Giammanco, Antonina Blanc, Valerie Montenegro, Grace Klos, Coen Xie, Yan Kennedy, Susan Luo, Jianyang Chang, Sung-Hee Hla, Timothy Nalbantoglu, Ilke
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Published in
Cancer Research
HuR is a ubiquitous nucleocytoplasmic RNA-binding protein that exerts pleiotropic effects on cell growth and tumorigenesis. In this study, we explored the impact of conditional, tissue-specific genetic deletion of HuR on intestinal growth and tumorigenesis in mice. Mice lacking intestinal expression of HuR (Hur (IKO) mice) displayed reduced levels ...
Dinami, Roberto Ercolani, Cristiana Petti, Eleonora Piazza, Silvano Ciani, Yari Sestito, Rosanna Sacconi, Andrea Biagioni, Francesca le Sage, Carlos Agami, Reuven
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Published in
Cancer Research
Telomeres consist of DNA tandem repeats that recruit the multiprotein complex shelterin to build a chromatin structure that protects chromosome ends. Although cancer formation is linked to alterations in telomere homeostasis, there is little understanding of how shelterin function is limited in cancer cells. Using a small-scale screening approach, ...
Palafox, Marta Ferrer, Irene Pellegrini, Pasquale Vila, Sergi Hernandez-Ortega, Sara Urruticoechea, Ander Climent, Fina Soler, Maria Teresa Muñoz, Purificación Viñals, Francesc
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Published in
Cancer Research
Paracrine signaling through receptor activator of NF-κB (RANK) pathway mediates the expansion of mammary epithelia that occurs during pregnancy, and activation of RANK pathway promotes mammary tumorigenesis in mice. In this study we extend these previous data to human cells and show that the RANK pathway promotes the development of mammary stem cel...
Sun, J. Masterman-Smith, M. D. Graham, N. A. Jiao, J. Mottahedeh, J. Laks, D. R. Ohashi, M. Dejesus, J. Kamei, K.-I. Lee, K.-B.
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Published in
Cancer Research
Sun, J. Masterman-Smith, M. D. Graham, N. A. Jiao, J. Mottahedeh, J. Laks, D. R. Ohashi, M. Dejesus, J. Kamei, K.-I. Lee, K.-B.
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Published in
Cancer Research
Chen, David Y Liu, Han Takeda, Shugaku Tu, Ho-Chou Sasagawa, Satoru Van Tine, Brian A Lu, Dongsi Cheng, Emily H-Y Hsieh, James J-D
Published in
Cancer Research
Taspase1, the mixed lineage leukemia and TFIIAalpha-beta cleaving protease, enables cell proliferation and permits oncogenic initiation. Here, we show its critical role in cancer maintenance and thus offer a new anticancer target. Taspase1 is overexpressed in primary human cancers, and deficiency of Taspase1 in cancer cells not only disrupts prolif...
Chang, Pei-Ching Fitzgerald, Latricia D Van Geelen, Albert Yoshihiro Izumiya Ellison, Thomas J Wang, Don-Hong Ann, David K Luciw, Paul A Kung, Hsing-Jien
Published in
Cancer Research
Gautschi, Oliver Tepper, Clifford G Purnell, Phillip R Yoshihiro Izumiya Evans, Christopher P Green, Tim P Desprez, Pierre Y Lara, Primo N Gandara, David R Mack, Philip C
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Published in
Cancer Research
K. L. Bennett B. Hackanson L. T. Smith C. D. Morrison J. C. Lang D. E. Schuller F. Weber C. Eng C. Plass larson reever
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Published in
Cancer Research
J. Wu larson reever
Published in
Cancer Research
