Subali, Dionysius Kwon, Mi Hye Bang, Won Seok Kang, Hee Eun
Published in
Canadian journal of physiology and pharmacology
Post-transplantation non-alcoholic fatty liver disease (NAFLD) is common in liver transplant recipients. Changes in the expression levels and activities of drug-metabolizing enzymes and drug transporters have been reported in patients with NAFLD and relevant rodent models. Here, we evaluated whether the pharmacokinetics of mycophenolic acid (MPA), ...
Peng, Hongmei Xu, Jiang Yang, Xiao-Ping Kassem, Kamal M Rhaleb, Imane A Peterson, Ed Rhaleb, Nour-Eddine
Published in
Canadian journal of physiology and pharmacology
Myocardial infarction (MI) in mice results in cardiac rupture at 4-7 days after MI, whereas cardiac fibrosis and dysfunction occur later. N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) has anti-inflammatory, anti-fibrotic, and pro-angiogenic properties. We hypothesized that Ac-SDKP reduces cardiac rupture and adverse cardiac remodeling, and improv...
Morissette, Marc P Susser, Shanel E Stammers, Andrew N Moffatt, Teri L Wigle, Jeffrey T Wigle, Theodore J Netticadan, Thomas Premecz, Sheena Jassal, Davinder S O'Hara, Kimberley A
...
Published in
Canadian journal of physiology and pharmacology
Exercise enhances cardiac sarcoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) function through unknown mechanisms. The present study tested the hypothesis that the positive effects of exercise on SERCA2a expression and function in the left ventricle is dependent on adenosine-monophosphate-activated protein kinase (AMPK) α2 function. AMPKα2 kinase-dead ...
Iuchi, Katsuya Nishimaki, Kiyomi Kamimura, Naomi Ohta, Shigeo
Published in
Canadian journal of physiology and pharmacology
Molecular hydrogen (H2) was believed to be an inert and nonfunctional molecule in mammalian cells; however, we overturned the concept by reporting the therapeutic effects of H2 against oxidative stress. Subsequently, extensive studies revealed multiple functions of H2 by exhibiting the efficacies of H2 in various animal models and clinical studies....
Zangerolamo, Lucas Soares, Gabriela Moreira Vettorazzi, Jean Franciesco do Amaral, Maria Esméria Carneiro, Everardo Magalhães Olalla-Saad, Sara Teresinha Boschero, Antonio Carlos Barbosa-Sampaio, Helena Cristina
Published in
Canadian journal of physiology and pharmacology
ARHGAP21 is a Rho-GAP that controls GTPases activity in several tissues, but its role on liver lipid metabolism is unknown. Thus, to achieve the Rho-GAP role in the liver, control and ARHGAP21-haplodeficient mice were fed chow (Ctl and Het) or high-fat diet (Ctl-HFD and Het-HFD) for 12 weeks, and pyruvate and insulin tolerance tests, insulin signal...
Mogane, Conrad Mokotedi, Lebogang P Millen, Aletta M E Michel, Frederic S
Published in
Canadian journal of physiology and pharmacology
The effect of hyperlipidemia on the cardiovascular system is uncertain in females. The aim of the present study was to determine whether administration of a lipogenic diet alters cardiovascular parameters in female rats. Fifty female Sprague-Dawley rats were assigned into 2 groups of rats receiving a standard or a high-fat, high-sucrose diet (HFHS)...
Stamenkovic, Aleksandra Pierce, Grant N Ravandi, Amir
Published in
Canadian journal of physiology and pharmacology
Over the past decade, there has been intense investigation in trying to understand the pathological role that oxidized phospholipids play in cardiovascular disease. Phospholipids are targets for oxidation, particularly during conditions of excess free radical generation. Once oxidized, they acquire novel roles uncharacteristic of their precursors. ...
George, Akash K Master, Kruyanshi Majumder, Avisek Homme, Rubens Petit Laha, Anwesha Sandhu, Harpal S Tyagi, Suresh C Singh, Mahavir
Published in
Canadian journal of physiology and pharmacology
Circular RNAs (circRNAs) are being hailed as a newly rediscovered class of covalently closed transcripts that are produced via alternative, noncanonical pre-mRNA back-splicing events. These single-stranded RNA molecules have been identified in organisms ranging from the worm (Cortés-López et al. 2018. BMC Genomics, 19: 8; Ivanov et al. 2015. Cell R...
Darwesh, Ahmed M Jamieson, K Lockhart Wang, Chuying Samokhvalov, Victor Seubert, John M
Published in
Canadian journal of physiology and pharmacology
Impaired mitochondrial function and activation of NLRP3 inflammasome cascade has a significant role in the pathogenesis of myocardial ischemia-reperfusion (IR) injury. The current study investigated whether eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or their corresponding CYP epoxygenase metabolites 17,18-epoxyeicosatetraenoic acid (1...
Nagalingam, Raghu S Al-Hattab, Danah S Czubryt, Michael P
Published in
Canadian journal of physiology and pharmacology
Fibroblasts have long been recognized as important stromal cells, playing key roles in synthesizing and maintaining the extracellular matrix, but historically were treated as a relatively uniform cell type. Studies in recent years have revealed a surprising level of heterogeneity of fibroblasts across tissues, and even within organs such as the ski...
