Einsele, Hermann Rasche, Leo Topp, Max S. Martin Kortüm, K. Duell, Johannes
Published in
Bone Marrow Transplantation
One of the remaining and unresolved problems in allogeneic stem cell transplantation, especially following a T cell-depleted transplant as often performed in the setting of haploidentical transplantation, is the relapse of the underlying hematological malignancy. It has been demonstrated that in the last years we have made major progress in control...
Mendt, Mayela Rezvani, Katayoun Shpall, Elizabeth
Published in
Bone Marrow Transplantation
Mesenchymal stem/stromal cells (MSCs) are commonly used as a source of cellular therapy due to their strong immunosuppressive and regenerative effects. One of the key mechanisms of MSC efficacy appears to derive from their paracrine activity. Recently, it has been shown that the secretion of different factors through extracellular vesicles known as...
Nagler, Arnon Ruggeri, Annalisa
Published in
Bone Marrow Transplantation
Allogeneic stem cell transplantations (alloSCT) from haploidentical (>2 HLA mismatch) donors (HaploSCT) are constantly increasing in Europe. From 2005 to 2015 numbers of HaploSCT increased by close to 300%. In parallel, there is a major shift from T deplete (CD34+ megadose) to T replete (non-T deplete) HaploSCT. Graft versus host disease (GVHD) pro...
Negrin, Robert S.
Published in
Bone Marrow Transplantation
Immune regulation is critically important in health and disease. These immune effects have direct relevance in the setting of allogeneic hematopoietic cell transplantation (HCT), principally for the control of aberrant immune reactions, such as graft-versus-host disease (GVHD). Murine models have been critically important to evaluate the potential ...
Lv, Meng Chang, Ying-jun Huang, Xiao-jun
Published in
Bone Marrow Transplantation
As one of the three successful approaches for haplo-identical stem cell transplantation (haplo-SCT) in recent decades, “Beijing protocol” was based on immune tolerance induced by granulocyte colony-stimulating factor plus anti-thymocyte globulin, which included individualized conditioning regimens, novel donor selection algorithm, and risk-directed...
Rezvani, Katayoun
Published in
Bone Marrow Transplantation
The generation of autologous T cells expressing a chimeric antigen receptor (CAR) have revolutionized the field of adoptive cellular therapy. CAR-T cells directed against CD19 have resulted in remarkable clinical responses in patients affected by B-lymphoid malignancies. However, the production of allogeneic CAR-T cells products remains expensive a...
Ciurea, Stefan O.
Published in
Bone Marrow Transplantation
Haploidentical transplantation is increasingly performed worldwide due to novel methods to control alloreactivity between the donor and recipient. This major advancement has increased donor availability to almost all patients in need. Outcomes with haploidenitcal donors have also improved and prompted many groups to compare outcomes between haploid...
Gale, Robert Peter
Published in
Bone Marrow Transplantation
Many typescripts in this issue describe increasing use of HLA-haplotype-matched transplants in persons with leukaemia and report outcomes. Consequently, my goal is not to repeat these data but to focus on controversies and challenges relevant to this topic including: (1) what is the best technique for performing these transplants; (2) who is the be...
Oevermann, Lena Schulte, Johannes H. Hundsdörfer, Patrick Hakimeh, Dani Kogel, Friederike Lang, Peter Corbacioglu, Selim Eggert, Angelika Sodani, Pietro
Published in
Bone Marrow Transplantation
We review current approaches in HLA-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for pediatric patients with hemoglobinopathies with a focus on recent developments using TCRα/β+/CD19+ depleted grafts in patients with β-thalassemia major (TM) or sickle cell disease (SCD) in two European transplant units. Eleven TM and three SC...
Prezioso, Lucia Manfra, Ilenia Bonomini, Sabrina Schifano, Chiara Segreto, Roberta Monti, Alessandro Sammarelli, Gabriella Todaro, Giannalisa Sassi, Maria Bertaggia, Ilaria
...
Published in
Bone Marrow Transplantation
In patients with hematological malignancies at high risk for relapse, a mismatched hematopoietic stem cells transplants can be offered with no undue delay between decision-making and transplantation as virtually all patients have a full-haplotype mismatched member who could serve immediately as a donor. Using a T-cell depletion approach, these pati...
