Ibemere, Stephanie O Oyedeji, Charity I Preiss, Liliana Van Althuis, Laura E Hankins, Jane S Azul, Melissa Burns, Ebony N Glassberg, Jeffrey Hagar, Ward Hussain, Faiz
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Published in
British journal of haematology
Individuals with sickle cell disease (SCD) have historically been considered underweight. Despite increasing body mass index (BMI) in the general population, the prevalence of overweight and obese status remains unclear in the adult SCD population. Our primary aim was to determine the prevalence of overweight and obese status and to identify associ...
Chen, Mengxiang Ouyang, Fu Wu, Tao Hu, Yunfei Du, Yan Huang, Yunhong
Published in
British journal of haematology
Yazer, Mark H Díaz-Valdés, José R Triulzi, Darrell J Cap, Andrew P
Published in
British journal of haematology
Kulis, Marta Martin-Subero, Jose Ignacio
Published in
British journal of haematology
Chronic lymphocytic leukaemia (CLL) is not only characterised by driver genetic alterations but by extensive epigenetic changes. Over the last decade, epigenomic studies have described the DNA methylome, chromatin accessibility, histone modifications and the three-dimensional (3D) genome architecture of CLL. Beyond its regulatory role, the DNA meth...
Khwaja, Jahanzaib D'Sa, Shirley Lunn, Michael P Sive, Jonathan
Published in
British journal of haematology
POEMS syndrome is a rare multisystem paraneoplastic disorder due to an underlying low-level plasma cell dyscrasia. Due to its rarity, there are limited data to guide treatment and there are no consensus guidelines. Therapy choices are dictated by patient characteristics, disease factors and local funding arrangements. The goals of therapy are to er...
Salomao, Norman Maslah, Nabih Giulianelli, Anouk Drevon, Louis Aguinaga, Lorea Gu, Xiaolian Cassinat, Bruno Giraudier, Stephane Fenaux, Pierre Fahraeus, Robin
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Published in
British journal of haematology
The human homologues of murine double minute 2 (MDM2) and 4 (MDM4) negatively regulate p53 tumour suppressor activity and are reported to be frequently overexpressed in human malignancies, prompting clinical trials with drugs that prevent interactions between MDM2/MDM4 and p53. Bone marrow samples from 111 patients with acute myeloblastic leukaemia...
Cai, Xuan Wu, Jin An, Zhuo-Yu Wang, Chen-Cong Zhu, Xiao-Lu He, Yun Fu, Hai-Xia Huang, Xiao-Jun Zhang, Xiao-Hui
Published in
British journal of haematology
The abnormal immunomodulatory functions of mesenchymal stem cells (MSCs) have been implicated in the development of immune thrombocytopenia (ITP). Recent studies have suggested important effects of complement on immune cell function. However, whether complement modulates bone marrow MSCs function in ITP is poorly defined. Tacrolimus has recently be...
Sánchez-Lanzas, Raúl Kalampalika, Foteini Ganuza, Miguel
Published in
British journal of haematology
Our view on the role and composition of the bone marrow (BM) has dramatically changed over time from a simple nutrient for the bone to a highly complex multicellular tissue that sustains haematopoiesis. Among these cells, multipotent haematopoietic stem cells (HSCs), which are predominantly quiescent, possess unique self-renewal capacity and multil...
Bertinchamp, Rémi Garzaro, Margaux Boutboul, David Galicier, Lionel Meignin, Véronique Calvani, Julien Djerad, Mohammed El Hadi Rozenbaum, Willy Simon, Philippe Oksenhendler, Eric
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Published in
British journal of haematology
Li, Menguan Liu, Liu Ding, Bingjie Song, Xuewen Xia, Ao Han, Yu Song, Yongping Wei, Xudong Zhou, Hu
Published in
British journal of haematology
