Phillips, Darren C Buchanan, Fritz G Cheng, Dong Solomon, Larry R Xiao, Yu Xue, John Tahir, Stephen K Smith, Morey L Zhang, Haichao Widomski, Deborah
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Published in
Cancer research
TNF Receptor Apoptosis-Inducing Ligand (TRAIL) can activate cell surface death receptors resulting in potent tumor cell death via induction of the extrinsic apoptosis pathway. Eftozanermin alfa (ABBV-621) is a second-generation TRAIL receptor agonist engineered as an IgG1-Fc mutant backbone linked to two sets of trimeric native single chain TRAIL r...
Broadfield, Lindsay A Gonçalves Duarte, João André Schmieder, Roberta Broekaert, Dorien Veys, Koen Planque, Mélanie Vriens, Kim Karasawa, Yasuaki Napolitano, Francesco Fujita, Suguru
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Published in
Cancer research
Hepatic fat accumulation is associated with diabetes and hepatocellular carcinoma (HCC). Here we characterize the metabolic response that high fat availability elicits in livers prior to disease development. After a short term on a high fat diet, otherwise healthy mice showed elevated hepatic glucose uptake and increased glucose contribution to ser...
Grönholm, Mikaela Feodoroff, Michaela Antignani, Gabriella Martins, Beatriz Hamdan, Firas Cerullo, Vincenzo
Published in
Cancer research
Cancer immunotherapy has revolutionized the way tumors are treated. Nevertheless, efficient and robust testing platforms are still missing, including clinically relevant human ex vivo tumor assays that allow pre-treatment testing of cancer therapies and selection of the most efficient and safe therapy for a specific patient. In the case of immunoth...
Ren, Jinghua He, Jiayi Zhang, Hongji Xia, Yujia Hu, Zhiwei Loughran, Patricia Billiar, Timothy Huang, Hai Tsung, Allan
Published in
Cancer research
Surgical removal of malignant tumors is a mainstay in controlling most solid cancers. However, surgical insult also increases the risk of tumor recurrence and metastasis. Tissue trauma activates the innate immune system locally and systemically, mounting an inflammatory response. Platelets and neutrophils are two crucial players in the early innate...
Sottnik, Joseph L Vanderlinden, Lauren A Joshi, Molishree Chauca-Diaz, Ana Owens, Charles Hansel, Donna E Sempeck, Colin Ghosh, Debashis Theodorescu, Dan
Published in
Cancer research
The androgen receptor (AR) is important in the development of both experimental and human bladder cancer. However, the role of AR in bladder cancer growth and progression is less clear, with literature indicating that more advanced stage and grade disease are associated with reduced AR expression. To determine the mechanisms underlying these relati...
Lu, Junhao Chen, Lihong Song, Zheng Das, Mousumi Chen, Jiandong
Published in
Cancer research
The p53 tumor suppressor is frequently inactivated by mutations in cancer. Most p53 mutations are located in the DNA binding domain, causing local disruption of DNA binding surface or global misfolding. Rescuing the structural defect of mutant p53 is an attractive therapeutic strategy, but its potential remains unproven due to a lack of drugs capab...
Tasaki, Yoshihiko Suzuki, Miho Katsushima, Keisuke Shinjo, Keiko Iijima, Kenta Murofushi, Yoshiteru Naiki-Ito, Aya Hayashi, Kazuki Qiu, Chenjie Takahashi, Akiko
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Published in
Cancer research
Overcoming drug resistance is one of the biggest challenges in cancer chemotherapy. In this study, we examine whether targeting the long non-coding RNA taurine upregulated gene 1 (TUG1) could be an effective therapeutic approach to overcome drug resistance in pancreatic ductal adenocarcinoma (PDAC). TUG1 was expressed at significantly higher levels...
Anderson, Nicholas R Minutolo, Nicholas G Gill, Saar Klichinsky, Michael
Published in
Cancer research
Adoptive cell therapy with genetically modified T cells has generated exciting outcomes in hematologic malignancies, but its application to solid tumors has proven challenging. This gap has spurred the investigation of alternative immune cells as therapeutics. Macrophages are potent immune effector cells whose functional plasticity leads to antitum...
Panzarino, Nicholas J Krais, John J Cong, Ke Peng, Min Mosqueda, Michelle Nayak, Sumeet U Bond, Samuel M Calvo, Jennifer A Doshi, Mihir B Bere, Matt
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Published in
Cancer research
Defects in DNA repair and the protection of stalled DNA replication forks are thought to underlie the chemosensitivity of tumors deficient in the hereditary breast cancer genes BRCA1 and BRCA2 (BRCA). Challenging this assumption are recent findings that indicate chemotherapies, such as cisplatin used to treat BRCA-deficient tumors, do not initially...
Sequeira, Gonzalo R Sahores, Ana Dalotto-Moreno, Tomás Perrotta, Ramiro M Pataccini, Gabriela Vanzulli, Silvia I Polo, María L Radisky, Derek C Sartorius, Carol A Novaro, Virginia
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Published in
Cancer research
The role of active antitumor immunity in hormone receptor-positive (HR+) breast cancer has been historically underlooked. The aim of this study was to determine the contribution of the immune system to antiprogestin-induced tumor growth inhibition using a hormone-dependent breast cancer model. BALB/c-GFP+ bone marrow (BM) cells were transplanted in...
