Hao, Yupei Zhang, Jinyuan Yang, Lin Zhou, Chunhua Yu, Ze Gao, Fei Hao, Xin Pang, Xiaolu Yu, Jing
Published in
British journal of clinical pharmacology
This study aimed to establish a prediction model of quetiapine concentration in patients with schizophrenia and depression, based on real-world data via machine learning techniques to assist clinical regimen decisions. A total of 650 cases of quetiapine therapeutic drug monitoring (TDM) data from 483 patients at the First Hospital of Hebei Medical ...
Houston, Martin G McMenamin, Úna Johnston, Brian McDowell, Ronald D Hughes, Carmel M Murchie, Peter Cardwell, Chris R
Published in
British journal of clinical pharmacology
There is evidence gastrointestinal (GI) motility may play a role in the development of GI cancers. Weak opioids (codeine and dihydrocodeine) decrease GI motility, but their effect on GI cancer risk has not been assessed. We aim to assess the association between weak opioids and cancers of the GI tract. A series of nested case-control studies was co...
Moorthy, Ganesh Pouliot, Gayle Pageau Graham, Lorraine Pilling, Elizabeth Jung, Lindsey Alcobi, Rachael Zhu, Yali Li, Yan Sidhu, Sharan Forte, Pablo
...
Published in
British journal of clinical pharmacology
Two phase 1 studies characterized the oral bioavailability of AZD4635 (potential anticancer therapy) and factors that may influence its pharmacokinetics (PKs; food, smoking, proton-pump inhibitors [PPIs] and CYP1A2 inhibitors) to support continued clinical development of AZD4635. Study 1 (comparative PK study; nonsmokers) consists of Part A and Par...
Duncan, Andrew Morrison, Ian Bryson, Scott
Published in
British journal of clinical pharmacology
Copper deficiency resulting from prescribing zinc in high doses is a rare but life-changing diagnosis that is frequently overlooked. The aim of this study is to gauge how often zinc-induced copper deficiency is missed, to raise awareness of the condition and to stress the need for guidelines for prescribing zinc. Suspected cases of zinc-induced cop...
Martins, Frederico Severino Martins, José Eduardo Severino Severino, Patricia Annaert, Pieter Sy, Sherwin K B
Published in
British journal of clinical pharmacology
The combination of daptomycin and ceftaroline used as salvage therapy is associated with higher survival and decreased clinical failure in complicated methicillin-resistant Staphylococcus aureus (MRSA) infections that are resistant to standard MRSA treatment. This study aimed to evaluate dosing regimens for coadministration of daptomycin and ceftar...
Reig-Lopez, Javier Tang, Weifeng Fernandez-Teruel, Carlos Merino-Sanjuan, Matilde Mangas-Sanjuan, Victor Boulton, David W Sharma, Pradeep
Published in
British journal of clinical pharmacology
To use population physiologically based pharmacokinetic (PopPBPK) modelling to optimize target expression, kinetics and clearance of HER1/2 directed therapeutic monoclonal antibodies (mAbs). Thus, to propose a general workflow of PopPBPK modelling and its application in clinical pharmacology. Full PBPK model of pertuzumab (PTZ) was developed in pat...
Colom, Helena Blasi, Annabel Montoro, Bruno Arévalo, Angel-Guillermo Cendrós, Josep Maria Sabaté, Antoni
Published in
British journal of clinical pharmacology
Fibrinogen is the key substrate for coagulation. Fibrinogen pharmacokinetics (PK) after single doses of fibrinogen concentrate (FC), using modelling approaches, has only been evaluated in congenital afibrinogenaemic patients. The aims of this study are to characterize the fibrinogen PK in patients with acquired-chronic (cirrhosis) or acute-hypofibr...
Woods, Richard H
Published in
British journal of clinical pharmacology
The interleukin-23 (IL-23) inhibitor risankizumab was recently approved for the treatment of moderate-to-severe plaque psoriasis in the United States. Low rates of cerebrovascular accident (CVA) were observed in risankizumab-treated patients during clinical trials. The aim of this study was to determine whether risankizumab may be associated with C...
Tenenbein, Milton
Published in
British journal of clinical pharmacology
There is no high-quality evidence regarding the benefit of any gastrointestinal decontamination procedure in the overdose patient. The original and twice reaffirmed position of the AACT and EAPCCT is based upon the best evidence and practical considerations. WBI was recommended as a treatment for the ingestion of modified release pharmaceuticals, i...
Yin, Yi-Wei Liu, Xiao-Qin Gu, Jia-Qin Li, Zi-Ran Jiao, Zheng
Published in
British journal of clinical pharmacology
Edoxaban is a non-vitamin K antagonist oral anticoagulant (NOAC) widely used for the long-term prevention of stroke in patients with non-valvular atrial fibrillation (NVAF). Adherence to NOAC therapy has been unsatisfactory and decreases over time. Remedial strategies are currently used to address the non-adherence events. Current recommendations, ...
