Rodríguez-Núñez, Iván Pontes, Roberto Romero, Fernando Campos, Ruy Ribeiro
Published in
Canadian journal of physiology and pharmacology
Chronic nicotine exposure may increase cardiovascular risk by impairing the autonomic function. Besides, physical exercise (PE) has shown to improve cardiovascular health. We thus aimed to investigate the effects of PE on baroreflex sensitivity (BRS), heart rate variability (HRV), and sympathetic nerve activity (SNA) in chronically-nicotine exposed...
Do Vale, Gabriel T Ricci, Sthefany Teodoro Silva, Alessandra Oliveira Tirapelli, Carlos Renato Ceron, Carla Speroni
Published in
Canadian journal of physiology and pharmacology
Chronic ethanol consumption and sepsis cause oxidative stress and renal dysfunction. This study aimed to examine whether chronic ethanol consumption sensitizes the mice kidney to sub-lethal cecal ligation and puncture (SL-CLP) sepsis, leading to impairment of renal function by tissue oxidative and inflammatory damage. Male C57BL/6J mice were treate...
Wei, Dan Wu, Shaofei Liu, Jie Zhang, Xiaoqian Guan, Xiaoling Gao, Li Xu, Zhipeng
Published in
Canadian journal of physiology and pharmacology
Theobromine, a methylxanthine present in cocoa, has been shown to possess many beneficial pharmacological properties such as anti-oxidative stress, anti-inflammatory property, and anti-microbial activity. In this study, we investigated the effects of theobromine on NAFLD and the possible underlying mechanisms in vivo and in vitro. The results showe...
Zhao, Yanjun Yang, Xijun Meng, Fufen Li, Wenxian
Published in
Canadian journal of physiology and pharmacology
Microglial inflammation, involved in the occurrence and development of sepsis-associated encephalopathy, exhibits upregulation of proinflammatory cytokine and proinflammatory enzyme expression, leading to inflammation-induced neuronal cell apoptosis. TIR domain containing adaptor molecule-2 (TICAM-2) participates in lipopolysaccharide (LPS) mediate...
Mansour, Suzan Mohamed Aly, Sara Hassan, Seham Hassan M Zaki, Hala Fahmy
Published in
Canadian journal of physiology and pharmacology
Diabetes mellitus is associated with an increased risk of cardiac complications, this study aimed to investigate effect of sitagliptin (SITA) alone or combined with γ-irradiation on diabetes-associated cardiac injury. Rats were treated with SITA (100 mg/kg/day; p.o.) for 2 weeks followed by single dose whole body γ-irradiation (3 Gy). Solitary admi...
Wahba, Nehal S Ghareib, Salah A Abdelghany, Rasha Hassan Abdel-Aal, Mohamed Alsemeh, Amira E
Published in
Canadian journal of physiology and pharmacology
The current study aimed to investigate the molecular mechanisms of metformin and vitamin D3-induced nephroprotection in a MetS rat model, evaluating the capacity of vitamin D3 to potentiate metformin action. MetS was induced by 10% fructose in drinking water and 3% salt of the diet. After 6 weeks, serum lipid profile and uric acid were measured, an...
Zhao, Yanjun Yi, Wenjing Lu, Yi Li, Wenxian Wang, Hongbing
Published in
Canadian journal of physiology and pharmacology
Excessively activated microglia exhibit increased migration, resulting in tissue damage and chronic inflammation. Src was confirmed to play an important role in regulation of cell motility following lipopolysaccharide (LPS) treatment. SET8 plays an important part in multiple cellular signal pathways. In this study, we speculated SET8 is involved in...
Park, Sung Jin Yu, Yang Beyak, Michael J
Published in
Canadian journal of physiology and pharmacology
Mechanical stimulation of the gastrointestinal tract is an important stimulus of satiety and can be transduced by transient receptor potential (TRP) channels. Several studies have revealed attenuated vagally-mediated satiety responses including mechanosensitivity in diet-induced obesity. However, ion channels underlying this hyposensitivity have no...
Wang, Shu Huang, Yuqing Luo, Guangyan Yang, Xin Huang, Wei
Published in
Canadian journal of physiology and pharmacology
Diabetic nephropathy (DN) is a common and complicated chronic kidney disease around the world. To elucidate and find effective therapies of DN is of vital importance. In this paper, we have discovered that Cyanidin-3-O-glucoside (C3G), which is one of the anthocyanins, could alleviate high glucose induced podocytes dysfunction. MTT, flow cytometry ...
Brown, Sean M Larsen, Nicholas K Thankam, Finosh G Agrawal, Devendra K
Published in
Canadian journal of physiology and pharmacology
Patients diagnosed with atrial fibrillation (AF) have been rising due to increased incidence, enhanced detection methods, and greater survival rates following diagnosis. Due to this increase, AF is now the most commonly diagnosed arrhythmia in clinical practice. AF is characterized by irregular, high-frequency contractions of atrial myocytes that l...
