Quan, Yongjun Zhang, Xiaodong Ping, Hao
Published in
Cancer Cell International
BackgroundEpigenetic reprogramming reportedly has a crucial role in prostate cancer (PCa) progression. RNA modification is a hot topic in epigenetics, and N6-methyladenosine (m6A) accounts for approximately 60% of RNA chemical modifications. The aim of this study was to evaluate the m6A modification patterns in PCa patients and construct a risk pre...
Li, Wei Huang, Bai-sheng Xiong, Yuan-yuan Yang, Li-jian Wu, Li-xiang
Published in
Cancer Cell International
BackgroundGlioblastoma is one of the most common fatal intracranial malignancies. Lysine-specific demethylase 1 (LSD1) reportedly has therapeutic effects on a variety of tumors. This study explored the therapeutic effect of LSD1 inhibition on glioblastoma cell lines and the possible underlying mechanisms.MethodsThe MTT assay was utilized to screen ...
Li, Baibei Deng, Huachu Zhou, Ziyan Tang, Bo
Published in
Cancer Cell International
BackgroundIn recent years, the Fibrinogen to pre-albumin ratio (FPR) has been reported in many studies to be significantly associated with the prognosis of various cancers. This systematic review and meta-analysis aimed to investigate the prognostic value of FPR in malignant tumors of the digestive system based on available evidence.MethodsThe rele...
Zhang, Wei Wang, Bo Lin, Yilin Yang, Yang Zhang, Zhen Wang, Quan Zhang, Haoran Jiang, Kewei Ye, Yingjiang Wang, Shan
...
Published in
Cancer Cell International
BackgroundCircular RNAs (circRNAs) have emerged as vital regulators of the initiation and progression of diverse kinds of human cancers. In this study, we explored the role of hsa_circ_0000231 and its downstream pathway in CRC.MethodsThe expression profile of circRNAs in 5 pairs of CRC tissues and adjacent normal tissues were analyzed by Microarray...
Ma, Zijian Chen, Ganyi Chen, Yiqian Guo, Zizhang Chai, Hao Tang, Yu Zheng, Lin Wei, Ke Pan, Chunfeng Ma, Zhifei
...
Published in
Cancer Cell International
BackgroundNon-small cell lung cancer (NSCLC) is still one of the diseases with the highest mortality and morbidity, and lung adenocarcinoma (LUAD) accounts for more than half of all NSCLC cases in most countries. miRNA can be used as a potential biological marker and treatment for lung adenocarcinoma. However, the effect of miR-937-3p to the invasi...
Yang, Jihua Wei, XiaoHong Hu, Fang Dong, Wei Sun, Liao
Published in
Cancer Cell International
BackgroundMolecular markers play an important role in predicting clinical outcomes in pancreatic adenocarcinoma (PAAD) patients. Analysis of the ferroptosis-related genes may provide novel potential targets for the prognosis and treatment of PAAD.MethodsRNA-sequence and clinical data of PAAD was downloaded from The Cancer Genome Atlas (TCGA) and Ge...
Meng, Jiali Wei, Yuanchao Deng, Qing Li, Ling Li, Xiaolong
Published in
Cancer Cell International
BackgroundHepatocellular carcinoma (HCC) is a primary liver cancer with a high mortality rate. However, the molecular mechanism of HCC formation remains to be explored and studied.ObjectiveTo investigate the expression of TOP2A in hepatocellular carcinoma (HCC) and its prognosis.MethodsThe data set of hepatocellular carcinoma was downloaded from GE...
Zhu, Ke-Yun Tian, Yao Li, Ying-Xi Meng, Qing-Xiang Ge, Jie Cao, Xu-Chen Zhang, Ti Yu, Yue
Published in
Cancer Cell International
BackgroundKrüppel‐like factors (KLFs) are zinc finger proteins which participate in transcriptional gene regulation. Although increasing evidence indicate that KLFs are involved in carcinogenesis and progression, its clinical significance and biological function in breast cancer are still limited.MethodsWe investigated all the expression of KLFs (K...
Boruah, Nabamita Singh, Chongtham Sovachandra Swargiary, Pooja Dkhar, Hughbert Chatterjee, Anupam
Published in
Cancer Cell International
BackgroundRaw areca nut (RAN) consumption induces oral, esophageal and gastric cancers, which are significantly associated with the overexpression of pituitary tumor transforming gene 1/securin and chromosomal instability (CIN). An association of Securin/PTTG1 upregulation and gastric cancer in human was also demonstrated earlier. Since the molecul...
Zhang, Xin Zhang, Hongwei Liao, Zhibin Zhang, Jiacheng Liang, Huifang Wang, Weixing Yu, Jia Dong, Keshuai
Published in
Cancer Cell International
BackgroundThe Src homology and collagen 4 (SHC4) is an important intracellular adaptor protein that has been shown to play a pro-cancer role in melanoma and glioma. However, the biological function and detailed mechanisms of SHC4 in hepatocellular carcinoma progression are unclear. This study aimed to evaluate the potential prognostic and treatment...
