Remsik, Jan Wilcox, Jessica A. Babady, N. Esther McMillen, Tracy A. Vachha, Behroze A. Halpern, Neil A. Dhawan, Vikram Rosenblum, Marc Iacobuzio-Donahue, Christine A. Avila, Edward K.
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Published in
Cancer Cell
Remsik et al. analyze the cerebrospinal fluid of cancer patients with neurologic symptoms of COVID-19 and detect unique markers of inflammation and neurodegeneration, present weeks after initial SARS-CoV-2 infection. Cytokine storming, both systemically and intracranially, likely contribute to neurologic dysfunction, indicating a potential therapeu...
Sato, Yasuyoshi Fujiwara, Yu Fukuda, Naoki Hayama, Brian Ito, Yoshinori Ohno, Shinji Takahashi, Shunji
Published in
Cancer Cell
Abdul-Jawad, Sultan Baù, Luca Alaguthurai, Thanussuyah del Molino del Barrio, Irene Laing, Adam G. Hayday, Thomas S. Monin, Leticia Muñoz-Ruiz, Miguel McDonald, Louisa Francos Quijorna, Isaac
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Published in
Cancer Cell
Following SARS-Cov-2 infection, Sultan et al. showed that the majority of solid cancer patients cleared virus, recovered from COVID-19, and re-established their prior immunological status. In contrast, hematological cancer patients demonstrated delayed or negligible seroconversion, prolonged shedding, and sustained immune dysregulation highlighting...
Schmidt, Andrew L Bakouny, Ziad Bhalla, Sheena Steinharter, John A Tremblay, Douglas A Awad, Mark M Kessler, Alaina J Haddad, Robert I Evans, Michelle Busser, Fiona
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Published in
Cancer cell
Ozaki, Yukinori Masuda, Jun Kataoka, Akemi Oikado, Katsunori Uehiro, Natsue Inagaki, Lina Kato, Chieko Morizono, Hidetomo Takano, Toshimi Ueno, Takayuki
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Published in
Cancer Cell
Bakouny, Ziad Hawley, Jessica E Choueiri, Toni K Peters, Solange Rini, Brian I Warner, Jeremy L Painter, Corrie A
Published in
Cancer cell
Patients with cancer have been disproportionately affected by the COVID-19 pandemic. This effect has included the adverse outcomes in patients with cancer who develop COVID-19, the impact of the COVID-19 pandemic on the delivery of cancer care, and the severe disruption to cancer research. However, patients with cancer are a heterogeneous populatio...
Abidi, Maheen Aboulafia, David M. Accordino, Melissa K. Acoba, Jared D. Ahluwalia, Manmeet S. Ahmad, Syed A. Ajmera, Archana Alimohamed, Saif I. Altman, Jessica Angevine, Anne H.
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Published in
Cancer Cell
When the COVID-19 pandemic began, formal frameworks to collect data about affected patients were lacking. The COVID-19 and Cancer Consortium (CCC19) was formed to collect granular data on patients with cancer and COVID-19 at scale and as rapidly as possible. CCC19 has grown from five initial institutions to 125 institutions with >400 collaborators....
Bernabe-Ramirez, Carolina Velazquez, Ana I. Olazagasti, Coral Bergerot, Cristiane Decat Bergerot, Paulo Gustavo Soto-Perez-de-Celis, Enrique Duma, Narjust
Published in
Cancer Cell
Countries in Latin America and the Caribbean have become hotspots of the novel coronavirus (COVID-19) pandemic, exacerbating socioeconomic inequalities and overwhelming fragmented health systems. Studies from the United States and Europe have highlighted the disproportionate effects of COVID-19 on patients with cancer and the disruption it has caus...
Ros, Susana Wright, Alan J. D'Santos, Paula Hu, De-en Hesketh, Richard L. Lubling, Yaniv Georgopoulou, Dimitra Lerda, Giulia Couturier, Dominique-Laurent Razavi, Pedram
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Published in
Cancer Cell
Ros et al. find that imaging of hyperpolarized [1-13C]pyruvate metabolism allows early detection of response and resistance to PI3Kα inhibition in PIK3CA -mutant ER+ breast cancer, which could be used clinically to guide treatment. Increased expression of FOXM1 results in resistance to PI3Kα inhibition and sustains LDH expression.
Cordon-Cardo, Carlos Pujadas, Elisabet Wajnberg, Ania Sebra, Robert Patel, Gopi Firpo-Betancourt, Adolfo Fowkes, Mary Sordillo, Emilia Paniz-Mondolfi, Alberto Gregory, Jill
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Published in
Cancer cell
Coronavirus disease 2019 (COVID-19), like cancer, is a complex disease with clinical phases of progression. Initially conceptualized as a respiratory disease, COVID-19 is increasingly recognized as a multi-organ and heterogeneous illness. Disease staging is a method for measuring the progression and severity of an illness using objective clinical a...