Janic, Branislava Brown, Stephen L. Neff, Ryan Liu, Fangchao Mao, Guangzhao Chen, Yalei Jackson, Latoya Chetty, Indrin J. Movsas, Benjamin Wen, Ning
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Published in
Cancer Biology & Therapy
Gold nanoparticles (AuNPs) have been shown to enhance cancer radiotherapy (RT) gain by localizing the absorption of radiation energy in the tumor while sparing surrounding normal tissue from radiation toxicity. Previously, we showed that AuNPs enhanced RT induced DNA damage and cytotoxicity in MCF7 breast cancer cells. Interestingly, we found that ...
Arend, Rebecca C. Jackson-Fisher, Amy Jacobs, Ira A. Chou, Jeffrey Monk, Bradley J.
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Cancer Biology & Therapy
Recently approved therapies have contributed to a significant progress in the management of ovarian cancer; yet, more options are needed to further improve outcomes in patients with advanced disease. Here we review the rationale and ongoing clinical trials of novel combination strategies involving chemotherapy, poly ADP ribose polymerase, programme...
Xu, Keqing Shi, Jie Mo, Dongping Yang, Yanhua Fu, Qiang Luo, Ying
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Cancer Biology & Therapy
Colon cancer is the third most common cancer worldwide. Many miRNAs have been reported to be involved in colon cancer progression. However, there are only a few studies on the role of miR-219a-1 in colon cancer, and the molecular mechanisms involved remain unclear. The aim of this study was to investigate the miR-219a-1 level in patients with colon...
Kim, Jiho Beidler, Peter Wang, Hongjie Li, Chang Quassab, Abdullah Coles, Cari Drescher, Charles Carter, Darrick Lieber, André
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Cancer Biology & Therapy
Greater than 80% of all cancer cases are carcinomas, formed by the malignant transformation of epithelial cells. One of the key features of epithelial tumors is the presence of intercellular junctions, which link cells to one another and act as barriers to the penetration of molecules. This study assessed the expression of desmoglein-2, an epitheli...
Konishi, Hiromi Hayashi, Masami Taniguchi, Kohei Nakamura, Mayumi Kuranaga, Yuki Ito, Yuko Kondo, Yoichi Sasaki, Hiroshi Terai, Yoshito Akao, Yukihiro
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Published in
Cancer Biology & Therapy
Cervical cancer is the fourth-most prevalent malignancy in women. For advanced cervical cancer, radiotherapy is a major treatment. Micro RNAs (miRNAs) are small, noncoding RNAs that negatively regulate the target gene expression posttranscriptionally. miR-22 is frequently downregulated in various cancers including cervical cancer, and is associated...
Sun, Dantong Liu, Dong Liu, Qiaoling Hou, Helei
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Cancer Biology & Therapy
Immune checkpoint inhibitors have demonstrated promising efficacy and tolerable safety for advanced malignancies. However, a proportion of patients who had received immunotherapy may experience hyperprogressive disease and a resultant poor prognosis. Here, we report a patient with advanced esophageal squamous carcinoma who developed hyperprogressiv...
Xuan, Liang Sun, Bing Meng, Xiangying Liu, Chao Cong, Yang Wu, Shikai
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Cancer Biology & Therapy
Docetaxel is an important anti-microtubule agent used to treat a variety of solid tumors, including breast cancer; notably, docetaxel-containing regimens improve outcomes for patients in metastatic, adjuvant, and neoadjuvant settings. However, the effectiveness of docetaxel in clinical practice can be compromised by suboptimal management of side ef...
Huang, Xiao-Bin Song, Kai-Jing Chen, Guo-Bin Liu, Rui Jiang, Zhuo-Fei He, Yuan-Li
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Cancer biology & therapy
Cervical cancer (CC) is the second most common malignancy in women worldwide. The mechanism underlying CC development remains unclear. Recently, Circular RNAs (circRNAs)have attracted attention because of its role in tumorigenesis. To investigate circRNAsin CC, RNA sequencing was employed to characterize circRNA expression profile between CC tissue...
Price, Timothy Ang, Agnes Boedigheimer, Michael Kim, Tae Won Li, Jin Cascinu, Stefano Ruff, Paul Satya Suresh, Attili Thomas, Anne Tjulandin, Sergei
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Published in
Cancer Biology & Therapy
Background Antibodies against epidermal growth factor receptor (EGFR), panitumumab, a fully human monoclonal antibody, and cetuximab, a human/mouse chimeric monoclonal antibody, have shown clinical efficacy in metastatic colorectal cancer (mCRC). In the phase 3 noninferiority ASPECCT (ClinicalTrials.gov, NCT01001377) study, panitumumab was demonstr...
Pattison, Amanda M Barton, Joshua R Entezari, Ariana A Zalewski, Alicja Rappaport, Jeff A Snook, Adam E Waldman, Scott A
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Cancer biology & therapy
Most sporadic colorectal cancer reflects acquired mutations in the adenomatous polyposis coli (APC) tumor suppressor gene, while germline heterozygosity for mutant APC produces the autosomal dominant disorder Familial Adenomatous Polyposis (FAP) with a predisposition to colorectal cancer. In these syndromes, loss of heterozygosity (LOH) silences th...
