Hutten, Stefan J. de Bruijn, Roebi Lutz, Catrin Badoux, Madelon Eijkman, Timo Chao, Xue Ciwinska, Marta Sheinman, Michael Messal, Hendrik Herencia-Ropero, Andrea
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Published in
Cancer Cell
Hutten et al. generate 115 DCIS-MIND models and characterize them with genomic, transcriptomic, and imaging data. With this biobank they identify risk factors associated with progression of ductal carcinoma in situ to invasive breast cancer and create a collection of 19 distributable DCIS models, providing a resource for further research.
Wu, Mary Y. Shepherd, Scott T.C. Fendler, Annika Carr, Edward J. Au, Lewis Harvey, Ruth Dowgier, Giulia Hobbs, Agnieszka Herman, Lou S. Ragno, Martina
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Published in
Cancer Cell
Wu et al. report that patients with hematologic malignancies have reduced immunity against SARS-CoV-2 Omicron subvariants and Sotrovimab retains neutralizing capacity against all tested Omicron subvariants.
Coelho, Matthew A Cooper, Sarah Strauss, Magdalena E Karakoc, Emre Bhosle, Shriram Gonçalves, Emanuel Picco, Gabriele Burgold, Thomas Cattaneo, Chiara M Veninga, Vivien
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Published in
Cancer cell
Interferon-γ (IFN-γ) signaling mediates host responses to infection, inflammation and anti-tumor immunity. Mutations in the IFN-γ signaling pathway cause immunological disorders, hematological malignancies, and resistance to immune checkpoint blockade (ICB) in cancer; however, the function of most clinically observed variants remains unknown. Here,...
Ehmsen, Sidse Pedersen, Rune M. Bang, Line L. Asmussen, Anders Kragh, Amalie Holm, Dorte K. Sydenham, Thomas V. Jensen, Thøger G. Jeppesen, Stefan S. Frederiksen, Henrik
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Published in
Cancer Cell
Ehmsen et al. evaluate the neutralizing capacity to current SARS-CoV-2 variants in patients with cancer before and after receiving the BNT162b2 bivalent mRNA vaccine booster. Bivalent vaccine provides some protection against BQ.1.1 but fails to protect against XBB.1 and XBB.1.5 in patients with cancer.
Amodio, Vito Lamba, Simona Chilà, Rosaria Cattaneo, Chiara M. Mussolin, Benedetta Corti, Giorgio Rospo, Giuseppe Berrino, Enrico Tripodo, Claudio Pisati, Federica
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Published in
Cancer Cell
The impact of MMR heterogeneity on immune surveillance of colon cancers is largely unexplored. This proof-of-concept study by Amodio et al. suggests that MMR heterogeneity can be exploited through an endogenous vaccination approach based on pharmacological modulation of the DNA MMR, which potentiates cancer immunogenicity.
Salcher, Stefan Sturm, Gregor Horvath, Lena Untergasser, Gerold Kuempers, Christiane Fotakis, Georgios Panizzolo, Elisa Martowicz, Agnieszka Trebo, Manuel Pall, Georg
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Published in
Cancer Cell
Salcher et al. integrate non-small cell lung cancer (NSCLC) single-cell datasets, refine patient stratification, and reveal histological and genotypic associations with tumor microenvironment (TME) composition. Single-cell sequencing of cells with low mRNA content identifies tissue-resident neutrophil (TRN) subpopulations with non-canonical functio...
Li, Ruoyan Ferdinand, John R. Loudon, Kevin W. Bowyer, Georgina S. Laidlaw, Sean Muyas, Francesc Mamanova, Lira Neves, Joana B. Bolt, Liam Fasouli, Eirini S.
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Published in
Cancer Cell
Li et al. use single-cell and spatial sequencing to examine the cellular features of kidney tumors and classify cancer cells according to function. They find a more invasive phenotype at the interface separating tumor with normal kidney, which appears to be driven by IL-1β signaling in macrophages.
Chryplewicz, Agnieszka Scotton, Julie Tichet, Mélanie Zomer, Anoek Shchors, Ksenya Joyce, Johanna A Homicsko, Krisztian Hanahan, Douglas
Published in
Cancer cell
Glioblastoma (GBM) is poorly responsive to therapy and invariably lethal. One conceivable strategy to circumvent this intractability is to co-target distinctive mechanistic components of the disease, aiming to concomitantly disrupt multiple capabilities required for tumor progression and therapeutic resistance. We assessed this concept by combining...
Rovira-Clavé, Xavier Drainas, Alexandros P Jiang, Sizun Bai, Yunhao Baron, Maya Zhu, Bokai Dallas, Alec E Lee, Myung Chang Chu, Theresa P Holzem, Alessandra
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Published in
Cancer cell
Intratumoral heterogeneity is a seminal feature of human tumors contributing to tumor progression and response to treatment. Current technologies are still largely unsuitable to accurately track phenotypes and clonal evolution within tumors, especially in response to genetic manipulations. Here, we developed epitopes for imaging using combinatorial...
Ehmsen, Sidse Asmussen, Anders Jeppesen, Stefan S Nilsson, Anna Christine Kragh, Amalie Frederiksen, Henrik Ditzel, Henrik J
Published in
Cancer cell
