Xu, Yuqiu Feng, Qingyang Chen, Yijiao Mao, Yihao Zhang, Zhiyuan Lv, Yang Zheng, Peng Yu, Shanchao He, Guodong Xu, Jianmin
...
Published in
Cancer Management and Research
Purpose Colorectal cancer (CRC) is one of the most common malignant tumors worldwide. Ovarian metastases (OM), which are low in frequency, are reported to occur in 3–14% of women with CRC and have a poor prognosis. Studies have shown that surgical treatment may benefit patients with ovarian metastases arising from CRC. However, the precise benefit ...
Savukaitytė, Aistė Gudoitytė, Greta Bartnykaitė, Agnė Ugenskienė, Rasa Juozaitytė, Elona
Published in
Cancer Management and Research
Background Mutations within genes encoding components of the PI3K/AKT/mTOR (phosphoinositide 3-kinase/protein kinase B/mechanistic target of rapamycin) signaling axis frequently activate the pathway in breast cancer, making it an attractive therapeutic target. Inhibition of mTORC1 (mechanistic target of rapamycin complex 1) activity upon aspirin tr...
Si, Hailong Wang, Huiling Xiao, Haijuan Fang, Yu Wu, Zhaoli
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Cancer Management and Research
Background Celastrol is a potential anti-tumor agent in hepatocellular carcinoma (HCC). Identifying the molecular determinants of the anti-HCC effect of celastrol is still challenging. In this study, we undertook to associate circular RNAs (circRNAs) with the anti-HCC molecular determinants of celastrol. Methods Cell colony formation, proliferation...
Ren, Qingqi Fu, Shunjun Wang, Dongping Ju, Weiqiang He, Xiaoshun
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Cancer Management and Research
Background Leucine aminopeptidases (LAPs) have been reported to be involved in tumor cell proliferation, invasion and angiogenesis. However, the relationship between serum leucine aminopeptidases and prognosis of hepatocellular carcinoma (HCC) patients who underwent liver transplantation (LT) was not yet reported. We aimed to evaluate the prognosti...
Qi, Liqiang Sun, Bo Yang, Beibei Lu, Su
Published in
Cancer Management and Research
Introduction Long intergenic non-protein coding RNA 665 (LINC00665) has been revealed to contribute cancer progression in many cancer types including liver and gastric cancer. However, the roles of LINC00665 in breast cancer (BC) remain to be explored. Methods We explored LINC00665 expression in BC tissues and normal tissues at GEPIA. Then, its exp...
Wang, Chen Tong, Jiaqi Tang, Mengqiu Lu, Yunyun Liang, Gaofeng Zhang, Zhanchun Chen, Tian
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Cancer Management and Research
Background Various inflammatory biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR), have been well authenticated to predict clinical outcomes in numerous types of cancer. The optimal treatment for patients with locally advanced esophageal squamous cell carcinoma (ESCC) located in the middle or upper ...
Feng, Wanguo Zhu, Ruixi Ma, Junlong Song, Han
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Cancer Management and Research
Background Long noncoding RNA (lncRNA) has been reported to play important roles in tumor initiation. However, how lncRNA ELFN1-AS1 affects retinoblastoma development remains unclear. Thus, we sought to elucidate its functions in retinoblastoma progression. Methods ELFN1-AS1 expression was measured in retinoblastoma tissues and normal tissues by qR...
Wang, Fanghan Li, Xiangfeng Jia, Xigao Geng, Luxin
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Cancer Management and Research
Background The dysregulated circular RNAs (circRNAs) are relevant to the development of non-small cell lung cancer (NSCLC). Nevertheless, the function and mechanism of circRNA zinc finger protein 609 (circZNF609) in NSCLC development remain uncertain. Methods Sixty-two NSCLC patients were recruited. circZNF609, microRNA-623 (miR-623) and forkhead b...
Liu, Zhiyong Yao, Weitao Zhao, Yao Liu, Oufei Zhang, Peng Ge, Hong
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Cancer Management and Research
Purpose Anlotinib is a novel tyrosine kinase inhibitor with promising anti-tumor activity in patients with advanced soft tissue sarcomas (STS) in China. Liposomal doxorubicin monotherapy showed an encouraging effect on this disease. The aim of this study was to evaluate the efficacy and safety of anlotinib combined with liposomal doxorubicin follow...
Shen, Ye Ou, Jinping Wang, Bingjie Wang, Lihong Xu, Junhui Cen, Xinan
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Cancer Management and Research
Background This study assessed the clinical characteristics of gastrointestinal bleeding (GIB), obstruction (GIO), and perforation (GIP) in patients with primary gastrointestinal diffuse large B-cell lymphoma (PGI-DLBCL) and the influence on long-term survival. Methods A retrospective analysis was performed of 148 patients with PGI-DLBCL admitted t...
