Wang, Peng Hu, Xiao-Xia Li, Ying-Hui Gao, Nan-Yong Chen, Guo-Quan Chen, Jia-le
Published in
Canadian journal of physiology and pharmacology
This study was to evaluate the effect of resveratrol on the pharmacokinetics of ticagrelor in rats and the metabolism of ticagrelor in human cytochrome P450 (CYP) 3A4 (CYP3A4) and liver microsomes. Eighteen Sprague-Dawley rats were randomly divided into three groups: group A (control group), group B (50 mg/kg resveratrol), and group C (150 mg/kg re...
Rodríguez-Núñez, Iván Pontes, Roberto B Romero, Fernando Campos, Ruy R
Published in
Canadian journal of physiology and pharmacology
Chronic nicotine exposure may increase cardiovascular risk by impairing the cardiac autonomic function. Besides, physical exercise (PE) has shown to improve cardiovascular health. Thus, we aimed to investigate the effects of PE on baroreflex sensitivity (BRS), heart rate variability (HRV), and sympathetic nerve activity (SNA) in chronically nicotin...
Nogueira, Jonatas E Amorim, Mateus R Pinto, Ana P da Rocha, Alisson L da Silva, Adelino S R Branco, Luiz G S
Published in
Canadian journal of physiology and pharmacology
Physical exercise-induced skeletal muscle damage may be characterized by increased oxidative stress, inflammation, and apoptosis which may be beneficial when exercise is regular, but it is rather harmful when exercise is exhaustive and performed acutely by unaccustomed individuals. Molecular hydrogen (H2) has emerged as a potent antioxidant, anti-i...
Wang, Gang Chen, Shurui Shao, Zhenya Li, Yankun Wang, Wei Mao, Liang Li, Jian Mei, Xifan
Published in
Canadian journal of physiology and pharmacology
Metformin, the first medication that is often prescribed for the treatment of type 2 diabetes mellitus, was recently found to be neuroprotective. To study the mechanism underlying the neuroprotective effect of metformin, we pretreated primary spinal cord neurons with 50 µM or 100 µM metformin for 2 h prior to treatment with hydrogen peroxide (H2O2)...
Rodrigues, Renata F Martins, Carolina C Rosa, Suzan G Nogueira, Cristina W
Published in
Canadian journal of physiology and pharmacology
Studies reveal that oxidative stress is associated with adverse effects of long-term morphine treatment. The m-trifluoromethyl-diphenyl diselenide (CF3) is a multi-target organoselenium compound that has antioxidant properties in different experimental models. This study aimed to investigate the CF3 effects against redox imbalance in peripheral and...
Providello, Maiara Voltarelli Portapilla, Gisele Bulhões Oliveira, Pedro Alexandre Sampaio da Silva, Carla Brigagão Pacheco Anchieta, Naira Ferreira Tirapelli, Carlos Renato de Albuquerque, Sérgio
Published in
Canadian journal of physiology and pharmacology
Cardiac damage during the acute phase of Chagas disease (CD) is associated with an increase in pro-inflammatory markers and oxidative stress. Melatonin (MEL) has emerged as a promising therapy for CD due to its antioxidant and immunomodulatory properties; however, the protective action of MEL in the cardiac tissue, as well as its direct action on t...
Lin, Hongru Wu, Xuehan Yang, Yaqin Wang, Ziwei Huang, Weilu Wang, Ling-Fang Liu, Quan-Wen Guan, Xiao-Hui Deng, Ke-Yu Li, Tao-Sheng
...
Published in
Canadian journal of physiology and pharmacology
Inflammation-induced activation and dysfunction of endothelial cells play an important role in the pathology of multiple vascular diseases. Nicaraven, a potent hydroxyl radical scavenger, has recently been found to have anti-inflammatory roles; however, the mechanism of its action is not fully understood. Here we investigated the effects of Nicarav...
Wei, Dan Wu, Shaofei Liu, Jie Zhang, Xiaoqian Guan, Xiaoling Gao, Li Xu, Zhipeng
Published in
Canadian journal of physiology and pharmacology
Theobromine, a methylxanthine present in cocoa, has been shown to possess many beneficial pharmacological properties such as anti-oxidative stress, anti-inflammatory property, and anti-microbial activity. In this study, we investigated the effects of theobromine on nonalcoholic fatty liver disease (NAFLD) and the possible underlying mechanisms in v...
Magder, Sheldon Magder, Alexandr Samoukovic, Gordan
Published in
Canadian journal of physiology and pharmacology
The hydrogen ion concentration ([H+]) in intracellular cytoplasmic fluid (ICF) must be maintained in a narrow range in all species for normal protein functions. Thus, mechanisms regulating ICF are of fundamental biological importance. Studies on the regulation of ICF [H+] have been hampered by use of pH notation, failure to consider the roles playe...
Diab, Antonios M Carleton, Bruce C Goralski, Kerry B
Published in
Canadian journal of physiology and pharmacology
Coronavirus disease 2019 (COVID-19) has resulted in the death of over 18 000 Canadians and has impacted the lives of all Canadians. Many Canadian research groups have expanded their research programs to include COVID-19. Over the past year, our knowledge of this novel disease has grown and has led to the initiation of a number of clinical vaccine a...
