Martin, Ludovic Kaci, Nabil Benoist-Lasselin, Catherine Mondoloni, Marine Decaudaveine, Suzanne Estibals, Valentin Cornille, Maxence Loisay, Léa Flipo, Justine Demuynck, Benoît
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Published in
Bone Research
A gain-of-function mutation in the fibroblast growth factor receptor 3 gene (FGFR3) results in achondroplasia (ACH), the most frequent form of dwarfism. Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways. Identification of new and relevant compounds targeting the FGFR3 signaling pathway is o...
Li, Xinhua Yang, Shuting Yuan, Gongsheng Jing, Dian Qin, Ling Zhao, Hu Yang, Shuying
Published in
Bone research
Type II collagen-positive (Col2+) cells have been reported as skeletal stem cells (SSCs), but the contribution of Col2+ progenitors to skeletal development both prenatally and postnatally during aging remains unclear. To address this question, we generated new mouse models with ablation of Col2+ cells at either the embryonic or postnatal stages. Th...
Guo, Dong Lin, Chuangxin Lu, Yuheng Guan, Hong Qi, Weizhong Zhang, Hongbo Shao, Yan Zeng, Chun Zhang, Rongkai Zhang, Haiyan
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Published in
Bone Research
Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis (RA). Fatty acid-binding protein 4 (FABP4), a novel adipokine that regulates inflammation and angiogenesis, has been extensively studied in a variety of organs and diseases. However, the effect of FABP4 on RA remains unclear. Here, we found that F...
Zhen, Gehua Fu, Yuhan Zhang, Chi Ford, Neil C. Wu, Xiaojun Wu, Qichao Yan, Dong Chen, Xueming Cao, Xu Guan, Yun
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Published in
Bone Research
The field of research on pain originating from various bone diseases is expanding rapidly, with new mechanisms and targets asserting both peripheral and central sites of action. The scope of research is broadening from bone biology to neuroscience, neuroendocrinology, and immunology. In particular, the roles of primary sensory neurons and non-neuro...
Qin, Qizhi Gomez-Salazar, Mario Cherief, Masnsen Pagani, Chase A Lee, Seungyong Hwang, Charles Tower, Robert J Onggo, Sharon Sun, Yuxiao Piplani, Abhinav
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Published in
Bone research
The functional interdependence of nerves and blood vessels is a well-established concept during tissue morphogenesis, yet the role of neurovascular coupling in proper and aberrant tissue repair is an emerging field of interest. Here, we sought to define the regulatory relationship of peripheral nerves on vasculature in a severe extremity trauma mod...
Ding, Peng Tan, Qiyuan Wei, Zhanying Chen, Qiyu Wang, Chun Qi, Luyue Wen, Li Zhang, Changqing Yao, Chen
Published in
Bone research
Toll-like receptors (TLRs) play pivotal roles in inflammation and provide important links between the immune and skeletal systems. Although the activation of TLRs may affect osteoclast differentiation and bone metabolism, whether and how TLRs are required for normal bone remodeling remains to be fully explored. In the current study, we show for the...
Li, Yusheng Xie, Wenqing Xiao, Wenfeng Dou, Dou
Published in
Bone Research
Osteoarthritis (OA) in China is gradually becoming an important scientific research area that has had a significant impact on research and development (R&D) activities in the OA field worldwide. This article summarizes the R&D progress related to OA in China in recent years. The National Natural Science Foundation of China (NSFC) is a national fund...
Tian, Taoran Li, Yanjing Lin, Yunfeng
Published in
Bone Research
The physicochemical nature of DNA allows the assembly of highly predictable structures via several fabrication strategies, which have been applied to make breakthroughs in various fields. Moreover, DNA nanostructures are regarded as materials with excellent editability and biocompatibility for biomedical applications. The ongoing maintenance and re...
Chen, Yishan Yu, Yeke Wen, Ya Chen, Juan Lin, Junxin Sheng, Zixuan Zhou, Wenyan Sun, Heng An, Chengrui Chen, Jiansong
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Published in
Bone Research
Chen, Yishan Yu, Yeke Wen, Ya Chen, Juan Lin, Junxin Sheng, Zixuan Zhou, Wenyan Sun, Heng An, Chengrui Chen, Jiansong
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Published in
Bone research
Articular cartilage damage is a universal health problem. Despite recent progress, chondrocyte dedifferentiation has severely compromised the clinical outcomes of cell-based cartilage regeneration. Loss-of-function changes are frequently observed in chondrocyte expansion and other pathological conditions, but the characteristics and intermediate mo...
