Ford, Kirsty Hanley, Christopher J Mellone, Massimiliano Szyndralewiez, Cedric Heitz, Freddy Wiesel, Philippe Wood, Oliver Machado, Maria Lopez, Maria-Antoinette Ganesan, Anusha-Preethi
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Published in
Cancer research
Determining mechanisms of resistance to αPD-1/PD-L1 immune-checkpoint immunotherapy is key to developing new treatment strategies. Cancer-associated fibroblasts (CAF) have many tumor-promoting functions and promote immune evasion through multiple mechanisms, but as yet, no CAF-specific inhibitors are clinically available. Here we generated CAF-rich...
Martin, Maria Laura Adileh, Mohammad Hsu, Kuo-Shun Hua, Guoqiang Lee, Sang Gyu Li, Christy Fuller, John D Rotolo, Jimmy A Bodo, Sahra Klingler, Stefan
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Published in
Cancer research
Tissue survival responses to ionizing radiation are nonlinear with dose, rather yielding tissue-specific descending curves that impede straightforward analysis of biologic effects. Apoptotic cell death often occurs at low doses, while at clinically relevant intermediate doses, double-strand break misrepair yields mitotic death that determines outco...
McCann, Jennifer J Vasilevskaya, Irina A Poudel Neupane, Neermala Shafi, Ayesha A McNair, Christopher Dylgjeri, Emanuela Mandigo, Amy C Schiewer, Matthew J Schrecengost, Randy S Gallagher, Peter
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Published in
Cancer research
Emerging evidence indicates the deubiquitinase USP22 regulates transcriptional activation and modification of target substrates to promote pro-oncogenic phenotypes. Here, in vivo characterization of tumor-associated USP22 upregulation and unbiased interrogation of USP22-regulated functions in vitro demonstrated critical roles for USP22 in prostate ...
Patel, Rachana Brzezinska, Elspeth A Repiscak, Peter Ahmad, Imran Mui, Ernest Gao, Meiling Blomme, Arnaud Harle, Victoria Tan, Ee Hong Malviya, Gaurav
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Published in
Cancer research
Inhibition of the androgen receptor (AR) is the main strategy to treat advanced prostate cancers. AR-independent treatment-resistant prostate cancer is a major unresolved clinical problem. Patients with prostate cancer with alterations in canonical WNT pathway genes, which lead to β-catenin activation, are refractory to AR-targeted therapies. Here,...
Mukhopadhyay, Suman Goswami, Debanjan Adiseshaiah, Pavan P. Burgan, William Yi, Ming Guerin, Theresa M. Kozlov, Serguei V. Nissley, Dwight V. McCormick, Frank
Published in
Cancer research
Oncogenic KRAS-induced NRF2 upregulates glutaminolysis. Targeting glutamine metabolism downregulates chemoresistance markers, diminishes stress granule accumulation and dampens GPX4. Restricting glutaminolysis bolsters the effect of gemcitabine against pancreatic cancer.
Hawk, Ernest T Colbert Maresso, Karen
Published in
Cancer research
E-cigarettes have the ability to deliver nicotine in a manner that is similar to, and, theoretically, safer than, combusted tobacco. However, these devices are extremely heterogeneous and regulation has struggled to keep up with their rapid evolution. A compilation of early data suggest that e-cigarettes may contain numerous toxic substances, inclu...
Muralidhar, Sathya Filia, Anastasia Nsengimana, Jérémie Poźniak, Joanna O'Shea, Sally J Diaz, Joey M Harland, Mark Randerson-Moor, Juliette A Reichrath, Jörg Laye, Jonathan P
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Published in
Cancer research
1α,25-Dihydroxyvitamin D3 signals via the vitamin D receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As patients with melanoma commonly avoid sun exposure, and consequent vitamin D deficiency might worsen outcomes, we interrogated 703 primary...
Hong, Beom-Jin Park, Woo-Yong Kim, Hwa-Ryeon Moon, Jin Woo Lee, Ho Yeon Park, Jun Hyung Kim, Seon-Kyu Oh, Youngbin Roe, Jae-Seok Kim, Mi-Young
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Published in
Cancer research
Genetic and epigenetic changes (e.g., histone methylation) contribute to cancer development and progression, but our understanding of whether and how specific mutations affect a cancer's sensitivity to histone demethylase (KDM) inhibitors is limited. Here, we evaluated the effects of a panel of KDM inhibitors on lung adenocarcinomas (LuAC) with var...
Shin, Seung Jun Dodd-Eaton, Elissa B Peng, Gang Bojadzieva, Jasmina Chen, Jingxiao Amos, Christopher I Frone, Megan N Khincha, Payal Mai, Phuong L Savage, Sharon A
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Published in
Cancer research
Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome associated with an autosomal dominant mutation inheritance in the TP53 tumor suppressor gene and a wide spectrum of cancer diagnoses. The previously developed R package, LFSPRO, is capable of estimating the risk of an individual being a TP53 mutation carrier. However, an accurate estim...
Shin, Seung Jun Dodd-Eaton, Elissa B Gao, Fan Bojadzieva, Jasmina Chen, Jingxiao Kong, Xianhua Amos, Christopher I Ning, Jing Strong, Louise C Wang, Wenyi
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Published in
Cancer research
Li-Fraumeni syndrome (LFS) is a rare autosomal dominant disorder associated with TP53 germline mutations and an increased lifetime risk of multiple primary cancers (MPC). Penetrance estimation of time to first and second primary cancer within LFS remains challenging due to limited data and the difficulty of characterizing the effects of a primary c...
