Hanikoglu, Aysegul Kucuksayan, Ertan Hanikoglu, Ferhat Ozben, Tomris Menounou, Georgia Sansone, Anna Chatgilialoglu, Chrys Di Bella, Giuseppe Ferreri, Carla
Published in
Canadian journal of physiology and pharmacology
Breast cancer is a worldwide commonly found malignancy in women and effective treatment is regarded as a huge clinical challenge even in the presence of several treatment options. Extensive literature is available demonstrating polyphenols as phytopharmaceutical anticancer agents. Among the polyphenols, quercetin and curcumin have been reported to ...
Boardman, Neoma T Falck, Aleksander Tank Lund, Trine Chu, Xi Martin-Armas, Montserrat Norvik, Jon V Jenssen, Trond G Ytrehus, Kirsti
Published in
Canadian journal of physiology and pharmacology
Uric acid is a purine degradation product but also an important antioxidant and reactive oxygen species (ROS) scavenger. Experimental settings that mimic myocardial ischemia-reperfusion have not included uric acid despite that it is always present in human extracellular fluid and plasma. We hypothesized that uric acid has an important role in myoca...
Kocak, Zumrut Temiz-Resitoglu, Meryem Guden, Demet Sinem Vezir, Ozden Sucu, Nehir Balcı, Senay Tamer-Gumus, Lulufer Tunctan, Bahar Malik, Kafait U Sahan-Firat, Seyhan
...
Published in
Canadian journal of physiology and pharmacology
Mammalian target of rapamycin (mTOR) has been recognized with potential immunomodulatory properties playing an important role in various physiopathological processes including ischemia-reperfusion (I/R) injury. I/R injury stimulate reactive oxygen and nitrogen species by activating nicotinamide adenine dinucleotide phosphate oxidase and inducible n...
Ali, Fatma F Abdelzaher, Walaa Yehia Ibrahim, Randa Ahmed Elroby Ali, Doaa Mohamed
Published in
Canadian journal of physiology and pharmacology
Although heme oxygenase-1 (HO-1) is part of an endogenous defense system implicated in the homeostatic response, its role in cell proliferation and tumor progression is still controversial. Endometrial hyperplasia (EH) is associated with high risk of endometrial cancer (EC). Therefore, we aimed to evaluate the effect of hemin, a HO-1 inducer, again...
Marocolo, Moacir Katayama, Pedro L Meireles, Anderson Barbosa Neto, Octávio
Published in
Canadian journal of physiology and pharmacology
Several studies have reported that high doses of synthetic anabolic androgenic steroids (AAS) can have serious negative effects on health, including the cardiovascular system. The aim of this study was to evaluate the combined effects of AAS and exercise training on ventricular repolarization and cardiac autonomic modulation in rats. Male Wistar ra...
Kim, Jeongnam Kim, Byung Joo
Published in
Canadian journal of physiology and pharmacology
Interstitial cells of Cajal (ICCs) are pacemaker cells in the gastrointestinal (GI) tract and generate pacemaker potentials. In this study, we investigated the effects of caffeic acid phenethyl ester (CAPE) on the pacemaker potentials of ICCs from the mouse small or large intestine. Using the whole-cell patch-clamp configuration, we found that CAPE...
McAllister, Matthew John Waldman, Hunter Scott Renteria, Liliana Isa Gonzalez, Andrew Edward Butawan, Matthew B Bloomer, Richard
Published in
Canadian journal of physiology and pharmacology
Ingestion of ketone supplements, caffeine and medium chain triglycerides (MCTs) may all be effective strategies to increase blood levels of the ketone body beta-hydroxybutyrate (D-BHB). However, acute ingestion of a bolus of lipids may increase oxidative stress (OS). The purpose of the study was to investigate the impact of adding varying amounts o...
Yu, Li Fu, Jinling Yu, Na Wu, Yazhen Han, Ning
Published in
Canadian journal of physiology and pharmacology
Diabetic retinopathy (DR) is a devastating complication of diabetes. The aim of the present study is to investigate the exact role and mechanism of lncRNA MALAT1 (MALAT1) in the progress of DR. Oxygen-induced retinopathy (OIR) mouse model and high glucose (HG)-stimulated human retinal microvascular endothelial cells (HRMECs) were employed to mimic ...
Djuric, M Nikolic Turnic, T Kostic, S Stankovic, S Radonjic, K Djuric, D Zivkovic, V Jakovljevic, V Stevanovic, P
Published in
Canadian journal of physiology and pharmacology
This study aimed to investigate the effects of propofol through evaluating its interaction with nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO). Wistar male rats were divided in 4 groups: (1) bolus injection of propofol (1% 10 mg/mL, 100 mg/kg bw, i.p.); (2) Nω-nitro-l-arginine methyl ester (L-NAME; NO synthase inhibitor, 60 mg/...
Subali, Dionysius Kwon, Mi Hye Bang, Won Seok Kang, Hee Eun
Published in
Canadian journal of physiology and pharmacology
Post-transplantation non-alcoholic fatty liver disease (NAFLD) is common in liver transplant recipients. Changes in the expression levels and activities of drug-metabolizing enzymes and drug transporters have been reported in patients with NAFLD and relevant rodent models. Here, we evaluated whether the pharmacokinetics of mycophenolic acid (MPA), ...
