Tyan, Kevin Baginska, Joanna Brainard, Martha Giobbie-Hurder, Anita Severgnini, Mariano Manos, Michael Haq, Rizwan Buchbinder, Elizabeth I Ott, Patrick A Hodi, F Stephen
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Cancer immunology, immunotherapy : CII
Immune checkpoint inhibitors (ICIs) often cause immune-related adverse events (irAEs), most of which are treated with corticosteroids despite evidence suggesting that corticosteroids may blunt antitumor efficacy. We sought to identify cytokine changes that correlate with irAEs and study the impact of corticosteroid treatment on cytokine levels. We ...
Sisman, Gurhan Barbur, Erol Saka, Didem Erdamar Cetin, Sibel
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Cancer immunology, immunotherapy : CII
Advancements in medicine have enabled the use of monoclonal antibodies in the field of oncology. However, the new adverse effects of immunotherapeutic agents are still being reported. We present the first case of pembrolizumab-induced fatal colitis with concurrent Giardia infection in a patient with metastatic ovarian cancer. A 47-year-old woman wi...
Panoskaltsis, Nicki
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Cancer immunology, immunotherapy : CII
Cytokine release syndrome (CRS) is the result of massive pro-inflammatory cytokine release and imbalance in the absence of adequate immunomodulation from signals such as interleukin (IL)-10, resulting in ongoing inflammation, tissue damage and death if left uncontrolled. Although CRS can result from different pro-inflammatory insults, the treatment...
Zhang, Fan Bai, Hua Gao, Ranran Fei, Kailun Duan, Jianchun Zhang, Zemin Wang, Jie Hu, Xueda
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Cancer immunology, immunotherapy : CII
Understanding of the functional states and clonal dynamics of T cells after immune checkpoint blockade (ICB) is valuable for improving these therapeutic strategies. Here we performed Smart-seq2 single-cell RNA sequencing (scRNA-seq) analysis on 3,110 peripheral T cells of non-small cell lung cancer (NSCLC) patients before and after the initiation o...
Guo, Qingming Zhao, Peng Zhang, Zhen Zhang, Jinyu Zhang, Zheng Hua, Yanan Han, Bin Li, Ning Zhao, Xiaowen Hou, Lin
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Cancer immunology, immunotherapy : CII
As ideal cells that can be used for adoptive cell therapy, γδ T cells are a group of homogeneous cells with high proliferative and tumor killing ability. However, γδ T cells are apt to apoptosis and show decreased cytotoxicity under persistent stimulation in vitro and cannot aggregate at tumor sites efficiently in vivo, both of which are two main o...
Komura, Naoko Mabuchi, Seiji Shimura, Kotaro Yokoi, Eriko Kozasa, Katsumi Kuroda, Hiromasa Takahashi, Ryoko Sasano, Tomoyuki Kawano, Mahiru Matsumoto, Yuri
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Cancer immunology, immunotherapy : CII
The aim of this study was to investigate the role of myeloid-derived suppressor cells (MDSC) in the induction of cancer stem-like cells (CSC) and programmed death ligand 1 (PD-L1) expression in ovarian cancer. CSC were defined as tumor cells expressing high levels of aldehyde dehydrogenase 1 (ALDH 1). We inoculated G-CSF-expressing or Mock-expressi...
Liang, Jie-Ying Xi, Shao-Yan Shao, Qiong Yuan, Yun-Fei Li, Bin-Kui Zheng, Yun Wang, De-Shen Wu, Xiao-Jun Ding, Pei-Rong Chen, Gong
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Cancer immunology, immunotherapy : CII
Various scoring systems have been proposed to predict the postoperative prognosis of colorectal liver metastasis (CRLM), including the clinical risk score (CRS), the immunoscore and so on. Recently, histopathological growth patterns (HGPs) have been recognized. However, the correlation between HGPs and the immunoscore, and their prognostic values i...
Stegantseva, Maria V Shinkevich, Veronika A Tumar, Elena M Meleshko, Alexander N
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Cancer immunology, immunotherapy : CII
Neuroblastoma is an example of a difficult-to-treat tumor with high incidence of relapse. DNA vaccination could be applied as a relapse prophylactic option for patients with high-risk neuroblastoma. Its efficacy depends directly on a target antigen of choice and a delivery method. Three neuroblastoma-associated antigens (tyrosine hydroxylase, Survi...
Cuzzubbo, Stefania Banissi, Claire Rouchon, Marie Sophie Tran, Thi Tanchot, Corinne Tartour, Eric Carpentier, Antoine F
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Cancer immunology, immunotherapy : CII
Peptide vaccines represent an attractive alternative to conventional anti-tumor therapies, but have not yet achieved significant clinical efficacy with commonly used formulations. Combination of short antigenic peptides, synthetic melanin and TLR9 agonist (Toll-like receptor 9, CpG-28) was reported as highly efficient to trigger strong CD8 + T-cell...
Dong, Haidong
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Cancer immunology, immunotherapy : CII
