Boutet, Marie Gauthier, Ludiane Leclerc, Marine Gros, Gwendoline de Montpreville, Vincent Nathalie Théret Emmanuel Donnadieu Mami-Chouaib, Fathia
Published in
Cancer Research
Homing of CD8+ T lymphocytes to the tumor microenvironment is an important step for mounting a robust antitumor immune response. TGFβ is responsible for CD103 (αEβ7) integrin induction in activated intraepithelial CD8+ T lymphocytes. However, the interplay between TGFβ and CD103 and their contribution to T-cell infiltration and antitumor activity r...
Popova, Tatiana Manié, Elodie Valentina Boeva Battistella, Aude Goundiam, Oumou Smith, Nicholas K. Mueller, Christopher R. Raynal, Virginie Mariani, Odette Sastre-Garau, Xavier
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Published in
Cancer Research
CDK12 is a recurrently mutated gene in serous ovarian carcinoma, whose downregulation is associated with impaired expression of DNA damage repair genes and subsequent hypersensitivity to DNA-damaging agents and PARP1/2 inhibitors. In this study, we investigated the genomic landscape associated with CDK12 inactivation in patients with serous ovarian...
Marusiak, Anna A Stephenson, Natalie L Baik, Hayeon Trotter, Eleanor W Li, Yaoyong Blyth, Karen Mason, Susan Chapman, Phil Puto, Lorena A Read, Jon A
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Published in
Cancer research
MLK4 is a member of the mixed-lineage family of kinases that regulate the JNK, p38, and ERK kinase signaling pathways. MLK4 mutations have been identified in various human cancers, including frequently in colorectal cancer, where their function and pathobiological importance have been uncertain. In this study, we assessed the functional consequence...
Shanker, Anil Pellom, Samuel T Jr Dudimah, Duafalia F Thounaojam, Menaka C de Kluyver, Rachel L Brooks, Alan D Yagita, Hideo McVicar, Daniel W Murphy, William J Longo, Dan L
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Published in
Cancer research
Cancer immunotherapy shows great promise but many patients fail to show objective responses, including in cancers that can respond well, such as melanoma and renal adenocarcinoma. The proteasome inhibitor bortezomib sensitizes solid tumors to apoptosis in response to TNF-family death ligands. Because T cells provide multiple death ligands at the tu...
Messai, Yosra Noman, Muhammad Zaeem Hasmim, Meriem Janji, Bassam Tittarelli, Andrés Boutet, Marie Véronique Baud Viry, Elodie Billot, Katy Nanbakhsh, Arash
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Published in
Cancer Research
Clear cell renal cell carcinomas (RCC) frequently display inactivation of von Hippel-Lindau (VHL) gene leading to increased level of hypoxia-inducible factors (HIF). In this study, we investigated the potential role of HIF2α in regulating RCC susceptibility to natural killer (NK) cell-mediated killing. We demonstrated that the RCC cell line 786-0 w...
Giammanco, Antonina Blanc, Valerie Montenegro, Grace Klos, Coen Xie, Yan Kennedy, Susan Luo, Jianyang Chang, Sung-Hee Hla, Timothy Nalbantoglu, Ilke
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Published in
Cancer Research
HuR is a ubiquitous nucleocytoplasmic RNA-binding protein that exerts pleiotropic effects on cell growth and tumorigenesis. In this study, we explored the impact of conditional, tissue-specific genetic deletion of HuR on intestinal growth and tumorigenesis in mice. Mice lacking intestinal expression of HuR (Hur (IKO) mice) displayed reduced levels ...
Thompson, Kenneth W Stefanie Marquez Reisman, David
Published in
Cancer Research
White, Nathan S McDonald, Carrie McDonald, Carrie R Farid, Niky Kuperman, Josh Karow, David Schenker-Ahmed, Natalie M Bartsch, Hauke Rakow-Penner, Rebecca Holland, Dominic
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Published in
Cancer research
Diffusion-weighted imaging (DWI) has been at the forefront of cancer imaging since the early 2000s. Before its application in clinical oncology, this powerful technique had already achieved widespread recognition due to its utility in the diagnosis of cerebral infarction. Following this initial success, the ability of DWI to detect inherent tissue ...
Dinami, Roberto Ercolani, Cristiana Petti, Eleonora Piazza, Silvano Ciani, Yari Sestito, Rosanna Sacconi, Andrea Biagioni, Francesca le Sage, Carlos Agami, Reuven
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Published in
Cancer Research
Telomeres consist of DNA tandem repeats that recruit the multiprotein complex shelterin to build a chromatin structure that protects chromosome ends. Although cancer formation is linked to alterations in telomere homeostasis, there is little understanding of how shelterin function is limited in cancer cells. Using a small-scale screening approach, ...
Esteves, Pauline Pecqueur, Claire Ransy, Céline Esnous, Catherine Lenoir, Véronique Frédéric Bouillaud Bulteau, Anne-Laure Anne Lombes Prip-Buus, Carina Ricquier, Daniel
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Published in
Cancer Research
Cancer cells tilt their energy production away from oxidative phosphorylation (OXPHOS) toward glycolysis during malignant progression, even when aerobic metabolism is available. Reversing this phenomenon, known as the Warburg effect, may offer a generalized anticancer strategy. In this study, we show that overexpression of the mitochondrial membran...
