Ishiyama, Noboru O'Connor, Matthew Salomatov, Andrei Romashko, Darlene Thakur, Shalabh Mentes, Ahmet Hopkins, Julia F Frampton, Garrett M Albacker, Lee A Kohlmann, Anna
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Published in
Cancer research
Amplification of HER2 can drive the proliferation of cancer cells, and several inhibitors of HER2 have been successfully developed. Recent advances in next-generation sequencing now reveal that HER2 is subject to mutation, with over 2,000 unique variants observed in human cancers. Several examples of oncogenic HER2 mutations have been described, an...
Yoon, Sang Jun Combs, Joseph A Falzone, Aimee Prieto-Farigua, Nicolas Caldwell, Samantha Ackerman, Hayley D Flores, Elsa R DeNicola, Gina M
Published in
Cancer research
Cysteine plays critical roles in cellular biosynthesis, enzyme catalysis, and redox metabolism. The intracellular cysteine pool can be sustained by cystine uptake or de novo synthesis from serine and homocysteine. Demand for cysteine is increased during tumorigenesis for generating glutathione to deal with oxidative stress. While cultured cells hav...
Sweeney, Shawn M Hamadeh, Hisham K Abrams, Natalie Adam, Stacey J Brenner, Sara Connors, Dana E Davis, Gerard J Fiore, Louis Gawel, Susan H Grossman, Robert L
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Published in
Cancer research
Big data in healthcare can enable unprecedented understanding of diseases and their treatment, particularly in oncology. These data may include electronic health records, medical imaging, genomic sequencing, payor records, and data from pharmaceutical research, wearables, and medical devices. The ability to combine datasets and use data across many...
Gallon, John Rodriguez-Calero, Antonio Benjak, Andrej Akhoundova, Dilara Maletti, Sina Amstutz, Ursula Hewer, Ekkehard Genitsch, Vera Fleischmann, Achim Rushing, Elisabeth J
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Published in
Cancer research
Metastases from primary prostate cancers to rare locations, such as the brain, are becoming more common due to longer life expectancy resulting from improved treatments. Epigenetic dysregulation is a feature of primary prostate cancer, and distinct DNA methylation profiles have been shown to be associated with the mutually exclusive SPOP-mutant or ...
Sweeney, Shawn M Hamadeh, Hisham K Abrams, Natalie Adam, Stacey J Brenner, Sara Connors, Dana E Davis, Gerard J Fiore, Louis D Gawel, Susan H Grossman, Robert L
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Published in
Cancer research
The analysis of big healthcare data has enormous potential as a tool for advancing oncology drug development and patient treatment, particularly in the context of precision medicine. However, there are challenges in organizing, sharing, integrating, and making these data readily accessible to the research community. This review presents five case s...
Wood, Colin S. Pennel, Kathryn A.F. Leslie, Holly Legrini, Assya Cameron, Andrew J. Melissourgou-Syka, Lydia Quinn, Jean A. van Wyk, Hester C. Hay, Jennifer Roseweir, Antonia K.
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Published in
Cancer Research
Strong immune responses in primary colorectal cancer correspond with better patient survival following surgery compared with tumors with predominantly stromal microenvironments. However, biomarkers to identify patients with colorectal cancer liver metastases (CRLM) with good prognosis following surgery for oligometastatic disease remain elusive. Th...
Zhang, Rongxin Shu, Huiling Wang, Yuqi Tao, Tiantong Tu, Jing Wang, Cheng Mergny, Jean-Louis Sun, Xiao
Published in
Cancer Research
G-quadruplexes (G4) are noncanonical secondary genome structures. Aberrant formation of G4s can impair genome integrity. Investigation of the relationship between G4s and somatic structural variants (SV) in cancers could provide a better understanding of the role of G4 formation in cancer development and progression. In this study, we combined bioi...
Blatti, Charles de la Fuente, Jesús Gao, Huanyao Marín-Goñi, Irene Chen, Zikun Zhao, Sihai D Tan, Winston Weinshilboum, Richard Kalari, Krishna R Wang, Liewei
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Published in
Cancer research
Survival rates of patients with metastatic castration-resistant prostate cancer (mCRPC) are low due to lack of response or acquired resistance to available therapies, such as abiraterone (Abi). A better understanding of the underlying molecular mechanisms is needed to identify effective targets to overcome resistance. Given the complexity of the tr...
El-Deiry, Wafik S.
Published in
Cancer Research
Tumor suppressor TP53 is an important gene in human cancer because it is mutated in the majority of tumors, leading to loss-of-function or gain-of-function phenotypes. Mutated TP53 acts like an oncogene, driving cancer progression and causing poor patient outcomes. The role of mutated p53 in cancer has been known for over three decades, yet there i...
Chambers, Courtney Cermakova, Katerina Chan, Yuen San Kurtz, Kristen Wohlan, Katharina Lewis, Andrew Henry Wang, Christiana Pham, Anh Dejmek, Milan Sala, Michal
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Published in
Cancer research
In acute myeloid leukemia (AML), SWI/SNF chromatin remodeling complexes sustain leukemic identity by driving high levels of MYC. Previous studies have implicated the hematopoietic transcription factor PU.1 (SPI1) as an important target of SWI/SNF inhibition, but PU.1 is widely regarded to have pioneer-like activity. As a result, many questions have...
