Sa, Woller Sb, Ravula Fc, Tucci G, Beaton M, Corr Rr, Isseroff Athena Soulika M, Chigbrow Ka, Eddinger Tl, Yaksh
...
Published in
Brain Behavior and Immunity
Objective: Pain resulting from local tissue injury or inflammation typically resolves with time. Frequently, however, this pain may unexpectedly persist, becoming a pathological chronic state. Increasingly, the innate and adaptive immune systems are being implicated in the initiation and maintenance of these persistent conditions. In particular, To...
Sa, Woller Sb, Ravula Fc, Tucci G, Beaton M, Corr Rivkah Isseroff Am, Soulika Marianne Chigbrow Ka, Eddinger Tl, Yaksh
...
Published in
Brain Behavior and Immunity
Objective: Pain resulting from local tissue injury or inflammation typically resolves with time. Frequently, however, this pain may unexpectedly persist, becoming a pathological chronic state. Increasingly, the innate and adaptive immune systems are being implicated in the initiation and maintenance of these persistent conditions. In particular, To...
Moynes, Derek M. Vanner, Stephen J. Lomax, Alan E.
Published in
Brain Behavior and Immunity
Inflammation involving the helper T cell 17 (Th17) subset of lymphocytes has been implicated in a number of diseases that affect the nervous system. As the canonical cytokine of Th17 cells, interleukin 17A (IL-17A) is thought to contribute to these neuroimmune interactions. The main receptor for IL-17A is expressed in many neural tissues. IL-17A ha...
Alboni, Silvia Cervia, Davide Sugama, Shuei Conti, Bruno
Published in
Journal of Neuroinflammation
Interleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. Work on IL-18 null mice, the...
Boitard, Chloé Cavaroc, Amandine Sauvant, Julie Aubert, Agnès Castanon, Nathalie Layé, Sophie Ferreira, Guillaume
Published in
Brain Behavior and Immunity
In addition to metabolic and cardiovascular disorders, obesity pandemic is associated with chronic low-grade inflammation as well as adverse cognitive outcomes. However, the existence of critical periods of development that differ in terms of sensitivity to the effects of diet-induced obesity remains unexplored. Using short exposure to a high-fat d...
Page, Gayle G. Opp, Mark R. Kozachik, Sharon L.
Published in
Brain Behavior and Immunity
Studies in humans suggest that female sex, reduced sleep opportunities and biological stress responsivity increase risk for developing persistent pain conditions. To investigate the relative contribution of these three factors to persistent pain, we employed the Sciatic Inflammatory Neuritis (SIN) model of repeated left sciatic perineurial exposure...
Della Gatta, Paul A. Garnham, Andrew P. Peake, Jonathan M. Cameron-Smith, David
Published in
Brain Behavior and Immunity
Aging is associated with increased circulating pro-inflammatory and lower anti-inflammatory cytokines. Exercise training, in addition to improving muscle function, reduces these circulating pro-inflammatory cytokines. Yet, few studies have evaluated changes in the expression of cytokines within skeletal muscle after exercise training. The aim of th...
Prieto-Hinojosa, Adria Knight, Andrea Compton, Claude Gleeson, Michael Travers, Paul J.
Published in
Brain Behavior and Immunity
Athletes undergoing intensive training schedules have chronic exposure to stress-induced hormones such as cortisol that can depress immune function. We compared the circulating levels of T cell receptor excision circles (TREC), a marker of recent thymic emigrants, as well as the levels of naïve and memory subsets in a group of elite endurance athle...
Hutson, Lee W. Szczytkowski, Jennifer L. Saurer, Timothy B. Lebonville, Christina Fuchs, Rita A. Lysle, Donald T.
Published in
Brain Behavior and Immunity
Dopamine receptor stimulation is critical for heroin-conditioned immunomodulation; however, it is unclear whether the ventral tegmental area (VTA) contributes to this phenomenon. Hence, rats received repeated pairings of heroin with placement into a distinct environmental context. At test, they were re-exposed to the previously heroin-paired enviro...
Flex, Andrea Giovannini, Silvia Biscetti, Federico Liperoti, Rosa Spalletta, Gianfranco Straface, Giuseppe Landi, Francesco Angelini, Flavia Caltagirone, Carlo Ghirlanda, Giovanni
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Published in
Neurodegenerative Diseases
Background: A number of studies associate Alzheimer's disease (AD) with APOE polymorphism and alleles which favor the increased expression of immunological mediators such as cytokines or acute-phase proteins. Objective: In this study we evaluated the distribution of a set of functionally important polymorphisms of genes encoding prototypical inflam...
