Publication search

Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity

Published in Cancer Cell

Hutton et al. use mass cytometry to chart stromal cells and describe mesenchymal states and lineages in pancreatic ductal adenocarcinoma. CD105 ( Eng ) expression distinguishes two pancreatic fibroblast lineages with distinct functions. CD105pos fibroblasts are tumor permissive, whereas CD105neg fibroblasts suppress tumor growth in a manner depende...

TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma

Published in Cancer Cell

Using CRISPR-Cas9 screens, Seong et al. demonstrate that the E3 ligase TRIM8 degrades the EWS/FLI fusion oncoprotein in Ewing sarcoma cells. Knockout of TRIM8 is selectively lethal in Ewing sarcoma compared with >700 non-Ewing cancer models. TRIM8 loss increases EWS/FLI protein levels, which is toxic to Ewing sarcoma cells.

COVID-19 provides an opportunity to transform cancer research.

Published in Cancer cell

Humoral and cellular immune responses in SARS-CoV-2 mRNA-vaccinated patients with cancer.

Published in Cancer cell

Anti-spike antibody response to SARS-CoV-2 booster vaccination in patients with B cell-derived hematologic malignancies

Published in Cancer Cell

Antibody and T cell immune responses following mRNA COVID-19 vaccination in patients with cancer

Published in Cancer Cell

Antibody response to SARS-CoV-2 vaccines in patients with hematologic malignancies

Published in Cancer Cell

Immune responses to COVID-19 vaccines in patients with cancer: Promising results and a note of caution

Published in Cancer Cell

SARS-CoV-2 vaccines are effective in preventing COVID-19. Patients with cancer are at high risk for severe COVID-19 and are appropriately prioritized for vaccination. Several studies in this issue of Cancer Cell add to our knowledge of the heterogeneity of immune responses to vaccination among patients with cancer and identify important areas for f...

Recovery of cancer screening tests and possible associated disparities after the first peak of the COVID-19 pandemic

Published in Cancer Cell

Highly variable SARS-CoV-2 spike antibody responses to two doses of COVID-19 RNA vaccination in patients with multiple m...

Published in Cancer Cell