Chakraborty, Subhajit Nandi, Piyasa Mishra, Jagdish Niharika, Roy, Ankan Manna, Soumen Baral, Tirthankar Mishra, Prahallad Mishra, Pradyumna Kumar Patra, Samir Kumar
...
Published in
Cancer letters
Cellular physiology is critically regulated by multiple signaling nexuses, among which cell death mechanisms play crucial roles in controlling the homeostatic landscape at the tissue level within an organism. Apoptosis, also known as programmed cell death, can be induced by external and internal stimuli directing the cells to commit suicide in unfa...
Feng, Ji Wang, Zi-Xuan Bin, Jin-Lian Chen, Yong-Xin Ma, Jing Deng, Jing-Huan Huang, Xiao-Wei Zhou, Jing Lu, Guo-Dong
Published in
Cancer letters
Lysosomes are crucial organelles responsible for the degradation of cytosolic materials and bulky organelles, thereby facilitating nutrient recycling and cell survival. However, lysosome also acts as an executioner of cell death, including ferroptosis, a distinctive form of regulated cell death that hinges on iron-dependent phospholipid peroxidatio...
Cao, Canhui Xu, Qian Zhu, Zhixian Xu, Miaochun Wei, Ye Lin, Shitong Cheng, Sheng Zhi, Wenhua Hong, Ping Huang, Xingyu
...
Published in
Cancer letters
Human papillomavirus (HPV) is predominantly associated with HPV-related cancers, however, the precise mechanisms underlying the HPV-host epigenetic architectures in HPV carcinogenesis remain elusive. Here, we employed high-throughput chromosome conformation capture (Hi-C) to comprehensively map HPV16/18-host chromatin interactions. Our study identi...
Cheng, Siyuan Li, Lin Yu, Xiuping
Published in
Cancer letters
A substantial volume of RNA sequencing data have been generated from cancer cell lines. However, it requires specific bioinformatics skills to compare gene expression levels across cell lines. This has hindered non-bioinformaticians from fully utilizing these valuable datasets in their research. To bridge this gap, we established a curated Pan-canc...
He, Yuanming Jiang, Shuoyi Cui, Yaoli Liang, Jingpei Zhong, Yueya Sun, Yuening Moran, Michael F Huang, Zhenqian He, Guisong Mao, Xinliang
...
Published in
Cancer letters
Induction of pyroptosis is proposed as a promising strategy for the treatment of hematological malignancies, but little is known. In the present study, we find clioquinol (CLQ), an anti-parasitic drug, induces striking myeloma and leukemia cell pyroptosis on a drug screen. RNA sequencing reveals that the interferon-inducible genes IFIT1 and IFIT3 a...
Jiang, Xuefei Yang, Lanlan Chen, Guanxing Feng, Xingzhi Liu, Yiting Gao, Qianling Mai, Mingru Chen, Calvin Yu-Chian Ye, Shubiao Yang, Zihuan
...
Published in
Cancer letters
Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide. Understanding the underlying mechanism driving CRC progression and identifying potential therapeutic drug targets are of utmost urgency. We previously utilized LC-MS-based proteomic profiling to identify proteins associated with postoperative progression in stage II/III CR...
Chauhan, Nitish Patro, Birija Sankar
Published in
Cancer letters
In the era of personalized therapy, precise targeting of subcellular organelles holds great promise for cancer modality. Taking into consideration that lysosome represents the intersection site in numerous endosomal trafficking pathways and their modulation in cancer growth, progression, and resistance against cancer therapies, the lysosome is prop...
Tang, Rui Yin, Jianqiong Liu, Yuanxin Xue, Jianxin
Published in
Cancer letters
Radiotherapy plays a pivotal role in the control and eradication of tumors, but it can also induce radiation injury to surrounding normal tissues while targeting tumor cells. In recent years, FLASH-Radiotherapy (FLASH-RT) has emerged as a cutting-edge research focus in the field of radiation therapy. By delivering high radiation doses to the treatm...
Yang, Zi-Yi Zhao, Cheng Liu, Shi-Lei Pan, Li-Jia Zhu, Yi-di Zhao, Jing-Wei Wang, Hua-Kai Ye, Yuan-Yuan Qiang, Jing Shi, Liu-Qing
...
Published in
Cancer letters
Gallbladder cancer (GBC) is a highly malignant and rapidly progressing tumor of the human biliary system, and there is an urgent need to develop new therapeutic targets and modalities. Non-POU domain-containing octamer-binding protein (NONO) is an RNA-binding protein involved in the regulation of transcription, mRNA splicing, and DNA repair. NONO e...
Cao, Min Tang, Yancheng Luo, Yufei Gu, Fen Zhu, Yuyuan Liu, Xu Yan, Chenghao Hu, Wei Wang, Shaogui Chao, Xiaojuan
...
Published in
Cancer letters
Cancer is considered as the second leading cause of mortality, and cancer incidence is still growing rapidly worldwide, which poses an increasing global health burden. Although chemotherapy is the most widely used treatment for cancer, its effectiveness is limited by drug resistance and severe side effects. Mitophagy is the principal mechanism that...
