Cooper-Knock, Johnathan Julian, Thomas H Feneberg, Emily Highley, J Robin Sidra, Maurice Turner, Martin R Talbot, Kevin Ansorge, Olaf Allen, Scott P Moll, Tobias
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Published in
Brain pathology (Zurich, Switzerland)
We describe an autosomal dominant, multi-generational, amyotrophic lateral sclerosis (ALS) pedigree in which disease co-segregates with a heterozygous p.Y374X nonsense mutation within TDP-43. Mislocalization of TDP-43 and formation of insoluble TDP-43-positive neuronal cytoplasmic inclusions is the hallmark pathology in >95% of ALS patients. Neurop...
Balakrishnan, Karthik Hleihil, Mohammad Bhat, Musadiq A Ganley, Robert P Vaas, Markus Klohs, Jan Zeilhofer, Hanns Ulrich Benke, Dietmar
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Brain pathology (Zurich, Switzerland)
Cerebral ischemia is the leading cause for long-term disability and mortality in adults due to massive neuronal death. Currently, there is no pharmacological treatment available to limit progressive neuronal death after stroke. A major mechanism causing ischemia-induced neuronal death is the excessive release of glutamate and the associated overexc...
Fracassi, Anna Marcatti, Michela Tumurbaatar, Batbayar Woltjer, Randall Moreno, Sandra Taglialatela, Giulio
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Brain pathology (Zurich, Switzerland)
The existence of individuals who remain cognitively intact despite presenting histopathological signs of Alzheimer's disease (AD), here referred to as "Nondemented with AD neuropathology" (NDAN), suggests that some mechanisms are triggered to resist cognitive impairment. Exposed phosphatidylserine (ePS) represents a neuronal "eat-me" signal involve...
Zhan, Lixuan Chen, Meiyan Pang, Taoyan Li, Xinyu Long, Long Liang, Donghai Peng, Linhui Sun, Weiwen Xu, En
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Brain pathology (Zurich, Switzerland)
Epigenetic modification contributes to the pathogenesis of cerebral ischemia. Piwil2 belongs to the PIWI proteins subfamily and has a key role in the regulation of gene transcription through epigenetics. However, the roles of Piwil2 in cerebral ischemia have not been investigated. In this study, we aim to elucidate the roles and the underlying mole...
Schwaiger, Carmen Haider, Thomas Endmayr, Verena Zrzavy, Tobias Gruber, Victoria E Ricken, Gerda Simonovska, Anika Hametner, Simon Schwab, Jan M Höftberger, Romana
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Brain pathology (Zurich, Switzerland)
The myelin-associated inhibitor Nogo-A (Reticulon 4, RTN4) restricts axonal outgrowth, plasticity, and neural circuitry formation in experimental models of spinal cord injury (SCI) and is targeted in clinical interventions starting treatment within 4 weeks post-SCI. Specifically, Nogo-A expressed by oligodendroglia restricts compensatory neurite sp...
Hielscher, Thomas Sill, Martin Sievers, Philipp Stichel, Damian Brandner, Sebastian Jones, David T W von Deimling, Andreas Sahm, Felix Maas, Sybren L N
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Brain pathology (Zurich, Switzerland)
Risk prediction for meningioma tumors was until recently almost exclusively based on morphological features of the tumor. To improve risk prediction, multiple models have been established that incorporate morphological and molecular features for an integrated risk prediction score. One such model is the integrated molecular-morphologic meningioma i...
Miller, Michael L Griepp, Daniel W Sun, Yu Tamir, Sean Farber, Rebecca Straus Otten, Marc L Al-Dalahmah, Osama
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Brain pathology (Zurich, Switzerland)
Fifty-three-year-old woman presented with chronic, episodic headache. © 2022 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.
Fisher, Robert A Miners, J Scott Love, Seth
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Brain pathology (Zurich, Switzerland)
Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional changes to the cerebral vasculature contribute to disease pathology and cognitive decline in Alzheimer's disease (AD). In this review, we discuss the contribution of cerebral amyloid angiopathy and non-amyloid small vessel disease in AD, and the accompanying ch...
Fan, Bu-Fang Hao, Bo Dai, Yun-Da Xue, Li Shi, Yan-Wei Liu, Lu Xuan, Shou-Min Yang, Ning Wang, Xiao-Guang Zhao, Hu
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Brain pathology (Zurich, Switzerland)
Stress-induced neuroepigenetic programming gains growing more and more interest in the studies of the etiology of posttraumatic stress disorder (PTSD). However, seldom attention is focused on DNA demethylation in fear memory generalization, which is the core characteristic of PTSD. Here, we show that ten-eleven translocation protein 3 (TET3), the m...
Laville, David Godfraind, Catherine Dal Col, Pierre Vassal, François Boutet, Claire Péoc'h, Michel Forest, Fabien
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Brain pathology (Zurich, Switzerland)