Published in British medical bulletin
Immune-mediated liver and gastrointestinal diseases are chronic conditions that lack curative treatments. Despite advances in the understanding and treatment of these conditions, they frequently remain refractory to treatment and represent a significant unmet need. Cellular therapies are an emerging option and hold the potential to have a major imp...
Published in British medical bulletin
Osteoarthritis is a common degenerative musculoskeletal disease of synovial joints. It is characterized by a metabolic imbalance resulting in articular cartilage degradation, reduced elastoviscosity of synovial fluid and an altered chondrocyte phenotype. This is often associated with reduced mobility, pain and poor quality of life. Subsequently, wi...
Published in British medical bulletin
Several studies have shown that inflammatory bowel diseases (IBD) patients treated with thiopurines have an increased risk of developing skin cancer. This review is based on recent published literature regarding the use of thiopurines in IBD and skin malignancies. Exposure to thiopurines is significantly associated with nonmelanoma skin cancer, but...
Published in British medical bulletin
Idiopathic intracranial hypertension (IIH) is becoming a recognized condition due to the increasing incidence linked to a global obesity epidemic. All English papers on PubMed, Cochrane and Scholar between inception until 1 March 2020 were considered. Studies suggest central adiposity has a pathogenic role. Recent weight gain is a risk factor and w...
Published in British medical bulletin
Evidence-based policy decision-making is a dominant paradigm in health but realizing this ideal has proven challenging. This paper conceptually maps health policy, policy studies and social science literature critically engaged with evidence and decision-making. No new data were generated or analysed in support of this review. Barriers to evidence-...
Published in British medical bulletin
Suicidal behaviours and non-suicidal self-harm (NSSH) are global public health concerns that affect millions of lives. This review is a narrative synthesis of systematic reviews, meta-analyses of randomized control trials (RCTs) and landmark studies published in scientific journals. Restricting access to lethal means reduces the likelihood of futur...
Published in British medical bulletin
The role of the immune system in tendon healing relies on polymorphonucleocytes, mast cells, macrophages and lymphocytes, the 'immune cells' and their cytokine production. This systematic review reports how the immune system affects tendon healing. We registered our protocol (registration number: CRD42019141838). After searching PubMed, Embase and ...
Published in British medical bulletin
Introduction With a worldwide ageing population, the importance of the prevention and management of osteoporotic fragility fractures is increasing over time. In this review, we discuss in detail the epidemiology of fragility fractures, how this is shaped by pharmacological interventions and how novel screening programmes can reduce the clinical and...
Published in British medical bulletin
Human infections with avian influenza viruses (AIV) represent a persistent public health threat. The principal risk factor governing human infection with AIV is from direct contact with infected poultry and is primarily observed in Asia and Egypt where live-bird markets are common. Changing patterns of virus transmission and a lack of obvious disea...
Published in British medical bulletin
Osteoarthritis (OA) is a most common orthopaedic condition, often complicated by inflammatory features. A systematic search in PubMed, Embase, Google Scholar and Scopus databases (to January 2019) was performed to define the effect obtained in patients with OA of the knee by injections of ozone, on pain and physical function. Six RCTs and 353 patie...
