Published in Biotechnology advances
In recent years, extracellular vesicles (EVs), specifically exosomes, have emerged as a promising strategy for treating a wide spectrum of pathologies, such as cancer and COVID-19, as well as promoting tissue regeneration in various conditions, including cardiomyopathies and spinal cord injuries. Despite the great potential of EV-based therapies, p...
Published in Biotechnology advances
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the deadly coronavirus disease 2019 (Covid-19) and is a concerning hazard to public health. This virus infects cells by establishing a contact between its spike protein (S-protein) and host human angiotensin-converting enzyme 2 (hACE2) receptor, subsequently initiat...
Published in Biotechnology advances
Peroxygenases are an emerging new class of enzymes allowing selective oxyfunctionalisation reactions in a cofactor-independent way different from well-known P450 monooxygenases. Herein, we focused on recent developments from organic synthesis, molecular biotechnology and reaction engineering viewpoints that are devoted to bring these enzymes in ind...
Published in Biotechnology advances
The ability to engineer biological systems, whether to introduce novel functionality or improved performance, is a cornerstone of biotechnology and synthetic biology. Typically, this requires the generation of genetic diversity to explore variations in phenotype, a process that can be performed at many levels, from single molecule targets (i.e., in...
Published in Biotechnology advances
Aquaculture is playing an increasingly important role in meeting global demands for seafood, particularly in low and middle income countries. Genetic improvement of aquaculture species has major untapped potential to help achieve this, with selective breeding and genome editing offering exciting avenues to expedite this process. However, limitation...
Published in Biotechnology advances
Keratin is an insoluble and protein-rich epidermal material found in e.g. feather, wool, hair. It is produced in substantial amounts as co-product from poultry processing plants and pig slaughterhouses. Keratin is packed by disulfide bonds and hydrogen bonds. Based on the secondary structure, keratin can be classified into α-keratin and β-keratin. ...
Published in Biotechnology Advances
• Overview on current DNA data storage technologies and commercialization hurdles • Insights from leading DNA data storage experts and investment financing data • DNA synthesis remains the biggest challenge in the industry • Archiving cold data is the low-hanging fruit in DNA data storage • Upwards trend in investment landscape suggests optimal sta...
Published in Biotechnology advances
The Vero cell line is considered the most used continuous cell line for the production of viral vectors and vaccines. Historically, it is the first cell line that was approved by the WHO for the production of human vaccines. Comprehensive experimental data on the production of many viruses using the Vero cell line can be found in the literature. Ho...
Published in Biotechnology advances
Bioelectrochemical systems combine electrodes and reactions driven by microorganisms for many different applications. The conversion of organic material in wastewater into electricity occurs in microbial fuel cells (MFCs). The power densities produced by MFCs are still too low for application. One way of increasing their performance is to combine t...
Published in Biotechnology Advances
A major feature of twenty-first century medical research is the development of therapeutic strategies that use ‘biologics’ (large molecules, usually engineered proteins) and living cells instead of, or as well as, the small molecules that were the basis of pharmacology in earlier eras. The high power of these techniques can bring correspondingly hi...
