Liu, Jingkai Liu, Qiaofei Zhang, Xiang Cui, Ming Li, Tong Zhang, Yalu Liao, Quan
Published in
Cancer Cell International
Background Emerging evidence has shown that intra-tumor immune features are associated with response to immune checkpoint blockade (ICB) therapy. Accordingly, patient stratification is needed for identifying target patients and designing strategies to improve the efficacy of ICB therapy. We aimed to depict the specific immune features of patients w...
Liu, Jingxian Yang, Jinghong Hou, Yuhe Zhu, Zhenwei He, Jie Zhao, Hao Ye, Xidong Li, Dengke Wu, Zhaohui Huang, Zhongxi
...
Published in
Cancer Cell International
Qi, Liqiang Sun, Bo Yang, Beibei Lu, Su
Published in
Cancer Cell International
Background Circular RNAs (circRNAs) have been demonstrated to play significant roles in regulating gene expression in tumorigenesis, including breast cancer (BC). This study was designed to explore the role and underlying molecular mechanisms of circMMP11 in BC. Methods The real-time quantitative polymerase chain reaction (RT-qPCR) assay was used f...
Chen, Jihui Wang, Zhipeng Gao, Shouhong Wu, Kejin Bai, Fang Zhang, Qiqiang Wang, Hongyu Ye, Qin Xu, Fengjing Sun, Hong
...
Published in
Cancer Cell International
Aim Pemetrexed, a new generation antifolate drug, has been approved for the treatment of locally advanced or metastatic breast cancer. However, factors affecting its efficacy and resistance have not been fully elucidated yet. ATP-binding cassette (ABC) transporters are predictors of prognosis as well as of adverse effects of several xenobiotics. Th...
Liang, Li Liu, Mengling Sun, Xun Yuan, Yitao Peng, Ke Rashid, Khalid Yu, Yiyi Cui, Yuehong Chen, Yanjie Liu, Tianshu
...
Published in
Cancer Cell International
Background The anti-epidermal growth factor receptor (EGFR) antibody introduces adaptable variations to the transcriptome and triggers tumor immune infiltration, resulting in colorectal cancer (CRC) treatment resistance. We intended to identify genes that play essential roles in cetuximab resistance and tumor immune cell infiltration. Methods A cet...
Wu, Rui Zhuang, Hao Mei, Yu-Kun Sun, Jin-Yu Dong, Tao Zhao, Li-Li Fan, Zhi-Ning Liu, Li
Published in
Cancer Cell International
Background Esophageal cancer is associated with high incidence and mortality worldwide. Differential expression genes (DEGs) and weighted gene co-expression network analysis (WGCNA) are important methods to screen the core genes as bioinformatics methods. Methods The DEGs and WGCNA were combined to screen the hub genes, and pathway enrichment analy...
Chen, Jia-xin Xu, Da Cao, Jian-wei Zuo, Li Han, Zhi-tao Tian, Yi-jun Chu, Chuan-min Zhou, Wang Pan, Xiu-wu Cui, Xin-gang
...
Published in
Cancer Cell International
Background Renal cell carcinoma (RCC) is one of the most common malignant tumors originating from the renal parenchymal urinary epithelial system. Tripartite motif 47 (TRIM47) is a member of the TRIM family proteins, which has E3 ligase activity and has been demonstrated to be involved in the occurrence and prognosis of many tumors. The main purpos...
Niu, Xinhao Zhu, Zhe Bao, Juan
Published in
Cancer Cell International
Background Controlling Nutritional Status (CONUT) score is a novel nutrition-based biomarker that has been reported for predicting survival in various cancers. However, the relationship between CONUT score and prognosis of urological cancers remains unclear. Hence, we performed this meta-analysis to evaluate the prognostic significance of CONUT sco...
Li, Ji Zhu, Chen Yue, Peipei Zheng, Tianyu Li, Yan Wang, Biao Meng, Xin Zhang, Yao
Published in
Cancer Cell International
Background Abnormal energy metabolism is one of the characteristics of tumor cells, and it is also a research hotspot in recent years. Due to the complexity of digestive system structure, the frequency of tumor is relatively high. We aim to clarify the prognostic significance of energy metabolism in digestive system tumors and the underlying mechan...
Huang, Chuanqian Chen, Renli Zheng, Fangjing Tang, Yirong Wang, Xiukang Chen, Zichun Lai, Xiaolan
Published in
Cancer Cell International
Background Gastric cancer (GC) is one of the most common cancers and the third leading cause of cancer related mortality worldwide. The 5-year survival rate is rather low owing to advanced unresectable and distant metastasis. The EMT has been widely implicated in the stemness, metastatic dormancy, and chemoresistance of different solid tumors. Give...