García-Hidalgo, María C Benítez, Iván D Perez-Pons, Manel Molinero, Marta Belmonte, Thalía Rodríguez-Muñoz, Carlos Aguilà, María Santisteve, Sally Torres, Gerard Moncusí-Moix, Anna
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Published in
British journal of pharmacology
The post-acute sequelae of SARS-CoV-2 infection pose a significant global challenge, with nearly 50% of critical COVID-19 survivors manifesting persistent lung abnormalities. The lack of understanding about the molecular mechanisms and effective treatments hampers their management. Here, we employed microRNA (miRNA) profiling to decipher the system...
Brown, Simon D Klimi, Eftychia Bakker, Wilfried A M Beqqali, Abdelaziz Baker, Andrew H
Published in
British journal of pharmacology
Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have unveiled a fascinating range of non-coding RNAs (ncRNAs) that play a pivotal role in regulating vSMC function. This review aims to provide an in-depth analysis of the...
Bibi, Alessia Bartekova, Monika Gandhi, Shrey Greco, Simona Madè, Alisia Sarkar, Moumita Stopa, Victoria Tastsoglou, Spyros de Gonzalo-Calvo, David Devaux, Yvan
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Published in
British journal of pharmacology
Cardiac remodelling involves structural, cellular and molecular alterations in the heart after injury, resulting in progressive loss of heart function and ultimately leading to heart failure. Circular RNAs (circRNAs) are a recently rediscovered class of non-coding RNAs that play regulatory roles in the pathogenesis of cardiovascular diseases, inclu...
Bernasconi, Riccardo Kuster, Gabriela M
Published in
British journal of pharmacology
Life expectancy in cancer patients has been extended in recent years, thanks to major breakthroughs in therapeutic developments. However, this also unmasked an increased incidence of cardiovascular diseases in cancer survivors, which is in part attributable to cancer therapy-related cardiovascular toxicity. Non-coding RNAs (ncRNAs) have received mu...
Euler, Gerhild Parahuleva, Mariana
Published in
British journal of pharmacology
Atherosclerosis is a chronic proinflammatory disease of the vascular wall resulting in narrowing of arteries due to plaque formation, thereby causing reduced blood supply that is the leading cause for diverse end-organ damage with high mortality rates. Monocytes/macrophages, activated by elevated circulating lipoproteins, are significantly involved...
Sopić, Miron Vladimirov, Sandra Munjas, Jelena Mitić, Tijana Hall, Ignacio Fernando Jusic, Amela Ruzic, Dusan Devaux, Yvan
Published in
British journal of pharmacology
Noncoding RNAs (ncRNAs) are pivotal for various pathological processes, impacting disease progression. The potential for leveraging ncRNAs to prevent or treat atherosclerosis and associated cardiovascular diseases is of great significance, especially given the increasing prevalence of atherosclerosis in an ageing and sedentary population. Together,...
Liu, Huilin Huang, Chao Liu, Zhenni Li, Yuhan Zhu, Yanan Gao, Min Chen, Jing Zhang, Hui Xiao, Zhengtao Zhao, Wei
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Published in
British journal of pharmacology
Cardiac glycosides (CGs), traditionally prescribed for heart failure and arrhythmias, show anticancer potential. However, their mechanisms for preferential inhibition of tumour tissue and constituent malignant cells are not fully elucidated. This study aims to elucidate the therapeutic benefits of CGs in targeting specific tumours and dissect their...
Zielinski, Jana L Lee, Chiao Hwei Gunatilaka, Avanka Gao, Bryan Stewart, Alastair G
Published in
British journal of pharmacology
Mechanopharmacology is an emerging interdisciplinary field that investigates drug action using biomechanically appropriate in vitro systems to the relevant (patho)physiology. This review outlines emerging technologies and techniques which aim to bridge the gap between mechanical cues influencing cellular biology and conventional pharmacology. We de...
Wang, Chunmiao Liang, Dandan Shen, Xiaoyan Chen, Xuyang Lai, Linfang Hou, Huaxin
Published in
British journal of pharmacology
Emerging evidence has highlighted that paraptosis may be an effective strategy for treating liver cancer. In our previous studies, Compound 4a induced paraptosis in cancer cells. Here, the characteristics of Compound 4a-induced paraptosis were further revealed and, for the first time, the target and related molecular mechanisms of Compound 4a-induc...
Bertacchini, Gabriela L Sonego, Andreza B Lisboa, Sabrina S F Lagatta, Davi C Resstel, Leonardo B M
Published in
British journal of pharmacology
The dorsal hippocampus (dHIP) is pivotal for learning, memory, and defensive responses. Transient receptor potential vanilloid type 1 (TRPV1) receptors in the dHIP modulate contextual fear conditioning by triggering a cascade involving glutamate release, nitric oxide (NO) formation and cyclic guanosine monophosphate (cGMP) production. The present s...
