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Bupivacaine cardiotoxicity — hypercarbia is bad but hypocapnia may be worse

Published in Canadian Journal of Anesthesia

Editorial elective

Published in Canadian Journal of Anesthesia

Canadian contributions to the introduction and use of divinyl ether

Published in Canadian Journal of Anesthesia

In conclusion, Dr. Gelfan and Bell’s early work was a brief practical study, typical of the uninhibited work of many of the pioneers in anesthesia, who willingly participated as “guinea pigs“ in their continuing search to advance the body of medical knowledge in the pharmacology of anesthetic agents. Their work provides inspiring examples of how Ca...

N-acetylcysteine to reduce renal failure after cardiac surgery: a systematic review and meta-analysis

Published in Canadian Journal of Anesthesia

Purpose: To assess the effect of N-acetylcysteine (NAC) on acute renal failure and important clinical outcomes after cardiac surgery. Methods: Two reviewers performed literature searches, using EMBASE and PubMed, of randomized controlled trials investigating the renoprotective effect of N-acetylcysteine in cardiac surgery. Treatment effects were ca...

Pharmacogenomics and perioperative medicine — Implications for modern clinical practice

Published in Canadian Journal of Anesthesia

Genetic variation plays an important role in chronic disease and in perioperative patient management. It was our intent in this short review to cite practical examples of relevant overlap between pharmacoge-nomics and clinical anesthesiology. The influence of genetics on patient safety is seen throughout the perioperative period, when evaluating pa...

Regional anesthesia and pre-existing neurological disease —I

Published in Canadian Journal of Anesthesia

Multiple finger joint replacement and continuous physiotherapy using ultrasound guided, bilateral infraclavicular cathet...

Published in Canadian Journal of Anesthesia

The relation of plasma cholinesterases to response to clinical doses of succinylcholine

Published in Canadian Journal of Anesthesia

The plasma cholinesterase of a normal adult is capable of destroyingin vitro up to 120 mg. per minute of succinylcholine chloride. This great speed of destruction cannot be obtainedin vivo, yet the normal plasma cholinesterase can effectively cope with a considerable excess of succinylcholine. The rate of destruction of succinylcholine for any give...

Continuing medical education: Ultrasound guidance for regional blockade — basic concepts

Published in Canadian Journal of Anesthesia

Fluid resuscitation in the management of early septic shock (FINESS): a randomized controlled feasibility trial

Published in Canadian Journal of Anesthesia

Background: It is unknown whether fluid resuscitation with colloid or crystalloid in patients with severe sepsis or septic shock is associated with an improvement in clinical outcome. This randomized controlled trial determined the feasibility of conducting a large trial testing resuscitation with pentastarchvs normal saline in early septic shock, ...