Hamilton, Ashleigh C. Donnelly, David W. Loughrey, Maurice B. Turkington, Richard C. Fox, Colin Fitzpatrick, Deirdre O’Neill, Ciaran E. Gavin, Anna T. Coleman, Helen G.
Published in
British Journal of Cancer
Background The restructuring of healthcare systems to cope with the demands of the COVID-19 pandemic has led to a reduction in clinical services such as cancer screening and diagnostics. Methods Data from the four Northern Ireland pathology laboratories were used to assess trends in pathological cancer diagnoses from 1st March to 12th September 202...
Yan, Yihe Zheng, Leting Du, Qiang Cui, Xiao Dong, Kun Guo, Yarong Geller, David A.
Published in
British Journal of Cancer
BackgroundCHK1 is considered an oncogene with overexpression in numerous cancers. However, CHK1 signalling regulation in hepatocellular carcinoma (HCC) remains unclear.MethodsCHEK1 mRNA, protein, pri-miR-195 and miR-195 expression in HCC tissue was determined by qPCR, WB and IF staining assay. Survival analyses in HCC with high- and low-CHEK1 mRNA ...
Lasorella, Anna Iavarone, Antonio
Published in
British Journal of Cancer
Classification of cancer should lead to informative patients’ stratification and selective therapeutic vulnerabilities. A pathway-based classification of glioblastoma uncovered a mitochondrial subtype with a unique sensitivity to inhibitors of oxidative phosphorylation. Precision targeting of cancer metabolism could provide therapeutic opportunitie...
Dave, Rajiv V. Kim, Baek Courtney, Alona O’Connell, Rachel Rattay, Tim Taxiarchi, Vicky P. Kirkham, Jamie J. Camacho, Elizabeth M. Fairbrother, Patricia Sharma, Nisha
...
Published in
British Journal of Cancer
Assaad, Souad Zrounba, Philippe Cropet, Claire Blay, Jean-Yves
Published in
British Journal of Cancer
Background Over 30 million COVID-19 cases have been diagnosed worldwide from late 2019. Among frail persons, cancer patients are at high risk of death from COVID-19. Methods The French prospective cohort ONCOVID-19 enrolled patients with solid or haematological tumour, receiving anticancer treatment and presenting with clinical symptoms suggestive ...
Miller, Katelyn D. Schug, Zachary T.
Published in
British Journal of Cancer
Recent advances in our understanding of tumour heterogeneity alongside studies investigating altered metabolism within transformed tissue have identified metabolic pathways critical to cancer cell survival. Leveraging this information presents a promising new avenue for the generation of cancer-specific therapeutics and improved patient outcomes.
Semaan, Alexander Bernard, Vincent Kim, Dong U. Lee, Jaewon J. Huang, Jonathan Kamyabi, Nabiollah Stephens, Bret M. Qiao, Wei Varadhachary, Gauri R. Katz, Matthew H.
...
Published in
British Journal of Cancer
BackgroundLimited accessibility of the tumour precludes longitudinal characterisation for therapy guidance in pancreatic ductal adenocarcinoma (PDAC).MethodsWe utilised dielectrophoresis-field flow fractionation (DEP-FFF) to isolate circulating tumour cells (CTCs) in 272 blood draws from 74 PDAC patients (41 localised, 33 metastatic) to non-invasiv...
Chen, Fenfang Han, Yujiao Kang, Yibin
Published in
British Journal of Cancer
The bone marrow has been widely recognised to host a unique microenvironment that facilitates tumour colonisation. Bone metastasis frequently occurs in the late stages of malignant diseases such as breast, prostate and lung cancers. The biology of bone metastasis is determined by tumour-cell-intrinsic traits as well as their interaction with the mi...
Jordan, Allan Michael
Published in
British Journal of Cancer
The sequencing of tumour or blood samples is increasingly used to stratify patients into clinical trials of molecularly targeted agents, and this approach has frequently demonstrated clinical benefit for those who are deemed eligible. But what of those who have no clear and evident molecular driver? What of those deemed to have “nil actionable” mut...
Kregting, Lindy M. Kaljouw, Sylvia de Jonge, Lucie Jansen, Erik E. L. Peterse, Elisabeth F. P. Heijnsdijk, Eveline A. M. van Ravesteyn, Nicolien T. Lansdorp-Vogelaar, Iris de Kok, Inge M. C. M.
Published in
British Journal of Cancer
