Boutet, Marie Gauthier, Ludiane Leclerc, Marine Gros, Gwendoline de Montpreville, Vincent Nathalie Théret Emmanuel Donnadieu Mami-Chouaib, Fathia
Published in
Cancer Research
Homing of CD8+ T lymphocytes to the tumor microenvironment is an important step for mounting a robust antitumor immune response. TGFβ is responsible for CD103 (αEβ7) integrin induction in activated intraepithelial CD8+ T lymphocytes. However, the interplay between TGFβ and CD103 and their contribution to T-cell infiltration and antitumor activity r...
Marusiak, Anna A Stephenson, Natalie L Baik, Hayeon Trotter, Eleanor W Li, Yaoyong Blyth, Karen Mason, Susan Chapman, Phil Puto, Lorena A Read, Jon A
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Published in
Cancer research
MLK4 is a member of the mixed-lineage family of kinases that regulate the JNK, p38, and ERK kinase signaling pathways. MLK4 mutations have been identified in various human cancers, including frequently in colorectal cancer, where their function and pathobiological importance have been uncertain. In this study, we assessed the functional consequence...
Shanker, Anil Pellom, Samuel T Jr Dudimah, Duafalia F Thounaojam, Menaka C de Kluyver, Rachel L Brooks, Alan D Yagita, Hideo McVicar, Daniel W Murphy, William J Longo, Dan L
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Published in
Cancer research
Cancer immunotherapy shows great promise but many patients fail to show objective responses, including in cancers that can respond well, such as melanoma and renal adenocarcinoma. The proteasome inhibitor bortezomib sensitizes solid tumors to apoptosis in response to TNF-family death ligands. Because T cells provide multiple death ligands at the tu...
Messai, Yosra Noman, Muhammad Zaeem Hasmim, Meriem Janji, Bassam Tittarelli, Andrés Boutet, Marie Véronique Baud Viry, Elodie Billot, Katy Nanbakhsh, Arash
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Published in
Cancer Research
Clear cell renal cell carcinomas (RCC) frequently display inactivation of von Hippel-Lindau (VHL) gene leading to increased level of hypoxia-inducible factors (HIF). In this study, we investigated the potential role of HIF2α in regulating RCC susceptibility to natural killer (NK) cell-mediated killing. We demonstrated that the RCC cell line 786-0 w...
Giammanco, Antonina Blanc, Valerie Montenegro, Grace Klos, Coen Xie, Yan Kennedy, Susan Luo, Jianyang Chang, Sung-Hee Hla, Timothy Nalbantoglu, Ilke
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Published in
Cancer Research
HuR is a ubiquitous nucleocytoplasmic RNA-binding protein that exerts pleiotropic effects on cell growth and tumorigenesis. In this study, we explored the impact of conditional, tissue-specific genetic deletion of HuR on intestinal growth and tumorigenesis in mice. Mice lacking intestinal expression of HuR (Hur (IKO) mice) displayed reduced levels ...
Thompson, Kenneth W Stefanie Marquez Reisman, David
Published in
Cancer Research
Dinami, Roberto Ercolani, Cristiana Petti, Eleonora Piazza, Silvano Ciani, Yari Sestito, Rosanna Sacconi, Andrea Biagioni, Francesca le Sage, Carlos Agami, Reuven
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Published in
Cancer Research
Telomeres consist of DNA tandem repeats that recruit the multiprotein complex shelterin to build a chromatin structure that protects chromosome ends. Although cancer formation is linked to alterations in telomere homeostasis, there is little understanding of how shelterin function is limited in cancer cells. Using a small-scale screening approach, ...
Kulkarni, Ashish A Roy, Bhaskar Rao, Poornima S Wyant, Gregory A Mahmoud, Ayaat Ramachandran, Madhumitha Sengupta, Poulomi Goldman, Aaron Kotamraju, Venkata Ramana Basu, Sudipta
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Published in
Cancer research
The centrality of phosphoinositide-3-kinase (PI3K) in cancer etiology is well established, but clinical translation of PI3K inhibitors has been limited by feedback signaling, suboptimal intratumoral concentration, and an insulin resistance "class effect." This study was designed to explore the use of supramolecular nanochemistry for targeting PI3K ...
Janouskova, Hana Maglott, Anne Leger, David Y Bossert, Catherine Noulet, Fanny Guerin, Eric Guenot, Dominique Pinel, Sophie Chastagner, Pascal Plenat, François
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Published in
Cancer Research
Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. In this study, we show that high expression of the α5 integrin subunit compromises temozolomide-induced tumor suppressor p53 activity in human glioblastoma cells. We found that depletion of the α5 integrin subunit increased p53 activity and temozolomide se...
Palafox, Marta Ferrer, Irene Pellegrini, Pasquale Vila, Sergi Hernandez-Ortega, Sara Urruticoechea, Ander Climent, Fina Soler, Maria Teresa Muñoz, Purificación Viñals, Francesc
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Published in
Cancer Research
Paracrine signaling through receptor activator of NF-κB (RANK) pathway mediates the expansion of mammary epithelia that occurs during pregnancy, and activation of RANK pathway promotes mammary tumorigenesis in mice. In this study we extend these previous data to human cells and show that the RANK pathway promotes the development of mammary stem cel...
