Xue, Yue Lian, Wenwen Zhi, Jiaqi Yang, Wenjuan Li, Qianjin Guo, Xingyi Gao, Jiahao Qu, Hao Lin, Weiqiang Li, Zhongqi
...
Published in
British Journal of Cancer
BackgroundTamoxifen resistance remains a significant clinical challenge for the therapy of ER-positive breast cancer. It has been reported that the upregulation of transcription factor SOX9 in ER+ recurrent cancer is sufficient for tamoxifen resistance. However, the mechanisms underlying the regulation of SOX9 remain largely unknown.MethodsThe acet...
Sim, Sung Hoon Park, In Hae Jung, Kyung Hae Kim, Sung-Bae Ahn, Jin-Hee Lee, Kyung-Hun Im, Seock-Ah Im, Young-Hyuck Park, Yeon Hee Sohn, Joohyuk
...
Published in
British Journal of Cancer
BackgroundThe continuum of anti-HER2 agents is a standard treatment of HER2 + metastatic breast cancer (MBC). This study evaluated the efficacy of lapatinib plus vinorelbine in patients progressed on both trastuzumab and lapatinib treatments.MethodsA total of 149 patients were randomly assigned to lapatinib with vinorelbine (LV) (n = 75; lapatinib,...
Rouyer, Magali Oudard, Stéphane Joly, Florence Fizazi, Karim Tubach, Florence Jove, Jérémy Lacueille, Clémentine Lamarque, Stéphanie Guiard, Estelle Balestra, Aurélie
...
Published in
British Journal of Cancer
BackgroundCabazitaxel is a treatment of metastatic castration-resistant prostate cancer (mCRPC) after docetaxel failure. The FUJI cohort aimed to confirm the real-life overall and progression-free survival (OS, PFS) and safety of cabazitaxel.MethodsMulticentre, non-interventional cohort of French mCRPC patients initiating cabazitaxel between 2013 a...
Darlix, Amélie Louvel, Guillaume Fraisse, Julien Jacot, William Brain, Etienne Debled, Marc Mouret-Reynier, Marie Ange Goncalves, Anthony Dalenc, Florence Delaloge, Suzette
...
Published in
British Journal of Cancer
BackgroundMetastatic breast cancer (MBC) behaviour differs depending on hormone receptors (HR) and human epidermal growth factor receptor (HER2) statuses.MethodsThe kinetics of central nervous system (CNS) metastases (CNS metastasis-free survival, CNSM-FS) and subsequent patient’s prognosis (overall survival, OS) according to the molecular subtype ...
Jesinghaus, Moritz Boxberg, Melanie Wilhelm, Dirk Münch, Stefan Dapper, Hendrik Quante, Michael Schlag, Christoph Lange, Sebastian Budczies, Jan Konukiewitz, Björn
...
Published in
British Journal of Cancer
BackgroundCellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant therapy.MethodsWe evaluated ce...
Rostgaard, Klaus Hjalgrim, Henrik Madanat-Harjuoja, Laura Johannesen, Tom B. Collin, Sofia Hjalgrim, Lisa L.
Published in
British Journal of Cancer
BackgroundThe present study aimed to assess whether the widespread concern of inferior cancer survival in adolescents and young adults (AYAs) compared with children and adults holds true in a Nordic setting with important differences in healthcare organisation compared with the United States (e.g. free access to healthcare) and the United Kingdom (...
Vissio, Elena Metovic, Jasna Osella-Abate, Simona Bertero, Luca Migliaretti, Giuseppe Borella, Fulvio Benedetto, Chiara Sapino, Anna Cassoni, Paola Castellano, Isabella
...
Published in
British Journal of Cancer
BackgroundThe Eighth edition of the American Joint Committee on Cancer (AJCC) staging system (2018) for breast cancer (BC) introduced the prognostic stage. Moreover, multigene assessment has been indicated to tailor staging in T1/T2/N0, ER-positive/HER2-negative BC. However, many National Health Systems do not provide reimbursement for routine test...
Tuna, Musaffe Ju, Zhenlin Yoshihara, Kosuke Amos, Christopher I. Tanyi, Janos L. Mills, Gordon B.
Published in
British Journal of Cancer
BackgroundMutation of TP53 is the most frequent genetic alteration in high-grade serous ovarian cancer (HGSOC). The impact of hotspot mutations of TP53 and protein levels on patient outcomes in HGSOC has not been fully elucidated.MethodsThe study population (n = 791) comprised of HGSOC samples with TP53 mutation from TCGA and other publicly availab...
Hamester, Fabienne Legler, Karen Wichert, Beatrice Kelle, Nicole Eylmann, Kathrin Rossberg, Maila Ding, Yi Kürti, Sascha Schmalfeldt, Barbara Milde-Langosch, Karin
...
Published in
British Journal of Cancer
BackgroundMaturation of complex N-glycans involves the action of Golgi mannosidases and plays a major role in cancer progression. We recently showed a favourable prognostic role of α-mannosidase MAN1A1 in breast cancer mainly caused by alteration of certain adhesion molecules.MethodsWe analysed the protein expression of MAN1A1 in ovarian cancer (n ...
El-Kenawi, Asmaa Gatenbee, Chandler Robertson-Tessi, Mark Bravo, Rafael Dhillon, Jasreman Balagurunathan, Yoganand Berglund, Anders Visvakarma, Naveen Ibrahim-Hashim, Arig Choi, Jung
...
Published in
British Journal of Cancer
BackgroundTumours rapidly ferment glucose to lactic acid even in the presence of oxygen, and coupling high glycolysis with poor perfusion leads to extracellular acidification. We hypothesise that acidity, independent from lactate, can augment the pro-tumour phenotype of macrophages.MethodsWe analysed publicly available data of human prostate cancer...
