Demirel, Sadettin Sahinturk, Serdar Isbil, Naciye Ozyener, Fadil
Published in
Canadian journal of physiology and pharmacology
This study investigated the effects of irisin on vascular smooth muscle contractility in rat thoracic aorta, and the hypothesis that mitogen-activated protein kinase kinase (MEK1/2) signaling pathway, voltage-gated potassium (KV) channels, small-conductance calcium-activated potassium (SKCa) channels, and large-conductance calcium-activated potassi...
Dai, Yi Zeng, Zhenhua Deng, Shuo Zou, Sanbao Dou, Tingyang
Published in
Canadian journal of physiology and pharmacology
β-elemene (Bel) is a sesquiterpene compound that has shown potential in the antinociceptive treatment. This study focused on the function of Bel in neuropathic pain relief in mice. A murine model with spared nerve injury (SNI) was established and treated with Bel. The paw withdrawal thresholds in response to mechanical and thermal stimulations were...
Estrada-Soto, Samuel Cerón-Romero, Litzia Navarrete-Vázquez, Gabriel Rosales-Ortega, Edgar Gómez-Zamudio, Jaime Cruz, Miguel Villalobos-Molina, Rafael
Published in
Canadian journal of physiology and pharmacology
The current study aimed to determine the antidiabetic and antidyslipidemic activities of moronic acid methyl ester (1) (compound 1) by in vivo, in vitro, in silico, and molecular biology studies. Compound 1 was evaluated to establish its dose-dependent antidiabetic and antihyperglycemic (50 mg/kg) activities, in diabetic and normoglycemic male CD1 ...
Tumanova, Tatiana S Kokurina, Tatiana N Rybakova, Galina I Aleksandrov, Viacheslav G
Published in
Canadian journal of physiology and pharmacology
The arterial baroreflex (BR) is an important neural mechanism for the stabilization of arterial pressure (AP). It is known that the insular cortex (IC) and other parts of the central autonomic network (CAN) are able to modulate the BR arc, altering baroreflex sensitivity (BRS). In addition, the sensitivity of the BR changes under the influence of h...
Kutlay, Özden Aktan, Arzu Keskin Aslan, Esra
Published in
Canadian journal of physiology and pharmacology
Cyclophosphamide is a chemotherapeutic drug that is widely used in the clinic and can cause multi-organ toxicity. Apelin-13 is an endogenous adipocytokine with antioxidant properties. Therefore, this study investigated the possibility of apelin-13 being a potential therapeutic agent on cardiac toxicity and nephrotoxicity caused by cyclophosphamide....
Oldfield, Christopher J Moffatt, Teri L Dolinsky, Vernon W Duhamel, Todd A
Published in
Canadian journal of physiology and pharmacology
Sarco(endo)plasmic reticulum calcium (Ca2+) ATPase (SERCA) transports Ca2+ in muscle. Impaired SERCA activity may contribute to diabetic myopathy. Sirtuin (SIRT) 3 regulates muscle metabolism and function; however, it is unknown if SIRT3 regulates muscle SERCA activity or acetylation. We determined if SIRT3 overexpression enhances SERCA activity in...
Shang, Peng Liu, Ying Jia, Junqing
Published in
Canadian journal of physiology and pharmacology
Paeonol is the bioactive component in Paeonia lactiflora Pall., Cynanchum paniculatum and Paeonia × suffruticosa Andr. Paeonol has been previously demonstrated to inhibit the release of tumor necrosis factor α (TNF-α) and interluekin 6 (IL-6) in chondrocytes. Sirtuin 1 (SIRT1) is downregulated in degraded cartilage and paeonol could induce nuclear ...
Liu, Huan Ru, Ning-Yu Cai, Yue Lyu, Qiang Guo, Chi-Hua Zhou, Ying Li, Shao-Hua Cheng, Jiu-Hua Chang, Jin-Rui Ma, Jin
...
Published in
Canadian journal of physiology and pharmacology
Functional and structural adaptation of common carotid artery could be one of the important causes of postflight orthostatic intolerance after microgravity exposure, the mechanisms of which remain unclear. Recent evidence indicates that long-term spaceflight increases carotid artery stiffness, which might present a high risk to astronaut health and...
Ortiz, Mario I Cariño-Cortés, Raquel Muñoz-Pérez, Víctor M Medina-Solís, Carlo Eduardo Castañeda-Hernández, Gilberto
Published in
Canadian journal of physiology and pharmacology
The objective of the present study was to scrutinize the effect of nitric oxide (NO), cyclic GMP (cGMP), potassium channel blockers, and metformin on the citral-produced peripheral antinociception. The rat paw 1% formalin test was used to assess nociception and antinociception. Rats were treated with local peripheral administration of citral (10-10...
Ye, Fengying Lu, Qiuyun Kong, Bihua Li, Yanqiu
Published in
Canadian journal of physiology and pharmacology
To evaluate the effect of two concentrations of intravenous administration of nicardipine hydrochloride on nicardipine-related phlebitis in patients with preeclampsia. A total of 100 preeclampsia patients were administered with nicardipine hydrochloride and divided into the low-concentration (LC) and high-concentration (HC) groups. The incidence an...
