Aine, Mattias Boyaci, Ceren Hartman, Johan Häkkinen, Jari Mitra, Shamik Campos, Ana Bosch Nimeus, Emma Ehinger, Anna Vallon-Christersson, Johan Borg, Åke
...
Published in
Breast Cancer Research
BackgroundBreast cancer in young adults has been implicated with a worse outcome. Analyses of genomic traits associated with age have been heterogenous, likely because of an incomplete accounting for underlying molecular subtypes. We aimed to resolve whether triple-negative breast cancer (TNBC) in younger versus older patients represent similar or ...
Gilmore, Nikesha Mohile, Supriya Lei, Lianlian Culakova, Eva Mohamed, Mostafa Magnuson, Allison Loh, Kah Poh Maggiore, Ronald Belcher, Elizabeth Conlin, Alison
...
Published in
Breast Cancer Research
BackgroundFrailty is associated with an increased risk of chemotherapy toxicity. Cellular markers of inflammation can help identify patients with frailty characteristics. However, the role of cellular markers of inflammation in identifying patients at risk of developing chemotherapy-induced frailty and their clinical utility are not fully understoo...
Shang, Lihua Hattori, Masaya Fleming, Gini Jaskowiak, Nora Hedeker, Donald Olopade, Olufunmilayo I. Huo, Dezheng
Published in
Breast Cancer Research
PurposeTo evaluate weight change patterns over time following the diagnosis of breast cancer and to examine the association of post-diagnosis weight change and survival outcomes in Black and White patients.MethodsThe study included 2888 women diagnosed with non-metastatic breast cancer in 2000–2017 in Chicago. Longitudinal repeated measures of weig...
Johansson, Anna L. V. Trewin, Cassia B. Fredriksson, Irma Reinertsen, Kristin V. Russnes, Hege Ursin, Giske
Published in
Breast Cancer Research
BackgroundIn breast cancer, immunohistochemistry (IHC) subtypes, together with grade and stage, are well-known independent predictors of breast cancer death. Given the immense changes in breast cancer treatment and survival over time, we used recent population-based data to test the combined influence of IHC subtypes, grade and stage on breast canc...
Altoe, Mirella L. Kalinsky, Kevin Marone, Alessandro Kim, Hyun K. Guo, Hua Hibshoosh, Hanina Tejada, Mariella Crew, Katherine D. Accordino, Melissa K. Trivedi, Meghna S.
...
Published in
Breast Cancer Research
BackgroundThe purpose of this study is to evaluate whether the changes in optically derived parameters acquired with a diffuse optical tomography breast imager system (DOTBIS) in the contralateral non-tumor-bearing breast in patients administered neoadjuvant chemotherapy (NAC) for breast cancer are associated with pathologic complete response (pCR)...
Rohan, Thomas E. Arthur, Rhonda Wang, Yihong Weinmann, Sheila Ginsberg, Mindy Loi, Sherene Salgado, Roberto
Published in
Breast Cancer Research
BackgroundIt is well established that tumors are antigenic and can induce an immune response by the host, entailing lymphocytic infiltration of the tumor and surrounding stroma. The extent and composition of the immune response to the tumor, assessed through evaluation of tumor-infiltrating lymphocyte counts, has been shown in many studies to have ...
Rozenblit, Mariya Mun, Sophia Soulos, Pamela Adelson, Kerin Pusztai, Lajos Mougalian, Sarah
Published in
Breast Cancer Research
BackgroundThere is currently no clinical trial data regarding the efficacy of everolimus exemestane (EE) following prior treatment with CDK4/6 inhibitors (CDK4/6i). This study assesses the use and efficacy of everolimus exemestane in patients with metastatic HR+ HER2− breast cancer previously treated with endocrine therapy (ET) or endocrine therapy...
Asperger, Hannah Stamm, Nadia Gierke, Berthold Pawlak, Michael Hofmann, Ute Zanger, Ulrich M. Marton, Annamaria Katona, Robert L. Buhala, Andrea Vizler, Csaba
...
Published in
Breast Cancer Research
An amendment to this paper has been published and can be accessed via the original article.
Chen, Chong Pan, Yundi Bai, Lipeng Chen, Huilin Duan, Zhaojun Si, Qin Zhu, Ruizhe Chuang, Tsung-Hsien Luo, Yunping
Published in
Breast Cancer Research
BackgroundMicroRNAs have been reported to participate in tumorigenesis, treatment resistance, and tumor metastasis. Novel microRNAs need to be identified and investigated to guide the clinical prognosis or therapy for breast cancer.MethodThe copy number variations (CNVs) of MIR3613 from Cancer Genome Atlas (TCGA) or Cancer Cell Line Encyclopedia (C...
Jiao, Xuanmao Wang, Min Zhang, Zhao Li, Zhiping Ni, Dong Ashton, Anthony W. Tang, Hsin-Yao Speicher, David W. Pestell, Richard G.
Published in
Breast Cancer Research
BackgroundTriple-negative breast cancer (BCa) (TNBC) is a deadly form of human BCa with limited treatment options and poor prognosis. In our prior analysis of over 2200 breast cancer samples, the G protein-coupled receptor CCR5 was expressed in > 95% of TNBC samples. A humanized monoclonal antibody to CCR5 (leronlimab), used in the treatment of HIV...