Kawata, Eri Lazo-Langner, Alejandro Xenocostas, Anargyros Hsia, Cyrus C Howson-Jan, Kang Deotare, Uday Saini, Lalit Yang, Ping Broadbent, Robert Levy, Michael
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Published in
British journal of haematology
Next-generation sequencing (NGS) increasingly influences diagnosis, prognosis and management of myelodysplastic syndrome (MDS). In addition to marrow morphology and flow cytometry, our institution performs cytogenetics (CG) and NGS-based testing routinely in patients with suspected MDS. We evaluated the relative value of NGS in the assessment of pa...
Gordon, Max J Huang, Julie Chan, Rebecca J Bhargava, Pankaj Danilov, Alexey V
Published in
British journal of haematology
Comorbidities influence survival in patients with chronic lymphocytic leukaemia (CLL) treated with chemo-immunotherapy or ibrutinib. While idelalisib has been studied in patients with comorbidities, their impact has not been investigated. We analysed 481 patients treated with idelalisib on two randomised trials (NCT01659021 and NCT01539512). Comorb...
Bringhen, Sara Voorhees, Peter M Plesner, Torben Mellqvist, Ulf-Henrik Reeves, Brandi Sonneveld, Pieter Byrne, Catriona Nordström, Eva Harmenberg, Johan Obermüller, Jakob
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Published in
British journal of haematology
An updated survival analysis was conducted for the Phase II study O-12-M1 of melphalan flufenamide (melflufen) plus dexamethasone in patients with relapsed/refractory multiple myeloma (RRMM) with two or more prior lines of therapy (including bortezomib and lenalidomide). Partial response or better was seen in 31%. After a 46-month median overall su...
Humbert, Olivier Samuelson, Clare Kiem, Hans-Peter
Published in
British journal of haematology
Genome editing therapies represent a significant advancement in next-generation, precision medicine for the management of haematological diseases, and CRISPR/Cas9 has to date been the most successful implementation platform. From discovery in bacteria and archaea over three decades ago, through intensive basic research and pre-clinical development ...
Booth, Stephen Collins, Graham
Published in
British journal of haematology
Despite considerable progress in the treatment of patients with lymphoid malignancies in recent decades, the prognosis of patients with relapsed or refractory lymphomas often remains disappointing. Increasing evidence has established the relevance of epigenetic alterations in the pathogenesis of lymphoid malignancies, and a succession of agents has...
Lee, Shin Fujita, Kei Morishita, Tetsuji Negoro, Eiju Oiwa, Kana Tsukasaki, Hikaru Yamamura, Osamu Ueda, Takanori Yamauchi, Takahiro
Published in
British journal of haematology
Reflecting the increasing risk in elderly patients with diffuse large B cell lymphoma (DLBCL), prognostic predictors other than the International Prognostic Index have attracted more attention. This study presents the first analysis of the prognostic utility of the Geriatric Nutritional Risk Index (GNRI) in combination with the Charlson Comorbidity...
Milojkovic, Dragana Cross, Nicholas C P Ali, Sahra Byrne, Jenny Campbell, Gavin Dignan, Fiona L Drummond, Mark Huntly, Brian Marshall, Scott McMullin, Mary Frances
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Published in
British journal of haematology
Management of chronic myeloid leukaemia (CML) has recently undergone dramatic changes, prompting the European LeukemiaNet (ELN) to issue recommendations in 2013; however, it remains unclear whether real-world CML management is consistent with these goals. We report results of UK TARGET CML, a retrospective observational study of 257 patients with c...
Sonnevi, Kristina Wästerlid, Tove Melén, Christopher M Harrysson, Sara Smedby, Karin E Wahlin, Björn E
Published in
British journal of haematology
Diffuse large B-cell lymphoma (DLBCL) incidence rises with increasing age. Rituximab-anthracycline-based regimens offer a potential cure but also risks of adverse events, especially in the elderly. Using Swedish registers, we conducted a nationwide, population-based study of DLBCL in the very elderly. We obtained information on clinical characteris...
Radich, Jerald
Published in
British journal of haematology
Most cancer cases occur in areas of low resources. The diagnosis, treatment and monitoring of cancers is especially challenging in these locations. Unique partnerships exist between non-profit organisations and pharmaceutical companies to provide free drugs to CML patients throughout the world if the diagnosis can be rigorously and unambiguously es...
Rodriguez-Pinilla, Socorro Maria Domingo-Domenech, Eva Climent, Fina Sanchez, Joaquin Perez Seoane, Carlos Lopez Jimenez, Javier Garcia-Cosio, Monica Caballero, Dolores Blanco Muñez, Oscar Javier Carpio, Cecilia
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Published in
British journal of haematology
We investigated the clinicopathological features and prognostic factors of patients with peripheral T-cell lymphoma (PTCL) in 13 sites across Spain. Relevant clinical antecedents, CD30 expression and staining pattern, prognostic indices using the International Prognostic Index and the Intergruppo Italiano Linfomi system, treatments, and clinical ou...
