Bajic, Zorislava Sobot, Tanja Uletilovic, Snezana Mandic-Kovacevic, Nebojsa Cvjetkovic, Tanja Malicevic, Ugljesa Đukanović, Đorđe Duran, Mladen Vesic, Nikolina Avram, Sanja
...
Published in
Canadian journal of physiology and pharmacology
Type 2 diabetes mellitus (T2DM) increases the risk of cardiovascular disease, especially myocardial injury. Due to their hypoglycemic effects, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are efficiently used for T2DM management. GLP-1RAs also have anti-inflammatory and antioxidative effects, and can improve cardiac function. The aim of thi...
Ghavami, Ghazaleh Adibzadeh, Setare Amiri, Shahin Sardari, Soroush
Published in
Canadian journal of physiology and pharmacology
The emergence of SARS-CoV-2 from China in December 2019 led to the COVID-19 pandemic, which has affected tens of millions of humans worldwide. Various in silico research via bio-cheminformatics methods was performed to examine the efficiency of a range of repurposed approved drugs with a new role as antiSARS-CoV-2 drugs. The current study has been ...
Bkaily, Ghassan Al-Shahrani, Maram Ali Nader, Moni Jacques, Danielle
Published in
Canadian journal of physiology and pharmacology
In this study, we wanted to verify whether the effect of insulin on calcium homeostasis depends on the heart's development stage. Using a quantitative 3D confocal microscopy, we tested the effect of a high insulin concentration (100 µU) in freshly cultured ventricular cardiomyocytes from newborn and adult rats. Our results showed that the cytosolic...
Pandey, Sneha Gupta, Kirti Bagang, Newly Singh, Gaaminepreet Rajput, Sakshi
Published in
Canadian journal of physiology and pharmacology
Aberrant activation of Wnt/β-catenin induces renal dysfunction by initiating pro-apoptotic cascades, fibrosis, oxidative and inflammatory burden. This study tested the therapeutic effects of Wnt/β-catenin inhibitor pyrvinium against cisplatin-induced acute kidney injury (AKI) in rats. Cisplatin was administered at a single dose of 5 mg/kg (i.p.) an...
Ahmadian Salami, Ali Alavi, Mohaddeseh Sadat Souri, Mohammad Saeid Roohbakhsh, Ali
Published in
Canadian journal of physiology and pharmacology
The main side effects of opioid use are physiological and psychological dependence. The transient receptor potential channels, including transient receptor potential ankyrin 1 (TRPA1), are involved in various neurological disorders. We aimed to evaluate the effect of TRPA1 inhibition on morphine-induced conditioned place preference (CPP) and physic...
Abdul, Yasir Karakaya, Eda Chandran, Raghavendar Jamil, Sarah Ergul, Adviye
Published in
Canadian journal of physiology and pharmacology
Cellular senescence plays a pivotal role in the aging and progression of neurodegenerative diseases, including vascular cognitive impairment and dementia (VCID). In postmortem brains from individuals with VCID, endothelin-1 (ET-1) levels closely correlate with blood barrier breakdown and cerebral hypoperfusion. Brain microvascular endothelial cells...
Deng, Aiqing Ma, Limin Ji, Qiuhong Xing, Jiajun Qin, Jianxin Zhou, Xueli Wang, Xin Wang, Shouyan Wu, Jianjun Chen, Xia
...
Published in
Canadian journal of physiology and pharmacology
Autophagy has been implicated in stroke. Our previous study showed that the FoxO3 transcription factor promotes autophagy after transient cerebral ischemia/reperfusion (I/R). However, whether the Akt/FoxO3 signaling pathway plays a regulatory role in autophagy in cerebral I/R-induced oxidative stress injury is still unclear. The present study aims ...
Xi, Xuemei Zheng, Xiaofei Zhang, Rongxian Zeng, Liangbang
Published in
Canadian journal of physiology and pharmacology
The pathogenesis of coronary artery disease (CAD) is closely related to an abnormal function of the coronary arteries due to myocardial ischemia, hypoxia, or necrosis, which poses a threat to human health. Therefore, this study was conducted to evaluate the role of circFOXP1 in controlling endothelial cell function during atherosclerosis (AS), and ...
Desita, Eryna Ayu Nugra Arfian, Nur Setyaningsih, Wiwit Ananda Wahyu Sari, Dwi Cahyani Ratna
Published in
Canadian journal of physiology and pharmacology
Kidney ischemia-reperfusion injury (IRI) causes acute kidney injury with increasing risk of maladaptive repair through endothelin-1 (ET-1)/endothelin type A receptor (ETAR) signaling. Calcitriol shows renoprotection in kidney fibrosis, however, its effects on vasoactive substances expression and vascular remodeling following kidney IRI remain uncle...
Wong, Nathan D
Published in
Canadian journal of physiology and pharmacology
Globally, nearly 500 million adults currently have diabetes, which is expected to increase to approximately 700 million by 2040. Cardiovascular diseases (CVD), including coronary heart disease, stroke, heart failure, and peripheral arterial disease, are the principal causes of death in persons with diabetes. Key to the prevention of CVD is optimiza...
