Yang, Fan Wang, Tiecheng Du, Peng Fan, Haitao Dong, Xushuai Guo, Hua
Published in
Cancer Cell International
BackgroundGrowing studies have focused on the role of microRNA-21 (miR-21) in glioma, thus our objective was to discuss the effect of M2 bone marrow-derived macrophage (BMDM)-derived exosomes (BMDM-Exos) shuffle miR-21 on biological functions of glioma cells by regulating paternally expressed gene 3 (PEG3).MethodsSeventy-one cases of human glioma t...
Ren, Qianqian Zhu, Peng Zhang, Hui Ye, Tianhe Liu, Dehan Gong, Zhao Xia, Xiangwen
Published in
Cancer Cell International
BackgroundImmunotherapies targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have been approved for gastric cancer (GC) patients. However, a large proportion of patients with T-cell-inflamed tumor microenvironment do not respond to the PD-1/PD-L1 blockade. The stromal component of the tumor microenvironment has been asso...
Wang, Xicheng Wang, Xining Xu, Yunxiuxiu Yan, Maolin Li, Wenxin Chen, Jie Chen, Tao
Published in
Cancer Cell International
BackgroundIncreasing evidence has proven that the γ-secretase complex plays significant roles in the carcinogenesis of malignancies. However, the independent effect of nicastrin (NCSTN), the largest constituent of the γ-secretase complex, on the progression of hepatocellular carcinoma (HCC) remains to be discovered.MethodsIn our study, we used open...
Gao, Jin Yuan, Yuan Zhang, Lili Yu, Shaorong Lu, Jianwei Feng, Jifeng Hu, Sainan
Published in
Cancer Cell International
BackgroundBreast cancer is the leading cause of cancer-related mortality in women worldwide. Long non-coding RNAs (lncRNAs) are of critical importance in tumor drug resistance. Herein, this study aims to determine the roles of lncRNA ZEB1-AS1 in drug resistance of breast cancer involving microRNA-129-5p (miR-129-5p) and ZEB1.MethodsMicroarray-based...
Huo, Xiaodong Wang, Huixing Huo, Bin Wang, Lei Yang, Kuo Wang, Jinhuan Wang, Lili Wang, Haitao
Published in
Cancer Cell International
BackgroundExtensive studies revealed that long non-coding RNAs (lncRNAs) could act as a regulator in tumors, including lung adenocarcinoma (LUAD). LncRNA FTX transcript, XIST regulator (FTX) has been reported to regulate the biological behaviors of some cancers. Nevertheless, its functional role and molecular mechanism remain obscure in LUAD. Our c...
Li, Chunmei Zheng, Ya Pu, Ke Zhao, Da Wang, Yuping Guan, Quanlin Zhou, Yongning
Published in
Cancer Cell International
BackgroundGastric cancer (GC) is the fifth most frequently diagnosed cancer and the third leading cause of cancer-related mortality. Lack of prognostic indicators for patient survival hinders GC treatment and survival.Methods and resultsMethylation profile data of patients with GC obtained from The Cancer Genome Atlas (TCGA) database were analyzed ...
Qian, Chong-Sheng Li, Ling-Jie Huang, Hai-Wen Yang, Hai-Fei Wu, De-Pei
Published in
Cancer Cell International
BackgroundLncRNA NEAT1 has been identified as a tumour driver in many human cancers. However, the underlying mechanism of lncRNA NEAT1 in diffuse large B-cell lymphoma (DLBCL) progression is unclear.MethodsThe expression levels of NEAT1, GLI1 and miR-34b-5p were detected by RT-qPCR and Western blotting in DLBCL tissues and cell lines. MTT and colon...
Li, Xuelu Pan, Bo Song, Xiaoqing Li, Ning Zhao, Dongyi Li, Man Zhao, Zuowei
Published in
Cancer Cell International
BackgroundPapillary carcinoma is an uncommon type of breast cancer. Additionally, patients with huge breast papillary carcinoma are extremely rare in clinical practice. To improve therapeutic effect on such patients, it is urgent to explore biologically and clinically relevant models of the disease to discover effective drugs.MethodsWe collected su...
Weihua, Zeng Guorong, Zou Xiaolong, Cao Weizhan, Li
Published in
Cancer Cell International
BackgroundIncreasing reports have confirmed that microRNAs play an important role in breast cancer progression, particularly in triple-negative breast cancer (TNBC). The aim of our study was to investigate the role of miR-33a in TNBC progression.MethodsPCR assays were performed to detect miR-33a and EZH2 expression in TNBC tissues, adjacent nontumo...
Li, Chang Tian, Yuan Liang, Yun Li, Qingchun
Published in
Cancer Cell International
BackgroundCurrently, multiple circular RNAs (circRNAs) have been verified to act as essential regulators in the progression of gastric cancer (GC). We aimed to investigate the role of circ_0008035 in GC progression.MethodsQuantitative real-time polymerase chain reaction (qRT-PCR) was utilized to measure the expression of circ_0008035 and miR-599. 3...
