Jin, Mingming Liu, Xiyu Wu, Yue Lou, Yuqing Li, Xue Huang, Gang
Published in
Cancer Cell International
Dysregulation of circular RNAs (circRNAs) has recently been found to play an important role in the progression and development of cancers such as non-small cell lung cancer (NSCLC). Yet the functions of many circRNAs in NSCLC remain unclear. In this study, the circRNA expression profiles in NSCLC tumor tissues and adjacent non-tumorous tissues were...
Kurpińska, Anna Suraj-Prażmowska, Joanna Stojak, Marta Jarosz, Joanna Mateuszuk, Łukasz Niedzielska-Andres, Ewa Smolik, Magdalena Wietrzyk, Joanna Kalvins, Ivars Walczak, Maria
...
Published in
Cancer Cell International
Background Protein disulphide isomerases (PDIs) play an important role in cancer progression. However, the relative contribution of the various isoforms of PDI in tumorigenesis is not clear. Methods The content of PDI isoforms in 22 cancer cells lines was investigated using LC–MS/MS-based proteomic analysis. The effects of PDIA1, PDIA3 and PDIA17 i...
Kalantari, Elham Razmi, Mahdieh Tajik, Fatemeh Asadi-Lari, Mohsen Ghods, Roya Madjd, Zahra
Published in
Cancer Cell International
Background The oncogenic role of doublecortin-like kinase 1 (DCLK1) as a putative cancer stem cell (CSC) marker has been clarified in colorectal cancer (CRC). Isoform-specific functions of DCLK1 have shed new light on different functions of DCLK1 short (DCLK1-S) and DCLK1 long (DCLK1-L) isoforms in tumor initiation, growth, and metastasis. Therefor...
Zhang, Juan Wang, Lei Li, Shuyi Gao, Xuefeng Liu, Zhong
Published in
Cancer Cell International
Background Colorectal cancer (CRC) with pulmonary metastasis usually indicates a poor prognosis, whereas patients may benefit from adoptive cell therapy. Tumor-specific cytotoxic T lymphocytes (CTLs) have been reported as a promising treatment for CRC. However, the antitumor effect of CTLs remains limited partially due to insufficient production of...
Ghasemian, Majid Rajabibazl, Masoumeh Sahebi, Unes Sadeghi, Samira Maleki, Reza Hashemnia, Veys Mirfakhraie, Reza
Published in
Cancer Cell International
MIR4435-2HG ( LINC00978 ) is a long non-coding RNA (lncRNA) that acts as an oncogene in almost all cancers. This lncRNA participates in the molecular cascades involved in other disorders such as coronary artery diseases, osteonecrosis, osteoarthritis, osteoporosis, and periodontitis. MIR4435-2HG exerts its functions via the spectrum of different ...
Yuan, Yunfeng Ping, Wei Zhang, Ruijie Hao, Zhipeng Zhang, Ni
Published in
Cancer cell international
Esophageal squamous cell carcinoma (ESCC) is the leading cause of cancer-related death worldwide with a poor prognosis. Given that DEPDC1B plays a key role in multiple cancers, the role of this molecule in ESCC was explored to identify potential targets for ESCC patients. The expression level of DEPDC1B in ESCC was revealed based on the TCGA databa...
Liao, Xingchen Wang, Wei Yu, Baoping Tan, Shiyun
Published in
Cancer Cell International
Background Thrombospondin-2 (THBS2) is a versatile glycoprotein that regulates numerous biological functions, including the apoptosis-proliferation balance in endothelial cells, and it has been linked to tumor angiogenesis. However, the exact role of THBS2 in human cancer remains unknown. This study aimed to determine THBS2 expression in a pan-canc...
Zhong, Qiu-Hua Zha, Si-Wei Lau, Andy T. Y. Xu, Yan-Ming
Published in
Cancer Cell International
Nuclear factor of activated T-cells, cytoplasmic 4 (NFATc4), a transcription factor of NFAT family, which is activated by Ca2+/calcineurin signaling. Recently, it is reported that aberrantly activated NFATc4 participated and modulated in the initiation, proliferation, invasion, and metastasis of various cancers (including cancers of the lung, breas...
Cui, Yankang Shen, Tianyi Xu, Feng Zhang, Jing Wang, Yuhao Wu, Jiajin Bu, Hengtao Fu, Dian Fang, Bo Lv, Huichen
...
Published in
Cancer Cell International
Background Studies over the past decade have shown that competitive endogenous RNA (ceRNA) plays an essential role in the tumorigenesis and progression of clear cell renal cell carcinoma (ccRCC). Meanwhile, immune checkpoint blocker is gradually moving towards the first-line treatment of ccRCC. Hence, it’s urgent to develop a new prediction model f...
Wang, Chen Shao, Shiqing Deng, Li Wang, Shelian Zhang, Yongyan
Published in
Cancer cell international
