Hao, Huifei Hou, Yuxuan Li, Aicheng Niu, Li Li, Shaolan He, Bingqiang Zhang, Xingyuan Song, Honghua Cai, Rixin Zhou, Yue
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Published in
CNS neuroscience & therapeutics
Macrophage migration inhibitory factor (MIF) is an important mediator of neuropathology in various central nervous system (CNS) diseases. However, little is known about its inducers for production from the nerve cells, as well as the underlying regulatory mechanism. Injury-induced HIF-1α has been shown to exacerbate neuroinflammation by activating ...
Zhu, Wenshuang Liu, Feng Fu, Jilian Qin, Wen Xue, Kaizhong Tang, Jie Zhang, Yong Yu, Chunshui
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CNS neuroscience & therapeutics
The amplitude of low-frequency fluctuations (ALFF) of resting-state functional MRI signals is a reliable neuroimaging measure of spontaneous brain activity. Inconsistent ALFF alterations have been reported in major depressive disorder (MDD) possibly due to clinical heterogeneity. This study was designed to investigate clinically sensitive and insen...
Chen, Jie-Ru Chen, Jia-Qi Hu, Ji-Cheng Huang, Run-Sheng Shen, Liang Gu, Hai Chai, Xiao-Qing Wang, Di
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CNS neuroscience & therapeutics
Postoperative delirium (POD) is a common postoperative complication, and the potential relationship between cigarette smoking and POD is still unclear. The current study evaluated the relationship between preoperative smoking status in patients suffering from osteoarthritic pain and POD after total knee arthroplasty (TKA). A total of 254 patients w...
Mellado, Susana Cuesta, Carlos M Montagud, Sandra Rodríguez-Arias, Marta Moreno-Manzano, Victoria Guerri, Consuelo Pascual, María
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CNS neuroscience & therapeutics
Extracellular vesicles (EVs) are heterogeneous membrane vesicles secreted by cells in extracellular spaces that play an important role in intercellular communication under both normal and pathological conditions. Mesenchymal stem cells (MSC) are anti-inflammatory and immunoregulatory cells capable of secreting EVs, which are considered promising mo...
Gao, Ju Jiang, Rongtao Tang, Xiaowei Chen, Jiu Yu, Miao Zhou, Chao Wang, Xiang Zhang, Hongying Huang, Chengbing Yang, Yong
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Published in
CNS neuroscience & therapeutics
Deficit schizophrenia (DS), defined by primary and enduring negative symptoms, has been proposed as a promising homogeneous subtype of schizophrenia. It has been demonstrated that unimodal neuroimaging characteristics of DS were different from non-deficit schizophrenia (NDS), however, whether multimodal-based neuroimaging features could identify de...
Wang, Jing Zhu, Mengna Sun, Jingyi Feng, Lina Yang, Mingfeng Sun, Baoliang Mao, Leilei
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CNS neuroscience & therapeutics
Stroke has been associated with devastating clinical outcomes, with current treatment strategies proving largely ineffective. Therefore, there is a need to explore alternative treatment options for addressing post-stroke functional deficits. Gene therapy utilizing adeno-associated viruses (AAVs) as a critical gene vector delivering genes to the cen...
Ma, Wei-Xiang Li, Lei Kong, Ling-Xi Zhang, Hui Yuan, Ping-Chuan Huang, Zhi-Li Wang, Yi-Qun
Published in
CNS neuroscience & therapeutics
The lateral periaqueductal gray (LPAG), which mainly contains glutamatergic neurons, plays an important role in social responses, pain, and offensive and defensive behaviors. Currently, the whole-brain monosynaptic inputs to LPAG glutamatergic neurons are unknown. This study aims to explore the structural framework of the underlying neural mechanis...
Lv, Chuanxiang Han, Shuai Sha, Zhuang Liu, Mingqi Dong, Shiying Zhang, Chunyun Li, Zean Zhang, Kang Lu, Shouyong Xu, Zhiyang
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Published in
CNS neuroscience & therapeutics
We aimed to assess the effects of cerebral glucagon-like peptide-1 receptor (GLP-1R) activation on the glymphatic system and whether this effect was therapeutic for traumatic brain injury (TBI). Immunofluorescence was employed to evaluate glymphatic system function. The blood-brain barrier (BBB) permeability, microvascular basement membrane, and ti...
He, Hailan Zhang, Huiwen Chen, Hui He, Fang Yin, Fei Stauber, Tobias Zou, Xiaomin Peng, Jing
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CNS neuroscience & therapeutics
Christianson syndrome (CS) is caused by mutations in SLC9A6 and is characterized by global developmental delay, epilepsy, hyperkinesis, ataxia, microcephaly, and behavioral disorder. However, the molecular mechanism by which these SLC9A6 mutations cause CS in humans is not entirely understood, and there is no objective method to determine the patho...
Yang, Yujiao Chen, Dong Wang, Jing Wang, Jie Yan, Zhaofen Deng, Qinqin Zhang, Liping Luan, Guoming Wang, Mengyang Li, Tianfu
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Published in
CNS neuroscience & therapeutics
In physiological situations, the anterior cingulate cortex (ACC) and anterior insular cortex (AIC) are prone to coactivation. The functional connectivity and interaction between ACC and AIC in the context of epilepsy remain unclear. This study aimed to investigate the dynamic coupling between these two brain regions during seizures. Patients who un...
