Min, Fuli Dong, Zhaofei Zhong, Shuisheng Li, Ze Wu, Hong Zhang, Sai Zhang, Linming Zeng, Tao
Published in
CNS neuroscience & therapeutics
This study aims to investigate how the E3 ubiquitin ligase LITAF influences mitochondrial autophagy by modulating MCL-1 ubiquitination, and its role in the development of epilepsy. Employing single-cell RNA sequencing (scRNA-seq) to analyze brain tissue from epilepsy patients, along with high-throughput transcriptomics, we identified changes in gen...
Yu, Li Jin, Weifeng Deng, Defang Wang, Yiru Chen, Qianqian Zhang, Yangyang Wan, Haitong Chen, Yunxiang Chen, Ying He, Yu
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Published in
CNS neuroscience & therapeutics
Ischemic stroke is a prevalent and life-threatening cerebrovascular disease that is challenging to treat and associated with a poor prognosis. Astragaloside IV (AS-IV), a primary bioactive component of Astragali radix, has demonstrated neuroprotective benefits in previous studies. This study aimed to explore the mechanisms through which AS-IV may t...
Du, Zhiqiang Jiang, Ying Shen, Yuan Zhou, Qin Gong, Peng Zhu, Haohao
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CNS neuroscience & therapeutics
The study found a significant causal relationship between coffee intake and obsessive-compulsive disorder, showing a negative correlation. There was no causal relationship between coffee intake and other mental disorders. The sensitivity analysis test found no pleiotropy affecting the results, and no single nucleotide polymorphism had a major impac...
Li, Guo Cai, Xueli Wang, Yifeng
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CNS neuroscience & therapeutics
Attentional bias modification training (ABMT) is commonly employed to regulate negative attentional bias (NAB) and, in turn, to prevent or alleviate depressive symptoms. Recent advancements in attention switch theory have facilitated the development of a novel training paradigm that may enhance the efficacy of such interventions. A total of fifty-s...
Zhou, Hetong Wang, Minmin Xu, Ting Zhang, Xiaomei Zhao, Xudong Tang, Lili Zhao, Pengfei Wang, Dandan Lai, Jianbo Wang, Fei
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CNS neuroscience & therapeutics
Non-invasive brain stimulation (NIBS), such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), has emerged as a promising alternative in the precise treatment of clinical symptoms, such as the cognitive impairment of bipolar disorder (BD). Optimizing the neurocognitive effects by combining tDC...
Sun, Jian Yan, Jiuqi Zhao, Liang Wei, Xiang Qiu, Chang Dong, Wenwen Luo, Bei Zhang, Wenbin
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CNS neuroscience & therapeutics
Patients with disorders of consciousness (DOC) undergoing spinal cord stimulation (SCS) for arousal treatment require an assessment of their conscious state before and after the procedure. This is typically evaluated using behavioral scales (CRS-R), but this method can be influenced by the subjectivity of the physician. Event-related potentials (ER...
Zhong, Yi Kang, Xianhui Bai, Xiaofeng Pu, Bei Smerin, Daniel Zhao, Liang Xiong, Xiaoxing
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CNS neuroscience & therapeutics
Periodontitis, a non-communicable chronic inflammation disease resulting from dysbiosis of the oral microbiota, has been demonstrated to have a positive association with the risk of ischemic stroke (IS). The major periodontal pathogens contribute to the progression of stroke-related risk factors such as obesity, diabetes, atherosclerosis, and hyper...
Cheng, Zizhang Zuo, Jinyi Peng, Xintao Zhang, Haoran Su, Wenlong Luan, Guoming Guan, Yuguang
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CNS neuroscience & therapeutics
Previous studies suggest potential associations between epilepsy, anti-epileptic drugs (AEDs), and levels of vitamin D and vitamin D-binding protein (VDBP). This study aims to investigate the causal relationships among these variables using Mendelian Randomization (MR) methods. Using summary data from genome-wide association studies on serum 25-hyd...
Zhu, Yin Zou, Wenjun Sun, Baihan Shen, Kelv Xia, Feiyun Wang, Hao Jiang, Fengxian Lu, Zhengfeng
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CNS neuroscience & therapeutics
To investigate the regulation of ginsenoside Rg1 on the PI3K/AKT pathway through the lncRNA-Malat1/miR-124-3p/ Laminin gamma1 (Lamc1) axis, activating astrocytes (As) to promote the repair of spinal cord injury (SCI). Bioinformatics analysis was used to predict miRNA targeting Lamc1 and lncRNA targeting miR-124-3p, which were then validated through...
Dong, Jinpeng Wang, Zhun Li, Lixuan Zhang, Mengxue Wang, Sixuan Luo, Yuan Dong, Ying Wang, Xiaokun Wang, Yongan Wang, Kaiyuan
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CNS neuroscience & therapeutics
Postoperative neurocognitive disorder (PND) refers to the cognitive impairment experienced by patients after surgery. As a target of sevoflurane, a kind of inhalation anesthetic, the balance of the GABAergic system can be disrupted during the perioperative period. In this study, we explored the promoting effect of abnormal elevation of the α5 subty...