Pulsifer, Margaret
Published in
Brain sciences
Down syndrome (DS), caused by triplication of chromosome 21, is the most common genetic cause of intellectual disability (ID), with an estimated incidence of one in 700 live births [...].
Bonini, Fabien Mosser, Sébastien Mor, Flavio Maurizio Boutabla, Anissa Burch, Patrick Béduer, Amélie Roux, Adrien Braschler, Thomas
Published in
Brain sciences
Recent advances in biomaterials offer new possibilities for brain tissue reconstruction. Biocompatibility, provision of cell adhesion motives and mechanical properties are among the present main design criteria. We here propose a radically new and potentially major element determining biointegration of porous biomaterials: the favorable effect of i...
Hom, Christy L Kirby, Katharine A Ricks-Oddie, Joni Keator, David B Krinsky-McHale, Sharon J Pulsifer, Margaret B Rosas, Herminia Diana Lai, Florence Schupf, Nicole Lott, Ira T
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Published in
Brain sciences
Accurate identification of the prodromal stage of Alzheimer's disease (AD), known as mild cognitive impairment (MCI), in adults with Down syndrome (MCI-DS) has been challenging because there are no established diagnostic criteria that can be applied for people with lifelong intellectual disabilities (ID). As such, the sequence of cognitive decline ...
Grasso, Stephanie M Peña, Elizabeth D Kazemi, Nina Mirzapour, Haideh Neupane, Rozen Bonakdarpour, Borna Gorno-Tempini, Maria Luisa Henry, Maya L
Published in
Brain sciences
Anomia is an early and prominent feature of primary progressive aphasia (PPA) and other neurodegenerative disorders. Research investigating treatment for lexical retrieval impairment in individuals with progressive anomia has focused primarily on monolingual speakers, and treatment in bilingual speakers is relatively unexplored. In this series of s...
Fleming, Victoria Piro-Gambetti, Brianna Bazydlo, Austin Zammit, Matthew Alexander, Andrew L Christian, Bradley T Handen, Benjamin Plante, David T Hartley, Sigan L
Published in
Brain sciences
Adults with Down syndrome are at a high risk for disordered sleep. These sleep problems could have marked effects on aging and Alzheimer's disease, potentially altering white matter integrity. This study examined the associations between disordered sleep assessed via an actigraph accelerometer worn on 7 consecutive nights, presence of diagnosis of ...
Harp, Jordan P Koehl, Lisa M Pelt, Kathryn L Van Hom, Christy L Doran, Eric Head, Elizabeth Lott, Ira T Schmitt, Frederick A
Published in
Brain sciences
Primary care integration of Down syndrome (DS)-specific dementia screening is strongly advised. The current study employed principal components analysis (PCA) and classification and regression tree (CART) analyses to identify an abbreviated battery for dementia classification. Scale- and subscale-level scores from 141 participants (no dementia n = ...
Gutterman, Jennifer Lee-Miller, Trevor Friel, Kathleen M Dimitropoulou, Katherine Gordon, Andrew M
Published in
Brain sciences
Children with unilateral spastic cerebral palsy (USCP) have impairments in motor planning, impacting their ability to grasp objects. We examined the planning of digit position and force and the flexibility of the motor system in covarying these during object manipulation. Eleven children with a left hemisphere lesion (LHL), nine children with a rig...
Handen, Benjamin Clare, Isabel Laymon, Charles Petersen, Melissa Zaman, Shahid O'Bryant, Sid Minhas, Davneet Tudorascu, Dana Brown, Stephanie Christian, Bradley
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Published in
Brain sciences
Acute regression has been reported in some individuals with Down syndrome (DS), typically occurring between the teenage years and mid to late 20s. Characterized by sudden, and often unexplained, reductions in language skills, functional living skills and reduced psychomotor activity, some individuals have been incorrectly diagnosed with Alzheimer's...
Krasko, Maryann N Hoffmeister, Jesse D Schaen-Heacock, Nicole E Welsch, Jacob M Kelm-Nelson, Cynthia A Ciucci, Michelle R
Published in
Brain sciences
Parkinson's disease (PD) is a progressive, degenerative disorder that affects 10 million people worldwide. More than 90% of individuals with PD develop hypokinetic dysarthria, a motor speech disorder that impairs vocal communication and quality of life. Despite the prevalence of vocal deficits in this population, very little is known about the path...
Goodwin, Amy Hendry, Alexandra Mason, Luke Bazelmans, Tessel Begum Ali, Jannath Pasco, Greg Charman, Tony Jones, Emily J H Johnson, Mark H Team, The Basis/Staars
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Published in
Brain sciences
Mapping infant neurocognitive differences that precede later ADHD-related behaviours is critical for designing early interventions. In this study, we investigated (1) group differences in a battery of measures assessing aspects of attention and activity level in infants with and without a family history of ADHD or related conditions (ASD), and (2) ...