Ahmadi, Nahid Hosseini, Mir-Jamal Rostamizadeh, Kobra Anoush, Mahdieh
Published in
Brain research
Alzheimer's disease (AD) is one of the greatest geriatric medicinal challenges of our century and is the main disease leading to dementia. Despite extensive scientific research advances, available disease-modifying treatment strategies remained limited; thus, increasing demand for new drugs. In recent years, medicinal plants attracted attention due...
Godfrey, Donald A Carlson, Lissette Park, Jami L Ross, C David
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Brain research
Although there is strong evidence for cholinergic projections to the rat inferior colliculus, especially from the pedunculopontine tegmental nucleus (Noftz et al., 2020), there is a lack of information about the quantitative prevalence of the enzymes of acetylcholine metabolism in its various portions. We have used microdissection of freeze-dried s...
Mehranfard, Danial Linares, Andrea Chabbra, Alesa Campos, Glenda de Souza, Aline M A Ji, Hong West, Crystal Sandberg, Kathryn Speth, Robert C
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Brain research
Women who undergo oophorectomy prior to the age of natural menopause have a higher risk of neurological and psychological impairment. Treatment with the angiotensin receptor blocker (ARB) losartan for 10 weeks following ovariectomy of Long-Evans rats at 3 months of age reduced the ovariectomy-induced cognitive decrements. Following completion of th...
Feng, Tian Hu, Xinran Fukui, Yusuke Tadokoro, Koh Bian, Zhihong Morihara, Ryuta Yamashita, Toru Abe, Koji
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Brain research
Scallop-derived plasmalogen (sPlas) has both anti-oxidative and anti-inflammation activities, but its efficacy has not been investigated in ischemic stroke models where oxidative stress, inflammation, and neurovascular unit (NVU) damage accelerates pathophysiological progression. Therefore, in the present study, we aimed to assess the neuroprotecti...
Muradashvili, Nino Charkviani, Mariam Sulimai, Nurul Tyagi, Neetu Crosby, Jeff Lominadze, David
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Brain research
Traumatic brain injury (TBI) is associated with increased blood content of fibrinogen (Fg), called hyperfibrinogenemia (HFg), which results in enhanced cerebrovascular permeability and leads to short-term memory (STM) reduction. Previously, we showed that extravasated Fg was deposited in the vasculo-astrocyte interface and was co-localized with cel...
Marques, Danuzia A Gargaglioni, Luciane H Joseph, Vincent Bretzner, Frédéric Bícego, Kênia C Fournier, Stéphanie Kinkead, Richard
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Brain research
The neural network that regulates breathing shows a significant sexual dimorphism. Ovarian hormones contribute to this distinction as, in rats, ovariectomy reduces the ventilatory response to CO2. Microglia are neuroimmune cells that are sensitive to neuroendocrine changes in their environment. When reacting to challenging conditions, these cells s...
Kanda, Hirosato Kobayashi, Kimiko Yamanaka, Hiroki Okubo, Masamichi Dai, Yi Noguchi, Koichi
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Brain research
Prostaglandin E2 (PGE2) is a lipid mediator which plays a role in the generation of inflammatory and neuropathic pain. In the peripheral nervous system, PGE2 sensitizes nociceptive afferent neurons through E-prostanoid (EP) receptors. In the central nervous system, PGE2 modulates pain sensitivity and contributes to the development of neuropathic pa...
Cleber Gama de Barcellos Filho, Procópio... Campos Zanelatto, Leonardo Amélia Aparecida Santana, Barbara Calado, Rodrigo T Rodrigues Franci, Celso
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Brain research
Chronic stress is related to the acceleration of telomere shortening. Recent work showed a correlation between chronic psychosocial stress and reduced telomere length in certain cells. The exposure of T lymphocytes to cortisol promoted a significant reduction in telomerase activity. Although stress can promote changes in telomere length, whether in...
Feng, Pengjiu Zhang, Aimin Su, Ming Cai, Hai Wang, Xiaogang Zhang, Yan
Published in
Brain research
There is an increasing interest concerning the contribution of astrocytes to the intrinsic bioremediation of ischemic brain injury. The aim of this work was to disclose the effects and mechanism of dexmedetomidine (DEX) on the apoptosis of astrocytes under oxygen glucose deprivation (OGD) condition. Primary cultured astrocytes separated from Spragu...
Cai, Xiao Ouyang, Mingkun Yin, Yulong Zhang, Qingfang
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Brain research
Bilinguals differ substantially in their second language (L2) proficiency, but it remains unclear whether language proficiency modulates the effect of L2 semantically related distractors in L2 spoken word production. In the present study, two groups of high proficiency and low proficiency Chinese-English bilinguals named target pictures in their L2...
