Ouyang, Jiawei Zhong, Yu Zhang, Yijie Yang, Liting Wu, Pan Hou, Xiangchan Xiong, Fang Li, Xiayu Zhang, Shanshan Gong, Zhaojian
...
Published in
British journal of cancer
Alternative splicing (AS) is a key process in which precursor RNAs produce different mature RNAs, and the disorder of AS is a key factor in promoting cancer development. Compared with coding RNA, studies on the functions of long non-coding RNAs (lncRNAs) are far from enough. In fact, lncRNA is an important participant and regulator in the process o...
Camiña, Nuria Penning, Trevor M
Published in
British journal of cancer
Electrophilic and oxidative stress is caused when homeostatic mechanisms are disrupted. A major defense mechanism involves the activation of the nuclear factor erythroid 2-related factor 2 (NRF2) transcription factor encoded by the NFE2L2 gene, which can accelerate the detoxification of electrophilic carcinogens and prevent cancer and on the other ...
Allen, Victoria Coulombe, Josée Zhao, Huijun Kreps, Lauren M Cook, David P Pryce, Benjamin Clemons, Mark Vanderhyden, Barbara C Gray, Douglas A Addison, Christina L
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Published in
British journal of cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer. As few tools exist to study ILC metastasis, we isolated ILC cells with increased invasive properties to establish a spontaneously metastasising xenograft model. MDA-MB-134VI ILC cells were placed in transwells for 7 days. Migrated cells were isolated and expanded to c...
Nakajima, Kosei Ino, Yoshinori Naito, Chie Nara, Satoshi Shimasaki, Mari Ishimoto, Utako Iwasaki, Toshimitsu Doi, Noriteru Esaki, Minoru Kishi, Yoji
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Published in
British journal of cancer
The treatment of pancreatic cancer (PDAC) remains clinically challenging, and neoadjuvant therapy (NAT) offers down staging and improved surgical resectability. Abundant fibrous stroma is involved in malignant characteristic of PDAC. We aimed to investigate tissue remodelling, particularly the alteration of the collagen architecture of the PDAC mic...
Na, Rong Wei, Jun Sample, Chris J Gielzak, Marta Choi, Sodam Cooney, Kathleen A Rabizadeh, Daniel Walsh, Patrick C Zheng, Lilly S Xu, Jianfeng
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Published in
British journal of cancer
Recently, a novel HOXB13 variant (X285K) was observed in men of African descent with prostate cancer (PCa) in Martinique. Little is known about this or other variants in HOXB13 which may play a role in PCa susceptibility in African-American (AA) men. We sequenced HOXB13 in an AA population of 1048 men undergoing surgical treatment for PCa at Johns ...
Wheatley, Roseanna C Kilgour, Elaine Jacobs, Timothy Lamarca, Angela Hubner, Richard A Valle, Juan W McNamara, Mairéad G
Published in
British journal of cancer
Biliary tract cancers, including intra- and extra-hepatic cholangiocarcinoma as well as gallbladder cancer, are associated with poor prognosis and the majority of patients present with advanced-stage, non-resectable disease at diagnosis. Biliary tract cancer may develop through an accumulation of genetic and epigenetic alterations and can be influe...
Karas, Spinel Etheridge, Amy S Nickerson, Deborah A Cox, Nancy J Mohlke, Karen L Cecchin, Erika Toffoli, Giuseppe Mathijssen, Ron H J Forrest, Alan Bies, Robert R
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Published in
British journal of cancer
Irinotecan (CPT-11) is an anticancer agent widely used to treat adult solid tumours. Large interindividual variability in the clearance of irinotecan and SN-38, its active and toxic metabolite, results in highly unpredictable toxicity. In 217 cancer patients treated with intravenous irinotecan single agent or in combination, germline DNA was used t...
Dash, Pujarini Ghatak, Souvik Topi, Geriolda Satapathy, Shakti Ranjan Ek, Fredrik Hellman, Karin Olsson, Roger Mehdawi, Lubna M Sjölander, Anita
Published in
British journal of cancer
Despite intense research, the prognosis for patients with advanced colorectal cancer (CRC) remains poor. The prostaglandin D2 receptors DP1 and DP2 are explored here as potential therapeutic targets for advanced CRC. A CRC cohort was analysed to determine whether DP1 and DP2 receptor expression correlates with patient survival. Four colon cancer ce...
Byun, Dohyun Hong, SungEun Ryu, Seaun Nam, Yeonju Jang, Hajin Cho, Yoonkyoung Keum, NaNa Oh, Hannah
Published in
British journal of cancer
The evidence for the associations between early-life adiposity and female cancer risks is mixed. Little is known about the exact shape of the relationships and whether the associations are independent of adult adiposity. We conducted dose-response meta-analyses of prospective studies to summarise the relationships of early-life body mass index (BMI...
Chen, Siteng Jiang, Liren Gao, Feng Zhang, Encheng Wang, Tao Zhang, Ning Wang, Xiang Zheng, Junhua
Published in
British journal of cancer
Traditional histopathology performed by pathologists through naked eyes is insufficient for accurate survival prediction of clear cell renal cell carcinoma (ccRCC). A total of 483 whole slide images (WSIs) data from three patient cohorts were retrospectively analyzed. We performed machine learning algorithm to identify optimal digital pathological ...
