Correction: MicroRNA-17-5p regulates EMT by targeting vimentin in colorectal cancer
Published in British Journal of Cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
First-in-human, dose-escalation, phase 1 study of anti-angiopoietin-2 LY3127804 as monotherapy and in combination with r...
Published in British Journal of Cancer
BackgroundThis is the first-in-human study of novel anti-angiopoietin-2 (Ang-2) monoclonal antibody LY3127804 as monotherapy and in combination with ramucirumab in advanced solid tumours.MethodsPatients received intravenous LY3127804 monotherapy (4, 8, 12, 16, 20 and 27 mg/kg) in part A; LY3127804 (8, 12, 16, 20 and 27 mg/kg) with 8 mg/kg ramucirum...
Integrated clinico-molecular profiling of appendiceal adenocarcinoma reveals a unique grade-driven entity distinct from ...
...Published in British Journal of Cancer
BackgroundAppendiceal adenocarcinoma (AA) is an orphan disease with unique clinical attributes but often treated as colorectal cancer (CRC). Understanding key molecular differences between AA and CRC is critical.MethodsWe performed retrospective analyses of AA patients (N = 266) with tumour and/or blood next-generation sequencing (NGS) (2013–2018) ...
Current concepts in tumour-derived organoids
Published in British Journal of Cancer
Cancer comprises a collection of highly proliferative and heterogeneous cells growing within an adaptive and evolving tumour microenvironment. Cancer survival rates have significantly improved following decades of cancer research. However, many experimental and preclinical studies do not translate to the bedside, reflecting the challenges of modell...
Association of obesity status and metabolic syndrome with site-specific cancers: a population-based cohort study
Published in British Journal of Cancer
BackgroundObesity and metabolic syndrome (MetS) appear in clusters and are both associated with an increased risk of cancer. However, it remains unknown whether obesity status with or without MetS increases the risk of site-specific cancers.MethodsWe used data derived from 390,575 individuals (37–73 years old) from the UK Biobank who were enrolled ...
Association between adjuvant chemotherapy and survival in patients with rectal cancer and pathological complete response...
...Published in British Journal of Cancer
BackgroundFor patients with locally advanced rectal cancer (LARC), it is unclear whether neoadjuvant chemoradiotherapy-induced pathologic complete response (pCR) individuals would further benefit from adjuvant chemotherapy (ACT).MethodsThe pCR individuals who received different ACT cycles were paired by propensity score matching. Overall survival (...
Suppression of G6PD induces the expression and bisecting GlcNAc-branched N-glycosylation of E-Cadherin to block epitheli...
Published in British Journal of Cancer
BackgroundAs the rate-limit enzyme of the pentose phosphate pathway, glucose-6-phosphate dehydrogenase (G6PD) plays important roles in tumour progression, but the exact mechanism through which G6PD controls cancer metastasis remains unclear.MethodsG6PD expression in resected oral squamous cell carcinoma (OSCC) samples was analysed by immunohistoche...
Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal ade...
Published in British Journal of Cancer
BackgroundGastroesophageal adenocarcinoma (GOA) has poor clinical outcomes and lacks reliable blood markers. Here we present circulating tumour DNA (ctDNA) as an emerging biomarker.MethodsForty patients (17 palliative and 23 curative) were followed by serial plasma monitoring. Primary tumour DNA was analysed by targeted next-generation sequencing t...
Intratumoural immunotherapies for unresectable and metastatic melanoma: current status and future perspectives
Published in British Journal of Cancer
The emergence of human intratumoural immunotherapy (HIT-IT) is a major step forward in the management of unresectable melanoma. The direct injection of treatments into melanoma lesions can cause cell lysis and induce a local immune response, and might be associated with a systemic immune response. Directly injecting immunotherapies into tumours ach...
The significance of highlighting the oestrogen receptor low category in breast cancer
Published in British Journal of Cancer
The latest ASCO/CAP guideline has recommended to report oestrogen receptor (ER) low cases (ERlo; 1–10%) as “ER low positive category”, prompting us to compare the clinicopathologic features, biomarkers, survival and treatment of the ERlo cases with other subgroups (ER negative (ERneg) and ER high (ERhi)). ERlo cases revealed more similar clinicopat...
