Ó Breasail, Mícheál Janha, Ramatoulie Zengin, Ayse Pearse, Camille Jarjou, Landing Prentice, Ann Ward, Kate A.
Published in
Calcified Tissue International
Between-scanner differences in measures of bone and body composition can obscure or exaggerate physiological differences in multi-site studies or the magnitude of changes in longitudinal studies. We conducted a cross-calibration study at two bone imaging centres in The Gambia, West Africa where DXA (dual-energy X-ray absorptiometry) and pQCT (perip...
Rufus-Membere, Pamela Holloway-Kew, Kara L Diez-Perez, Adolfo Appelman-Dijkstra, Natasha M Bouxsein, Mary L Eriksen, Erik F Farr, Joshua N Khosla, Sundeep Kotowicz, Mark A Nogues, Xavier
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Published in
Calcified tissue international
Impact microindentation (IMI) is a novel technique for assessing bone material strength index (BMSi) in vivo, by measuring the depth of a micron-sized, spherical tip into cortical bone that is then indexed to the depth of the tip into a reference material. The aim of this study was to define the reference intervals for men and women by evaluating h...
Koepke, Leon-Gordian von Kroge, Simon Heuer, Annika Kammal, Anna Lena Ondruschka, Benjamin Rolvien, Tim Viezens, Lennart
Published in
Calcified Tissue International
The odontoid process (dens) of the second cervical vertebra (axis) is prone to fracture. While the importance of its skeletal integrity has been previously noted, representative three-dimensional microarchitecture analyses in humans are not available. This study aimed to determine the bone microarchitecture of the axis using high-resolution quantit...
Treurniet, Sanne Bevers, Melissa S. A. M. Wyers, Caroline E. Micha, Dimitra Teunissen, Bernd P. Elting, Mariet W. van den Bergh, Joop P. Eekhoff, Elisabeth M. W.
Published in
Calcified Tissue International
Pregnancy- and lactation-associated osteoporosis (PLO) is a rare form of osteoporosis, of which the pathogenesis and best treatment options are unclear. In this report, we describe the case of a 34-year old woman diagnosed with severe osteoporosis and multiple vertebral fractures after her first pregnancy, who was subsequently treated with teripara...
Shahen, V. A. Schindeler, A. Rybchyn, M. S. Girgis, C. M. Mulholland, B. Mason, R. S. Levinger, I. Brennan-Speranza, T. C.
Published in
Calcified Tissue International
Patients with type 2 diabetes mellitus (T2DM) experience a higher risk of fractures despite paradoxically exhibiting normal to high bone mineral density (BMD). This has drawn into question the applicability to T2DM of conventional fracture reduction treatments that aim to retain BMD. In a primary human osteoblast culture system, high glucose levels...
Heilmeier, Ursula Burghardt, Andrew J. Tse, Justin J. Kapoor, Puneet Stok, Kathryn S. Manske, Sarah Voll, Reinhard E. Schett, Georg Finzel, Stephanie
Published in
Calcified Tissue International
Hereditary hemochromatosis (HH) causes unbalanced iron deposition in many organs including the joints leading to severe cartilage loss and bone damage in the metacarpophalangeal joints (MCPJ). High-resolution peripheral quantitative computed tomography (HR-pQCT) and its joint space width (JSW) quantification algorithm quantifies in vivo 3D joint mo...
Alonso, N Zelzer, S Eibinger, G Herrmann, M
Published in
Calcified tissue international
Recent research activities have provided new insights in vitamin D metabolism in various conditions. Furthermore, substantial progress has been made in the analysis of vitamin D metabolites and related biomarkers, such as vitamin D binding protein. Liquid chromatography tandem mass spectrometric (LC-MS/MS) methods are capable of accurately measurin...
Alonso, N Meinitzer, A Fritz-Petrin, E Enko, D Herrmann, M
Published in
Calcified tissue international
Vitamin K, a cofactor for the γ-glutamyl carboxylase enzyme, is required for the post-translational activation of osteocalcin and matrix Gla protein, which play a key role in bone and muscle homeostasis. In vivo and in vitro models for osteoporosis and sarcopenia suggest the vitamin K could exert a positive effect in both conditions. In bone, it in...
Heijboer, Annemieke C Cavalier, Etienne
Published in
Calcified tissue international
Two decades after the discovery of the hormone FGF23, we know more about phosphate homeostasis as it turned out that FGF23 is the central hormone that regulates this. Hereditary hypophosphatemic rickets and tumor-induced osteomalacia could by then be explained, by autonomous FGF23 production, and the nephrology field was excited by this new marker ...
Ladang, Aurélie Beaudart, Charlotte Reginster, Jean-Yves Al-Daghri, Nasser Bruyère, Olivier Burlet, Nansa Cesari, Matteo Cherubini, Antonio da Silva, Mario Coelho Cooper, Cyrus
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Published in
Calcified tissue international
In clinical trials, biochemical markers provide useful information on the drug's mode of action, therapeutic response and side effect monitoring and can act as surrogate endpoints. In pharmacological intervention development for sarcopenia management, there is an urgent need to identify biomarkers to measure in clinical trials and that could be use...
