A call for the appropriate application of clinical pharmacological principles in the search for safe and efficacious COV...
Published in British journal of clinical pharmacology
Population pharmacokinetics of clofarabine for allogeneic hematopoietic cell transplantation in paediatric patients.
Published in British journal of clinical pharmacology
Clofarabine has recently been evaluated as part of the conditioning regimen for allogeneic hematopoietic stem cell transplantation (HCT) in children. Pharmacokinetic (PK) exposure of different agents commonly used in conditioning regimens is strongly related to HCT outcome. Consequently, the PK of clofarabine may be important for outcome. This repo...
A systematic literature review of LASA error interventions.
Published in British journal of clinical pharmacology
The aim of this systematic review was to explore and evaluate the efficacy of interventions to reduce the prevalence of look-alike, sound-alike (LASA) medication name errors. We conducted a systematic review of the literature, searching PubMed, EMBASE, Scopus, and Web of Science up to December 2016, and re-ran the search in February 2020 for later ...
Fixed-dose combination antibiotics: The search for evidence using the example of ampicillin-cloxacillin.
Published in British journal of clinical pharmacology
High consumption of irrational fixed-dose combination (FDC) antibiotics may pose a threat of antimicrobial resistance. In India, ampicillin-cloxacillin was the second highest sold FDC antibiotic behind amoxicillin and clavulanic acid. There remain, however, questions about its efficacy and safety and a lack of regulatory approval. We undertook a li...
Why dose adjust systemic exposure when looking for associations with adverse events in tacrolimus-treated transplant rec...
Published in British journal of clinical pharmacology
Pregabalin poisoning and rising recreational use: a retrospective observational series.
Published in British journal of clinical pharmacology
With rising use worldwide, pregabalin is increasingly implicated in poisoning deaths. We aimed to investigate the clinical effects and complications of pregabalin poisoning. This is a retrospective review of patients presenting with pregabalin poisoning to two tertiary toxicology units from 1 July 2014 to 30 June 2019. Patients were identified from...
Racing to immunity: Journey to a COVID-19 vaccine and lessons for the future.
Published in British journal of clinical pharmacology
SARS-CoV-2 is the novel coronavirus behind the COVID-19 pandemic. Since its emergence, the global scientific community has mobilized to study this virus, and an overwhelming effort to identify COVID-19 treatments is currently ongoing for a variety of therapeutics and prophylactics. In order to better understand these efforts, we compiled a list of ...
Risk assessment of using off-label morphine sulfate in a population-based retrospective cohort of opioid-dependent patie...
Published in British journal of clinical pharmacology
Several addictovigilance studies have described the off-label use of morphine sulfate (MS) for nonchronic pain in opioid use disorder (OUD) patients as an alternative to conventional opioid substitution treatments (OSTs). This study primarily sought to compare the incidence of unintentional opioid-related overdose in the year following the prescrip...
Regulatory science: Regulation is too important to leave it to the regulators.
Published in British journal of clinical pharmacology
Is there a safe and effective way to wean patients off long-term glucocorticoids?
Published in British journal of clinical pharmacology
Glucocorticoids are highly effective medicines in the treatment of inflammatory disorders. However they cause severe adverse reactions, particularly where taken at high doses systemically for prolonged periods. Systemic glucocorticoids are therefore given at dosage sufficient to control the disease, then withdrawn as fast as is possible to minimise...
