Nishida, Ryota Fukui, Tomoaki Niikura, Takahiro Kumabe, Yohei Yoshikawa, Ryo Takase, Kyohei Yamamoto, Yuya Kuroda, Ryosuke Oe, Keisuke
Published in
Bone
We previously demonstrated that transcutaneous CO2 application promotes muscle fiber-type switching, fracture healing, and osteogenesis by increasing blood flow and angiogenesis. Here, we aimed to investigate the preventive effects of transcutaneous CO2 application on disuse osteoporosis and muscle atrophy in a rat hindlimb suspension model. Eleven...
Yu, Ting Chen, Manci Wen, Jing Liu, Juan Li, Ke Jin, Lei Yue, Jiang Yang, Zheqiong Xi, Jinlei
Published in
Bone
Glucocorticoids (GCs) are extensively used as anti-inflammatory and immunosuppressive medications in the long-term treatment of rheumatic disorders, respiratory diseases, renal diseases, and organ transplantation. Prolonged use of GCs can reduce bone mineral density, leading to osteoporosis (Glucocorticoid Induced Osteoporosis, GIOP) and fracture. ...
Civil, Rita Brook, Matthew S Santos, Lívia Varley, Ian Elliott-Sale, Kirsty J Lensu, Sanna Ahtiainen, Juha P Kainulainen, Heikki Koch, Lauren G Britton, Steven L
...
Published in
Bone
Bone is influenced by many factors such as genetics and mechanical loading, but the short-term physiological effects of these factors on bone (re)modelling are not well characterised. This study investigated the effects of endurance trainability phenotype, sex, and interval running training (7-week intervention) on bone collagen formation in rats u...
O'Leary, Thomas J Izard, Rachel M Tang, Jonathan C Y Fraser, William D Greeves, Julie P
Published in
Bone
Military training increases tibial density and size. Female sex hormones may influence the adaption of bone to loading, but it is unknown if women using different hormonal contraceptives adapt similarly to military training. One hundred and sixteen women (57 women not using hormonal contraceptives [non-users], 38 combined oral contraceptive pill [C...
Behanova, Martina Medibach, Amadea Haschka, Judith Kraus, Daniel Raimann, Adalbert Mindler, Gabriel T Zwerina, Jochen Kocijan, Roland
Published in
Bone
To assess physical and mental health domains of health related quality of life (HRQoL) as well as fatigue in rare bone disease (RBD) patients and to compare to patients with osteoporosis (OPO) and healthy controls (CTRL) without known bone diseases and to study associations of Fatique Severity Scale (FSS) with eight domains of HRQoL. Monocentric, c...
Prijatelj, Vid Grgic, Olja Uitterlinden, André G Wolvius, Eppo B Rivadeneira, Fernando Medina-Gomez, Carolina
Published in
Bone
Bone Health Index (BHI) has been proposed as a useful instrument for assessing bone health in children. However, its relationship with fracture risk remains unknown. We aimed to investigate whether BHI is associated with bone mineral density (BMD) and prevalent fracture odds in children from the Generation R Study. We also implemented genome-wide a...
Del Rio Cantero, Natalia Mourelle Martínez, María Rosa Sagastizabal Cardelús, Belén De Nova García, Joaquín Manuel
Published in
Bone
Osteogenesis imperfecta (OI) is a congenital disease comprising a heterogeneous group of inherited connective tissue disorders. The main treatment in children is bisphosphonate therapy. Previous animal studies have shown that bisphosphonates delay tooth eruption. The aim of this study is to determine whether patients with OI treated with pamidronat...
Rowe, Cassie J Nwaolu, Uloma Salinas, Daniela Lansford, Jefferson L McCarthy, Conor F Anderson, Joseph A Valerio, Michael S Potter, Benjamin K Spreadborough, Philip J Davis, Thomas A
...
Published in
Bone
Blast-related traumatic heterotopic ossification (tHO) impacts clinical outcomes in combat-injured patients, leading to delayed wound healing, inflammatory complications, and reduced quality of life. Blast injured patients often have significant burns. This study investigated whether a partial thickness thermal burn injury exacerbates blast-related...
Kohler, Rachel Creecy, Amy Williams, David R Allen, Matthew R Wallace, Joseph M
Published in
Bone
Osteogenesis imperfecta (OI) is a hereditary bone disease in which gene mutations affect collagen formation, leading to a weak, brittle bone phenotype that can cause severe skeletal deformity and increased fracture risk. OI interventions typically repurpose osteoporosis medications to increase bone mass, but this approach does not address compromis...
Park, So Jeong Ji, Eunhye Yoo, Hyun Ju Kim, Kyunggon Ji, Sunghwan Baek, Ji Yeon Lee, Jin Young Jung, Hee-Won Jang, Il-Young Lee, Eunju
...
Published in
Bone
In vitro and animal experiments demonstrated that lumican exerts anabolic effects on bone and muscle by stimulating osteoblastogenesis, suppressing osteoclastogenesis and increasing myogenesis. However, the relationship between circulating lumican and musculoskeletal phenotypes in humans remains unclear. We aimed to analyze the relationship between...
