Emad, Amin Ray, Tania Jensen, Tor W. Parat, Meera Natrajan, Rachael Sinha, Saurabh Ray, Partha S.
Published in
Breast Cancer Research
BackgroundCancer cells are known to display varying degrees of metastatic propensity, but the molecular basis underlying such heterogeneity remains unclear. Our aims in this study were to (i) elucidate prognostic subtypes in primary tumors based on an epithelial-to-mesenchymal-to-amoeboid transition (EMAT) continuum that captures the heterogeneity ...
Terkelsen, Thilde Russo, Francesco Gromov, Pavel Haakensen, Vilde Drageset Brunak, Søren Gromova, Irina Krogh, Anders Papaleo, Elena
Published in
Breast Cancer Research
BackgroundStudies on tumor-secreted microRNAs point to a functional role of these in cellular communication and reprogramming of the tumor microenvironment. Uptake of tumor-secreted microRNAs by neighboring cells may result in the silencing of mRNA targets and, in turn, modulation of the transcriptome. Studying miRNAs externalized from tumors could...
Paul, Ritama Luo, Ming Mo, Xueying Lu, Jason Yeo, Syn Kok Guan, Jun-Lin
Published in
Breast Cancer Research
An amendment to this paper has been published and can be accessed via the original article.
Byerly, Jessica H. Port, Elisa R. Irie, Hanna Y.
Published in
Breast Cancer Research
BackgroundProtein kinase C theta, (PRKCQ/PKCθ) is a serine/threonine kinase that is highly expressed in a subset of triple-negative breast cancers (TNBC) and promotes their growth, anoikis resistance, epithelial-mesenchymal transition (EMT), and invasion. Here, we show that PRKCQ regulates the sensitivity of TNBC cells to apoptosis triggered by sta...
Blohmer, Martin Zhu, Li Atkinson, Jennifer M. Beriwal, Sushil Rodríguez-López, Joshua L. Rosenzweig, Margaret Brufsky, Adam M. Tseng, George Lucas, Peter C. Lee, Adrian V.
...
Published in
Breast Cancer Research
BackgroundBreast cancer is the most common malignancy to spread to the orbit and periorbit, and the invasive lobular carcinoma (ILC) histologic subtype of breast cancer has been reported to form these ophthalmic metastases (OM) more frequently than invasive ductal carcinomas (IDC). We herein report our single academic institution experience with br...
Finlay-Schultz, Jessica Jacobsen, Britta M. Riley, Duncan Paul, Kiran V. Turner, Scott Ferreira-Gonzalez, Andrea Harrell, J. Chuck Kabos, Peter Sartorius, Carol A.
Published in
Breast Cancer Research
BackgroundBreast cancer is a highly heterogeneous disease characterized by multiple histologic and molecular subtypes. While a myriad of breast cancer cell lines have been developed over the past 60 years, estrogen receptor alpha (ER)+ disease and some mutations associated with this subtype remain underrepresented. Here we describe six breast cance...
Guo, Hua Ding, Qingqing Gong, Yun Gilcrease, Michael Z. Zhao, Min Zhao, Jun Sui, Dawen Wu, Yun Chen, Hui Liu, Hui
...
Published in
Breast Cancer Research
BackgroundIn the evaluation of PD-L1 expression to select patients for anti-PD-1/PD-L1 treatment, uniform guidelines that account for different immunohistochemistry assays, different cell types and different cutoff values across tumor types are lacking. Data on how different scoring methods compare in breast cancer are scant.MethodsUsing FDA-approv...
Bergqvist, Malin Elebro, Karin Sandsveden, Malte Borgquist, Signe Rosendahl, Ann H.
Published in
Breast Cancer Research
BackgroundObesity induces molecular changes that may favor tumor progression and metastatic spread, leading to impaired survival outcomes in breast cancer. Adenylate cyclase-associated protein 1 (CAP1), an actin regulatory protein and functional receptor for the obesity-associated adipokine resistin, has been implicated with inferior cancer prognos...
Roberts, Melyssa S. Anstine, Lindsey J. Finke, Viviane S. Bryson, Benjamin L. Webb, Bryan M. Weber-Bonk, Kristen L. Seachrist, Darcie D. Majmudar, Parth R. Keri, Ruth A.
Published in
Breast Cancer Research
BackgroundTriple-negative breast cancer (TNBC) is characterized by high rates of recurrence and poor overall survival. This is due, in part, to a deficiency of targeted therapies, making it essential to identify therapeutically targetable driver pathways of this disease. While epidermal growth factor receptor (EGFR) is expressed in 60% of TNBCs and...
Maliniak, Maret L. Cheriyan, Aswathy Miriam Sherman, Mark E. Liu, Yuan Gogineni, Keerthi Liu, Jiaqi He, Jiabei Krishnamurti, Uma Miller-Kleinhenz, Jasmine Ashiqueali, Ryan
...
Published in
Breast Cancer Research
BackgroundCrown-like structures in breast adipose tissue (CLS-B), composed of necrotic adipocytes encircled by macrophages, are associated with obesity and hypothesized to worsen breast cancer prognosis; however, data are sparse, particularly in multi-racial populations.MethodsWe assessed specimens for CLS-B from 174 African-American and 168 White ...
