Coyoy-Salgado, Angélica Segura-Uribe, Julia J Manuel Gallardo, Juan Estrada-Cruz, Norma A Camacho-Arroyo, Ignacio Guerra-Araiza, Christian
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Brain research
Estrogen replacement therapy decreases some risk factors of the metabolic syndrome but increases the risk of some types of cancer. Tibolone (TIB) has shown similar neuroprotective effects as estrogens. This study aimed to evaluate the effects of TIB on metabolic parameters and the expression of sex hormone receptors in the CNS in ovariectomised rat...
Wang, Wei-En Ho, Rachel L M Ribeiro-Dasilva, Margarete C Fillingim, Roger B Coombes, Stephen A
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Brain research
Grannonico, Marta Brandolini, Laura Varrassi, Giustino Sebastiani, Pierluigi Colanardi, Alessia Paladini, Antonella Piroli, Alba Allegretti, Marcello Di Loreto, Silvia
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Brain research
C5a is a crucial terminal effector of the C cascade, mostly involved in pain and neuroinflammatory conditions. DF3016A is a novel potent and selective C5a receptor (C5aR) inhibitor that crosses the blood-brain barrier (BBB) and may have pharmacological properties. We have previously demonstrated a protective effect of DF3016A on injured primary cor...
Zhang, Li Chen, Chen Qi, Jian
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Brain research
"Stress-induced hyperalgesia (SIH)" is a phenomenon that stress can lead to an increase in pain sensitivity. Epigenetic mechanisms have been known to play fundamental roles in stress and pain. Histone acetylation is an epigenetic feature that is changed in numerous stress-related disease situations. However, epigenetic mechanism for SIH is not well...
Chen, Grace H Chiao, Chuan-Chin
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Brain research
The axons of retinal ganglion cells (RGCs) in adult mammals fail to regenerate after injury. It has been suggested that some extrinsic factors, such as neural activity, may promote the regeneration process. The present study tested the hypothesis that environmental stress such as slightly elevated osmolarity and temperature can enhance neural activ...
Yasuda, Naomi Sasaki, Masanori Kataoka-Sasaki, Yuko Nagahama, Hiroshi Kocsis, Jeffery D Kawaharada, Nobuyoshi Honmou, Osamu
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Brain research
Ischemic spinal cord injury (iSCI) is a devastating complication of aortic surgery, with few strategies for prevention. Intravenous infusion of mesenchymal stem cells (MSCs) for iSCI has been shown to provide functional improvement through protection of gray matter. The purpose of this study was to investigate additional mechanisms which may exert ...
Kong, Xiang-Chen Zhang, Dan Qian, Cheng Liu, Geng-Tao Bao, Xiu-Qi
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Brain research
Calmels, Claire
Published in
Brain research
Over the last two decades, there were many investigations on motor expertise but inconsistencies across findings exist. Thus, to unravel these discrepancies, we conducted a novel literature review, applying stricter inclusion criteria relative to those used in previous reviews. Consequently, this paper reviews the most recent MRI and fMRI literatur...
Gao, Jingmei Fang, Lei Sun, Danyang Shen, Yiming Hu, Yiming Li, Ning Chang, Jin Li, Wei Tan, Jian
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Brain research
The codelivery of different therapeutics is a promising option because of its synergetic effects of drugs. In this study, a new combination therapy that used the doxorubicin-loaded and 131I-labeled nanoliposomes (131I-DOX-NL) was proposed to delay tumor growth of gliomas, which are characterized by significant mortality and morbidity. 131I-DOX-NL w...
Egger, Karl Rau, Alexander Yang, Shan Klöppel, Stefan Abdulkadir, Ahmed Kellner, Elias Frings, Lars Hellwig, Sabine Urbach, Horst
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Brain research
Previous studies showed voxel-based volumetry as a helpful tool in detecting pathologic brain atrophy. Aim of this study was to investigate whether the inclusion of CSF volume improves the imaging based diagnostic accuracy using combined automated voxel- and region-based volumetry. In total, 120 individuals (30 healthy elderly, 30 frontotemporal de...
