Wandishin, Clayton M Robbins, Charles John Tyson, Darren R Harris, Leonard A Quaranta, Vito
Published in
Cancer biology & therapy
The drug-induced proliferation (DIP) rate is a metric of in vitro drug response that avoids inherent biases in commonly used metrics such as 72 h viability. However, DIP rate measurements rely on direct cell counting over time, a laborious task that is subject to numerous challenges, including the need to fluorescently label cells and automatically...
Zheng, Andrew Bilbao, Michelle Sookram, Janhvi Linden, Kimberly M Morgan, Andrew B Ostrovsky, Olga
Published in
Cancer biology & therapy
Epigenetic therapy augments neoadjuvant chemotherapy (NACT) in breast cancer and may aid post-surgical wound healing affected by NACT. Our study investigates: (1) The cytotoxicity of classic paclitaxel chemotherapy on triple negative breast cancer (TNBC) independently and in combination with epigenetic drugs. (2) The sustainable inhibition of breas...
Chen, Zibo Zheng, Lin Chen, Yulong Liu, Xiuxia Kawakami, Masanori Mustachio, Lisa Maria Roszik, Jason Ferry-Galow, Katherine V Parchment, Ralph E Liu, Xin
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Published in
Cancer biology & therapy
Cancer metastasis is a major cause of cancer-related mortality. Strategies to reduce metastases are needed especially in lung cancer, the most common cause of cancer mortality. We previously reported increased ubiquitin-specific peptidase 18 (USP18) expression in lung and other cancers. Engineered reduction of USP18 expression repressed lung cancer...
Bajpai, Sagar Jin, Hong Ri Mucha, Bartosz Diehl, J Alan
Published in
Cancer biology & therapy
Overexpression of c-myc via increased transcription or decreased protein degradation is common to many cancer etiologies. c-myc protein degradation is mediated by ubiquitin-dependent degradation, and this ubiquitylation is regulated by several E3 ligases. The primary regulator is Fbxw7, which binds to a phospho-degron within c-myc. Here, we identif...
Gao, Haoji Wang, Weige Li, Qinyu
Published in
Cancer biology & therapy
Glioma-associated oncogene (Gli) antagonist-61 (GANT61) not only suppresses the malignant behavior of several cancers but also presents synergistic effects with other anticancer agents on suppressing the progression of cancers, while relevant information is rare in anaplastic thyroid carcinoma (ATC). This study aimed to explore the therapeutic effe...
Zhou, Yuru Kong, Yunyuan Jiang, Mei Kuang, Linju Wan, Jinhua Liu, Shuyuan Zhang, Qian Yu, Kuai Li, Na Le, Aiping
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Published in
Cancer biology & therapy
Curcumin, the primary bioactive component isolated from turmeric, has been found to possess a variety of biological functions, including anti-leukemia activity. However, the effect of curcumin in different leukemia cells vary. In this study, we demonstrated that curcumin induced the expression of AIM2, IFI16, and NLRC4 inflammasomes in leukemia cel...
Sotiropoulou, Georgia Zingkou, Eleni Pampalakis, Georgios
Published in
Cancer Biology & Therapy
Cheng, Xi Yu, Haiming Li, Jinying Han, Xiaona Meng, Erhong Zhou, Houqing Wang, Dongliang Niu, Beifang Zhang, Xiaotao
Published in
Cancer Biology & Therapy
Mediastinal yolk sac tumors (YSTs) are highly aggressive germ cell tumors with an extremely poor prognosis. Radiotherapy plays an important role in the treatment of mediastinal YSTs. To maximize benefit from radiotherapy in patients with mediastinal YSTs, exploring functionally relevant biomarkers is essential. Previous studies have demonstrated th...
Han, Yadong Qian, Xu Xu, Teng Shi, Yang
Published in
Cancer Biology & Therapy
microRNA-331-3p (miR-331-3p) has been displayed as an oncogene in pancreatic cancer (PC). The current research set out to elucidate how miR-331-3p in carcinoma-associated fibroblasts (CAFs)-derived extracellular vesicles (EVs) facilitated the tumorigenesis in PC. First, a dual-luciferase reporter assay was adopted to investigate the relationship be...
Zhang, Simei Cao, Shuang Gong, Mengyuan Zhang, Wunai Zhang, Weifan Zhu, Zeen Wu, Shuai Yue, Yangyang Qian, Weikun Ma, Qingyong
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Published in
Cancer Biology & Therapy
Melanoma is a highly aggressive cancer that can metastasize at early stage. The aim of this study is to clarify the role of Piezo1 and its potential mechanism in regulating the malignant phenotypes of melanoma. In the present study, we first showed that Piezo1 was abnormally expressed in melanoma, which accelerated the malignant progression by acti...
