Kumar, Ac Senthil Chander, Vimal Parthasarathy, Jayaganesh
Published in
Cancer investigation
Treatment plan for ovarian neoplasms differs for benign, borderline and malignant tumors. With a turnaround time of 15 to 20 minutes, frozen section has become a reliable intraoperative diagnostic tool. The aim of this study is to correlate the frozen section diagnosis with subsequent histopathologic diagnosis and determine the accuracy of frozen s...
Bouleftour, Wafa Daguenet, Elisabeth Tinquaut, Fabien Magne, Nicolas
Published in
Cancer investigation
Coronavirus disease outbreak has affected all aspect of clinical care including cancer clinical trials. To minimize exposure of frail cancer patients, an implementation of telemedicine was retained. The impact of this implementation on primary and secondary endpoints criteria of ongoing clinical trials was analyzed. Out of 128 oncology clinical tri...
Khaki, Ali Raza
Published in
Cancer investigation
Precision oncology has revolutionized the therapeutic landscape of oncology and is a goal for cancer drug development. However, lenient drug approvals by the United States Food and Drug Administration under the auspices of precision oncology are setting up this therapeutic approach to fail. In this commentary, I review two recent FDA drug approvals...
Alikhani, Mehdi Touati, Eliette Karimipoor, Morteza Vosough, Massoud Eybpoosh, Sana Mohammadi, Marjan
Published in
Cancer investigation
We have performed a systematic review and meta-analysis for evaluation of mitochondrial DNA copy number (mtDNA-CN) alterations in peripheral blood leukocytes (PBL), and tumor tissues of gastrointestinal tract (GIT) cancers. Analysis of the PBL demonstrated a significant decrease [OR: 0.63 (0.53, 0.76)] and increase [OR: 1.52 (1.10, 2.10)] prior to ...
Tian, Sun Wang, Fulong Lu, Shixun Chen, Gong
Published in
Cancer investigation
To dissect gene expression subgroups of FOLFOX resistance colorectal cancer(CRC) and predict FOLFOX response, gene expression data of 83 stage IV CRC tumor samples (FOLFOX responder n = 42, non-responder n = 41) are used to develop a novel iterative supervised learning method IML. IML identified two mutually exclusive subgroups of CRC patients that...
Kubicek, Pierre Fenouil, Tanguy Jacquemus, Julien Chapuis, Olivia Fléchon, Aude Dumesnil, Cécile Faure-Conter, Cécile
Published in
Cancer investigation
Extragonadal germ cell tumors (GCTs) are thought to arise as a result of local transformation of primordial gonadal cells (PGCs) that become misplaced during embryogenesis. With the exception of bilateral testis tumors, metachronous GCT (i.e., occurring at a site classically described for primary GCTs) are rare events. The clinical, radiological, a...
Lavergne, Francis Jay, Therese M
Published in
Cancer investigation
The review states that antidepressants (ADs) increase brain-derived neurotrophic factor (BDNF) transmission concomitantly in the brain and the blood: ADs increasing BDNF synthesis in specific areas of the central nervous system (CNS) could presumably affect megakaryocyte's production of platelets. ADs increase BDNF levels in the CNS and improve moo...
Li, Yujiao Hu, Chaosu
Published in
Cancer investigation
To assess clinicopathological characteristics and prognostic value of age stratification on overall survival (OS) and cancer-specific survival (CSS) for stage IV oral tongue squamous cell carcinoma. A total of 1357 patients were extracted from the SEER database between 2010 and 2014. Younger patients tended to be male and present with advanced N cl...
Sato, Nobuaki Shiota, Masaki Shiga, Ken-Ichiro Kashiwagi, Eiji Takeuchi, Ario Inokuchi, Junichi Yokomizo, Akira Naito, Seiji Eto, Masatoshi
Published in
Cancer investigation
We analyzed the association between smoking and oncological outcome after radical prostatectomy with neoadjuvant hormonal therapy. This study included men who had undergone radical prostatectomy with neoadjuvant hormonal therapy between 2003 and 2016. We evaluated the association between clinicopathological factors and smoking status as well as the...
DaCosta Byfield, Stacey Chastek, Benjamin Korrer, Stephanie Horstman, Thomas Malin, Jennifer Newcomer, Lee
Published in
Cancer investigation
Although physicians rely on clinical trial data to guide cancer treatment decisions, patient characteristics and outcomes often differ between real-world and clinical trial populations. We analyzed retrospective clinical data collected from a prior authorization (PA) tool linked with payer claims data to describe outcomes of first-line treatment fo...
