed potential genetic factors contributing to this outcome. In this study, childhood cancer survivors of African ancestry exposed to cardiotoxic therapies (...
Hu, Yi Yang, Chun Amorim, Tania Maqbool, Mohsin Lin, Jenny Li, Chen Fang, Chuanfeng Xue, Li Kwart, Ariel Fang, Hua
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Published in
Cancer research
Cisplatin chemotherapy is standard care for many cancers but is toxic to the kidneys. How this toxicity occurs is uncertain. In this study, we identified apurinic/apyrimidinic endonuclease 2 (APE2) as a critical molecule upregulated in the proximal tubule cells (PTC) following cisplatin-induced nuclear DNA and mitochondrial DNA damage in cisplatin-...
Wang, Teh-Wei Chern, Edward Hsu, Chao-Wei Tseng, Kuo-Chang Chao, Hsiao-Mei
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Cancer research
NAD-dependent deacetylase sirtuin-1 (SIRT1) is a class III histone deacetylase that positively regulates cancer-related pathways such as proliferation and stress resistance. SIRT1 has been shown to promote progression of colorectal cancer and is associated with cancer stemness, yet the precise mechanism between colorectal cancer stemness and SIRT1 ...
Smalley, Munisha Natarajan, Siva Kumar Mondal, Jayanta Best, Douglas Goldman, David Shanthappa, Basavaraja Pellowe, Moriah Dash, Chinmayee Saha, Tanmoy Khiste, Sachin
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Published in
Cancer research
Drug-induced resistance, or tolerance, is an emerging yet poorly understood failure of anticancer therapy. The interplay between drug-tolerant cancer cells and innate immunity within the tumor, the consequence on tumor growth, and therapeutic strategies to address these challenges remain undescribed. Here, we elucidate the role of taxane-induced re...
Rusert, Jessica M Juarez, Edwin F Brabetz, Sebastian Jensen, James Garancher, Alexandra Chau, Lianne Q Tacheva-Grigorova, Silvia K Wahab, Sameerah Udaka, Yoko T Finlay, Darren
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Published in
Cancer research
Medulloblastoma is among the most common malignant brain tumors in children. Recent studies have identified at least four subgroups of the disease that differ in terms of molecular characteristics and patient outcomes. Despite this heterogeneity, most patients with medulloblastoma receive similar therapies, including surgery, radiation, and intensi...
Guo, Wenzheng Li, Kaimi Sun, Beibei Xu, Dongliang Tong, Lingfeng Yin, Huijing Liao, Yueling Song, Hongyong Wang, Tong Jing, Bo
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Published in
Cancer research
Cancer cells need to generate large amounts of glutathione (GSH) to buffer oxidative stress during tumor development. A rate-limiting step for GSH biosynthesis is cystine uptake via a cystine/glutamate antiporter Xc-. Xc- is a sodium-independent antiporter passively driven by concentration gradients from extracellular cystine and intracellular glut...
Mestre-Farrera, Aida Bruch-Oms, Marina Peña, Raúl Rodríguez-Morató, José Alba-Castellón, Lorena Comerma, Laura Quintela-Fandino, Miguel Duñach, Mireia Baulida, Josep Pozo, Óscar J
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Published in
Cancer research
Tumors are complex tissues composed of transformed epithelial cells as well as cancer-activated fibroblasts (CAF) that facilitate epithelial tumor cell invasion. We show here that CAF and other mesenchymal cells rely much more on glutamine than epithelial tumor cells; consequently, they are more sensitive to inhibition of glutaminase. Glutamine dep...
Subramani, Elavarasan Radoul, Marina Najac, Chloe Batsios, Georgios Molloy, Abigail R Hong, Donghyun Gillespie, Anne Marie Santos, Romelyn Delos Viswanath, Pavithra Costello, Joseph F
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Cancer research
Although lower grade gliomas are driven by mutations in the isocitrate dehydrogenase 1 (IDH1) gene and are less aggressive than primary glioblastoma, they nonetheless generally recur. IDH1-mutant patients are increasingly being treated with temozolomide, but early detection of response remains a challenge and there is a need for complementary imagi...
Dasgupta, Atreyi Sierra, Laura Tsang, Susan V Kurenbekova, Lyazat Patel, Tajhal Rajapakshe, Kimal Shuck, Ryan L Rainusso, Nino Landesman, Yosef Unger, Thaddeus
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Published in
Cancer research
Rhabdomyosarcoma (RMS) is the most prevalent pediatric soft tissue sarcoma. Multimodal treatment including surgery and traditional chemotherapy with radiotherapy have contributed to improvements in overall survival rates. However, patients with recurrent or metastatic disease have 5-year survival rates of less than 30%. One reason for the lack of t...