Adamo, Barbara Bellet, Meritxell Paré, Laia Pascual, Tomás Vidal, Maria Pérez Fidalgo, José A. Blanch, Salvador Martinez, Noelia Murillo, Laura Gómez-Pardo, Patricia
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Published in
Breast Cancer Research
BackgroundThe biological effect of oral metronomic vinorelbine (mVNB) alone or in combination with endocrine therapy in patients with hormone receptor-positive (HR+)/HER2-negative breast cancer has been scarcely addressed.MethodsPostmenopausal women with untreated stage I–III HR+/HER2-negative breast cancer were randomized (1:1:1) to receive 3 week...
Ren, Jiang Smid, Marcel Iaria, Josephine Salvatori, Daniela C. F. van Dam, Hans Zhu, Hong Jian Martens, John W. M. ten Dijke, Peter
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Breast Cancer Research
BackgroundBone morphogenetic proteins (BMPs) have been reported to maintain epithelial integrity and to antagonize the transforming growth factor β (TGFβ)-induced epithelial to mesenchymal transition. The expression of soluble BMP antagonists is dysregulated in cancers and interrupts proper BMP signaling in breast cancer.MethodsIn this study, we mi...
Batalini, Felipe Peacock, Ellie G. Stobie, Lindsey Robertson, Alison Garber, Judy Weitzel, Jeffrey N. Tung, Nadine M.
Published in
Breast Cancer Research
The introduction of next-generation sequencing has resulted in testing multiple genes simultaneously to identify inherited pathogenic variants (PVs) in cancer susceptibility genes. PVs with low minor allele frequencies (MAFs) (
Leithner, Doris Horvat, Joao V. Marino, Maria Adele Bernard-Davila, Blanca Jochelson, Maxine S. Ochoa-Albiztegui, R. Elena Martinez, Danny F. Morris, Elizabeth A. Thakur, Sunitha Pinker, Katja
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Published in
Breast Cancer Research
BackgroundTo evaluate the diagnostic performance of radiomic signatures extracted from contrast-enhanced magnetic resonance imaging (CE-MRI) for the assessment of breast cancer receptor status and molecular subtypes.MethodsOne hundred and forty-three patients with biopsy-proven breast cancer who underwent CE-MRI at 3 T were included in this IRB-app...
Barrow, Maya A. Martin, Megan E. Coffey, Alisha Andrews, Portia L. Jones, Gieira S. Reaves, Denise K. Parker, Joel S. Troester, Melissa A. Fleming, Jodie M.
Published in
Breast Cancer Research
BackgroundIn the USA, the breast cancer mortality rate is 41% higher for African-American women than non-Hispanic White women. While numerous gene expression studies have classified biological features that vary by race and may contribute to poorer outcomes, few studies have experimentally tested these associations. CRYβB2 gene expression has drawn...
Mani, Chinnadurai Jonnalagadda, Shirisha Lingareddy, Jojireddy Awasthi, Sanjay Gmeiner, William H. Palle, Komaraiah
Published in
Breast Cancer Research
BackgroundBreast cancer remains as one of the most lethal types of cancer in women. Among various subtypes, triple-negative breast cancer (TNBC) is the most aggressive and hard to treat type of breast cancer. Mechanistically, increased DNA repair and cell cycle checkpoint activation remain as the foremost reasons behind TNBC tumor resistance to che...
Bosiljcic, Momir Cederberg, Rachel A. Hamilton, Melisa J. LePard, Nancy E. Harbourne, Bryant T. Collier, Jenna L. Halvorsen, Elizabeth C. Shi, Rocky Franks, S. Elizabeth Kim, Ada Y.
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Published in
Breast Cancer Research
BackgroundSolid tumors produce proteins that can induce the accumulation of bone marrow-derived cells in various tissues, and these cells can enhance metastatic tumor growth by several mechanisms. 4T1 murine mammary tumors are known to produce granulocyte colony-stimulating factor (G-CSF) and increase the numbers of immunosuppressive CD11b+Gr1+ mye...
Luo, Jing Hippe, Daniel S. Rahbar, Habib Parsian, Sana Rendi, Mara H. Partridge, Savannah C.
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Breast Cancer Research
BackgroundDiffusion-weighted imaging (DWI) can increase breast MRI diagnostic specificity due to the tendency of malignancies to restrict diffusion. Diffusion tensor imaging (DTI) provides further information over conventional DWI regarding diffusion directionality and anisotropy. Our study evaluates DTI features of suspicious breast lesions detect...
Riebensahm, Carlotta Joosse, Simon A. Mohme, Malte Hanssen, Annkathrin Matschke, Jakob Goy, Yvonne Witzel, Isabell Lamszus, Katrin Kropidlowski, Jolanthe Petersen, Cordula
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Published in
Breast Cancer Research
BackgroundThe incidence of brain metastases in breast cancer (BCBM) patients is increasing. These patients have a very poor prognosis, and therefore, identification of blood-based biomarkers, such as circulating tumor cells (CTCs), and understanding the genomic heterogeneity could help to personalize treatment options.MethodsBoth EpCAM-dependent (C...
Patel, Tejal A. Ensor, Joe E. Creamer, Sarah L. Boone, Toniva Rodriguez, Angel A. Niravath, Poly A. Darcourt, Jorge G. Meisel, Jane L. Li, Xiaoxian Zhao, Jing
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Published in
Breast Cancer Research
BackgroundNeoadjuvant dual human epidermal growth factor receptor (HER2) blockade with trastuzumab and pertuzumab plus paclitaxel leads to an overall pathologic complete response (pCR) rate of 46%. Dual HER2 blockade with ado-trastuzumab emtansine (T-DM1) and lapatinib plus nab-paclitaxel has shown efficacy in patients with metastatic HER2-positive...
