Zhang, Wenjie Ren, Hailiang Liao, Qianxiu Wu, Jian
Published in
Calcified tissue international
The study addresses the challenge of treating secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) patients, focusing on the cost-effectiveness of surgical versus pharmacological interventions. Conducting a retrospective analysis on 152 CKD patients with SHPT at the Third People's Hospital of Chengdu, the study matched 80 patients i...
Faitg, Julie D'Amico, Davide Rinsch, Chris Singh, Anurag
Published in
Calcified tissue international
The age-related loss of skeletal muscle function starts from midlife and if left unaddressed can lead to an impaired quality of life. A growing body of evidence indicates that mitochondrial dysfunction is causally involved with muscle aging. Muscles are tissues with high metabolic requirements, and contain rich mitochondria supply to support their ...
Wages, Nathan P Mousa, Mohamed H Clark, Leatha A Tavoian, Dallin Arnold, W David Elbasiouny, Sherif M Clark, Brian C
Published in
Calcified tissue international
Weakness, one of the key characteristics of sarcopenia, is a significant risk factor for functional limitations and disability in older adults. It has long been suspected that reductions in motor unit firing rates (MUFRs) are one of the mechanistic causes of age-related weakness. However, prior work has not investigated the extent to which MUFR is ...
Smith, Cassandra Sim, Marc Dalla Via, Jack Levinger, Itamar Duque, Gustavo
Published in
Calcified tissue international
Often observed with aging, the loss of skeletal muscle (sarcopenia) and bone (osteoporosis) mass, strength, and quality, is associated with reduced physical function contributing to falls and fractures. Such events can lead to a loss of independence and poorer quality of life. Physical inactivity (mechanical unloading), especially in older adults, ...
Evans, William J Cawthon, Peggy M
Published in
Calcified tissue international
Initial definitions of sarcopenia included the age-associated loss of skeletal muscle mass that was presumed to be associated with late-life reduced functional capacity, disability and loss of independence. Because no method for determination of muscle mass was available for large cohort studies of aging men and women, lean body mass determined by ...
Wood, Brian S Batchek, Dakota J Lynch, David H Spangler, Hillary B Gross, Danae C Petersen, Curtis L Batsis, John A
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Calcified tissue international
Sarcopenic Obesity is the co-existence of increased adipose tissue (obesity) and decreased muscle mass or strength (sarcopenia) and is associated with worse outcomes than obesity alone. The new EASO/ESPEN consensus provides a framework to standardize its definition. This study sought to evaluate whether there are preliminary differences observed in...
Meng, Meng Wang, Jiaying Wang, Changyuan Zhao, Jianyu Wang, Huihan Zhang, Yukun Sun, Huijun Liu, Mozhen
Published in
Calcified tissue international
In hyperlipidemia-induced osteoporosis, bone marrow mesenchymal stem cells (BMSCs) differentiate into more adipocytes than osteoblasts, leading to decreased bone formation. It is vital to elucidate the effects of hyperlipidemia on bone metabolism and seek new agents that regulate adipocyte-osteoblast lineage allocation. CoQ10, a rate-limiting coenz...
Hendrickx, Gretl Boudin, Eveline Mateiu, Ligia Yorgan, Timur A Steenackers, Ellen Kneissel, Michaela Kramer, Ina Mortier, Geert Schinke, Thorsten Van Hul, Wim
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Published in
Calcified tissue international
Pathogenic variants disrupting the binding between sclerostin (encoded by SOST) and its receptor LRP4 have previously been described to cause sclerosteosis, a rare high bone mass disorder. The sclerostin-LRP4 complex inhibits canonical WNT signaling, a key pathway regulating osteoblastic bone formation and a promising therapeutic target for common ...
Huang, Wei Xiao, Yingqi Zhang, Li Liu, Hu
Published in
Calcified tissue international
This study aimed to examine the association between sex hormone-binding globulin (SHBG) and osteoporosis through a cross-sectional study and a two-sample bidirectional Mendelian randomization (MR). We used the National Health and Nutrition Examination Survey (NHANES) 2013-2014 and 2015-2016 data, with exposure as serum SHBG and outcome as osteoporo...
Chen, Dongfeng Li, Ying Wang, Qiang Zhan, Peng
Published in
Calcified tissue international
Osteoporosis disproportionately affects older women, yet gender differences in human osteoblasts remain unexplored. Identifying mechanisms and biomarkers of osteoporosis will enable the development of preventative and therapeutic approaches. Transcriptome data of 187 osteoblast samples from men and women were compared. Differentially expressed gene...
